Cerebral stroke - preclinical diagnosis and in conditions of the hospital accident ward

AdmissionThe cerebral stroke is a direct distress of the health and the life. The patient with the suspicion of stroke requires urgent intervention irrespective of the course of manifestations and their degree of the intensity. During the help at the preclinical stage an evaluation of practical parameters and registering direction and dynamics of changes are most important in this respect. As part of dealing on the Hospital accident ward with the sick person with the stated cerebral stroke one should verify and implement changes in applied curing by team members medical lifeguards.Purpose of researchAnalysis of diagnostic and therapeutic standards is a purpose of the work applied with patients with the cerebral stroke at the preclinical stage and as part of the care on the Hospital accident ward. Materials and methodsInformation taken from medical documentation of course of the process of diagnostics and curing 130 patients with the diagnosed cerebral stroke at medical institutions in the province constitutes research material Lublin. Analysis of medical documentation covered years 2013 up to 2016.DiscussionThe most frequent object manifestations stated at patients from the examined group: giddiness, headache, disequilibrium, nausea and/or the vomiting, the dysphagia, visual disturbances, pareses and hypoesthesias. According to analysis results and with literature at sick persons with the cerebral stroke a computed axial tomography and a magnetic resonance, as well as additional examinations are made examinations leading the way.ConclusionsAccording to the analysis of the results amongst early complications they observed: cerebral oedema, widen/ing moving the arrangement of the cellular brain, the secondary ischaemia of the haemorrhagic stroke. All described disorders of the awareness were diagnosed in the early phase of the cerebral stroke i.e. 4-5 hours from the beginning of the riot of any neurological warning signals

Distinct DNA repair pathways involving RecA and nonhomologous end joining in Mycobacterium smegmatis

Mycobacterium smegmatis was used to study the relationship between DNA repair processes involving RecA and nonhomologous end joining (NHEJ). The effect of gene deletions in recA and/or in two genes involved in NHEJ (ku and ligD) was tested on the ability of bacteria to join breaks in plasmids transformed into them and in their response to chemicals that damage DNA. The results provide in vivo evidence that only NHEJ is required for the repair of noncompatible DNA ends. By contrast, the response of mycobacteria to mitomycin C preferentially involved a RecA-dependent pathway

Synthesis, structural characterization, antimicrobial and cytotoxic effects of aziridine, 2-aminoethylaziridine and azirine complexes of copper(II) and palladium(II).

The synthesis, spectroscopic and X-ray structural characterization of copper(II) and palladium(II) complexes with aziridine ligands as 2-dimethylaziridine HNCH2CMe2 (a), the bidentate N-(2-aminoethyl)aziridines C2H4NC2H4NH2 (b) or CH2CMe2NCH2CMe2NH2 (c) as well as the unsaturated azirine NCH2CPh (d) are reported. Cleavage of the cyclometallated Pd(II) dimer [μ-Cl(C6H4CHMeNMe2-C,N)Pd]2 with ligand a yielded compound [Cl(NHCH2CMe2)(C6H4CHMe2NMe2-C,N)Pd] (1a). The reaction of the aziridine complex trans-[Cl2Pd(HNC2H4)2] with an excess of aziridine in the presence of AgOTf gave the ionic chelate complex trans-[(C2H4NC2H4NH2-N,N′)2Pd](OTf)2 (2b) which contains the new ligand b formed by an unexpected insertion and ring opening reaction of two aziridines (“aziridine dimerization”). CuCl2 reacted in pure HNC2H4 or HNCH2CMe2 (b) again by “dimerization” to give the tris-chelated ionic complex [Cu(C2H4NC2H4NH2-N,N′)3]Cl2 (3b) or the bis-chelated complex [CuCl(C2H2Me2NC2H2Me2NH2-N,N′)2]Cl (4c). By addition of 2H-3-phenylazirine (d) to PdCl2, trans-[Cl2Pd(NCH2CPh)2] (5d) was formed. All new compounds were characterized by NMR, IR and mass spectra and also by X-ray structure analyses (except 3b). Additionally the cytotoxic effects of these complexes were examined on HL-60 and NALM-6 human leukemia cells and melanoma WM-115 cells. The antimicrobial activity was also determined. The growth of Gram-positive bacterial strains (S. aureus, S. epidermidis, E. faecalis) was inhibited by almost all tested complexes at the concentrations of 37.5–300.0 μg mL−1. However, MIC values of complexes obtained for Gram-negative E. coli and P. aeruginosa, as well as for C. albicans yeast, mostly exceeded 300 μg mL−1. The highest antibacterial activity was achieved by complexes 1a and 2b. Complex 2b also inhibited the growth of Gram-negative bacteria. Graphical abstract: Synthesis, structural characterization, antimicrobial and cytotoxic effects of aziridine, 2-aminoethylaziridine and azirine complexes of copper(ii) and palladium(ii

Influence of quorum sensing signal molecules on biofilm formation in Proteus mirabilis O18

The influence of basis of quorum sensing molecules on Proteus strains is much less known as compared to Pseudomonas or Escherichia. We have previously shown that a series of acylated homoserine lactones (acyl-HSL) does not influence the ureolytic, proteolytic, or hemolytic abilities, and that the swarming motility of Proteus mirabilis rods is strain specific. The aim of the presented study was to find out if the presence of a series of acyl-HSL influences biofilm formation of P. mirabilis laboratory strain belonging to O18 serogroup. This serogroup is characterized by the presence of a unique non-carbohydrate component, namely phosphocholine. Escherichia coli and P. mirabilis O18 strains used in this work contains cloned plasmids encoding fluorescent protein genes with constitutive gene expression. In mixed biofilms in stationary and continuous flow conditions, P. mirabilis O18 overgrow whole culture. P. mirabilis O18 strain has genetically proved a presence of AI–2 quorum sensing system. Differences in biofilm structure were observed depending on the biofilm type and culture methods. From tested acylated homoserine lactones (BHL, HHL, OHL, DHL, dDHL, tDHL), a significant influence had BHL on thickness, structure, and the amount of exopolysaccharides produced by biofilms formed by P. mirabilis O18 pDsRed2

Transitions to food democracy through multilevel governance

status: publishe

Ruchy społeczne a potrzeba zmiany w społeczeństwie obywatelskim. Podstawowe zagadnienia teoretyczne

Krajobraz przejawów obywatelskiego zaangażowania uległ w ostatnim czasie znaczącym przeobrażeniom. W miejsce dotychczas dominującej pozycji organizacji należących do III sektora pojawiły się ruchy społeczne. Są to nowi i niezmiernie istotni aktorzy polskiej sceny obywatelskiej, aktorzy z niepowtarzalnymi, dynamicznie aktualizującymi się tożsamościami zbiorowymi. W przeciwieństwie do wspomnianych organizacji pozarządowych nie dają się sprowadzić, a więc ograniczyć wyłącznie do ram instytucji i prawnych aspektów życia społecznego. Celem niniejszego artykułu jest omówienie podstawowych założeń teoretycznych, dotyczących ruchów społecznych, a związanych z kryteriami ich wyodrębniania, problemami definicyjnymi czy propozycjami ich typologizowania, przy jednoczesnym ukazaniu ich związku oraz dążeń do szeroko pojętej zmiany społecznej. Ponadto, w syntetyczny sposób, przedstawiam "miejsce" ruchów społecznych w społeczeństwie obywatelskim. Z jednej strony, widząc je jako istotne elemnty społeczeństwa obywatelskiego, z drugiej traktując je jako podmioty determinujące jego kształt

Recenzja: Barbara Jabłońska, Socjologia muzyki, Wydawnictwo Naukowe Scholar, Warszawa 2014.

Książka Barbary Jabłońskiej pt. "Socjoogia muzyki", wydana w 2014 r. nakładem Wydawnictwa Naukowego Scholar, jest monografią naukową, w której autorka - adiunkt w zakładzie Socjologii Teoretycznej Instytutu Socjologii Uniwersytetu Jagiellońskigo - wskrzesza dyskurs naukowy na temat ludzkich praktyk nakierowanych na muzykę, a także dokonuje swoistego ożywienia tradycji badań nad muzyką i społeczeństwem. Warto zaznaczyć, że wspomniana monografia jest pierwszym w literaturze polskiej tak kompleksowym ujeciem zagadnień z obszaru socjologii muzyki. Autorka poprzez odpowiedni dobór tematów, a także ciekawy ich opis opracowała rzetelne i jednocześnie przystępne studium obszaru do tej pory niezwykle słabo rozpoznanego, szczególnie na gruncie polskim