Health Conditions Among Unsheltered Adults in the U.S.

The California Policy Lab analyzed responses from more than 64,000 adults in the United States experiencing both sheltered and unsheltered homelessness. Unsheltered adults are far more likely to report suffering from chronic health conditions, mental health issues, and experiences with trauma and substance abuse problems as compared to homeless people who are living in shelters. As policymakers design interventions for unsheltered individuals and balance investments in emergency housing and permanent housing, they will need to consider whether emergency housing is adequate or appropriate for a highly vulnerable population, half of whom are trimorbid.This work has been supported, in part, by the University of California Multicampus Research Programs and Initiatives grant MRP-19-60077

The Grizzly, October 4, 2012

Campus Crime Rates • Banners Call for Student Power • UC Prepares to Vote • Professors up for Tenure • Resumania Offers Resume Aid • Phoenixville To-Dos • Marisa Roman Joins Ursinus Faculty • Grad School Guru Returns to Offer Tips and Advice • Opinion: We Should Distance Ourselves from Technology; Give CAB Events a Chance; Grizzly Staff Editorial • 3-0 UC Rugby Looks to Extend Streak • UC Recap: Mixed Week for the Bears • Coach Profile: Joe Groff, Volleyballhttps://digitalcommons.ursinus.edu/grizzlynews/1865/thumbnail.jp

The Grizzly, November 15, 2012

Website Sparks Campus Controversy • New Sculptures Share Connections with CIE Text • Underclassmen to Register on New Electronic System • Sandy Victims Still Need Aid • UCDC Fall Preview • Dr. Romano\u27s Book • Radio City Christmas Spectacular • Commuters at UC • Opinion: Disputed Website Shows Ursinus\u27 True Colors; It\u27s Becoming More Popular to Follow Celebrities\u27 Lives • Rough Time to be a Philadelphia Fan • Women\u27s Basketball Looks to Youth for Victories • Men\u27s Basketball Looks to Reboundhttps://digitalcommons.ursinus.edu/grizzlynews/1870/thumbnail.jp

The Grizzly, November 8, 2012

Hurricane Hits UC, Campus Evacuated • Sandy: Climate Change? • Alumni Give Back to Ursinus • Hillel Fosters an Open Community • Christmas Mall • New Faculty Members in Residence 2012 • Photography Club Returns to Campus • Henna Event in Celebration of TWLOHA Day • Opinion: Sandy Victims Deserve Respect, Support; Gender Roles Changing in America • Spotlight: Chris Rountree, Football • Men\u27s Swimming Looks to Have Big 2012 Season • Team Preview: Women\u27s Swimminghttps://digitalcommons.ursinus.edu/grizzlynews/1869/thumbnail.jp

The Grizzly, October 25, 2012

UCARE Directs Week of Local Service • UC Gears up for Homecoming • Report on Grads\u27 Successes • Grizzly Gala: Food, Drinks and Music • Teach for America • Homecoming Nominations • Headphone Disco • Opinion: Ursinus Sports Teams Need More Support; Varsity Teams and Athletes Overvalued at Ursinus • Ursinus Finalizes New Athletics Logo • Senior Spotlight: Kristin Hanratty, UC Volleyball • Homecoming Special for Class of \u2713https://digitalcommons.ursinus.edu/grizzlynews/1867/thumbnail.jp

The Grizzly, September 6, 2012

Ursinus Welcomes New Dean • Wismer Changes • Orientation Update • Dr. Heinzl Lecture • Gary Hodgson\u27s Tenure as Campus Safety Officer • Meet Mike Mullin, New R.D. • Gender-Neutral Bathrooms Arrive on UC Campus • Residence Life Offers Support for the Class of 2016 • Opinion: Athletes Frustrated by Dining Changes; Senator Rubio Would Have Been a Better V.P. Choice for the GOP • Field Hockey Looks to Keep Tradition • Under New Coach, Volleyball Begins 2012 Season • Lofty Expectations for Bears Footballhttps://digitalcommons.ursinus.edu/grizzlynews/1861/thumbnail.jp

The Grizzly, September 13, 2012

UC Remembers Lindsay Budnick • Greek Recruitment Changes • UC Fringe Returns • Film Fest to Celebrate Cultures • Bear Bucks Defined • CIE Fellows Aid CIE Students • CAB Welcomes New Executive Board and Events • Tree Planting Efforts Along the Perkiomen Creek • Opinion: New Allowances Limit SPINT Events; DNC Speakers Successfully Promote Obama • Season Preview: Women\u27s Soccer • Coach Profile: Kelly Wakeman, Women\u27s Soccer • Men\u27s Soccer Goes Young for Successhttps://digitalcommons.ursinus.edu/grizzlynews/1862/thumbnail.jp

Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

Here we report multiple lines of evidence for a comprehensive model of energy metabolism in the vertebrate eye. Metabolic flux, locations of key enzymes, and our finding that glucose enters mouse and zebrafish retinas mostly through photoreceptors support a conceptually new model for retinal metabolism. In this model, glucose from the choroidal blood passes through the retinal pigment epithelium to the retina where photoreceptors convert it to lactate. Photoreceptors then export the lactate as fuel for the retinal pigment epithelium and for neighboring Mu ̈ ller glial cells. We used human retinal epithelial cells to show that lactate can suppress consumption of glucose by the retinal pigment epithelium. Suppression of glucose consumption in the retinal pigment epithelium can increase the amount of glucose that reaches the retina. This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss

BaroFuse, a novel pressure-driven, adjustable-throughput perfusion system for tissue maintenance and assessment

Objectives: Microfluidic perfusion systems are used for assessing cell and tissue function while assuring cellular viability. Low perfusate flow rates, desired both for conserving reagents and for extending the number of channels and duration of experiments, conventionally depend on peristaltic pumps to maintain flow yet such pumps are unwieldy and scale poorly for high-throughput applications requiring 16 or more channels. The goal of the study was to develop a scalable multichannel microfluidics system capable of maintaining and assessing kinetic responses of small amounts of tissue to drugs or changes in test conditions. Methods: Here we describe the BaroFuse, a novel, multichannel microfluidics device fabricated using 3D-printing technology that uses gas pressure to drive large numbers of parallel perfusion experiments. The system is versatile with respect to endpoints due to the translucence of the walls of the perifusion chambers, enabling optical methods for interrogating the tissue status. The system was validated by the incorporation of an oxygen detection system that enabled continuous measurement of oxygen consumption rate (OCR). Results: Stable and low flow rates (1–20 μL/min/channel) were finely controlled by a single pressure regulator (0.5–2 psi). Control of flow in 0.2 μL/min increments was achieved. Low flow rates allowed for changes in OCR in response to glucose to be well resolved with very small numbers of islets (1–10 islets/channel). Effects of acetaminophen on OCR by precision-cut liver slices of were dose dependent and similar to previously published values that used more tissue and peristaltic-pump driven flow. Conclusions: The very low flow rates and simplicity of design and operation of the BaroFuse device allow for the efficient generation of large number of kinetic profiles in OCR and other endpoints lasting from hours to days. The use of flow enhances the ability to make measurements on primary tissue where some elements of native three-dimensional structure are preserved. We offer the BaroFuse as a powerful tool for physiological studies and for pharmaceutical assessment of drug effects as well as personalized medicine