Menhires/monolitos: estructuras monolíticas en el sector central de la cornisa cantábrica

Abordar el estudio de los menhires exige plantear previamenle una cuestión terminológica y por ende de conceptualización del fenómeno y en relación con ello de asignación cronocultural y funcional de las evidencias. El tema podria reducirse a tres grupos de preguntas: ¿es adecuada esta terminología para las manifestaciones de la zona?, ¿qué monumentos debemos considerar Menhires?, y ¿qué grupos humanos son responsables de su construcción y qué papel desempeñaron estas estructuras dentro de su sistema ideológico?.An approach to the study of menhirs requires some preliminary questios, first a terminological one and, consequently, of conceptualization of the phenomenon and in relation to this, questions about their chronocultural and functional context. The theme could be reduced to three groups of questions: is this term adequate for the manifestations of the area under study? What monuments should we consider Menhirs ?, and what human groups are responsible for their construction and what role did these structures play within their Ideological system

HispaVeg: a new online vegetation plot database for Spain

We describe a new online database, named HispaVeg, which currently holds data from 2663 vegetation plots of Spanish woodlands, scrublands and grasslands. Unlike other similar databases, a detailed description of the structure is stored with the floristic data of each plot (i.e., number and physiognomy of the vertical layers, cover values for each layer).Most of the vegetation plots are large rectangles (400 to 2000 square meters) with an average of 34 species per plot. The survey dates range from 1956 to present, with most of the records between 1964 and 1994. The elevation of the plots ranges from 0 to 2880, with most of the plots between 300 and 1500 m. HispaVeg is freely available to the scientific community. Users can query the online database, view printable reports for each plot and download spreadsheet-like raw data for subsets of vegetation plots

Computer System Proposal for the Evaluation and Accreditation of University Careers: Relevance and Social Impact Module.

  El Sistema Universitario de Programas de Acreditación formó parte del control del Mi- nisterio de Educación Superior que ha respetado las exigencias del contexto internacional, así como las metodologías y procedimientos empleados para crear una cultura de calidad en la comunidad universitaria, a partir del fortalecimiento de la autoevaluación y evalua- ción externa con vistas a la acreditación de programas e instituciones, que prepara a la organización. De ahí que se consideró necesario elevar la eficiencia en la gestión de la in- formación que genera el proceso de gestión de la información de la variable pertinencia e impacto social. Por lo que se propuso el desarrollo de una aplicación web que gestione de manera eficiente dicho proceso. Aplicación que estuvo guiada por las etapas que propuso la metodología SCRUM y soportada por el marco de trabajo "Symfony. poyado por el len- guaje de programación PHP, se utilizó la librería Jquery y auxiliados por Visual Paradigm como herramienta de Ingeniería de Software Asistida por Computadora.  The University System of Accreditation Programs (SUPRA) was part of the control of the Ministry of Higher Education that has respected the demands of the international con- text, as well as the methodologies and procedures used to create a culture of quality in the university community, from the strengthening of the self-evaluation and external eval- uation with a view to the accreditation of programs and institutions, which prepared the organization. Hence, it was necessary to increase the efficiency in the management of the information generated by the information management processof a variable related to pertinence and social impact. Therefore, it is proposed to develop a web application that efficiently manages this process. Application guided by the stages proposes the SCRUM methodology and supported by the "Symfony" framework with PHP, supported by the Jquery library and aided by Visual Paradigm as a Computer-Assisted Software Engineer- ing tool (CASE)

Cross-sectional study of height and weight in the population of Andalusia from age 3 to adulthood

<p>Abstract</p> <p>Background and objectives</p> <p>In Andalusia there were no studies including a representative sample of children and adolescent population assessing growth and weight increase. Our objectives were to develop reference standards for weight, height and BMI for the Andalusian pediatric population, from 3 to 18 years of age for both genders, and to identify the final adult height in Andalusia.</p> <p>Subjects and methods</p> <p>Two samples were collected. The first included individuals from 3 to 18 years of age (3592 girls and 3605 boys). They were stratified according type of study center, size of population of origin, age (32 categories of 0.5 years) and gender, using cluster sampling. Subjects from >18 to 23 years of age (947 women and 921 men) were sampled in 6 non-university educational centers and several university centers in Granada. Exclusion criteria included sons of non-Spanish mother or father, and individuals with chronic conditions and/or therapies affecting growth. Two trained fellows collected the data through February to December 2004, for the first sample, and through January to May 2005, for the second.</p> <p>Reference curves were adjusted using Cole's LMS method, and the quality of the adjustment was assessed using the tests proposed by Royston. In addition, a sensitivity analysis was applied to the final models obtained.</p> <p>Results</p> <p>Data for 9065 cases (4539 women and 4526 men) were obtained; 79.39% (n = 7197) in the up to 18 years of age group. In the first sampling only 0.07% (3 girls and 2 boys) refused to participate in the study. In addition, 327 students (4.5%) were absent when sampling was done. We present mean and standard deviation fort height, weight and BMI at 0.5 years intervals, from 3 to 23 years of age, for both genders. After adjustment with the different models, percentiles for height, weight (percentiles 3, 5, 10, 25, 50, 75, 90, 95, and 97) and BMI (percentiles 3, 5, 50, 85, 95, and 97) are presented for both genders.</p> <p>Conclusion</p> <p>This is the first study in Andalusia with a representative sample from the child-juvenile population to investigate weight, height and BMI in subjects from 3 to 23 years of age. The great variability observed in the values from sample of 18 to 23 years of age individuals, ensures the inclusion of extreme values, although random sampling was not used. There still is a lack of standard reference values for the Andalusian population younger done 3 years of age.</p

Evaluación del aprendizaje en bachillerato del estado de Sinaloa, México en tiempos de cuarentena

El objetivo de la investigación fue analizar la evaluación del aprendizaje en el bachillerato en tiempos de cuarentena dentro de un marco de educación inclusiva en un contexto de diversidad. El estudio siguió una metodología cualitativa apelando al diseño de la Teoría Fundamentada. La muestra correspondió a 23 docentes, indagados mediante un cuestionario y un registro constante de observación participante. Los resultados permitieron identificar que los educadores recurrieron a un enfoque de carácter estratégico para evaluar, el cual se caracterizó por ser humanista, flexible, constructivista, crítico, y sobre todo táctico, puesto que apeló al uso de distinto tipo de recursos y herramientas según las necesidades y posibilidades tanto de los discentes como de los pedagogos

Post-traumatic Endophthalmitis Caused by Nocardia nova

Introduction: Nocardia nova complex has been associated with infections in both immunocompetent and immunocompromised patients. Infection can be localized or disseminated, affecting skin and soft tissues, the respiratory system, bones and joints, the circulatory system and especially the central nervous system. Ocular infections such as keratitis, scleritis, conjunctivitis, dacryocystitis, orbital cellulitis and endophthalmitis due to Nocardia spp. are infrequently reported, and usually described after penetrating corneal trauma or ocular contact with plants and soils. Case presentation: An immunocompetent male presented with a history of penetrating ocular trauma that had evolved to infectious endophthalmitis, which was refractory to different antibiotic treatments. No micro-organisms were isolated from repeated conjunctival smear and corneal scraping cultures between the ocular trauma (August 2014) and the endophthalmitis diagnosis (November 2015). After this period, N. nova sensu stricto was isolated in aqueous humour aspirate. Treatment was adjusted and clinical improvement was obtained after an adequate microbiological procedure, including an optimal sampling and an antimicrobial-susceptibility testing report. Conclusion: Nocardia identification to the species level and performance of antimicrobial-susceptibility tests are both essential tools for treatment adjustment and clinical improvement

Leukemia multiclass assessment and classification from Microarray and RNA-seq technologies integration at gene expression level

In more recent years, a significant increase in the number of available biological experiments has taken place due to the widespread use of massive sequencing data. Furthermore, the continuous developments in the machine learning and in the high performance computing areas, are allowing a faster and more efficient analysis and processing of this type of data. However, biological information about a certain disease is normally widespread due to the use of different sequencing technologies and different manufacturers, in different experiments along the years around the world. Thus, nowadays it is of paramount importance to attain a correct integration of biologically-related data in order to achieve genuine benefits from them. For this purpose, this work presents an integration of multiple Microarray and RNA-seq platforms, which has led to the design of a multiclass study by collecting samples from the main four types of leukemia, quantified at gene expression. Subsequently, in order to find a set of differentially expressed genes with the highest discernment capability among different types of leukemia, an innovative parameter referred to as coverage is presented here. This parameter allows assessing the number of different pathologies that a certain gen is able to discern. It has been evaluated together with other widely known parameters under assessment of an ANOVA statistical test which corroborated its filtering power when the identified genes are subjected to a machine learning process at multiclass level. The optimal tuning of gene extraction evaluated parameters by means of this statistical test led to the selection of 42 highly relevant expressed genes. By the use of minimum- Redundancy Maximum-Relevance (mRMR) feature selection algorithm, these genes were reordered and assessed under the operation of four different classification techniques. Outstanding results were achieved by taking exclusively the first ten genes of the ranking into consideration. Finally, specific literature was consulted on this last subset of genes, revealing the occurrence of practically all of them with biological processes related to leukemia. At sight of these results, this study underlines the relevance of considering a new parameter which facilitates the identification of highly valid expressed genes for simultaneously discerning multiple types of leukemia.This work was supported by Project TIN2015-71873-R (Spanish Ministry of Economy and Competitiveness -MINECO- and the European Regional Development Fund -ERDF) and Junta de Andalucı´a (P12–TIC–2082)

Efecto citotóxico de fosfolipasas A2 del veneno de Crotalus durissus cumanensis de Colombia

Introduction.&nbsp;Snake venoms are an important source of proteins and peptides, which display various biological activities such as antibacterial, antiparasitic, antiviral, antitumor, antifungal and against platelet aggregation, among others.&nbsp;Phospholipases A2 present in snake venoms are the most studied proteins in these models. Active and&nbsp;inactive A2 phospholipases have been shown to possess catalytic activity against tumor cells. Objective.&nbsp;To isolate, purify and characterize the phospholipase A2 of the venom of Crotalus durissus cumanensis to evaluate its in vitro antitumor activity. Materials and methods.&nbsp;Isolation, purification and identification of crotoxin B was done with Size Exclusion Chromatography, Reversed Phase High-Performance Liquid Chromatography, RP-HPLC, and Mass Spectrometry. The cytotoxic effect on tumor cells (K562) and normal cells (peripheral blood mononuclear cells) was determined using the MTT technique. Results.&nbsp;The separation and subsequent identification of crotoxin B, found in the venom of C. d. cumanensis from Colombia, showed that this phospholipase A2 has a cytotoxic effect on peripheral blood mononuclear cells at a dose of 18.23 ± 0.57 μg / ml, whereas for K562 cells, it was 2.34 ± 0.199 μg/ml Conclusions.&nbsp;The results suggest the use of crotoxin B, isolated from the venom of C. d. cumanensis, as a possible therapeutic resource for human application.Introducción. Los venenos de serpientes representan una fuente importante de proteínas y péptidos, los cuales exhiben diversas actividades biológicas, tales como antibacterianas, antiparasitarias, antivirales, antitumorales, antifúngicas y contra la agregación plaquetaria, entre otras.&nbsp; Las fosfolipasas A2 presentes en los venenos de serpientes son las proteínas más estudiadas en estos modelos. Se ha demostrado que las fosfolipasas A2, activas e inactivas, poseen actividad catalítica contra células tumorales.&nbsp; Objetivo. Aislar, purificar y caracterizar la fosfolipasa A2 del veneno de Crotalus durissus cumanensis para evaluar su actividad antitumoral in vitro.&nbsp; Materiales y métodos. El aislamiento, la purificación y la identificación de la crotoxina B se hizo mediante la cromatografía de exclusión molecular, la cromatografía líquida de alto rendimiento de fase inversa (Reversed Phase High-Performance Liquid Chromatography, RP-HPLC) y la espectrometría de masas. El efecto citotóxico sobre células tumorales (K562) y células normales (células mononucleares de sangre periférica) se determinó utilizando la técnica de MTT.&nbsp; Resultados. La separación y posterior identificación de la crotoxina B del veneno de C. d. cumanensis de Colombia, permitieron evidenciar que esta fosfolipasa A2 posee efecto citotóxico sobre las células mononucleares de sangre periférica con una dosis de 18,23 ± 0,57 μg/ml, mientras que, para las células K562, fue de 2,34 ± 0,199 μg/ml.&nbsp; Conclusiones. Los resultados sugieren la posibilidad de utilizar la crotoxina B aislada del veneno de C. d. cumanensis como un posible recurso terapéutico para su aplicación en humanos.&nbsp; Palabras clave: Crotalus durissus cumanensis; citotoxicidad; fosfolipasas A2; crotoxina B.&nbsp

Aplicación de la metodología basada en Design Thinking para el aprendizaje de conceptos técnicos ferroviarios

Docentes e investigadores de las áreas de Ingeniería Mecánica y de Comunicación Audiovisual de la Universidad de Málaga participan en un proyecto Europeo Eramus+ denominado ASTONRail. Dentro de las actividades desarrolladas a lo largo de la ejecución de este proyecto, se diseñó un curso intensivo sobre diferentes temas dentro del ámbito ferroviario. Alumnos provenientes de distintas universidades asistieron a clases sobre seguridad ferroviaria, infraestructura, operación, administración y gestión, material rodante y tecnología. La impartición de la sesión sobre material rodante corrió a cargo de docentes de la Universidad de Málaga y de KTH Royal Institute of Technology de Estocolmo, Suecia. Para esta sesión se hizo uso de las metodologías denominadas Design Thinking, aprendizaje colaborativo y clase invertida. En este trabajo se describirá el proyecto dentro del cual se planificó la actividad y la motivación de la misma. Asimismo, se presentará el desarrollo de la actividad y la evaluación de los resultados alcanzados.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Aplicación de la metodología basada en Design Thinking para el aprendizaje de conceptos técnicos ferroviarios

Docentes e investigadores del área de Ingeniería Mecánica y del área de Comunicación Audivisual de la Universidad de Málaga participan en un proyecto Europeo Eramus+ denominado ASTONRail- Advanced approacheS and practices for rail training and education TO inNovate Rail study programmes & Improve rail higher education provision. El principal objetivo de la asociación estratégica ASTONRail es desarrollar un conjunto de herramientas, métodos, enfoques y prácticas profesionales innovadores para el desarrollo de habilidades ferroviarias y, como resultado, mejorar y modernizar la oferta actual de educación superior ferroviaria en Europa. Entre los socios de este proyecto se encuentran investigadores de las universidades de Zagreb (Croacia), Sapienza de Roma (Italia), TH Wildau (Alemania), Zilina (Eslovaquia), KTH (Suecia), siendo liderado por la Universidad de Aston (Reino Unido). Además, cuenta con la colaboración de Eurnex (Red de Excelencia de Investigación Ferroviaria Europea). Dentro de las actividades desarrolladas a lo largo de la ejecución de este proyecto, se diseñó un curso intensivo sobre diferentes temas dentro del ámbito ferroviario. El curso intensivo se llevó cabo en la universidad de Zagreb durante tres días. Alumnos provenientes de las universidades participantes en el proyecto asistieron a clases sobre seguridad ferroviaria, infraestructura, operación, administración y gestión, material rodante y tecnología. En estas sesiones, los alumnos recibieron formación específica sobre dichos temas, haciendo uso para ello de diversas metodologías docentes. La impartición de la sesión sobre material rodante corrió a cargo de docentes de la Universidad de Málaga y de la Universidad KTH. Para esta sesión se hizo uso de las metodologías denominadas Design Thinking, aprendizaje colaborativo y clase invertida