MP754: A Literature Review of the Effects of Intensive Forestry on Forest Structure and Plant Community Composition at the Stand and Landscape Levels

The effects of intensive forest management on forest structure and plant community composition are not well documented, particularly with respect to the forests in the Northeast. This review presents a six-part synthesis of the literature. The first section considers the effects of intensive forestry practices within the context of naturally regenerated stands. The second section reviews the changes associated with the planting of conifers in softwood sites, as well as those previously occupied by hardwood and mixed-wood stands. The third examines the impacts of intensive management specifically on bryophytes and lichens. The fourth section discusses changes in dead organic matter components of the stand and the fifth with the impact on tree pests. The final section views the effects of intensive forestry from the landscape-scale perspective and is followed by summary and conclusions. While this paper provides a summary of scientific information, it does not recommend policy or propose how the forest should be managed.https://digitalcommons.library.umaine.edu/aes_miscpubs/1022/thumbnail.jp

\u3ci\u3eDrosophila\u3c/i\u3e Model for Potential Plasticizer Induced Hyperactivity

Plasticizing additives such as phthalates, are known to cause disruptions in human nervous systems linked to neurological disorders, thus with the Drosophila activity monitoring (DAM) system test can be conducted to consider whether the flies are exhibiting hyperactivity (Hlisníková et al., 2021). Drosophila is a useful model for exposure of metabolic compounds followed by general and specific assays of their effects. Our experiments propose a link between exposure to phthalates and hyperactivity between humans that can be investigated with flies as a model for testing hyperactivity (Praveena et al., 2020). The link that is proposed is a cross-sectional study that collected urine samples of children and then scored kids based on attention-deficit/hyperactivity disorder (ADHD) (Kim et al., 2009). The DAM system is a method in which flies are individually monitored for activity during the day and night to notice any differences in general activity, locomotion, and circadian rhythms. The general activities of the flies would be examined alongside a baseline of Drosophila activity, alongside flies induced with glucose to measure any differences in hyperactivity. The addition of glucose is to give a baseline of what hyperactive flies will look like in their sleep cycle and movements in the DAM system We hypothesize a significant increase in hyperactivity in phthalate-exposed flies over both high-glucose and normal flies because phthalates are disrupters in the nervous system, thus may cause signs of hyperactivity when administered to the flies

Strong HIV-1-Specific T Cell Responses in HIV-1-Exposed Uninfected Infants and Neonates Revealed after Regulatory T Cell Removal

BACKGROUND: In utero transmission of HIV-1 occurs on average in only 3%–15% of HIV-1-exposed neonates born to mothers not on antiretroviral drug therapy. Thus, despite potential exposure, the majority of infants remain uninfected. Weak HIV-1-specific T-cell responses have been detected in children exposed to HIV-1, and potentially contribute to protection against infection. We, and others, have recently shown that the removal of CD4(+)CD25(+) T-regulatory (Treg) cells can reveal strong HIV-1 specific T-cell responses in some HIV-1 infected adults. Here, we hypothesized that Treg cells could suppress HIV-1-specific immune responses in young children. METHODOLOGY/PRINCIPAL FINDINGS: We studied two cohorts of children. The first group included HIV-1-exposed-uninfected (EU) as well as unexposed (UNEX) neonates. The second group comprised HIV-1-infected and HIV-1-EU children. We quantified the frequency of Treg cells, T-cell activation, and cell-mediated immune responses. We detected high levels of CD4(+)CD25(+)CD127(−) Treg cells and low levels of CD4(+) and CD8(+) T cell activation in the cord blood of the EU neonates. We observed HIV-1-specific T cell immune responses in all of the children exposed to the virus. These T-cell responses were not seen in the cord blood of control HIV-1 unexposed neonates. Moreover, the depletion of CD4(+)CD25(+) Treg cells from the cord blood of EU newborns strikingly augmented both CD4(+) and CD8(+) HIV-1-specific immune responses. CONCLUSIONS/SIGNIFICANCE: This study provides new evidence that EU infants can mount strong HIV-1-specific T cell responses, and that in utero CD4(+)CD25(+) T-regulatory cells may be contributing to the lack of vertical transmission by reducing T cell activation

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Drosophila Model for Potential Plasticizer Induced Hyperactivity

Plasticizing additives such as phthalates, are known to cause disruptions in human nervous systems linked to neurological disorders, thus with the Drosophila activity monitoring (DAM) system test can be conducted to consider whether the flies are exhibiting hyperactivity (Hlisníková et al., 2021). Drosophila is a useful model for exposure of metabolic compounds followed by general and specific assays of their effects. Our experiments propose a link between exposure to phthalates and hyperactivity between humans that can be investigated with flies as a model for testing hyperactivity (Praveena et al., 2020). The link that is proposed is a cross-sectional study that collected urine samples of children and then scored kids based on attention-deficit/hyperactivity disorder (ADHD) (Kim et al., 2009). The DAM system is a method in which flies are individually monitored for activity during the day and night to notice any differences in general activity, locomotion, and circadian rhythms. The general activities of the flies would be examined alongside a baseline of Drosophila activity, alongside flies induced with glucose to measure any differences in hyperactivity. The addition of glucose is to give a baseline of what hyperactive flies will look like in their sleep cycle and movements in the DAM system We hypothesize a significant increase in hyperactivity in phthalate-exposed flies over both high-glucose and normal flies because phthalates are disrupters in the nervous system, thus may cause signs of hyperactivity when administered to the flies

Supporting adaptation decisions through scenario planning: Enabling the effective use of multiple methods

Scenario planning is a technique used to inform decision-making under uncertainty, and is increasingly applied in the field of climate change adaptation and policy. This paper describes applications that combine previously distinct scenario methods in new and innovative ways. It draws on numerous recent independent case studies to illustrate emerging practices, such as far stronger connections between researcher-driven and participatory approaches and cycling between exploratory and normative perspectives. The paper concludes with a call for greater support for, and collaboration among, practitioners with the argument that mixed methods are most effective for decision-making in the context of climate change challenges

The evolution and ecology of multiple antipredator defences

Prey seldom rely on a single type of antipredator defence, often using multiple defences to avoid predation. In many cases, selection in different contexts may favour the evolution of multiple defences in a prey. However, a prey may use multiple defences to protect itself during a single predator encounter. Such "defence portfolios" that defend prey against a single instance of predation are distributed across and within successive stages of the predation sequence (encounter, detection, identification, approach (attack), subjugation and consumption). We contend that at present, our understanding of defence portfolio evolution is incomplete, and seen from the fragmentary perspective of specific sensory systems (e.g., visual) or specific types of defences (especially aposematism). In this review, we aim to build a comprehensive framework for conceptualizing the evolution of multiple prey defences, beginning with hypotheses for the evolution of multiple defences in general, and defence portfolios in particular. We then examine idealized models of resource trade-offs and functional interactions between traits, along with evidence supporting them. We find that defence portfolios are constrained by resource allocation to other aspects of life history, as well as functional incompatibilities between different defences. We also find that selection is likely to favour combinations of defences that have synergistic effects on predator behaviour and prey survival. Next, we examine specific aspects of prey ecology, genetics and development, and predator cognition that modify the predictions of current hypotheses or introduce competing hypotheses. We outline schema for gathering data on the distribution of prey defences across species and geography, determining how multiple defences are produced, and testing the proximate mechanisms by which multiple prey defences impact predator behaviour. Adopting these approaches will strengthen our understanding of multiple defensive strategies