Effects of short-term in-season break detraining on repeated-sprint ability and intermittent endurance according to initial performance of soccer player

To better understand the detraining effects in soccer, the purpose of the study was to ana- lyse if performance level of soccer players modulate repeated-sprint ability (RSA) and inter- mittent endurance changes during 2-weeks of detraining (i.e., in-season break). Seventeen professional and sixteen young elite soccer players of two different teams performed, before and after 2-weeks of detraining, the RSA test and the Yo-Yo Intermittent Recovery Test, level 1 (YYIR1). Before detraining, professional players perform better (p < 0.05) RSA best time (RSAbest) than young players. A decrease (p < 0.05) in RSAbest, RSA total time (RSAtotal) and mean time (RSAmean) performance was observed in both teams, without changes in RSA fatigue index (Sdec). No significant changes in distance covered during YYIR1 was observed in any team. Before detraining, faster players from both teams (FG) (following the median split technique, soccer players with RSAbest 3.95 s) performed bet- ter (p < 0.01) in RSAtotal, RSAmean and RSAbest, but worse (p < 0.01) in Sdec. Although FG and the slower players (SG, RSAbest > 3.95 s) showed a worse (p < 0.05) RSAtotal, RSAbest and RSAmean performance after detraining (ES = 1.5, 1.4 and 2.9; ES = 0.6, 1.2 and 0.6; for FG and SG, respectively), the deterioration was greater in the FG for RSAbest (p < 0.05) and RSAtotal (ES = 1.46). After detraining, FG improved (p < 0.05) Sdec performance. In conclu- sion, a 2-week in-season break (detraining) period induced a worse RSA, with no effect on intermittent endurance in professional and elite young soccer players, with greater detrimen- tal effects on RSAtotal and RSAbest in FG. In addition, Sdec does not seem to be sensitive to changes in RSA after a 2-week in-season break.S

Modelo de optimización para apoyar la planificación y programación de la producción en la industria porcina

167 p.El presente documento proporciona un avance en el ámbito de la Planificación de la Producción en la industria porcina chilena enmarcado en la tesis de magíster en gestión de operaciones, la cual en términos generales, tiene como objetivo central el diseño de un modelo de planificación de la producción, el cual es complementado con modelos de análisis de eficiencia a través de análisis envolvente de datos. En conjunto, estas herramientas proporcionan un sugerido de producción a los tomadores de decisiones considerando una configuración cercana al óptimo para asegurar el buen desempeño de los procesos centrales del sistema de producción en una planta faenadora y exportadora de carne de cerdo representativa del sector Porcícola chileno. La planificación y programación de la producción ha sido objeto de mucha investigación, la cual ha justificado la importancia de ésta dentro de las cadenas de valor de las empresas, tendiendo impactos en todo el proceso productivo. En este sentido, el año 2009 fue crítico para la industria porcina. La crisis financiera mundial con la caída de los mercados mundiales, el aumento de los precios de los insumos y del petróleo, las variaciones en el tipo de cambio y la pérdida de rentabilidad que se arrastraba desde el 2008, obligaron a realizar ajustes en la producción porcina nacional e internacional. Conversaciones con personal operativo de una empresa perteneciente a la Asociación Gremial de Productores de Cerdo de Chile (ASPROCER), indican la inexistencia de sistemas que apoyen el proceso de faena desde el punto de vista de la optimización de la producción. Luego de una minuciosa revisión de autores, se concluyó que la gran mayoría de éstos han enfocado los esfuerzos mediante la utilización de modelos jerárquicos para la producción, siendo el sector cárnico el menos referenciado, por lo que ésta tesis se presenta como un aporte al estado del arte y como soporte de una industria en vías de crecimiento.Palabras clave: Planificación de la producción, calendarización de la producción, industria porcina./ABSTRACT: This document provides an advance in the field of Production Planning in Chilean pork industry framed the thesis master's degree in operations management, which broadly aims at designing a central planning model production, which is complemented with models of efficiency analysis through data envelopment analysis. Together, these tools provide a suggested plan production decision makers considering a near-optimal settings to ensure the good performance of the core processes of the production system in a slaughtering plant and exporter of pork representative of Chilean pork industry. The planning and production scheduling has been the subject of much research, which has justified its importance within the value chains of companies, tending impacts on the production process. In this sense, the year 2009 was critical to the swine industry. The global financial crisis with the collapse of world markets, rising input prices and oil, changes in the exchange rate and loss of profitability crawling since 2008, forced to make adjustments in production national and international swine. Discussions with operational staff of a company belonging to ASPROCER indicate the lack of systems to support the slaughter process from the point of view of production optimization.After a thorough review authors concluded that the vast majority have focused their efforts through the use of hierarchical models for production, the meat sector being the least referenced, so this thesis is presented as a contribution to the state of art and as support for industry on a growth path. Key Words: production planning, scheduling production planning, pork industry

Synthesis, Biological Evaluation, and Molecular Docking Study of 3-Amino and 3-Hydroxy-seco A Derivatives of α-Amyrin and 3-Epilupeol as Inhibitors of COX-2 Activity and NF-kB Activation

In this study, a series of novel 3-seco-A derivatives of the natural triterpenes α-amyrin (1) and 3-epilupeol (2) were synthesized by a one-pot radical scission–oxidation procedure and evaluated in vitro and in vivo for their capacity to inhibit the inflammatory process. For the in vitro studies, the trans-4-hydroxy-l-proline methyl ester derivatives (1f and 2f) were consistently effective in inhibiting NO, IL-6, and TNF-α secretion, as well as inhibition of NF-κB activation, in RAW cells stimulated by LPS. The further in vivo anti-inflammatory study revealed that the trans-4-hydroxy-l-proline methyl ester derivatives (1f and 2f), together with 1g, were the most effective in inhibiting TPA-induced edema. Interestingly, the α-amyrin derivatives were the most potent inhibitors of COX-2, but inhibited COX-1 only to some extent. The hydroxyl derivative (1c) was selective for COX-2 inhibition (66.3 ± 1.1% at 17.5 μM) without affecting the COX-1 isoform and did not present toxicity. Molecular docking studies revealed that these compounds bind with their polar region in the cavity over Arg-120, and their lipophilic part is orientated to the HEM cofactor similarly to the natural substrate arachidonic acid in the catalytic site of COX-2. These results indicated that seco-A ursane derivatives could be considered promising candidates for the future development of selective NF-κB and COX-2 inhibitors.This work was supported by funding from the Consejo Nacional de Ciencia y Tecnología (Grants CB2014-01 240801 and LN294406). A.R.E. acknowledges fellowship no. 253953 from CONACyT. The authors thank Laboratorio Nacional de Estructura de Macromoléculas for the NMR and mass data and Dr. Mario Leyva of Universidad de Sonora and Dr. Zeferino Gómez of Universidad de Colima for the software facilities.Peer reviewe

Paleoecología y cultura material en el complejo tumular prehistórico de Castillejo del Bonete (Terrinches, Ciudad Real)

Castillejo del Bonete es un complejo tumular situado en el borde meridional de la Meseta Ibérica, ocupado en fechas calcolíticas y de la Edad del Bronce, vinculado a la Cultura de las Motillas. Materiales arqueológicos muy diversos han sido recuperados asociados a las arquitecturas del lugar (túmulos, corredores, potentes muros, etc.). Se presenta un avance de la investigación paleoecológica sobre las colecciones de carbón, polen y microvertebrados. Además se presentan cuentas de piedra y madera, colgantes de concha, material lítico, la colección cerámica, nuevas metalografías e industria metálica y botones de marfil. El conjunto de estas evidencias arqueológicas pone de manifiesto la celebración ritual de banquetes y ofrendas durante la Prehistoria Reciente en una cueva monumentalizada mediante túmulos en el interior de la Península Ibérica

Lo glocal y el turismo. Nuevos paradigmas de interpretación.

El estudio del turismo se realiza desde múltiples escalas y enfoques, este libro aborda muchos temas que es necesario discutir desde diversas perspectivas; es el caso de la reflexión sobre la propia disciplina y sus conceptos, así como los asuntos específicos referidos al impacto territorial, los tipos de turismo, las cuestiones ambientales, el tema de la pobreza, la competitividad, las políticas públicas, el papel de las universidades, las áreas naturales protegidas, la sustentabilidad, la cultura, el desarrollo, la seguridad, todos temas centrales documentados y expuestos con originalidad y dominio del asunto. Lo multiescalar es básico para la comprensión del sistema turístico, sistema formado de procesos globales, regionales y locales. El eje de discusión del libro es lo glocal, esa interacción entre lo nacional y local con lo global

Salud de los trabajadores

Actividad f&iacute;sica y su relaci&oacute;n con los factores de riesgo cardiovascular de carteros chilenosAn&aacute;lisis de resultados: riesgos psicosociales en el trabajo Suceso-Istas 21 en Cesfam Quell&oacute;nAusentismo laboral por enfermedades oftalmol&oacute;gicas, Chile 2009Brote de diarreas por norovirus, posterremoto-tsunami, Constituci&oacute;n, Regi&oacute;n del MauleCalidad de vida en profesionales de la salud p&uacute;blica chilenaCaracterizaci&oacute;n del reposo laboral en personal del SSMN durante el primer semestre de 2010Concentraci&oacute;n de nicotina en pelo en trabajadores no fumadores expuestos a humo de tabaco ambientalCondiciones de trabajo y bienestar/malestar docente en profesores de ense&ntilde;anza media de SantiagoDisfunci&oacute;n auditiva inducida por exposici&oacute;n a xilenoErgonom&iacute;a aplicada al estudio del s&iacute;ndrome de dolor lumbar en el trabajoEstimaci&oacute;n de la frecuencia de factores de riesgo cardiovascular en trabajadores de una empresa mineraExposici&oacute;n a plaguicidas inhibidores de la acetilcolinesterasa en Colombia, 2006-2009Factores de riesgo y da&ntilde;os de salud en conductores de una empresa peruana de transporte terrestre, 2009Las consecuencias de la cultura en salud y seguridad ocupacional en una empresa mineraPercepci&oacute;n de cambios en la pr&aacute;ctica m&eacute;dica y estrategias de afrontamientoPercepci&oacute;n de la calidad de vida en la Universidad del Biob&iacute;oPesos m&aacute;ximos aceptables para tareas de levantamiento manual de carga en poblaci&oacute;n laboral femeninaRiesgo coronario en trabajadores mineros seg&uacute;n la funci&oacute;n de Framingham adaptada para la poblaci&oacute;n chilenaTrastornos emocionales y riesgo cardiovascular en trabajadores de la salu

The earliest basketry in southern Europe: Hunter-gatherer and farmer plant-based technology in Cueva de los Murciélagos (Albuñol)

Copyright © 2023 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Plant material culture can offer unique insights into the ways of life of prehistoric societies; however, its perishable nature has prevented a thorough understanding of its diverse and complex uses. Sites with exceptional preservation of organic materials provide a unique opportunity for further research. The burial site of Cueva de los Murciélagos in southern Iberia, uncovered during 19th-century mining activities, contained the best-preserved hunter-gatherer basketry in southern Europe, together with other unique organic artifacts associated with the first farming communities, such as sandals and a wooden hammer. We present 14 14C dates for the perishable artifacts (N = 76), situating the assemblage between the Early and Middle Holocene (c. 7500 to 4200 cal BCE). Our integrated analysis includes raw material determination and technological and chrono-cultural contextualization of this unique and important set of materials.This work was supported by the project “De los museos al territorio: actualizando el estudio de la Cueva de los Murciélagos de Albuñol (Granada)” (MUTERMUR) (Referencia CM/JIN/2021-009) financed by the program of Young Researchers of Comunidad de Madrid (directed by F.M.-S. as the principal investigator). J.S. is funded by Ramon y Cajal fellowship (RYC2019-028346) by the Spanish Ministry of Science and Innovation (MCIN). M.C. is funded by a Ramón y Cajal fellowship (RYC2019-026697-I) and by the Spanish Ministry of Science and Innovation (MCIN). R.P.H., M.H.-O., and A.P.P. are members of the research group 2021-SGR 00190 funded by the AGAUR. R.P.H. is an ICREA academia researcher. M.M.-S. was funded by the Beatriz Galindo program as Junior Distinguished Researcher (BG20/00076)Peer reviewe

The earliest basketry in southern Europe: Hunter- gatherer and farmer plant-based technology in Cueva de los Murciélagos (Albuñol)

Plant material culture can offer unique insights into the ways of life of prehistoric societies; however, its perish- able nature has prevented a thorough understanding of its diverse and complex uses. Sites with exceptional preservation of organic materials provide a unique opportunity for further research. The burial site of Cueva de los Murciélagos in southern Iberia, uncovered during 19th-century mining activities, contained the best-pre- served hunter-gatherer basketry in southern Europe, together with other unique organic artifacts associated with the first farming communities, such as sandals and a wooden hammer. We present 14 14C dates for the perishable artifacts (N = 76), situating the assemblage between the Early and Middle Holocene (c. 7500 to 4200 cal BCE). Our integrated analysis includes raw material determination and technological and chrono-cul- tural contextualization of this unique and important set of materials.Peer reviewe

Impact of Biological Agents on Postsurgical Complications in Inflammatory Bowel Disease : A Multicentre Study of Geteccu

Background: The impact of biologics on the risk of postoperative complications (PC) in inflammatory bowel disease (IBD) is still an ongoing debate. This lack of evidence is more relevant for ustekinumab and vedolizumab. Aims: To evaluate the impact of biologics on the risk of PC. Methods: A retrospective study was performed in 37 centres. Patients treated with biologics within 12 weeks before surgery were considered "exposed". The impact of the exposure on the risk of 30-day PC and the risk of infections was assessed by logistic regression and propensity score-matched analysis. Results: A total of 1535 surgeries were performed on 1370 patients. Of them, 711 surgeries were conducted in the exposed cohort (584 anti-TNF, 58 vedolizumab and 69 ustekinumab). In the multivariate analysis, male gender (OR: 1.5; 95% CI: 1.2-2.0), urgent surgery (OR: 1.6; 95% CI: 1.2-2.2), laparotomy approach (OR: 1.5; 95% CI: 1.1-1.9) and severe anaemia (OR: 1.8; 95% CI: 1.3-2.6) had higher risk of PC, while academic hospitals had significantly lower risk. Exposure to biologics (either anti-TNF, vedolizumab or ustekinumab) did not increase the risk of PC (OR: 1.2; 95% CI: 0.97-1.58), although it could be a risk factor for postoperative infections (OR 1.5; 95% CI: 1.03-2.27). Conclusions: Preoperative administration of biologics does not seem to be a risk factor for overall PC, although it may be so for postoperative infections

Now, the part of intuition. Research, Art and Creation, 2018

Catálogo de Exposición del Máster en Investigación en Arte y Creación de la UCM. Muestra celebrada del 25 de septiembre al 10 de octubre de 2018 en la Sala de Exposiciones de la Facultad de Bellas Artes. C / Pintor el Greco 2, Ciudad Universitaria. 28040 Madrid. Comisariado de Javier Mañero Rodicio.Exhibition catalog of the Master in Art and Creation Research of the UCM. September 25 to October 10, 2018 in the Exhibition Hall of the Faculty of Fine Arts. C / Pintor El Greco 2, University City. 28040 Madrid. Curated by Javier Mañero Rodicio.Fac. de Bellas ArtesFALSEFacultad de Bellas Artes. Universidad Complutense de Madrid.pu