6,108 research outputs found
Type-II Interface Exciton in ZnSe/(Zn,Mn)Se Heterostructures
Two emission bands are observed in the photoluminescence spectrum of ZnSe/~Zn,Mn!Se heterostructures. These bands emerge in a magnetic field and are associated with interface excitons formed as a result of a magnetic-field-induced type-Iâtype-II transition of the band alignment. Time-resolved measurements yield lifetimes in the ns range signifying a relatively large spatial separation of electrons and holes and hence low optical oscillator strength. These features are confirmed by a theoretical analysis of the interface exciton state revealing a reduced importance of the electron-hole Coulomb interaction in comparison with type-II excitons in quantum wells
Tetrazine-Triggered Release of Carboxylic-Acid-Containing Molecules for Activation of an Anti-inflammatory Drug.
In addition to its use for the study of biomolecules in living systems, bioorthogonal chemistry has emerged as a promising strategy to enable protein or drug activation in a spatially and temporally controlled manner. This study demonstrates the application of a bioorthogonal inverse electron-demand Diels-Alder (iEDDA) reaction to cleave trans-cyclooctene (TCO) and vinyl protecting groups from carboxylic acid-containing molecules. The tetrazine-mediated decaging reaction proceeded under biocompatible conditions with fast reaction kinetics (<2â
min). The anti-inflammatory activity of ketoprofen was successfully reinstated after decaging of the nontoxic TCOprodrug in live macrophages. Overall, this work expands the scope of functional groups and the application of decaging reactions to a new class of drugs
Photon assisted Levy flights of minority carriers in n-InP
We study the photoluminescence spectra of n-doped InP bulk wafers, both in
the reflection and the transmission geometries relative to the excitation beam.
From the observed spectra we estimate the spatial distribution of minority
carriers allowing for the spectral filtering due to re-absorption of
luminescence in the wafer. This distribution unambiguously demonstrates a
non-exponential drop-off with distance from the excitation region. Such a
behavior evidences an anomalous photon-assisted transport of minority carriers
enhanced owing to the high quantum efficiency of emission. It is shown that the
transport conforms very well to the so-called Levy-flights process
corresponding to a peculiar random walk that does not reduce to diffusion. The
index gamma of the Levy flights distribution is found to be in the range gamma
= 0.64 to 0.79, depending on the doping. Thus, we propose the high-efficiency
direct-gap semiconductors as a remarkable laboratory system for studying the
anomalous transport.Comment: 12 pages, 9 figure
Power saturation in standard and double-AR unfolded laser diode cavities
We report modeling and experimental results that demonstrate mechanisms limiting the output power of broad area semiconductor lasers. The modeling comprises numerical simulations of the laser cavity with evolution of non-uniform carrier density, photon density, temperature and index. We measure unfolded laser cavities to validate simulation methods and input parameters. © 2016 IEICE-ES
Two pathways of proton transfer reaction to (triphos)Cu(η1-BH4) via a dihydrogen bond [triphos = 1,1,1-tris(diphenylphosphinomethyl)ethane]
The interaction of alcohols of variable strength with the copper(i) borohydride complex (triphos)Cu(η1-BH4) results in a great variety of DHB complexes which encompass different mechanisms involving MâH and EâH bond (E = B, O) activation steps
Longitudinal spin transport in diluted magnetic semiconductor superlattices: the effect of the giant Zeeman splitting
Longitudinal spin transport in diluted magnetic semiconductor superlattices
is investigated theoretically. The longitudinal magnetoconductivity (MC) in
such systems exhibits an oscillating behavior as function of an external
magnetic field. In the weak magnetic field region the giant Zeeman splitting
plays a dominant role which leads to a large negative magnetoconductivity. In
the strong magnetic field region the MC exhibits deep dips with increasing
magnetic field. The oscillating behavior is attributed to the interplay between
the discrete Landau levels and the Fermi surface. The decrease of the MC at low
magnetic field is caused by the exchange interaction between the electron
in the conduction band and the magnetic ions.Comment: 6 pages, 9 figures, submitted to Phys. Rev.
Survey of variation in human transcription factors reveals prevalent DNA binding changes
Published in final edited form as:
Science. 2016 Mar 25; 351(6280): 1450â1454.
Published online 2016 Mar 24. doi: 10.1126/science.aad2257Sequencing of exomes and genomes has revealed abundant genetic variation affecting the coding sequences of human transcription factors (TFs), but the consequences of such variation remain largely unexplored. We developed a computational, structure-based approach to evaluate TF variants for their impact on DNA binding activity and used universal protein-binding microarrays to assay sequence-specific DNA binding activity across 41 reference and 117 variant alleles found in individuals of diverse ancestries and families with Mendelian diseases. We found 77 variants in 28 genes that affect DNA binding affinity or specificity and identified thousands of rare alleles likely to alter the DNA binding activity of human sequence-specific TFs. Our results suggest that most individuals have unique repertoires of TF DNA binding activities, which may contribute to phenotypic variation.National Institutes of Health; NHGRI R01 HG003985; P50 HG004233; A*STAR National Science Scholarship; National Science Foundatio
Tuning Carbon Dioxide Adsorption Affinity of Zinc(II) MOFs by Mixing Bis(pyrazolate) Ligands with N-Containing Tags
The four zinc(II) mixed-ligand metal-organic frameworks (MIXMOFs) Zn(BPZ)x(BPZNO2)1-x, Zn(BPZ)x(BPZNH2)1-x, Zn(BPZNO2)x(BPZNH2)1-x, and Zn(BPZ)x(BPZNO2)y(BPZNH2)1-x-y (H2BPZ = 4,4âČ-bipyrazole; H2BPZNO2 = 3-nitro-4,4âČ-bipyrazole; H2BPZNH2 = 3-amino-4,4âČ-bipyrazole) were prepared through solvothermal routes and fully investigated in the solid state. Isoreticular to the end members Zn(BPZ) and Zn(BPZX) (X = NO2, NH2), they are the first examples ever reported of (pyr)azolate MIXMOFs. Their crystal structure is characterized by a three-dimensional open framework with one-dimensional square or rhombic channels decorated by the functional groups. Accurate information about ligand stoichiometric ratio was determined (for the first time on MIXMOFs) through integration of selected ligands skeleton resonances from 13C cross polarized magic angle spinning solid-state NMR spectra collected on the as-synthesized materials. Like other poly(pyrazolate) MOFs, the four MIXMOFs are thermally stable, with decomposition temperatures between 708 and 726 K. As disclosed by N2 adsorption at 77 K, they are micro-mesoporous materials with Brunauer-Emmett-Teller specific surface areas in the range 400-600 m2/g. A comparative study (involving also the single-ligand analogues) of CO2 adsorption capacity, CO2 isosteric heat of adsorption (Qst), and CO2/N2 selectivity in equimolar mixtures at p = 1 bar and T = 298 K cast light on interesting trends, depending on ligand tag nature or ligand stoichiometric ratio. In particular, the amino-decorated compounds show higher Qst values and CO2/N2 selectivity vs the nitro-functionalized analogues; in addition, tag "dilution" [upon passing from Zn(BPZX) to Zn(BPZ)x(BPZX)1-x] increases CO2 adsorption selectivity over N2. The simultaneous presence of amino and nitro groups is not beneficial for CO2 uptake. Among the compounds studied, the best compromise among uptake capacity, Qst, and CO2/N2 selectivity is represented by Zn(BPZ)x(BPZNH2)1-x
An evaluation of metal removal during wastewater treatment: The potential to achieve more stringent final effluent standards
This is the author's accepted manuscript. The final published article is available from the link below. Copyright @ 2011 Taylor & Francis.Metals are of particular importance in relation to water quality, and concern regarding the impact of these contaminants on biodiversity is being encapsulated within the latest water-related legislation such as the Water Framework Directive in Europe and criteria revisions to the Clean Water Act in the United States. This review undertakes an evaluation of the potential of 2-stage wastewater treatment consisting of primary sedimentation and biological treatment in the form of activated sludge processes, to meet more stringent discharge consents that are likely to be introduced as a consequence. The legislation, sources of metals, and mechanisms responsible for their removal are discussed, to elucidate possible pathways by which the performance of conventional processes may be optimized or enhanced. Improvements in effluent quality, achievable by reducing concentrations of suspended solids or biochemical oxygen demand, may also reduce metal concentrations although meeting possible requirements for the removal of copper my be challenging
A Study of Cosmic Ray Secondaries Induced by the Mir Space Station Using AMS-01
The Alpha Magnetic Spectrometer (AMS-02) is a high energy particle physics
experiment that will study cosmic rays in the to range and will be installed on the International Space Station
(ISS) for at least 3 years. A first version of AMS-02, AMS-01, flew aboard the
space shuttle \emph{Discovery} from June 2 to June 12, 1998, and collected
cosmic ray triggers. Part of the \emph{Mir} space station was within the
AMS-01 field of view during the four day \emph{Mir} docking phase of this
flight. We have reconstructed an image of this part of the \emph{Mir} space
station using secondary and emissions from primary cosmic rays
interacting with \emph{Mir}. This is the first time this reconstruction was
performed in AMS-01, and it is important for understanding potential
backgrounds during the 3 year AMS-02 mission.Comment: To be submitted to NIM B Added material requested by referee. Minor
stylistic and grammer change
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