Evaluation of the oral production of level 2 medical students

El objetivo de la investigación fue aplicar una evaluación alterna a la producción oral de los estudiantes del nivel 2 de la Carrera de Medicina de la Facultad de Salud Pública de la Escuela Superior Politécnica de Chimborazo, Para ello se aplicó una investigación de campo, bibliográfica, de carácter educativo con interpretación descriptiva, utilizando una rúbrica diferente a la tradicional, la cual incluyó criterios de pronunciación y fluidez en técnicas y actividades tales como: entrevista, juego de roles, tarea de lectura en voz alta, tarea de finalización del diálogo y tareas con imágenes. La evaluación se aplicó a una muestra compuesta por estudiantes del segundo nivel paralelo “D” (Grupo de Control) y “E” (Grupo experimental). El grupo de control utilizó una evaluación tradicional; mientras que el grupo experimental adaptó a la rúbrica los criterios de fluidez y pronunciación. Los datos obtenidos de los grupos fueron procesados, analizados e interpretados mediante gráficos de barra estadísticos, que fueron comparados y permitieron concluir, que la evaluación del grupo experimental incide en la práctica de la producción oral del idioma inglés, pues al considerar la pronunciación y fluidez como retroalimentación en las técnicas utilizadas se mejoró el aprendizaje de los estudiantes con respecto a la destreza del habla.The objective of the research was to apply an alternative evaluation to the oral production of the students of level 2 of the Medicine Career of the Public Health Faculty of the Superior Polytechnic School of Chimborazo. For this purpose, a field, bibliographic and educational research with descriptive interpretation was applied, using a different rubric from the traditional one, which included pronunciation criteria and fluency in techniques and activities such as: interview, role-play, reading aloud task, dialogue completion task and picture-cued tasks. The evaluation was applied to a sample composed of students from the second level class "D" (Control Group) and "E" (Experimental Group). The control group used a traditional evaluation, while the experimental group adapted the criteria of fluency and pronunciation to the rubric. The data obtained from the groups were processed, analyzed and interpreted through statistical bar charts, which were compared and allowed to conclude that the evaluation of the experimental group affects the practice of the oral production of the English language, since considering the pronunciation and fluency as feedback in the techniques used, they improved the learning of the students regarding the speaking skill

Electrochemical affinity biosensors for fast detection of gene-specific methylations with no need for bisulfite and amplification treatments

This paper describes two different electrochemical affinity biosensing approaches for the simple, fast and bisulfite and PCR-free quantification of 5-methylated cytosines (5-mC) in DNA using the anti-5-mC antibody as biorecognition element. One of the biosensing approaches used the anti-5-mC as capture bioreceptor and a sandwich type immunoassay, while the other one involved the use of a specific DNA probe and the anti-5-mC as a detector bioreceptor of the captured methylated DNA. Both strategies, named for simplicity in the text as immunosensor and DNA sensor, respectively, were implemented on the surface of magnetic microparticles and the transduction was accomplished by amperometry at screen-printed carbon electrodes by means of the hydrogen peroxide/hydroquinone system. The resulting amperometric biosensors demonstrated reproducibility throughout the entire protocol, sensitive determination with no need for using amplification strategies, and competitiveness with the conventional enzyme-linked immunosorbent assay methodology and the few electrochemical biosensors reported so far in terms of simplicity, sensitivity and assay time. The DNA sensor exhibited higher sensitivity and allowed the detection of the gene-specific methylations conversely to the immunosensor, which detected global DNA methylation. In addition, the DNA sensor demonstrated successful applicability for 1 h-analysis of specific methylation in two relevant tumor suppressor genes in spiked biological fluids and in genomic DNA extracted from human glioblastoma cells.The financial support of the Spanish Ministerio de Economía y Competitividad CTQ2015-64402-C2-1-R and SAF2014-53209-R Research Projects, the PI17CIII/00045 research project from AESI and the NANOAVANSENS Program from the Comunidad de Madrid (S2013/MT-3029) and predoctoral contracts from the Spanish Ministerio de Economía y Competitividad (R.M. Torrente-Rodríguez and E. Povedano) and Universidad Complutense de Madrid (V. Ruiz-Valdepeñas Montiel) are also gratefully acknowledged.S

Co-occurrence of colistin-resistance genes mcr-1 and mcr-3 among multidrug-resistant Escherichia coli isolated from cattle, Spain, September 2015

Los genes de resistencia a colistina mcr-3 y mcr-1 se detectaron en un aislado de Escherichia coli de heces de ganado en un matadero español en 2015. Las secuencias de ambos genes se hibridaron a la misma banda de plásmidos de aproximadamente 250 kb, aunque la resistencia a la colistina no fue movilizable . El aislado producía betalactamasas de espectro extendido y pertenecía al serotipo O9: H10 y al tipo de secuencia ST533. Aquí informamos un gen mcr-3 detectado en Europa después de informes anteriores de Asia y los Estados Unidos.Colistin resistance genes mcr-3 and mcr-1 have been detected in an Escherichia coli isolate from cattle faeces in a Spanish slaughterhouse in 2015. The sequences of both genes hybridised to same plasmid band of ca 250 kb, although colistin resistance was non-mobilisable. The isolate was producing extended-spectrum beta-lactamases and belonged to serotype O9:H10 and sequence type ST533. Here we report an mcr-3 gene detected in Europe following earlier reports from Asia and the United States.• Ministerio de Economía, Industria y Competitividad. Proyecto AGL2016- 74882-C3 • Ministerio de Agricultura y Pesca (España) y Comunidad Autónoma de Comunidad Autónoma de Madrid. Ayuda S2013 / ABI-2747 • Junta de Extremadura y Fondo Europeo de Desarrollo Regional. Ayuda GR15075 e IB16073 • Fundación para la Ciencia y la Tecnología (Portugal). Ayudas UID / MAR / 04292/2013 • Fundación Tatiana de Guzmán El Bueno (España). Beca doctoral para María del Rocío Iglesias Parro • Instituto Nacional de Agricultura y Alimentación. Investigación y Tecnología (INIA). Beca doctoral para María del Rocío Iglesias Parro • Ministerio de Economía, Industria y Competitividad. Beca FPI2014-020, para Narciso Martín QuijadapeerReviewe

Disease phenotype and outcome depending on the age at disease onset in patients carrying the R92Q low-penetrance variant in TNFRSF1A gene

BACKGROUND: Tumor necrosis factor receptor-associated periodic syndrome (TRAPS) is an autosomal-dominant autoinflammatory disease caused by mutations in the TNFRSF1A gene. R92Q, a low-penetrance variant, is usually associated with a milder TRAPS phenotype than structural or pathogenic mutations. No studies differentiating R92Q-related disease in patients with pediatric and adult onset have been performed to date. OBJECTIVE: To analyze clinical features and disease outcomes in patients diagnosed with TRAPS associated with R92Q variant and to investigate differences between patients with pediatric and adult disease onset. METHODS: A retrospective review of patients with R92Q-related disease from four reference centers for autoinflammatory diseases was performed. Clinical and laboratory features, family history of autoinflammatory diseases, treatments received, and outcomes during follow-up were recorded and separately analyzed in pediatric and adult patients. Our results were included in the analysis with other reported pediatric and adult R92Q-related disease series. RESULTS: Our series encompassed 18 patients (9 females and 9 males) with R92Q variant. In 61% of patients, disease onset occurred during infancy and in 39%, during adulthood, with a median diagnostic delay of 5 years and a follow-up of 5.4 years. A positive family history of autoinflammatory disease was detected in 28% of patients. All patients presented with febrile recurrent episodes. Other common symptoms included arthralgia/arthritis (61%), myalgia (39%), asthenia/fatigue (44%), abdominal pain (39%), headache (33%), odynophagia (33%), skin rash (28%), and chest pain (22%). During attacks, 80% of patients increased acute phase reactants levels. No patient had developed amyloidosis during the study period. At the end of follow-up, 28% of patients were asymptomatic and treatment free, 50% were receiving non-steroidal anti-inflammatory drugs or glucocorticoids on demand, and 22% were being treated with biologic agents. When differences between pediatric and adult patients were globally analyzed, adults tended to have longer attacks duration and presented more frequently with chest pain and headache, while abdominal pain, vomiting, cervical adenitis, and pharyngitis predominated in pediatric patients. No differences in outcomes and treatment requirements were observed in both age groups. CONCLUSION: This study has contributed to characterize R92Q-related disease by identifying trends in disease phenotypes depending on the age at disease onset

La consulta previa y su influencia en los proyectos de interés nacional estratégico en Colombia

Artículo de investigaciónLa consulta previa es un derecho fundamental que consiste en un mecanismo de participación de las comunidades étnicas e indígenas sobre las medidas administrativas o legislativas que pueden afectar su integridad social, cultural y económica, entre otros. El desarrollo que este mecanismo ha presentado en Colombia, según cifras del Ministerio del Interior (2018) puede calificarse como desmedido. En este sentido, es necesario realizar un análisis acerca del exceso de consultas previas presentadas hoy en día en Colombia. Lo anterior, tiene como finalidad identificar las posibles mejoras que pueden desarrollarse a través de la reglamentación consiente de los procesos de consulta previa, a partir de la identificación real de las afectaciones que puede constituir cada proyecto (PINES). Ponderando el interés general y la necesidad de los proyectos que se encuentran en marcha.1. INTRODUCCIÓN 2. LA CONSULTA PREVIA COMO DERECHO FUNDAMENTAL 3. FUNDAMENTO CONSTITUCIONAL DE LA CONSULTA PREVIA 4. AUTODETERMINACIÓN, CONSENTIMIENTO PREVIO LIBRE E INFORMADO DE LAS COMUNIDADES ÉTNICAS CONCLUSIONES REFERENCIAS 5. PROYECTOS DE INTERÉS NACIONAL Y ESTRATÉGICOS – PINES 6. LA CONSULTA PREVIA Y LOS PROYECTOS DE INTERÉS NACIONAL Y ESTRATÉGICOS – PINES. 7. LA CONSULTA PREVIA Y LA CONSULTA POPULAR Y SU INFLUENCIA EN EL DESARROLLO DEL PAÍSPregradoAbogad

A Multimodal Intervention for Prevention of Overweight and Obesity in Schoolchildren. A Protocol Study "PREVIENE-CADIZ"

This paper describes the protocol for a study designed to address the high prevalence (40%) of childhood overweight and obesity in the province of Cadiz, Spain, as a reflection of what is happening worldwide. It is widely known that children who suffer from childhood obesity have a higher risk of developing chronic diseases in adulthood. This causes a decrease in the quality of life and an increase in health spending. In this context, it is necessary to intervene promoting healthy lifestyle habits from an early stage. The objective of this project will be to evaluate the effectiveness of a multimodal intervention (individual, school and family) called "PREVIENE-CaDIZ" [CADIZ-PREVENT]. The intervention will be focused mainly on diet, physical activity, sedentary lifestyle and sleep, to prevent overweight and obesity in schoolchildren from 8 to 9 years old in the province of Cadiz. It will consist of a 10-session education program carried out in the classroom by the teachers. In addition, children will be assigned two workbooks, one to work on in class and the other at home with parents. A workshop aimed at parents will be included to help teach them how to obtain healthier lifestyle habits. The proposed study will involve a quasi-experimental design with a control group

Prevención del sobrepeso y la obesidad infantil en escolares de la provincia de Cádiz. Estudio cuasiexperimental de la efectividad de una intervención multicomponente. PREVIENE-CÁDIZ. Informe de resultados.

En el presente documento se muestran los informes de los principales resultados obtenidos de la evaluación de los escolares participantes en el proyecto "Prevención del sobrepeso y la obesidad infantil en escolares de la provincia de Cádiz. Estudio cuasiexperimental de la efectividad de una intervención multicomponente. PREVIENE-CÁDIZ", mostrándose la comparativa entre el global de la muestra del estudio y segmentando por cada centro escolar participante, con el objetivo de que los centros escolares que han participado en el estudio puedan comprobar el estado de salud en el que se encuentran sus estudiantes con respecto al total de la provincia de Cádiz. De esta forma cada centro puede comprobar en qué aspectos (alimentación, actividad física, sedentarismo y/o descanso) deben hacer hincapié para mejorar el estado de salud de los estudiantes, tanto actuales como futuros.European ITI project PI-0007-2017477 página

El impacto del aprendizaje universitario colaborativo el rendimiento académico del estudiante: Una wiki para la ciencia política y de la administración

El objetivo del proyecto es llevar a la práctica una acción formativa basada en la web 2.0 con la participación de profesores y alumnos pertenecientes a distintos grados, facultades y universidades. En concreto, esta iniciativa pretende continuar con la wiki, www.dcpa.wikidot.com, que comenzó a realizarse en 2015 en virtud de la convocatoria de PIMCD. La wiki contribuye a que los estudiantes, de manera colaborativa, diseñen un proyecto educativo de integración curricular a partir de unos supuestos establecidos previamente por el profesor. Por lo tanto, este tipo de experiencia permite crear una base documental de gran utilidad para otros alumnos que estudian este tipo de asignaturas o para cualquier persona que muestren una inquietud o necesidad de buscar, encontrar o ampliar el conocimiento sobre determinadas cuestiones relacionadas con la ciencia política y la ciencia de la administració

RICORS2040 : The need for collaborative research in chronic kidney disease

Chronic kidney disease (CKD) is a silent and poorly known killer. The current concept of CKD is relatively young and uptake by the public, physicians and health authorities is not widespread. Physicians still confuse CKD with chronic kidney insufficiency or failure. For the wider public and health authorities, CKD evokes kidney replacement therapy (KRT). In Spain, the prevalence of KRT is 0.13%. Thus health authorities may consider CKD a non-issue: very few persons eventually need KRT and, for those in whom kidneys fail, the problem is 'solved' by dialysis or kidney transplantation. However, KRT is the tip of the iceberg in the burden of CKD. The main burden of CKD is accelerated ageing and premature death. The cut-off points for kidney function and kidney damage indexes that define CKD also mark an increased risk for all-cause premature death. CKD is the most prevalent risk factor for lethal coronavirus disease 2019 (COVID-19) and the factor that most increases the risk of death in COVID-19, after old age. Men and women undergoing KRT still have an annual mortality that is 10- to 100-fold higher than similar-age peers, and life expectancy is shortened by ~40 years for young persons on dialysis and by 15 years for young persons with a functioning kidney graft. CKD is expected to become the fifth greatest global cause of death by 2040 and the second greatest cause of death in Spain before the end of the century, a time when one in four Spaniards will have CKD. However, by 2022, CKD will become the only top-15 global predicted cause of death that is not supported by a dedicated well-funded Centres for Biomedical Research (CIBER) network structure in Spain. Realizing the underestimation of the CKD burden of disease by health authorities, the Decade of the Kidney initiative for 2020-2030 was launched by the American Association of Kidney Patients and the European Kidney Health Alliance. Leading Spanish kidney researchers grouped in the kidney collaborative research network Red de Investigación Renal have now applied for the Redes de Investigación Cooperativa Orientadas a Resultados en Salud (RICORS) call for collaborative research in Spain with the support of the Spanish Society of Nephrology, Federación Nacional de Asociaciones para la Lucha Contra las Enfermedades del Riñón and ONT: RICORS2040 aims to prevent the dire predictions for the global 2040 burden of CKD from becoming true