Crash recovery with partial amnesia failure model issues

Replicated systems are a kind of distributed systems whose main goal is to ensure that computer systems are highly available, fault tolerant and provide high performance. One of the last trends in replication techniques managed by replication protocols, make use of Group Communication Sys- tem, and more specifically of the communication primitive atomic broadcast for developing more eficient replication protocols. An important aspect in these systems consists in how they manage the disconnection of nodes {which degrades their service{ and the connec- tion/reconnection of nodes for maintaining their original support. This task is delegated in replicated systems to recovery protocols. How it works de- pends specially on the failure model adopted. A model commonly used for systems managing large state is the crash-recovery with partial amnesia be- cause it implies short recovery periods. But, assuming it implies arising several problems. Most of them have been already solved in the literature: view management, abort of local transactions started in crashed nodes { when referring to transactional environments{ or for example the reinclu- sion of new nodes to the replicated system. Anyway, there is one problem related to the assumption of this second failure model that has not been completely considered: the amnesia phenomenon. Phenomenon that can lead to inconsistencies if it is not correctly managed. This work presents this inconsistency problem due to the amnesia and formalizes it, de ning the properties that must be ful lled for avoiding it and de ning possible solutions. Besides, it also presents and formalizes an inconsistency problem {due to the amnesia{ which appears under a speci c sequence of events allowed by the majority partition progress condition that will imply to stop the system, proposing the properties for overcoming it and proposing di erent solutions. As a consequence it proposes a new majority partition progress condition. In the sequel there is deDe Juan Marín, R. (2008). Crash recovery with partial amnesia failure model issues [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/3302Palanci

On synchrony in dynamic distributed systems

[EN] Many modern distributed services are deployed in dynamic systems. Cloud services are an example. They are expected to provide service to a potentially huge amount of users and may require a wide geographical deployment in multiple data centres. Their service processes vary in volume in accordance with workload variations, showing an adaptive behaviour in order to minimise economical costs. Dynamic distributed systems may be classifed considering two axes: (a) the number of processes that compose the system, and (b) the diameter of the networking graph that interconnects those processes. Other important features of dynamic systems can be derived from these two characteristics, e.g., their attainable synchrony. We analyse the level of synchrony that may be achieved in each dynamic system class and revise the existing techniques for transforming an initially asynchronous large dynamic system into another one with a higher synchrony level. With this, a larger set of problems may be handled in dynamic distributed systems. This facilitates the implementation and provision of additional services in those systems.Muñoz-Escoí, FD.; Juan Marín, RD. (2018). On synchrony in dynamic distributed systems. Open Computer Science. 8(1):154-164. https://doi.org/10.1515/comp-2018-0014S1541648

Assessing citizen science data quality for bird monitoring in the Iberian Peninsula

Citizen science data on biodiversity has experienced signifcant growth, largely driven by advancements in technology that facilitate data sharing. In recent years, mobile applications have provided a substantial boost to both the collection and sharing of this data. While this accessible information is undoubtedly valuable, we must consider the numerous biases present in this data when used for high-quality research. In this study, we analyse citizen science data for the birds of the Iberian Peninsula, comprising over 23 million unique records after fltering for duplicates (i.e., instances where the same observation was uploaded more than once). Using a 10 × 10 km square grid, we present information on well-surveyed cells (completeness) as well as temporal, taxonomic, geographical, and land use coverages. We found that the completeness of information is generally high, with better coverage around densely populated areas such as major cities and coastal regions, as well as popular birding destinations, which are frequently visited. The Mediterranean ecoregion and wetlands exhibit the highest levels of surveying. Furthermore, we observed an increase in temporal coverage since the 1980s and broad taxonomic coverage across all bird orders in the Iberian region. Our results underscore the utility of citizen science for many locations, as expressed in 10 × 10 km cells. However, they also highlight the inadequate data completeness across part of the territory, particularly in forested or sparsely inhabited areas. These fndings not only identify cells suitable for bird diversity or conservation studies but also indicate areas where citizen-driven bird recording eforts should be encouragedTis work was fnancially supported by the following three projects: (1) “Agricultura y conservación de la avifauna esteparia en Andalucía. Evaluación de la biodiversidad a partir de conocimiento accesible digital (DAK) y estudios in situ” (Andalusian Research Plan 2014–2020. Ref. P20_00354) (Operative FEDER Program); (2) “Procesos de extinción en paisajes agrarios mediterráneos: evaluación de biodiversidad al inicio de una nueva Política Agraria Común mediante conocimiento accesible digital (DAK) y estudios in situ” (Ref. UHU-202076) (Operative FEDER Program) and (3) “Infuencia sobre la avifauna del uso y ocupación del territorio en el medio agrario andaluz por plantas fotovoltaicas y olivar intensivo y superintensivo” (BIOD22_00033_15_PPCB. Plan Complementario de I+D+i de Biodiversidad). Gross data for this study were provided by GBIF, eBird, and Observation.org. We extend special gratitude to Julio Rabadán from Observation.org for his invaluable suppor

CAP Theorem: Revision of its related consistency models

[EN] The CAP theorem states that only two of these properties can be simultaneously guaranteed in a distributed service: (i) consistency, (ii) availability, and (iii) network partition tolerance. This theorem was stated and proved assuming that "consistency" refers to atomic consistency. However, multiple consistency models exist and atomic consistency is located at the strongest edge of that spectrum. Many distributed services deployed in cloud platforms should be highly available and scalable. Network partitions may arise in those deployments and should be tolerated. One way of dealing with CAP constraints consists in relaxing consistency. Therefore, it is interesting to explore the set of consistency models not supported in an available and partition-tolerant service (CAP-constrained models). Other weaker consistency models could be maintained when scalable services are deployed in partitionable systems (CAP-free models). Three contributions arise: (1) multiple other CAP-constrained models are identified, (2) a borderline between CAP-constrained and CAP-free models is set, and (3) a hierarchy of consistency models depending on their strength and convergence is built.Muñoz-Escoí, FD.; Juan Marín, RD.; García Escriva, JR.; González De Mendívil Moreno, JR.; Bernabeu Aubán, JM. (2019). CAP Theorem: Revision of its related consistency models. The Computer Journal. 62(6):943-960. https://doi.org/10.1093/comjnl/bxy142S943960626Davidson, S. B., Garcia-Molina, H., & Skeen, D. (1985). Consistency in a partitioned network: a survey. ACM Computing Surveys, 17(3), 341-370. doi:10.1145/5505.5508Gilbert, S., & Lynch, N. (2002). Brewer’s conjecture and the feasibility of consistent, available, partition-tolerant web services. ACM SIGACT News, 33(2), 51-59. doi:10.1145/564585.564601Muñoz-Escoí, F. D., & Bernabéu-Aubán, J. M. (2016). A survey on elasticity management in PaaS systems. Computing, 99(7), 617-656. doi:10.1007/s00607-016-0507-8Brewer, E. (2012). CAP twelve years later: How the «rules» have changed. Computer, 45(2), 23-29. doi:10.1109/mc.2012.37Attiya, H., Ellen, F., & Morrison, A. (2017). Limitations of Highly-Available Eventually-Consistent Data Stores. IEEE Transactions on Parallel and Distributed Systems, 28(1), 141-155. doi:10.1109/tpds.2016.2556669Viotti, P., & Vukolić, M. (2016). Consistency in Non-Transactional Distributed Storage Systems. ACM Computing Surveys, 49(1), 1-34. doi:10.1145/2926965Burckhardt, S. (2014). Principles of Eventual Consistency. Foundations and Trends® in Programming Languages, 1(1-2), 1-150. doi:10.1561/2500000011Herlihy, M. P., & Wing, J. M. (1990). Linearizability: a correctness condition for concurrent objects. ACM Transactions on Programming Languages and Systems, 12(3), 463-492. doi:10.1145/78969.78972Lamport. (1979). How to Make a Multiprocessor Computer That Correctly Executes Multiprocess Programs. IEEE Transactions on Computers, C-28(9), 690-691. doi:10.1109/tc.1979.1675439Ladin, R., Liskov, B., Shrira, L., & Ghemawat, S. (1992). Providing high availability using lazy replication. ACM Transactions on Computer Systems, 10(4), 360-391. doi:10.1145/138873.138877Yu, H., & Vahdat, A. (2002). Design and evaluation of a conit-based continuous consistency model for replicated services. ACM Transactions on Computer Systems, 20(3), 239-282. doi:10.1145/566340.566342Curino, C., Jones, E., Zhang, Y., & Madden, S. (2010). Schism. Proceedings of the VLDB Endowment, 3(1-2), 48-57. doi:10.14778/1920841.1920853Das, S., Agrawal, D., & El Abbadi, A. (2013). ElasTraS. ACM Transactions on Database Systems, 38(1), 1-45. doi:10.1145/2445583.2445588Chen, Z., Yang, S., Tan, S., He, L., Yin, H., & Zhang, G. (2014). A new fragment re-allocation strategy for NoSQL database systems. Frontiers of Computer Science, 9(1), 111-127. doi:10.1007/s11704-014-3480-4Kamal, J., Murshed, M., & Buyya, R. (2016). Workload-aware incremental repartitioning of shared-nothing distributed databases for scalable OLTP applications. Future Generation Computer Systems, 56, 421-435. doi:10.1016/j.future.2015.09.024Elghamrawy, S. M., & Hassanien, A. E. (2017). A partitioning framework for Cassandra NoSQL database using Rendezvous hashing. The Journal of Supercomputing, 73(10), 4444-4465. doi:10.1007/s11227-017-2027-5Muñoz-Escoí, F. D., García-Escrivá, J.-R., Sendra-Roig, J. S., Bernabéu-Aubán, J. M., & González de Mendívil, J. R. (2018). Eventual Consistency: Origin and Support. Computing and Informatics, 37(5), 1037-1072. doi:10.4149/cai_2018_5_1037Fischer, M. J., Lynch, N. A., & Paterson, M. S. (1985). Impossibility of distributed consensus with one faulty process. Journal of the ACM, 32(2), 374-382. doi:10.1145/3149.21412

Research network on interoperability of applications and software for networked enterprises in the Valencian Region (INTERVAL)

Enterprise interoperability is a tool for enhancing the competitiveness of firms, and its importance is brought out by the fact one of the EC’s strategic aims is to accomplish interoperability among European firms by the year 2010. Nevertheless, in the particular case of the Valencian Region (Spain), research into enterprise interoperability is still badly structured, fragmented, overlapping and, in many cases, practically non-existent. The INTERVAL project has been set up in an attempt to solve this problem. The scheme plans to carry out a series of initiatives aimed at integrating research activities and applying them to the complicated Valencian business sector. By so doing these companies would benefit from the application of knowledge created specifically for them and adapted to fit their characteristics. In this paper we present the details of the project, including its goals, aims, activities, results achieved, the methodology used to accomplish them, the economic and/or technological advantages, as well as possible applications and future lines of research

Factors Associated with Postpartum Sexual Dysfunction in Spanish Women: A Cross-Sectional Study

(1) Background: Female sexual dysfunction (FSD) has a high prevalence globally, and perinatal factors favor FSD, especially in the postpartum period. The aim was to determine the prevalence and factors influencing FSD in the postpartum period; (2) Methods: An observational study carried out in three primary care centers in southern Spain, with women in the postpartum period who had a single low-risk birth. One hundred and seventeen women answered the Female Sexual Function questionnaire during the 4th month postpartum, between January 2020 and December 2021. Sociodemographic, obstetric, neonatal variables and level of self-esteem were analyzed. A multiple logistic regression model was carried out; (3) Results: 78.4% had high level of self-esteem. FSD prevalence was 89.7%. Factors related to FSD were having an instrumental vaginal delivery, women with university studies, and prenatal preparation. Maternal age ≥ 35, multiparity, pathological processes in the child, a medium–low level of self-esteem and newborn weight were associated with disorders in some of domains of sexual function; (4) Conclusions: FSD is highly prevalent in the postpartum period and is associated with preventable factors. A preventive approach by health professionals to these factors is essential. Health services should implement postpartum follow-up programs, which may coincide in time and place with newborn follow-up programs

Scalability approaches for causal multicast: a survey

The final publication is available at Springer via http://dx.doi.org/10.1007/s00607-015-0479-0Many distributed services need to be scalable: internet search, electronic commerce, e-government... In order to achieve scalability, high availability and fault tolerance, such applications rely on replicated components. Because of the dynamics of growth and volatility of customer markets, applications need to be hosted by adaptive, highly scalable systems. In particular, the scalability of the reliable multicast mechanisms used for supporting the consistency of replicas is of crucial importance. Reliable multicast might propagate updates in a pre-determined order (e.g., FIFO, total or causal). Since total order needs more communication rounds than causal order, the latter appears to be the preferable candidate for achieving multicast scalability, although the consistency guarantees based on causal order are weaker than those of total order. This paper provides a historical survey of different scalability approaches for reliable causal multicast protocols.This work was supported by European Regional Development Fund (FEDER) and Ministerio de Economia y Competitividad (MINECO) under research Grant TIN2012-37719-C03-01.Juan Marín, RD.; Decker, H.; Armendáriz Íñigo, JE.; Bernabeu Aubán, JM.; Muñoz Escoí, FD. (2016). Scalability approaches for causal multicast: a survey. Computing. 98(9):923-947. https://doi.org/10.1007/s00607-015-0479-0S923947989Adly N, Nagi M (1995) Maintaining causal order in large scale distributed systems using a logical hierarchy. In: IASTED Intnl Conf on Appl Inform, pp 214–219Aguilera MK, Chen W, Toueg S (1997) Heartbeat: a timeout-free failure detector for quiescent reliable communication. In: 11th Intnl Wshop on Distrib Alg (WDAG), Saarbrücken, pp 126–140Almeida JB, Almeida PS, Baquero C (2004) Bounded version vectors. In: 18th Intnl Conf Distrib Comput (DISC), Amsterdam, pp 102–116Almeida PS, Baquero C, Fonte V (2008) Interval tree clocks. In: 12th Intnl Conf Distrib Syst (OPODIS), Luxor, pp 259–274Almeida S, Leitão J, Rodrigues LET (2013) ChainReaction: a causal+ consistent datastore based on chain replication. In: 8th EuroSys Conf, Czech Republic, pp 85–98Álvarez A, Arévalo S, Cholvi V, Fernández A, Jiménez E (2008) On the interconnection of message passing systems. Inf Process Lett 105(6):249–254Amir Y, Stanton J (1998) The Spread wide area group communication system. Tech. rep., CDNS-98-4, The Center for Networking and Distributed Systems, The Johns Hopkins UnivAmir Y, Dolev D, Kramer S, Malki D (1992) Transis: a communication subsystem for high availability. In: 22nd Intnl Symp Fault-Tolerant Comp (FTCS), Boston, pp 76–84Anastasi G, Bartoli A, Spadoni F (2001) A reliable multicast protocol for distributed mobile systems: design and evaluation. IEEE Trans Parallel Distrib Syst 12(10):1009–1022Bailis P, Ghodsi A, Hellerstein JM, Stoica I (2013) Bolt-on causal consistency. In: Intnl Conf Mgmnt Data (SIGMOD), New York, pp 761–772Baldoni R, Raynal M, Prakash R, Singhal M (1996) Broadcast with time and causality constraints for multimedia applications. In: 22nd Intnl Euromicro Conf, Prague, pp 617–624Baldoni R, Friedman R, van Renesse R (1997) The hierarchical daisy architecture for causal delivery. In: 17th Intnl Conf Distrib Comput Syst (ICDCS), Maryland, pp 570–577Ban B (2002) JGroups—a toolkit for reliable multicast communication. http://www.jgroups.orgBaquero C, Almeida PS, Shoker A (2014) Making operation-based CRDTs operation-based. In: 14th Intnl Conf Distrib Appl Interop Syst (DAIS), Berlin, pp 126–140Benslimane A, Abouaissa A (2002) Dynamical grouping model for distributed real time causal ordering. Comput Commun 25:288–302Birman KP, Joseph TA (1987) Reliable communication in the presence of failures. ACM Trans Comput Syst 5(1):47–76Birman KP, Schiper A, Stephenson P (1991) Lightweigt causal and atomic group multicast. ACM Trans Comput Syst 9(3):272–314Cachin C, Guerraoui R, Rodrigues LET (2011) Introduction to reliable and secure distributed programming, 2nd edn. Springer, BerlinChandra P, Gambhire P, Kshemkalyani AD (2004) Performance of the optimal causal multicast algorithm: a statistical analysis. IEEE Trans Parall Distr 15(1):40–52Chandra TD, Toueg S (1996) Unreliable failure detectors for reliable distributed systems. J ACM 43(2):225–267de Juan-Marín R, Cholvi V, Jiménez E, Muñoz-Escoí FD (2009) Parallel interconnection of broadcast systems with multiple FIFO channels. In: 11th Intnl Symp on Distrib Obj, Middleware and Appl (DOA), Vilamoura, LNCS, vol 5870, pp 449–466Défago X, Schiper A, Urbán P (2004) Total order broadcast and multicast algorithms: taxonomy and survey. ACM Comput Surv 36(4):372–421Demers AJ, Greene DH, Hauser C, Irish W, Larson J, Shenker S, Sturgis HE, Swinehart DC, Terry DB (1987) Epidemic algorithms for replicated database maintenance. In: 6th ACM Symp on Princ of Distrib Comput (PODC), Canada, pp 1–12Du J, Elnikety S, Roy A, Zwaenepoel W (2013) Orbe: scalable causal consistency using dependency matrices and physical clocks. In: ACM Symp on Cloud Comput (SoCC), Santa Clara, pp 11:1–11:14Fernández A, Jiménez E, Cholvi V (2000) On the interconnection of causal memory systems. In: 19th Annual ACM Symp on Princ of Distrib Comput (PODC), Portland, pp 163–170Fidge CJ (1988) Timestamps in message-passing systems that preserve the partial ordering. In: 11th Australian Comput Conf, pp 56–66Friedman R, Vitenberg R, Chockler G (2003) On the composability of consistency conditions. Inf Process Lett 86(4):169–176Gilbert S, Lynch N (2002) Brewer’s conjecture and the feasibility of consistent, available, partition-tolerant web services. SIGACT News 33(2):51–59Gray J, Helland P, O’Neil PE, Shasha D (1996) The dangers of replication and a solution. In: SIGMOD Conf, pp 173–182Hadzilacos V, Toueg S (1993) Fault-tolerant broadcasts and related problems. In: Mullender S (ed) Distributed systems, chap 5, 2nd edn. ACM Press, pp 97–145Johnson S, Jahanian F, Shah J (1999) The inter-group router approach to scalable group composition. In: 19th Intnl Conf on Distrib Comput Syst (ICDCS), Austin, pp 4–14Kalantar MH, Birman KP (1999) Causally ordered multicast: the conservative approach. In: 19th Intnl Conf on Distrib Comput Syst (ICDCS), Austin, pp 36–44Kawanami S, Enokido T, Takizawa M (2004) A group communication protocol for scalable causal ordering. In: 18th Intnl Conf on Adv Inform Netw Appl (AINA), Fukuoka, pp 296–302Kawanami S, Nishimura T, Enokido T, Takizawa M (2005) A scalable group communication protocol with global clock. In: 19th Intnl Conf on Adv Inform Netw Appl (AINA), Taipei, pp 625–630Kshemkalyani AD, Singhal M (1998) Necessary and sufficient conditions on information for causal message ordering and their optimal implementation. Distrib Comput 11(2):91–111Kshemkalyani AD, Singhal M (2011) Distributed computing: principles, algorithms, and systems, 2nd edn. Cambridge University Press, New YorkLadin R, Liskov B, Shrira L, Ghemawat S (1992) Providing high availability using lazy replication. ACM Trans Comput Syst 10(4):360–391Lamport L (1978) Time, clocks, and the ordering of events in a distributed system. Commun ACM 21(7):558–565Laumay P, Bruneton E, de Palma N, Krakowiak S (2001) Preserving causality in a scalable message-oriented middleware. In: Intnl Conf on Distrib Syst Platf (Middleware), pp 311–328Liu N, Liu M, Cao J, Chen G, Lou W (2010) When transportation meets communication: V2P over VANETs. In: 30th Intnl Conf Distrib Comput Syst (ICDCS), GenovaLwin CH, Mohanty H, Ghosh RK (2004) Causal ordering in event notification service systems for mobile users. In: Intnl Conf Inform Tech: Coding Comput (ITCC), Las Vegas, pp 735–740Mahajan P, Alvisi L, Dahlin M (2011) Consistency, availability and covergence. Tech. rep., UTCS TR-11-22, The University of Texas at AustinMatos M, Sousa A, Pereira J, Oliveira R, Deliot E, Murray P (2009) CLON: overlay networks and gossip protocols for cloud environments. In: 11th Intnl Symp on Dist Obj, Middleware and Appl (DOA), Vilamoura, LNCS, vol 5870, pp 549–566Mattern F (1989) Virtual time and global states of distributed systems. In: Parallel and distributed algorithms, North-Holland, pp 215–226Mattern F, Fünfrocken S (1994) A non-blocking lightweight implementation of causal order message delivery. Lect Notes Comput Sci 938:197–213Meldal S, Sankar S, Vera J (1991) Exploiting locality in maintaining potential causality. In: 10th ACM Symp on Princ of Distrib Comp (PODC), Montreal, pp 231–239Meling H, Montresor A, Helvik BE, Babaoglu Ö (2008) Jgroup/ARM: a distributed object group platform with autonomous replication management. Softw Pract Exp 38(9):885–923Mosberger D (1993) Memory consistency models. Oper Syst Rev 27(1):18–26Mostéfaoui A, Raynal M (1993) Causal multicast in overlapping groups: towards a low cost approach. In: 4th Intnl Wshop on Future Trends of Distrib Comp Syst (FTDCS), Lisbon, pp 136–142Mostéfaoui A, Raynal M, Travers C, Patterson S, Agrawal D, El Abbadi A (2005) From static distributed systems to dynamic systems. In: 24th Symp on Rel Distrib Syst (SRDS), Orlando, pp 109–118Nishimura T, Hayashibara N, Takizawa M, Enokido T (2005) Causally ordered delivery with global clock in hierarchical group. In: ICPADS (2), Fukuoka, pp 560–564Parker DS Jr, Popek GJ, Rudisin G, Stoughton A, Walker BJ, Walton E, Chow JM, Edwards DA, Kiser S, Kline CS (1983) Detection of mutual inconsistency in distributed systems. IEEE Trans Softw Eng 9(3):240–247Pascual-Miret L (2014) Consistency models in modern distributed systems. An approach to eventual consistency. Master’s thesis, Depto. de Sistemas Informáticos y Computación, Univ. Politècnica de ValènciaPascual-Miret L, González de Mendívil JR, Bernabéu-Aubán JM, Muñoz-Escoí FD (2015) Widening CAP consistency. Tech. rep., IUMTI-SIDI-2015/003, Univ. Politècnica de València, ValenciaPeterson LL, Buchholz NC, Schlichting RD (1989) Preserving and using context information in interprocess communication. ACM Trans Comput Syst 7(3):217–246Pomares Hernández S, Fanchon J, Drira K, Diaz M (2001) Causal broadcast protocol for very large group communication systems. In: 5th Intnl Conf on Princ of Distrib Syst (OPODIS), Manzanillo, pp 175–188Prakash R, Baldoni R (2004) Causality and the spatial-temporal ordering in mobile systems. Mobile Netw Appl 9(5):507–516Prakash R, Raynal M, Singhal M (1997) An adaptive causal ordering algorithm suited to mobile computing environments. J Parallel Distrib Comput 41(2):190–204Raynal M, Schiper A, Toueg S (1991) The causal ordering abstraction and a simple way to implement it. Inf Process Lett 39(6):343–350Rodrigues L, Veríssimo P (1995a) Causal separators and topological timestamping: An approach to support causal multicast in large-scale systems. Tech. Rep. AR-05/95, Instituto de Engenharia de Sistemas e Computadores (INESC), LisbonRodrigues L, Veríssimo P (1995b) Causal separators for large-scale multicast communication. In: 15th Intnl Conf on Distrib Comput Syst (ICDCS), Vancouver, pp 83–91Schiper A, Eggli J, Sandoz A (1989) A new algorithm to implement causal ordering. In: 3rd Intnl Wshop on Distrib Alg (WDAG), Nice, pp 219–232Schiper N, Pedone F (2010) Fast, flexible and highly resilient genuine FIFO and causal multicast algorithms. In: 25th ACM Symp on Applied Comp (SAC), Sierre, pp 418–422Shapiro M, Preguiça NM, Baquero C, Zawirski M (2011) Convergent and commutative replicated data types. Bull EATCS 104:67–88Shen M, Kshemkalyani AD, Hsu TY (2015) Causal consistency for geo-replicated cloud storage under partial replication. In: Intnl Paral Distrib Proces Symp (IPDPS) Wshop, Hyderabad, pp 509–518Singhal M, Kshemkalyani AD (1992) An efficient implementation of vector clocks. Inf Process Lett 43(1):47–52Sotomayor B, Montero RS, Llorente IM, Foster IT (2009) Virtual infrastructure management in private and hybrid clouds. IEEE Internet Comput 13(5):14–22Stephenson P (1991) Fast ordered multicasts. PhD thesis, Dept. of Comp. Sc., Cornell Univ., IthacaStonebraker M (1986) The case for shared nothing. IEEE Database Eng Bull 9(1):4–9Vogels W (2009) Eventually consistent. Commun ACM 52(1):40–44Wischhof L, Ebner A, Rohling H (2005) Information dissemination in self-organizing intervehicle networks. IEEE Trans Intell Transp 6(1):90–101Yavatkar R (1992) MCP: a protocol for coordination and temporal synchronization in multimedia collaborative applications. In: 12th Intnl Conf on Distrib Comput Syst (ICDCS), Yokohama, pp 606–613Yen LH, Huang TL, Hwang SY (1997) A protocol for causally ordered message delivery in mobile computing systems. Mobile Netw Appl 2(4):365–372Zawirski M, Preguiça N, Duarte S, Bieniusa A, Balegas V, Shapiro M (2015) Write fast, read in the past: causal consistency for client-side applications. In: 16th Intnl Middleware Conf, VancouverZhou S, Cai W, Turner SJ, Lee BS, Wei J (2007) Critical causal order of events in distributed virtual environments. ACM Trans Mult Comp Commun Appl 3(3):1

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality