La inversión extranjera directa, las exportaciones, el producto interno bruto y el mercado laboral en Puerto Rico

In this paper, a vector autorregresive model (VAR) is applied to examine the interrelationship among foreign direct investment, exports, Gross Domestic Product (GDP), unemployment rate and labor force participation rate in Puerto Rico, taking into account a time period that includes the fiscal years from 1980 to 2010.  Four cointegrating vectors were found in the system which indicates that there is a long run relationship between the variables. The findings suggest that consecutive increases in foreign direct investment inflows could significantly reduce the unemployment rate and increase interest in joining the labor force in Puerto Rico.  The same result also applies to increases in export levels.  The variations in Gross Domestic Product are mainly explained in the long run by the unemployment rate.En este trabajo se utiliza un modelo de vectores autorregresivos (VAR) para examinar la interrelación entre la entrada de flujos de inversión extranjera directa (EFIED), las exportaciones, el producto interno bruto (PIB), la tasa de desempleo (TD) y la tasa de participación laboral (TPL) en Puerto Rico. Los datos utilizados incluyen los años fisca- les de 1980 al 2010. Se encontraron cuatro vectores cointegrados en el sistema, que evidencian la existencia de una relación de largo plazo entre las variables. Los hallazgos sugieren que aumentos consecutivos en la EFIED podrían reducir significativamente la TD e incrementar el interés de los puertorriqueños por ingresar en la fuerza laboral. El mismo resultado se refleja con relación a los incrementos en el nivel de exportaciones. Las variaciones en el PIB se explican principalmente en el largo plazo por la TD

Organic and inorganic selenium supplementation on the productive and reproductive performance of hair ewes

The objective of this study was to evaluate the effect of supplementation with organic and inorganic selenium on the productive and reproductive performance of ewes and their offspring. Selenium (Se) is an essential mineral for sheep, studies have found its intestinal absorption and biodisponibility in the animal is greater when it comes from an organic source. A total of 18 multiparous and 22 nulliparous ewes Pelibuey breed were used in this study, averaging 54.8 ± 9.4 kg and 39.7 ± 5.6 kg of body weight (BW). The experimental units were blocked by the number of parturitions (none or more than one). Then randomly assigned to one treatment: basal diet +1.2 ppm of organic Se (OSe, Sel- Plex®) or basal diet +1.2 ppm inorganic Se (ISe). Using the linear model PROC MIXED, BW changes were measured in ewes and average daily gain (ADG) in offspring. Fisher’s test, chi-squared test and t test were used for analyzing reproductive rates and production efficiency. No differences (P > 0.05) were found for BW changes, productive efficiency, and pregnancy rate between treatments. Prolificacy was higher (P 0.05) were found for birth weights of lambs. The ADG was higher (P < 0.05) for the offspring of ISe vs OSe ewes. This indicates that the OSe supplementation improves reproductive parameters, but not the productive such as ADG. Resumen El objetivo de este estudio fue evaluar el efecto de la suplementación con selenio orgánico e inorgánico sobre el desempeño productivo y reproductivo en ovejas de pelo. El selenio (Se) es un mineral esencial en ovinos; estudios han encontrado que su absorción intestinal y biodisponibilidad dentro del animal es mayor cuando proviene de una fuente orgánica (EFSA, 2014). Dieciocho ovejas multíparas y 22 nulíparas de raza Pelibuey con 54.8 ± 9.4 kg y 39.7 ± 5.6 kg de peso vivo fueron utilizadas para formar bloques, considerando número de partos (0 o 1 en adelante); luego asignadas aleatoriamente a un tratamiento: dieta basal +1.2 ppm Se orgánico (OSe, Sel-Plex®) o dieta basal +1.2 ppm Se inorgánico (ISe). Fue usado un modelo lineal PROC MIXED para cambios de peso en ovejas y ganancia diaria de peso (GDP) en crías; y las pruebas de Fisher, chi-cuadrada y t para parámetros reproductivos y eficiencia de producción. No se encontraron diferencias (P > 0.05) para cambios de peso, eficiencia productiva, porcentaje de preñez entre tratamientos. La prolificidad fue mayor (P 0.05) para pesos al nacimiento en corderos. La GDP fue mayor (P < 0.05) para corderos hijos de borregas bajo ISe vs OSe. Es concluyente que el OSe mejora parámetros reproductivos, pero no los productivos como las GDP

Cov-caldas: A new COVID-19 chest X-Ray dataset from state of Caldas-Colombia

The emergence of COVID-19 as a global pandemic forced researchers worldwide in various disciplines to investigate and propose efficient strategies and/or technologies to prevent COVID-19 from further spreading. One of the main challenges to be overcome is the fast and efficient detection of COVID-19 using deep learning approaches and medical images such as Chest Computed Tomography (CT) and Chest X-ray images. In order to contribute to this challenge, a new dataset was collected in collaboration with “S.E.S Hospital Universitario de Caldas” (https://hospitaldecaldas.com/) from Colombia and organized following the Medical Imaging Data Structure (MIDS) format. The dataset contains 7,307 chest X-ray images divided into 3,077 and 4,230 COVID-19 positive and negative images. Images were subjected to a selection and anonymization process to allow the scientific community to use them freely. Finally, different convolutional neural networks were used to perform technical validation. This dataset contributes to the scientific community by tackling significant limitations regarding data quality and availability for the detection of COVID-19. © 2022, The Author(s)

RyRCa2+ Leak Limits Cardiac Ca2+ Window Current Overcoming the Tonic Effect of Calmodulin in Mice

Ca2+ mediates the functional coupling between L-type Ca2+ channel (LTCC) and sarcoplasmic reticulum (SR) Ca2+ release channel (ryanodine receptor, RyR), participating in key pathophysiological processes. This crosstalk manifests as the orthograde Ca2+-induced Ca2+-release (CICR) mechanism triggered by Ca2+ influx, but also as the retrograde Ca2+-dependent inactivation (CDI) of LTCC, which depends on both Ca2+ permeating through the LTCC itself and on SR Ca2+ release through the RyR. This latter effect has been suggested to rely on local rather than global Ca2+ signaling, which might parallel the nanodomain control of CDI carried out through calmodulin (CaM). Analyzing the CICR in catecholaminergic polymorphic ventricular tachycardia (CPVT) mice as a model of RyR-generated Ca2+ leak, we evidence here that increased occurrence of the discrete local SR Ca2+ releases through the RyRs (Ca2+ sparks) causea depolarizing shift in activation and a hyperpolarizing shift inisochronic inactivation of cardiac LTCC current resulting in the reduction of window current. Both increasing fast [Ca2+]i buffer capacity or depleting SR Ca2+ store blunted these changes, which could be reproduced in WT cells by RyRCa2+ leak induced with Ryanodol and CaM inhibition.Our results unveiled a new paradigm for CaM-dependent effect on LTCC gating and further the nanodomain Ca2+ control of LTCC, emphasizing the importance of spatio-temporal relationships between Ca2+ signals and CaM function

Lineage Analysis of Circulating Trypanosoma cruzi Parasites and Their Association with Clinical Forms of Chagas Disease in Bolivia

Around 30–50% of Trypanosoma cruzi infections in Latin America cause chronic Chagas disease 10–30 years after the primary infection due to lack of effective treatment. The major clinical complications associated with chronic Chagas disease are cardiac myositis (leading to cardiac failure), and autonomous neuroplexus degeneration of the digestive tract that can cause megacolon or megaesophagus. Therefore, there are three major clinical forms of Chagas disease; cardiac, digestive and indeterminate (asymptomatic). The parasites, which can infect humans as well as other mammals, are transmitted by species of triatomines commonly found in the Americas. The parasite is divided in at least six discrete typing units: TcI, TcIIa–e. In humans, the TcI is mainly observed in Central America and northern parts of South America while the TcIIb/d/e is confined mainly to the southern cone of Latin America. We determined which DTU were prevalent in chronic patients in Bolivia, where the three clinical forms and several DTUs of the parasites are present, in order to determine whether there was a link between a particular parasite DTU and a particular clinical outcome. We found a vast majority of TcIId but its kDNA polymorphism showed no association with any of the clinical manifestations of chronic Chagas

Intravitreal bevacizumab in diabetic retinopathy. Recommendations from the Pan-American Collaborative Retina Study Group (PACORES): The 2016 knobloch lecture

The advent of intravitreal anti-vascular endothelial growth factor (anti-VEGF) medications has revolutionized the treatment of diabetic eye diseases. Herein, we report the outcomes of clinical studies carried out by the Pan-American Collaborative Retina Study Group (PACORES), with a specific focus on the efficacy of intravitreal bevacizumab in the management of diabetic macular edema and proliferative diabetic retinopathy. We will also discuss the use of intravitreal bevaci-zumab as a preoperative, adjuvant therapy before vitrectomy for prolif-erative diabetic retinopathy. Copyright © 2017 by Asia Pacific Academy of Ophthalmology

Molecular Chemistry to the Fore: New Insights into the Fascinating World of Photoactive Colloidal Semiconductor Nanocrystals

Colloidal semiconductor nanocrystals possess unique properties that are unmatched by other chromophores such as organic dyes or transition-metal complexes. These versatile building blocks have generated much scientific interest and found applications in bioimaging, tracking, lighting, lasing, photovoltaics, photocatalysis, thermoelectrics, and spintronics. Despite these advances, important challenges remain, notably how to produce semiconductor nanostructures with predetermined architecture, how to produce metastable semiconductor nanostructures that are hard to isolate by conventional syntheses, and how to control the degree of surface loading or valence per nanocrystal. Molecular chemists are very familiar with these issues and can use their expertise to help solve these challenges. In this Perspective, we present our group\u27s recent work on bottom-up molecular control of nanoscale composition and morphology, low-temperature photochemical routes to semiconductor heterostructures and metastable phases, solar-to-chemical energy conversion with semiconductor-based photocatalysts, and controlled surface modification of colloidal semiconductors that bypasses ligand exchange

Association Between Preexisting Versus Newly Identified Atrial Fibrillation and Outcomes of Patients With Acute Pulmonary Embolism

Background Atrial fibrillation (AF) may exist before or occur early in the course of pulmonary embolism (PE). We determined the PE outcomes based on the presence and timing of AF. Methods and Results Using the data from a multicenter PE registry, we identified 3 groups: (1) those with preexisting AF, (2) patients with new AF within 2 days from acute PE (incident AF), and (3) patients without AF. We assessed the 90-day and 1-year risk of mortality and stroke in patients with AF, compared with those without AF (reference group). Among 16 497 patients with PE, 792 had preexisting AF. These patients had increased odds of 90-day all-cause (odds ratio [OR], 2.81; 95% CI, 2.33-3.38) and PE-related mortality (OR, 2.38; 95% CI, 1.37-4.14) and increased 1-year hazard for ischemic stroke (hazard ratio, 5.48; 95% CI, 3.10-9.69) compared with those without AF. After multivariable adjustment, preexisting AF was associated with significantly increased odds of all-cause mortality (OR, 1.91; 95% CI, 1.57-2.32) but not PE-related mortality (OR, 1.50; 95% CI, 0.85-2.66). Among 16 497 patients with PE, 445 developed new incident AF within 2 days of acute PE. Incident AF was associated with increased odds of 90-day all-cause (OR, 2.28; 95% CI, 1.75-2.97) and PE-related (OR, 3.64; 95% CI, 2.01-6.59) mortality but not stroke. Findings were similar in multivariable analyses. Conclusions In patients with acute symptomatic PE, both preexisting AF and incident AF predict adverse clinical outcomes. The type of adverse outcomes may differ depending on the timing of AF onset.info:eu-repo/semantics/publishedVersio