2,341 research outputs found
Artificial Intelligence and Machine Learning in the Diagnosis and Management of Stroke: A Narrative Review of United States Food and Drug Administration-Approved Technologies
Stroke is an emergency in which delays in treatment can lead to significant loss of neurological function and be fatal. Technologies that increase the speed and accuracy of stroke diagnosis or assist in post-stroke rehabilitation can improve patient outcomes. No resource exists that comprehensively assesses artificial intelligence/machine learning (AI/ML)-enabled technologies indicated for the management of ischemic and hemorrhagic stroke. We queried a United States Food and Drug Administration (FDA) database, along with PubMed and private company websites, to identify the recent literature assessing the clinical performance of FDA-approved AI/ML-enabled technologies. The FDA has approved 22 AI/ML-enabled technologies that triage brain imaging for more immediate diagnosis or promote post-stroke neurological/functional recovery. Technologies that assist with diagnosis predominantly use convolutional neural networks to identify abnormal brain images (e.g., CT perfusion). These technologies perform comparably to neuroradiologists, improve clinical workflows (e.g., time from scan acquisition to reading), and improve patient outcomes (e.g., days spent in the neurological ICU). Two devices are indicated for post-stroke rehabilitation by leveraging neuromodulation techniques. Multiple FDA-approved technologies exist that can help clinicians better diagnose and manage stroke. This review summarizes the most up-to-date literature regarding the functionality, performance, and utility of these technologies so clinicians can make informed decisions when using them in practice
Posterior eye shape measurement with retinal OCT compared to MRI
PURPOSE. Posterior eye shape assessment by magnetic resonance imaging (MRI) is used to study myopia. We tested the hypothesis that optical coherence tomography (OCT), as an alternative, could measure posterior eye shape similarly to MRI. METHODS. Macular spectral-domain OCT and brain MRI images previously acquired as part of the Singapore Epidemiology of Eye Diseases study were analyzed. The right eye in the MRI and OCT images was automatically segmented. Optical coherence tomography segmentations were corrected for optical and display distortions requiring biometry data. The segmentations were fitted to spheres and ellipsoids to obtain the posterior eye radius of curvature (Rc) and asphericity (Qxz). The differences in Rc and Qxz measured by MRI and OCT were tested using paired t-tests. Categorical assignments of prolateness or oblateness using Qxz were compared. RESULTS. Fifty-two subjects (67.8 ± 5.6 years old) with spherical equivalent refraction from +0.50 to -5.38 were included. The mean paired difference between MRI and original OCT posterior eye Rc was 24.03 ± 46.49 mm (P = 0.0005). For corrected OCT images, the difference in Rc decreased to -0.23 ± 2.47 mm (P = 0.51). The difference between MRI and OCT asphericity, Qxz, was -0.052 ± 0.343 (P = 0.28). However, categorical agreement was only moderate (j = 0.50). CONCLUSIONS. Distortion-corrected OCT measurements of Rc and Qxz were not statistically significantly different from MRI, although the moderate categorical agreement suggests that individual differences remained. This study provides evidence that with distortion correction, noninvasive office-based OCT could potentially be used instead of MRI for the study of posterior eye shape
Neutral Particles in Light of the Majorana-Ahluwalia Ideas
The first part of this article (Sections I and II) presents oneself an
overview of theory and phenomenology of truly neutral particles based on the
papers of Majorana, Racah, Furry, McLennan and Case. The recent development of
the construct, undertaken by Ahluwalia [{\it Mod. Phys. Lett. A}{\bf 9} (1994)
439; {\it Acta Phys. Polon. B}{\bf 25} (1994) 1267; Preprints LANL
LA-UR-94-1252, LA-UR-94-3118], could be relevant for explanation of the present
experimental situation in neutrino physics and astrophysics.
In Section III the new fundamental wave equations for self/anti-self
conjugate type-II spinors, proposed by Ahluwalia, are re-casted to covariant
form. The connection with the Foldy-Nigam-Bargmann-Wightman- Wigner (FNBWW)
type quantum field theory is found. The possible applications to the problem of
neutrino oscillations are discussed.Comment: REVTEX file. 21pp. No figure
A Translational Pharmacology Approach to Predicting Outcomes of Preexposure Prophylaxis Against HIV in Men and Women Using Tenofovir Disoproxil Fumarate With or Without Emtricitabine
Background. A novel translational pharmacology investigation was conducted by combining an in vitro efficacy target with mucosal tissue pharmacokinetic (PK) data and mathematical modeling to determine the number of doses required for effective human immunodeficiency virus (HIV) preexposure prophylaxis (PrEP)
Time variation of the fine structure constant in the early universe and the Bekenstein model
We calculate bounds on the variation of the fine structure constant at the
time of primordial nucleosynthesis and at the time of neutral hydrogen
formation. We use these bounds and other bounds from the late universe to test
Bekenstein model. We modify the Kawano code, CAMB and CosmoMC in order to
include the possible variation of the fine structure constant. We use
observational primordial abundances of \De, \He and \Li, recent data from
the Cosmic Microwave Background and the 2dFGRS power spectrum, to obtain bounds
on the variation of . We calculate a piecewise solution to the scalar
field equation of Bekenstein model in two different regimes; i) matter and
radiation, ii) matter and cosmological constant. We match both solutions with
appropriate boundary conditions. We perform a statistical analysis using the
bounds obtained from the early universe and other bounds from the late universe
to constrain the free parameters of the model. Results are consistent with no
variation of in the early universe. Limits on are
inconsistent with the scale length of the theory being larger than Planck
scale. In order to fit all observational and experimental data, the assumption
implied in Bekenstein's model has to be relaxed.Comment: 13 pages, 8 figures,version accepted to be published in Astronomy and
Astrophysic
Access and utilisation of primary health care services comparing urban and rural areas of Riyadh Providence, Kingdom of Saudi Arabia
The Kingdom of Saudi Arabia (KSA) has seen an increase in chronic diseases. International evidence suggests that early intervention is the best approach to reduce the burden of chronic disease. However, the limited research available suggests that health care access remains unequal, with rural populations having the poorest access to and utilisation of primary health care centres and, consequently, the poorest health outcomes. This study aimed to examine the factors influencing the access to and utilisation of primary health care centres in urban and rural areas of Riyadh province of the KSA
The Atacama Cosmology Telescope: Extragalactic Sources at 148 GHz in the 2008 Survey
We report on extragalactic sources detected in a 455 square-degree map of the
southern sky made with data at a frequency of 148 GHz from the Atacama
Cosmology Telescope 2008 observing season. We provide a catalog of 157 sources
with flux densities spanning two orders of magnitude: from 15 to 1500 mJy.
Comparison to other catalogs shows that 98% of the ACT detections correspond to
sources detected at lower radio frequencies. Three of the sources appear to be
associated with the brightest cluster galaxies of low redshift X-ray selected
galaxy clusters. Estimates of the radio to mm-wave spectral indices and
differential counts of the sources further bolster the hypothesis that they are
nearly all radio sources, and that their emission is not dominated by
re-emission from warm dust. In a bright (>50 mJy) 148 GHz-selected sample with
complete cross-identifications from the Australia Telescope 20 GHz survey, we
observe an average steepening of the spectra between 5, 20, and 148 GHz with
median spectral indices of , , and . When the
measured spectral indices are taken into account, the 148 GHz differential
source counts are consistent with previous measurements at 30 GHz in the
context of a source count model dominated by radio sources. Extrapolating with
an appropriately rescaled model for the radio source counts, the Poisson
contribution to the spatial power spectrum from synchrotron-dominated sources
with flux density less than 20 mJy is C^{\rm Sync} = (2.8 \pm 0.3) \times
10^{-6} \micro\kelvin^2.Comment: Accepted to Ap
Interface properties and built-in potential profile of a LaCrO/SrTiO superlattice determined by standing-wave excited photoemission spectroscopy
LaCrO (LCO) / SrTiO (STO) heterojunctions are intriguing due to a
polar discontinuity along (001), two distinct and controllable interface
structures [(LaO)/(TiO) and (SrO)/(CrO)], and
interface-induced polarization. In this study, we have used soft- and hard
x-ray standing-wave excited photoemission spectroscopy (SW-XPS) to generate a
quantitative determination of the elemental depth profiles and interface
properties, band alignments, and the depth distribution of the
interface-induced built-in potentials in the two constituent oxides. We observe
an alternating charged interface configuration: a positively charged
(LaO)/(TiO) intermediate layer at the
LCO/STO interface and a negatively charged
(SrO)/(CrO) intermediate layer at the
STO/LCO interface. Using core-level SW data,
we have determined the depth distribution of species, including through the
interfaces, and these results are in excellent agreement with scanning
transmission electron microscopy and electron energy loss spectroscopy
(STEM-EELS) mapping of local structure and composition. SW-XPS also enabled
deconvolution of the LCO-contributed and STO- contributed
matrix-element-weighted density of states (MEWDOSs) from the valence band (VB)
spectra for the LCO/STO superlattice (SL). Monitoring the VB edges of the
deconvoluted MEWDOS shifts with a change in probing profile, the alternating
charge- induced built-in potentials are observed in both constituent oxides.
Finally, using a two-step simulation approach involving first core-level
binding energy shifts and then valence-band modeling, the built-in potential
gradients across the SL are resolved in detail and represented by the depth
distribution of VB edges.Comment: Main text: 29 pages, 5 figures; Supplementary Information: 20 pages,
10 figure
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of
continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a
fully coherent search, based on matched filtering, which uses the position and rotational parameters
obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto-
noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch
between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have
been developed, allowing a fully coherent search for gravitational waves from known pulsars over a
fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of
11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial
outliers, further studies show no significant evidence for the presence of a gravitational wave signal.
Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of
the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for
the first time. For an additional 3 targets, the median upper limit across the search bands is below the
spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried
out so far
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