1,019 research outputs found
New ternary copper(II) complexes of l-alanine and heterocyclic bases: DNA binding and oxidative DNA cleavage activity
Four new ternary copper(II) complexes of α-amino acid having polypyridyl bases of general formulation [Cu(l-ala)(B)(H2O)](X) (1–4), where l-ala is l-alanine, B is an N,N-donor heterocyclic base, viz. 2,2′-bipyridine (bpy, 1), 1,10-phenanthroline (phen, 2) and 5,6-phenanthroline dione (dione, 3), dipyrido[3,2:2′,3′-f]quinoxaline (dpq, 4), and X = View the MathML source/View the MathML source are synthesized, characterized by various spectroscopic and X-ray crystallographic methods. The complexes show a distorted square-pyramidal (4 + 1) CuN3O2 coordination geometry. The one-electron paramagnetic complexes (1–4) display a low energy d–d band near 600 nm in aqueous medium and show a quasi-reversible cyclic voltammetric response due to one-electron Cu(II)/Cu(I) reduction near −100 mV (versus SCE) in DMF–0.1 M TBAP. Binding interactions of the complexes with calf thymus DNA (CT-DNA) were investigated by UV–Vis absorption titration, ethidium bromide displacement assay, viscometric titration experiment and DNA melting studies. All the complexes barring the complexes 1 and 3 are avid binder to the CT-DNA in the DNA minor groove giving an order: 4 > 2 ⋙ 1, 3. The complexes 2 and 4 show appreciable chemical nuclease activity in the presence of 3-mercaptopropionic acid (MPA) as a reducing agent. Hydroxyl radical was investigated to be the DNA cleavage active species. Control experiments in the presence of distamycin-A show primarily minor groove-binding propensity for the complexes 2 and 4 to the DNA
Systemic hemodynamic and regional circulatory effects of centrally administered endothelin-1 are mediated through ETA receptors
Central endothelin (ET) has been implicated in the regulation of the cardiovascular system. The effect of intracerebroventricular (i.c.v.) administration of ET-1 or IRL 1620 (5, 15 and 45 ng) on the systemic hemodynamics and regional circulation was studied in anesthetized rats using a radioactive microsphere technique. Systemic hemodynamics and regional blood circulation were determined before (baseline) and at 30 min after the injection of each dose of ET-1 or IRL 1620. Administration of saline (5 μl, i.c.v.) did not produce any significant cardiovascular effects. The lower doses of ET-1 (5 and 15 ng) did not produce any significant effect on blood pressure (BP), heart rate (HR), cardiac output (CO), stroke volume (SV), total peripheral resistance (TPR) and regional blood circulation. However, the higher dose (45 ng) produced a transient rise (26%) followed by a sustained fall (48%) in BP. The decrease in BP was accompanied by significant decreases in CO (44%) and SV (39%), while HR and TPR were not affected. ET-1 (45 ng, i.c.v.) also produced a significant reduction in blood flow to the brain (75%), heart (49%), kidneys (66%), GIT (40%), portal system (52%) and musculo-skeletal system (38%), while blood flow to the skin was not affected. To determine pharmacological specificity of the central effects of ET-1, studies were performed in rats pretreated with BQ-123, a specific ETA receptor antagonist. Pretreatment with BQ-123 (10 μg, i.c.v.), 15 min prior to the administration of ET-1, completely antagonized the systemic hemodynamic as well as the regional circulatory effects of ET-1 (45 ng, i.c.v.). In order to determine whether stimulation of central ETB receptors produces any cardiovascular effects, studies were performed using IRL 1620, a specific ETB receptor agonist. Administration of IRL 1620 (5, 15 and 45 ng, i.c.v.) did not produce any effect on systemic hemodynamics and regional blood circulation in rats. It is concluded that ETA but not ETB receptors are involved in the central cardiovascular actions of ET
Need for improving the health system preparedness for road traffic injuries in Nepal.
The growth of motorised and mass transportation has improved the lives and lifestyles of many. This economic progress has major drawbacks including: increased air pollution, road traffic crashes/injuries (RTCs/RTIs). Some papers may refer to Road Traffic Accidents or RTAs, but experts recommend the more appropriate to use RTIs. In recent decades the proportion of RTI to all deaths has declined in high-income countries whereas it has risen in many low- and middle-income countries
Non-Hermitian quantum mechanics in non-commutative space
We study non Hermitian quantum systems in noncommutative space as well as a
\cal{PT}-symmetric deformation of this space. Specifically, a
\mathcal{PT}-symmetric harmonic oscillator together with iC(x_1+x_2)
interaction is discussed in this space and solutions are obtained. It is shown
that in the \cal{PT} deformed noncommutative space the Hamiltonian may or may
not possess real eigenvalues depending on the choice of the noncommutative
parameters. However, it is shown that in standard noncommutative space, the
iC(x_1+x_2) interaction generates only real eigenvalues despite the fact that
the Hamiltonian is not \mathcal{PT}-symmetric. A complex interacting
anisotropic oscillator system has also been discussed.Comment: 5 pages, revised versio
Implications of the HERA Events for the R-Parity Breaking SUSY Signals at Tevatron
The favoured R-parity violating SUSY scenarios for the anomalous HERA events
correspond to top and charm squark production via the and
couplings. In both cases the corresponding electronic
branching fractions of the squarks are expected to be . Consequently the
canonical leptoquark signature is incapable of probing these scenarios at the
Tevatron collider over most of the MSSM parameter space. We suggest alternative
signatures for probing them at Tevatron, which seem to be viable over the
entire range of MSSM parameters.Comment: 20 pages Latex file with 4 ps files containing 4 figure
Probing R-parity violating models of neutrino mass at the Tevatron via top Squark decays
We have estimated the limiting branching ratio of the R-parity violating
(RPV) decay of the lighter top squark, \tilde t_1 \ar l^+ d ( or
and d is a down type quark of any flavor), as a function of top squark
mass(\MST) for an observable signal in the di-lepton plus di-jet channel at
the Tevatron RUN-II experiment with 2 fb luminosity. Our simulations
indicate that the lepton number violating nature of the underlying decay
dynamics can be confirmed via the reconstruction of \MST. The above decay is
interesting in the context of RPV models of neutrino mass where the RPV
couplings () driving the above decay are constrained to be
small (\lsim 10^{-3} - 10^{-4} ). If is the next lightest super
particle - a theoretically well motivated scenario - then the RPV decay can
naturally compete with the R-parity conserving (RPC) modes which also have
suppressed widths. The model independent limiting BR can delineate the
parameter space in specific supersymmetric models, where the dominating RPV
decay is observable and predict the minimum magnitude of the RPV coupling that
will be sensitive to Run-II data. We have found it to be in the same ballpark
value required by models of neutrino mass, for a wide range of \MST. A
comprehensive future strategy for linking top squark decays with models of
neutrino mass is sketched.Comment: 28 pages, 14 Figure
Longitudinal double-spin asymmetry and cross section for inclusive neutral pion production at midrapidity in polarized proton collisions at sqrt(s) = 200 GeV
We report a measurement of the longitudinal double-spin asymmetry A_LL and
the differential cross section for inclusive Pi0 production at midrapidity in
polarized proton collisions at sqrt(s) = 200 GeV. The cross section was
measured over a transverse momentum range of 1 < p_T < 17 GeV/c and found to be
in good agreement with a next-to-leading order perturbative QCD calculation.
The longitudinal double-spin asymmetry was measured in the range of 3.7 < p_T <
11 GeV/c and excludes a maximal positive gluon polarization in the proton. The
mean transverse momentum fraction of Pi0's in their parent jets was found to be
around 0.7 for electromagnetically triggered events.Comment: 6 pages, 3 figures, submitted to Phys. Rev. D (RC
A Pre-Landing Assessment of Regolith Properties at the InSight Landing Site
This article discusses relevant physical properties of the regolith at the Mars InSight landing site as understood prior to landing of the spacecraft. InSight will land in the northern lowland plains of Mars, close to the equator, where the regolith is estimated to be ≥3--5 m thick. These investigations of physical properties have relied on data collected from Mars orbital measurements, previously collected lander and rover data, results of studies of data and samples from Apollo lunar missions, laboratory measurements on regolith simulants, and theoretical studies. The investigations include changes in properties with depth and temperature. Mechanical properties investigated include density, grain-size distribution, cohesion, and angle of internal friction. Thermophysical properties include thermal inertia, surface emissivity and albedo, thermal conductivity and diffusivity, and specific heat. Regolith elastic properties not only include parameters that control seismic wave velocities in the immediate vicinity of the Insight lander but also coupling of the lander and other potential noise sources to the InSight broadband seismometer. The related properties include Poisson’s ratio, P- and S-wave velocities, Young’s modulus, and seismic attenuation. Finally, mass diffusivity was investigated to estimate gas movements in the regolith driven by atmospheric pressure changes. Physical properties presented here are all to some degree speculative. However, they form a basis for interpretation of the early data to be returned from the InSight mission.Additional co-authors: Nick Teanby and Sharon Keda
Longitudinal scaling property of the charge balance function in Au + Au collisions at 200 GeV
We present measurements of the charge balance function, from the charged
particles, for diverse pseudorapidity and transverse momentum ranges in Au + Au
collisions at 200 GeV using the STAR detector at RHIC. We observe that the
balance function is boost-invariant within the pseudorapidity coverage [-1.3,
1.3]. The balance function properly scaled by the width of the observed
pseudorapidity window does not depend on the position or size of the
pseudorapidity window. This scaling property also holds for particles in
different transverse momentum ranges. In addition, we find that the width of
the balance function decreases monotonically with increasing transverse
momentum for all centrality classes.Comment: 6 pages, 3 figure
Measurement of the Bottom contribution to non-photonic electron production in collisions at =200 GeV
The contribution of meson decays to non-photonic electrons, which are
mainly produced by the semi-leptonic decays of heavy flavor mesons, in
collisions at 200 GeV has been measured using azimuthal
correlations between non-photonic electrons and hadrons. The extracted
decay contribution is approximately 50% at a transverse momentum of GeV/. These measurements constrain the nuclear modification factor for
electrons from and meson decays. The result indicates that meson
production in heavy ion collisions is also suppressed at high .Comment: 6 pages, 4 figures, accepted by PR
- …