S. Anselmi archiepiscopi Cantuariensis... Theologia commentariis et disputationibus, tum dogmaticas, tum scholasticis illustrata : tomus primus, De Deo Deique proprietatibus, in monologion sancti doctoris...

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S. Anselmi Archiepiscopi Cantuarensis... Theologia commentariis et disputationibus subtilitas, tum dogmaticis, tum scholasticis illustrata ... : tomus secundus... De Sacrosancto Trinitatis Mysterio...

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Kharitonov Theorem Based Robust Stability Analysis of a Wind Turbine Pitch Control System

Wind energy has recently become one of the most prominent technologies among electrical energy generation systems. As a result, wind-based renewable energy generation systems are incessantly growing, and wind turbines of different characteristics are being installed in many locations around the world. One drawback associated with different characteristics of the wind turbines is that controllers have to be designed individually for each of them. Additionally, stable performance of the wind turbines needs to be ensured in the whole range of their operating conditions. Nowadays, there are many causes for uncertainties in the actual performance of a horizontal axis wind turbine, such as variations in the characteristics of the wind turbine, fabrication tolerances of its elements or non-linearities related to different operating-points. Hence, in order to respond to these uncertainties and ensure the stability of the wind turbine, robust control and stability theories have been gaining importance during recent years. Nevertheless, the use of robust stability analyses with complex wind turbine models still needs to be faced and remarkably improved. In this paper, a stability analysis of the pitch system control of a horizontal axis wind turbine based on the Kharitonov robust stability method is proposed. The objective was to assess the robust stability of a pitch controller in response to uncertainties arising from varying operating conditions of the National Renewable Energies Laboratory (NREL) 5 MW class IIA wind turbine. According to the results, the proposed method could satisfactorily respond to limited variations in the characteristics of the model, but could lack accuracy in cases of bigger variations or employment of high order complex mathematical models.This research was financed by the Government of the Basque Country through the ELKARTEK program KK-2019/00099 MARGA and by EHU 12/26 research program of the University of the Basque Country UPV/EHU

Semantic Segmentation to Develop an Indoor Navigation System for an Autonomous Mobile Robot

In this study, a semantic segmentation network is presented to develop an indoor navigation system for a mobile robot. Semantic segmentation can be applied by adopting different techniques, such as a convolutional neural network (CNN). However, in the present work, a residual neural network is implemented by engaging in ResNet-18 transfer learning to distinguish between the floor, which is the navigation free space, and the walls, which are the obstacles. After the learning process, the semantic segmentation floor mask is used to implement indoor navigation and motion calculations for the autonomous mobile robot. This motion calculations are based on how much the estimated path differs from the center vertical line. The highest point is used to move the motors toward that direction. In this way, the robot can move in a real scenario by avoiding different obstacles. Finally, the results are collected by analyzing the motor duty cycle and the neural network execution time to review the robot’s performance. Moreover, a different net comparison is made to determine other architectures’ reaction times and accuracy values.This research was financed by the plant of Mercedes-Benz Vitoria through the PIF program to develop an intelligent production. Moreover, The Regional Development Agency of the Basque Country (SPRI) is gratefully acknowledged for their economic support through the research project “Motor de Accionamiento para Robot Guiado Automáticamente”, KK-2019/00099, Programa ELKARTEK

S. Anselmi Archiepiscopi Cantuariensis ... Theologia commentariis et disputationibus, tum dogmaticis, tum scholasticis illustrata : tomus tertius, De natura hominis pura et lapsa ...

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Philosophia nov-antiqua seu Disputationes in universam physiologiam Aristotelis : cuius antiquae sententiae sicut et D. Thomae plerunque noviter elucidantur speciatin fulciuntur et ab impugnationibus praesertin recentibus vindicantur ...

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Producción científica en innovación: Revisión sistemática de literatura

[ES] El presente estudio tiene como objetivo analizar artículos que abordan innovación , con el fin de identificar conceptos, definiciones y tipos de innovación. El método para llevar acabo el estudio fue una revisión sistemática de literatura (SLR) el cual consta de 3 fases. La fase 1 planificación; donde se orienta a seleccionar bases de datos pertinentes y la búsqueda a partir de palabras claves. La fase 2 conducción; se evalúa y extraen los datos con base a los objetivos planteados. Fase 3 informe de resultados; se enfoca a validar los criterios considerando calidad y pertinencia de los estudios encontrados. Hacer una búsqueda de la literatura para obtener cómo se define la innovación puede ser complicado, ya que la palabra innovación se emplea en diversos contextos, sectores y disciplinas, por lo cual dependiendo el enfoque de tema al que se pretenda indagar se obtendrán distintas narraciones sobre la definición de la innovación. Como resultado se obtuvo el análisis de 103 artículos publicados en acceso abierto, de enero 2017 a noviembre 2019, en las bases de datos de Web Of Science y Scopus , teniendo como hallazgo que las entidades de mayor publicación sobre el tema son la Unión Europea y los Estados Unidos de América, en lo que concierne a un enfoque de los sectores empresariales y académicos seguidos por el enfoque social y cultural.De La Torre Ramos, A.; Cortés Sáenz, D.; Aguirre Escárcega, F.; Matheus Marín, A. (2021). Producción científica en innovación: Revisión sistemática de literatura. En Proceedings INNODOCT/20. International Conference on Innovation, Documentation and Education. Editorial Universitat Politècnica de València. 529-536. https://doi.org/10.4995/INN2020.2020.11864OCS52953

Revisiting the epidemiology of bloodstream infections and healthcare-associated episodes: results from a multicentre prospective cohort in Spain (PRO-BAC Study)

PROBAC REIPI/GEIH-SEIMC/SAEI Group.The epidemiology of bloodstream infections (BSIs) is dynamic as it depends on microbiological, host and healthcare system factors. The aim of this study was to update the information regarding the epidemiology of BSIs in Spain considering the type of acquisition. An observational, prospective cohort study in 26 Spanish hospitals from October 2016 through March 2017 including all episodes of BSI in adults was performed. Bivariate analyses stratified by type of acquisition were performed. Multivariate analyses were performed by logistic regression. Overall, 6345 BSI episodes were included; 2510 (39.8%) were community-acquired (CA), 1661 (26.3%) were healthcare-associated (HCA) and 2056 (32.6%) hospital-acquired (HA). The 30-day mortality rates were 11.6%, 19.5% and 22.0%, respectively. The median age of patients was 71 years (interquartile range 60–81 years) and 3656 (58.3%; 95% confidence interval 57.1–59.6%) occurred in males. The proportions according to patient sex varied according to age strata. Escherichia coli (43.8%), Klebsiella spp. (8.9%), Staphylococcus aureus (8.9%) and coagulase-negative staphylococci (7.4%) were the most frequent pathogens. Multivariate analyses confirmed important differences between CA and HCA episodes, but also between HCA and HA episodes, in demographics, underlying conditions and aetiology. In conclusion, we have updated the epidemiological information regarding patients’ profiles, underlying conditions, frequency of acquisition types and aetiological agents of BSI in Spain. HCA is confirmed as a distinct type of acquisition.This work was financed by grants from Plan Nacional de I+D+i 2013–2016, Instituto de Salud Carlos III, Subdirección General de Redes y Centros de Investigación Cooperativa, Ministerio de Ciencia, Innovación y Universidades [PI16/01432] and the Spanish Network for Research in Infectious Diseases (REIPI) [RD16/0016/0001; RD16/0016/0008], co‐financed by the European Development Regional Fund ‘A way to achieve Europe’, Operative program Intelligent Growth 2014–2020

Compromising between European and US allergen immunotherapy schools: Discussions from GUIMIT, the Mexican immunotherapy guidelines

Background: Allergen immunotherapy (AIT) has a longstanding history and still remains the only disease-changing treatment for allergic rhinitis and asthma. Over the years 2 different schools have developed their strategies: the United States (US) and the European. Allergen extracts available in these regions are adapted to local practice. In other parts of the world, extracts from both regions and local ones are commercialized, as in Mexico. Here, local experts developed a national AIT guideline (GUIMIT 2019) searching for compromises between both schools. Methods: Using ADAPTE methodology for transculturizing guidelines and AGREE-II for evaluating guideline quality, GUIMIT selected 3 high-quality Main Reference Guidelines (MRGs): the European Academy of Allergy, Asthma and Immunology (EAACI) guideines, the S2k guideline of various German-speaking medical societies (2014), and the US Practice Parameters on Allergen Immunotherapy 2011. We formulated clinical questions and based responses on the fused evidence available in the MRGs, combined with local possibilities, patient's preference, and costs. We came across several issues on which the MRGs disagreed. These are presented here along with arguments of GUIMIT members to resolve them. GUIMIT (for a complete English version, see Supplementary data) concluded the following: Results: Related to the diagnosis of IgE-mediated respiratory allergy, apart from skin prick testing complementary tests (challenges, in vitro testing and molecular such as species-specific allergens) might be useful in selected cases to inform AIT composition. AIT is indicated in allergic rhinitis and suggested in allergic asthma (once controlled) and IgE-mediated atopic dermatitis. Concerning the correct subcutaneous AIT dose for compounding vials according to the US school: dosing tables and formula are given; up to 4 non-related allergens can be mixed, refraining from mixing high with low protease extracts. When using European extracts: the manufacturer's indications should be followed; in multi-allergic patients 2 simultaneous injections can be given (100% consensus); mixing is discouraged. In Mexico only allergoid tablets are available; based on doses used in all sublingual immunotherapy (SLIT) publications referenced in MRGs, GUIMIT suggests a probable effective dose related to subcutaneous immunotherapy (SCIT) might be: 50–200% of the monthly SCIT dose given daily, maximum mixing 4 allergens. Also, a table with practical suggestions on non-evidence-existing issues, developed with a simplified Delphi method, is added. Finally, dissemination and implementation of guidelines is briefly discussed, explaining how we used online tools for this in Mexico. Conclusions: Countries where European and American AIT extracts are available should adjust AIT according to which school is followed

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio