Assessing health-related quality of life in patients with inflammatory bowel disease, in Crete, Greece

BACKGROUND: Health Related Quality of Life (HRQoL) is an important outcome measure in Inflammatory Bowel Disease (IBD). The aim of our study was to assess HRQoL in a population of 135 Greek patients with IBD. METHODS: A cohort of 135 patients with IBD, 81 with ulcerative colitis (UC) and 54 with Crohn's disease (CD) were enrolled in our study. Demographic and disease-related data were recorded. HRQoL was assessed by a disease-specific and a generic questionnaire, IBDQ and SF-36, respectively. Disease activity was assessed by Harvey-Bradshaw Index and the Colitis Activity Index for CD and UC patients, respectively. RESULTS: Among all variables recorded in our study, only disease activity had a significant effect on HRQoL. Patients with active disease scored significantly lower on both IBDQ and SF-36 when compared to those in remission. Only two among the four IBDQ dimensions, bowel and systemic, had significant ability in distinguishing best patients in remission from those with active disease. CONCLUSIONS: IBD has a negative impact on HRQoL. Patients with active disease are more impaired than patients in remission. In our population of patients bowel and systemic dimensions had a predominant value in patients' perception of quality of life. Patients in our study using the same instrument scored higher than previously reported

HD 285507b:an eccentric hot Jupiter in the Hyades open cluster

We report the discovery of the first hot Jupiter in the Hyades open cluster. HD 285507b orbits a V=10.47 K4.5V dwarf ($M_* = 0.734 M_\odot$; $R_* = 0.656 R_\odot$) in a slightly eccentric ($e = 0.086^{+0.018}_{-0.019}$) orbit with a period of $6.0881^{+0.0019}_{-0.0018}$ days. The induced stellar radial velocity corresponds to a minimum companion mass of $M_{\rm p} \sin{i} = 0.917 \pm 0.033 M_{\rm Jup}$. Line bisector spans and stellar activity measures show no correlation with orbital phase, and the radial velocity amplitude is independent of wavelength, supporting the conclusion that the variations are caused by a planetary companion. Follow-up photometry indicates with high confidence that the planet does not transit. HD 285507b joins a small but growing list of planets in open clusters, and its existence lends support to a planet formation scenario in which a high stellar space density does not inhibit giant planet formation and migration. We calculate the circularization timescale for HD 285507b to be larger than the age of the Hyades, which may indicate that this planet's non-zero eccentricity is the result of migration via interactions with a third body. We also demonstrate a significant difference between the eccentricity distributions of hot Jupiters that have had time to tidally circularize and those that have not, which we interpret as evidence against Type II migration in the final stages of hot Jupiter formation. Finally, the dependence of the circularization timescale on the planetary tidal quality factor, $Q_{\rm p}$, allows us to constrain the average value for hot Jupiters to be $\log{Q_{\rm p}} = 6.14^{+0.41}_{-0.25}$.Comment: 11 pages, 6 figures, 3 tables. Accepted for publication in ApJ. Minor changes from v1: updated to match published versio