Esteban Terradas and Spanish technoscientific modernity

Science, technology and technoscience We live in an age in which science and technology play such important roles in the lives of individuals and nations that they figure among the most important affairs of any nation. And although many persist in seeing science and technology as separate disciplines -as island-universes separated by the deepest oceans-, they are increasingly interrelated and interdependent. Technology relies on science, but so also does science rely on technology. Naturally, it may still make sense to refer to `basic science', to science which becomes technology when `applied'. However, this is not always the case: without the stimulus of technology, without its skills and instruments, and without the problems posed by technology, basic science would likely become a banal and futile exercise. Nineteenth century electromagnetism is a prime example of this encounter between science and technology, an encounter that heralded the technoscience of today

Historia de la ciencia y divulgación

Aunque por su naturaleza intrínseca la historia de la ciencia no debería distinguirse de otras disciplinas históricas de, por poner algún ejemplo, la historia general, la historia de las ideas políticas, o la historia de la economía, el hecho es que en la práctica con frecuencia sí se distingue. Explicaré en qué consiste esa distinción

Elogio del mestizaje: historia, lenguaje y ciencia

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UBQLN4 Represses Homologous Recombination and Is Overexpressed in Aggressive Tumors

Genomic instability can be a hallmark of both human genetic disease and cancer. We identify a deleterious UBQLN4 mutation in families with an autosomal recessive syndrome reminiscent of genome instability disorders. UBQLN4 deficiency leads to increased sensitivity to genotoxic stress and delayed DNA double-strand break (DSB) repair. The proteasomal shuttle factor UBQLN4 is phosphorylated by ATM and interacts with ubiquitylated MRE11 to mediate early steps of homologous recombination-mediated DSB repair (HRR). Loss of UBQLN4 leads to chromatin retention of MRE11, promoting non-physiological HRR activity in vitro and in vivo. Conversely, UBQLN4 overexpression represses HRR and favors non-homologous end joining. Moreover, we find UBQLN4 overexpressed in aggressive tumors. In line with an HRR defect in these tumors, UBQLN4 overexpression is associated with PARP1 inhibitor sensitivity. UBQLN4 therefore curtails HRR activity through removal of MRE11 from damaged chromatin and thus offers a therapeutic window for PARP1 inhibitor treatment in UBQLN4-overexpressing tumors

Ilusiones y realidades en el desarrollo de la Física de Altas Energías

Not available.<br><br>En este artículo se analizan algunos aspectos tanto del (cambiante) apoyo social, político y militar a la física de altas energías (especialmente en Estados Unidos), como la actitud de algunos de sus protagonistas. Asimismo, se considera la cuestión de la intervención pública, en el denominado mundo posmoderno, en la orientación de la investigación científica