A study of the relationship between a child's achievement and adjustment in grades one and three.

Thesis (Ed.M.)--Boston Universit

A Survey for H2_2O Megamasers in Active Galactic Nuclei -- II. A Comparison of Detected and Undetected Galaxies

A survey for H2O megamaser emission from 354 active galaxies has resulted in the detection of 10 new sources, making 16 known altogether. The galaxies surveyed include a distance-limited sample (covering Seyferts and LINERs with recession velocities < 7000 km s^{-1}) and a magnitude-limited sample (covering Seyferts and LINERs with m(B) <= 14.5). In order to determine whether the H2O-detected galaxies are "typical" AGN or have special properties which facilitate the production of powerful masers, we have accumulated a database of physical, morphological, and spectroscopic properties of the observed galaxies. The most significant finding is that H2O megamasers are detected only in Seyfert 2 and LINER galaxies, not Seyfert 1s. Implications for this finding are discussed. LINERs are detected at a similar rate to Seyfert 2s, constituting a strong argument that at least some nuclear LINERs are AGN rather than starbursts, since starbursts have not been detected as H2O megamasers. We preferentially detect H2O emission from the nearer galaxies and from those which are apparently brighter at mid- and far-infrared and centimeter radio wavelengths. There is also a possible trend for the H2O-detected galaxies to be more intrinsically luminous in nuclear 6 cm radio emission than the undetected ones, though these data are incomplete. We find evidence that Seyfert 2s with very high (N(H) > 10^{24} cm^{-2}) X-ray absorbing columns of gas are more often detected as H2O maser emitters than Seyfert 2s with lower columns. It may be that the probability of detecting H2O maser emission in Seyfert galaxies increases with increasing column of cool gas to the nucleus, from Seyfert 1s through NLXGs to Seyfert 2s.Comment: 19 pages, 35 figures, 3 of the tables are contained in separate LaTeX files: Table 1-a, 1-b, and 3. Also, figure captions are contained in a separate file which must be compiled with plain TeX, not LaTe

Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II):Statistical analysis plan

<p>Abstract</p> <p>Background</p> <p>Previous studies had suggested that the outcome for patients with spontaneous lobar intracerebral haemorrhage (ICH) and no intraventricular haemorrhage (IVH) might be improved with early evacuation of the haematoma. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) set out to establish whether a policy of earlier surgical evacuation of the haematoma in selected patients with spontaneous lobar ICH would improve outcome compared to a policy of initial conservative treatment. It is an international, multi-centre, prospective randomised parallel group trial of early surgery in patients with spontaneous lobar ICH. Outcome is measured at six months via a postal questionnaire.</p> <p>Results</p> <p>Recruitment to the study began on 27 November 2006 and closed on 15 August 2012 by which time 601 patients had been recruited. The protocol was published in <it>Trials</it> (<url>http://www.trialsjournal.com/content/12/1/124/</url>). This update presents the analysis plan for the study without reference to the unblinded data. The trial data will not be unblinded until after follow-up is completed in early 2013. The main trial results will be presented in spring 2013 with the aim to publish in a peer-reviewed journal at the same time.</p> <p>Conclusion</p> <p>The data from the trial will provide evidence on the benefits and risks of early surgery in patients with lobar ICH.</p> <p>Trial registration</p> <p>ISRCTN: ISRCTN22153967</p

Expansion of airway basal epithelial cells from primary human non-small cell lung cancer tumors

Pre-clinical non-small cell lung cancer (NSCLC) models are poorly representative of the considerable inter- and intra-tumor heterogeneity of the disease in patients. Primary cell-based in vitro models of NSCLC are therefore desirable for novel therapy development and personalized cancer medicine. Methods have been described to generate rapidly proliferating epithelial cell cultures from multiple human epithelia using 3T3-J2 feeder cell culture in the presence of Y-27632, a RHO-associated protein kinase (ROCK) inhibitor, in what are known as "conditional reprograming conditions" (CRC) or 3T3+Y. In some cancer studies, variations of this methodology have allowed primary tumor cell expansion across a number of cancer types but other studies have demonstrated the preferential expansion of normal epithelial cells from tumors in such conditions. Here, we report our experience regarding the derivation of primary NSCLC cell cultures from 12 lung adenocarcinoma patients enrolled in the Tracking Cancer Evolution through Therapy (TRACERx) clinical study and discuss these in the context of improving the success rate for in vitro cultivation of cells from NSCLC tumors. This article is protected by copyright. All rights reserved

HI Narrow Self-Absorption in Dark Clouds: Correlations with Molecular Gas and Implications for Cloud Evolution and Star Formation

We present the results of a comparative study of HI narrow self-absorption (HINSA), OH, 13CO, and C18O in five dark clouds. The HINSA follows the distribution of the emission of the carbon monoxide isotopologues, and has a characteristic size close to that of 13CO. This confirms that the HINSA is produced by cold HI which is well mixed with molecular gas in well-shielded regions. The ratio of the atomic hydrogen density to total proton density for these sources is 5 to 27 x 10^{-4}. Using cloud temperatures and the density of HI, we set an upper limit to the cosmic ray ionization rate of 10^{-16} s^{-1}. Comparison of observed and modeled fractional HI abundances indicates ages for these clouds to be 10^{6.5} to 10^{7} yr. The low values of the HI density we have determined make it certain that the time scale for evolution from an atomic to an almost entirely molecular phase, must be a minimum of several million years. This clearly sets a lower limit to the overall time scale for star formation and the lifetime of molecular clouds

AzTEC millimeter survey of the COSMOS field - III. Source catalog over 0.72 sq. deg. and plausible boosting by large-scale structure

We present a 0.72 sq. deg. contiguous 1.1mm survey in the central area of the COSMOS field carried out to a 1sigma ~ 1.26 mJy/beam depth with the AzTEC camera mounted on the 10m Atacama Submillimeter Telescope Experiment (ASTE). We have uncovered 189 candidate sources at a signal-to-noise ratio S/N >= 3.5, out of which 129, with S/N >= 4, can be considered to have little chance of being spurious (< 2 per cent). We present the number counts derived with this survey, which show a significant excess of sources when compared to the number counts derived from the ~0.5 sq. deg. area sampled at similar depths in the Scuba HAlf Degree Extragalactic Survey (SHADES, Austermann et al. 2010). They are, however, consistent with those derived from fields that were considered too small to characterize the overall blank-field population. We identify differences to be more significant in the S > 5 mJy regime, and demonstrate that these excesses in number counts are related to the areas where galaxies at redshifts z < 1.1 are more densely clustered. The positions of optical-IR galaxies in the redshift interval 0.6 < z < 0.75 are the ones that show the strongest correlation with the positions of the 1.1mm bright population (S > 5 mJy), a result which does not depend exclusively on the presence of rich clusters within the survey sampled area. The most likely explanation for the observed excess in number counts at 1.1mm is galaxy-galaxy and galaxy-group lensing at moderate amplification levels, that increases in amplitude as one samples larger and larger flux densities. This effect should also be detectable in other high redshift populations.Comment: 21 pages, 17 figures, accepted for publication in MNRA

Are 12^{12}CO lines good indicators of the star formation rate in galaxies?

In this paper, we investigate the relevance of using the $^{12}$CO line emissions as indicators of star formation rates (SFR). For the first time, we present this study for a relatively large number of $^{12}$CO transitions (12) as well as over a large interval in redshift (from z$\sim$0 to z$\sim$6). For the nearby sources (D$\leq$10 Mpc), we have used homogeneous sample of $^{12}$CO data provided by Bayet et al. (2004, 2006), mixing observational and modelled line intensities. For higher-z sources (z $\geq$ 1), we have collected $^{12}$CO observations from various papers and have completed the data set of line intensities with model predictions which we also present in this paper. Finally, for increasing the statistics, we have included recent $^{12}$CO(1-0) and $^{12}$CO(3-2) observations of intermediate-z sources. Linear regressions have been calculated for identifying the tightest SFR-$^{12}$CO line luminosity relationships. We show that the \emph{total} $^{12}$CO, the $^{12}$CO(5-4), the $^{12}$CO(6-5) and the $^{12}$CO(7-6) luminosities are the best indicators of SFR (as measured by the far-infrared luminosity). Comparisons with theoretical approaches from Krumholz and Thompson (2007) and Narayanan et al. (2008) are also performed in this paper. Although in general agreement, the predictions made by these authors and the observational results we present here show small and interesting discrepancies. In particular, the slope of the linear regressions, for J$_{upper}\geq$ 4 $^{12}$CO lines are not similar between theoretical studies and observations. On one hand, a larger high-J $^{12}$CO data set of observations might help to better agree with models, increasing the statistics. On the other hand, theoretical studies extended to high redshift sources might also reduce such discrepancies.Comment: 10 pages, 3 figures and 4 tables, Accepted in MNRA

An ultraviolet-selected galaxy redshift survey - III: Multicolour imaging and non-uniform star formation histories

(abridged) We present panoramic u' and optical ground-based imaging observations of a complete sample of low-redshift (0<z<0.4) galaxies selected in the ultraviolet (UV) at 2000A using the balloon-borne FOCA instrument of Milliard et al. This survey is highly sensitive to newly-formed massive stars, and hence to actively star-forming galaxies. We use the new data to further investigate the stellar population and star formation properties of this sample. When combined with our earlier spectroscopic surveys, these new data allow us to compare star-formation measures derived from aperture-corrected Ha line fluxes, UV(2000A) and u'(3600A) continuum fluxes on a galaxy-by-galaxy basis. As expected from our earlier studies, we find broad correlations between the dust-corrected star-formation diagnostics, though the scatter is larger than that from observational errors, with significant offsets from trends expected according to simple star-formation history (SFH) models. Varying metallicities and/or initial mass functions seem unable to explain the observed discrepancies. We investigate the star-formation properties further by modelling the observed spectroscopic and photometric properties of the galaxies in our survey. Nearly half of the galaxies surveyed possess features that appear incompatible with simple constant or smoothly declining SFHs, favouring instead irregular or temporally-varying SFHs. We demonstrate how this can reconcile the majority of our observations, and determine empirical corrections to calculate intrinsic star formation rates from measures based on UV (or u') observations alone. We discuss the broader implications of our finding that a significant fraction of star-forming galaxies have complex SFHs, particularly in the context of recent determinations of the cosmic SFH.Comment: MNRAS; post-referee report version. 16 pages, 10 figure

Linking radio to infrared: a radio source count model

We investigate the populations and evolution of normal and active galaxies by extending the infrared source count model of Rowan-Robinson (2001) into the radio. The FIR-radio correlation is used to extend the SEDs to the radio region and it is assumed that there are two distinct populations of quasar: radio loud and radio quiet. It is found that the radio luminosity function and source count data are best fit when the fraction of quasars that are radio loud is allowed to increase with optical luminosity. This implications for this are discussed, as are the possible causes for the variation in radio loud fraction.Comment: 9 pages (TeX file), 9 figures (eps format), submitted to MNRAS and corrected for referee's comment

Mapping the cold dust temperatures and masses of nearby Kingfish galaxies with Herschel

Taking advantage of the sensitivity and angular resolution of the Herschel Space Observatory at far-infrared and submm wavelengths, we aim to characterize the physical properties of cold dust within nearby galaxies and study the robustness of the parameters we derive using different modified blackbody models. For a pilot subsample of the KINGFISH program, we perform 2 temperature fits of the Spitzer and Herschel photometric data (24 to 500um), with a warm and a cold component, globally and in each resolution element.At global scales, we observe ranges of values for beta_c(0.8 to 2.5) and Tc(19.1 to 25.1K).We compute maps of our parameters with beta fixed or free to test the robustness of the temperature and dust surface density maps we deduce. When the emissivity is fixed, we observe temperature gradients as a function of radius.When the emissivity is fitted as a free parameter, barred galaxies tend to have uniform fitted emissivities.Gathering resolved elements in a Tc-beta_c diagram underlines an anti-correlation between the two parameters.It remains difficult to assess whether the dominant effect is the physics of dust grains, noise, or mixing along the line of sight and in the beam. We finally observe in both cases that the dust column density peaks in central regions of galaxies and bar ends (coinciding with molecular gas density enhancements usually found in these locations).We also quantify how the total dust mass varies with our assumptions about the emissivity index as well as the influence of the wavelength coverage used in the fits. We show that modified blackbody fits using a shallow emissivity (beta_c < 2.0) lead to significantly lower dust masses compared to the beta_c < 2.0 case, with dust masses lower by up to 50% if beta_c=1.5 for instance.The working resolution affects our total dust mass estimates: masses increase from global fits to spatially-resolved fits.Comment: 26 pages, 12 figures, 4 tables, accepted for publication in MNRAS, 2012 June 2