Évolution géodynamique du domaine Est Téthysien (Asie du Sud Est) du Permien supérieur au Trias supérieur : études des bassins sédimentaires et des séries volcano-sédimentaires associées

The Permian and the Triassic (ca. 300 to 200 Ma) are characterized by a global change that has impacted the hydrosphere, the atmosphere and especially the biosphere that has underwent one of its biggest crisis at the permian-triassic boundary. Assessing the role of the East Tethyan domain (present day South East Asia) in the reorganization of the biosphere is hampered by a poor understanding of its paleogeographic evolution. Examination of the Luang Prabang Basin (Laos) Sam Nua and Song Da Basin (Vietnam) using sedimentological, geochronological and geochemical analysis brings new information about the geodynamic evolution of the Indochina bloc. These studies revealed the existence of two subduction zones bordering the Indochina bloc during the Late Permian and the Early Triassic, followed by a collision with the Indochina bloc during the Middle Triassic while the other subduction zone was still active up to the Late Triasic. The magmatic arcs related to the subduction zones might have representedimportant topographic heights in an area located at a low latitude. The occurrence of a rather diversified continental ecosystem in the Luang Prabang Basin during the Lower Triassic suggests that these topographic heights could have formed a refuge zone suitable to the maintaining and/or the recovery of the biosphere during or slightly after the Permian-triassic biotic crisis.Le Permien et le Trias (ca. 300 à 200 Ma) sont caractérisés par une réorganisation globale de la dynamique des enveloppes externes de la Terre et en particulier de la biosphère qui traverse l'une de ses plus grandes crises à la transition entre le Permien le Trias. L'évaluation du rôle du domaine Est Téthysien (actuelle Asie du Sud Est) dans les perturbations des enveloppes externes est mal établie en raison d'une mauvaise compréhension de son évolution paléogéographique au Permien et au Trias. Des éléments nouveaux sur la paléogéographie et l'évolution géodynamique du domaine Est Téthysien ont été déduits d'analyses sédimentologiques, géochronologiques et géochimiques réalisées dans les bassins sédimentaires de Luang Prabang (Laos), Sam Nua et Song Da (Nord du Vietnam). Ces études ont montré qu'un ensemble continental majeur du domaine Est Téthysien, le bloc Indochinois, est bordé par deux zones de subduction au Permien supérieur et au Trias inférieur, puis entre en collision avec le bloc Chine du Sud au Trias moyen tandis que le fonctionnement de l'autre zone de subduction, au niveau du Bassin de Luang Prabang, se poursuit jusqu'au Trias supérieur. Les arcs magmatiques liés à la présence des zones de subductions représentaient alors probablement des reliefs topographiques importants dans une zone située à faible latitude. La présence d'un écosystème continental relativement diversifié au Trias inférieur dans le Bassin de Luang Prabang suggère que ces reliefs aient pu constituer des zones refuges favorables au maintient et/ou au renouvellement de la biosphère lors de la crise biologique permo-triasique

Les séries fluvio-éoliennes du "Cutler Group" :: Permien (Utah, USA). Modèle architectural et expression des unités génétiques

National audienceL'essor qu'a connu la stratigraphie séquentielle dans les environnements continentaux a permis de définir des modèles architecturaux pour des séries fluvio-lacustres. Plus récemment, les modèles proposés ont intégré les dépôts éoliens dans les systèmes continentaux côtiers ou lacustres (préservation de l'éolien vs variations de la table d'eau, e.g. Carr-Crabaugh & Kocurek, 1998) ou dans les systèmes continentaux endoréiques (préservation de l'éolien vs climat (e.g. Clemmensen et al., 1998) ou préservation de l'éolien vs accommodation et flux de sédiments, e.g. Bourquin et al., 2009). Cependant, peu de modèles discutent les variations de préservation des dépôts éoliens par rapport aux environnements continentaux associés (fluvial, lac, playa) afin de prédire un modèle architectural des dépôts éoliens (du réservoir au bassin) en fonction du contexte géodynamique. L'objectif de cet exposé est de contraindre l'expression des unités génétiques et de proposer un modèle architectural montrant les variations de préservation des dépôts éoliens en fonction du contexte tectonique, climatique et eustatique. L'étude des séries du Permien inférieur, " Cutler Group ", du " Paradox Basin " (SE Utah), caractérisées par des dépôts fluvio-éoliens (e.g. Condon, 1997), a été réalisée à partir de 5 sections sédimentologiques. Elles sont localisées sur un profil proximal représenté par des dépôts dominés fluvial jusqu'à des dépôts dominés éolien dans le domaine distal (e.g. Mountney & Jagger, 2004). Une étude sédimentologique et stratigraphique détaillée permet de proposer une évolution spatiale et temporelle des environnements de dépôt. Nous avons ainsi mis en évidence (1) les variations d'expression des unités génétiques d'un environnement proximal à un environnement distal en climat semi-aride, (2) plusieurs modèles architecturaux montrant l'évolution verticale depuis un contexte de bassin côtier, à dunes éoliennes faiblement préservées, vers des environnements plus continentaux dominés éolien puis vers des systèmes fluvio-lacustres à faible préservation des dépôts éoliens

The volcaniclastic series from the luang prabang basin, Laos: A witness of a triassic magmatic arc?

International audienceThe paleogeographic evolution of South East Asia (SEA) during the early Mesozoic is still poorly understood and a number of models have recently been put forward to account for the geodynamic evolution of SEA. The Luang Prabang Basin (north Laos), located in the core of a “paleogeographic jigsaw” in SEA, recorded a long lasting volcanism that spanned for ∼ 35 my from the earliest Triassic up to Late Triassic as evidenced by combined stratigraphic and geochronological (U-Pb/zircon) analyses performed on both volcanic and volcaniclastic series. The volcanic rocks are arc tholeiites and calk-alkaline andesites to dacites. The volcaniclastic rocks contain, in part, volcaniclasts produced contemporaneously with sedimentation. Both the volcanic and volcaniclastic series display geochemical features characteristic of a subduction related volcanism. Therefore, the Luang Prabang Basin documents a magmatic arc in a good agreement with the recent recognition of neighboring ophiolitic rocks in the Luang Prabang area. Following a passive margin setting that prevailed from the late Carboniferous to the late Permian, an active margin then initiated along the western margin of the Indochina Block. This active magmatic arc developed as the result of an east-dipping subduction below the Indochina Block during most of the Triassic, at least from ca. 250 to 215 Ma. Subsequently, this oceanic subduction episode must have been followed by a continental collision of the Indochina Block with the eastern Simao Block, at a period that remains to be defined

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs

Life-threatening `breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS- CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in vaccinated people remains unknown. Here, we studied a cohort of 48 individuals ( age 20-86 years) who received 2 doses of an mRNA vaccine and developed a breakthrough infection with hypoxemic COVID-19 pneumonia 2 weeks to 4 months later. Antibody levels to the vaccine, neutralization of the virus, and auto- Abs to type I IFNs were measured in the plasma. Forty-two individuals had no known deficiency of B cell immunity and a normal antibody response to the vaccine. Among them, ten (24%) had auto-Abs neutralizing type I IFNs (aged 43-86 years). Eight of these ten patients had auto-Abs neutralizing both IFN-a2 and IFN-., while two neutralized IFN-omega only. No patient neutralized IFN-ss. Seven neutralized 10 ng/mL of type I IFNs, and three 100 pg/mL only. Seven patients neutralized SARS-CoV-2 D614G and the Delta variant (B.1.617.2) efficiently, while one patient neutralized Delta slightly less efficiently. Two of the three patients neutralizing only 100 pg/mL of type I IFNs neutralized both D61G and Delta less efficiently. Despite two mRNA vaccine inoculations and the presence of circulating antibodies capable of neutralizing SARS-CoV-2, auto-Abs neutralizing type I IFNs may underlie a significant proportion of hypoxemic COVID-19 pneumonia cases, highlighting the importance of this particularly vulnerable population

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men

Geodynamic evolution of the East Tethysian domain (South East Asia) from the Late Permian to the Late Triassic : sedimentary bassins and associated volcano-sedimentary series

Le Permien et le Trias (ca. 300 à 200 Ma) sont caractérisés par une réorganisation globale de la dynamique des enveloppes externes de la Terre et en particulier de la biosphère qui traverse l'une de ses plus grandes crises à la transition entre le Permien le Trias. L'évaluation du rôle du domaine Est Téthysien (actuelle Asie du Sud Est) dans les perturbations des enveloppes externes est mal établie en raison d'une mauvaise compréhension de son évolution paléogéographique au Permien et au Trias. Des éléments nouveaux sur la paléogéographie et l'évolution géodynamique du domaine Est Téthysien ont été déduits d'analyses sédimentologiques, géochronologiques et géochimiques réalisées dans les bassins sédimentaires de Luang Prabang (Laos), Sam Nua et Song Da (Nord du Vietnam). Ces études ont montré qu'un ensemble continental majeur du domaine Est Téthysien, le bloc Indochinois, est bordé par deux zones de subduction au Permien supérieur et au Trias inférieur, puis entre en collision avec le bloc Chine du Sud au Trias moyen tandis que le fonctionnement de l'autre zone de subduction, au niveau du Bassin de Luang Prabang, se poursuit jusqu'au Trias supérieur. Les arcs magmatiques liés à la présence des zones de subductions représentaient alors probablement des reliefs topographiques importants dans une zone située à faible latitude. La présence d'un écosystème continental relativement diversifié au Trias inférieur dans le Bassin de Luang Prabang suggère que ces reliefs aient pu constituer des zones refuges favorables au maintient et/ou au renouvellement de la biosphère lors de la crise biologique permo-triasique.The Permian and the Triassic (ca. 300 to 200 Ma) are characterized by a global change that has impacted the hydrosphere, the atmosphere and especially the biosphere that has underwent one of its biggest crisis at the permian-triassic boundary. Assessing the role of the East Tethyan domain (present day South East Asia) in the reorganization of the biosphere is hampered by a poor understanding of its paleogeographic evolution. Examination of the Luang Prabang Basin (Laos) Sam Nua and Song Da Basin (Vietnam) using sedimentological, geochronological and geochemical analysis brings new information about the geodynamic evolution of the Indochina bloc. These studies revealed the existence of two subduction zones bordering the Indochina bloc during the Late Permian and the Early Triassic, followed by a collision with the Indochina bloc during the Middle Triassic while the other subduction zone was still active up to the Late Triasic. The magmatic arcs related to the subduction zones might have representedimportant topographic heights in an area located at a low latitude. The occurrence of a rather diversified continental ecosystem in the Luang Prabang Basin during the Lower Triassic suggests that these topographic heights could have formed a refuge zone suitable to the maintaining and/or the recovery of the biosphere during or slightly after the Permian-triassic biotic crisis

Planktic Foraminifera throughout the Pleistocene: From Cell to Populations to Past Marine Hydrology

Among microfossils currently extracted from Cenozoic sediments to reconstruct past environments are planktic foraminifers. These small calcareous organisms are furthermore probably ranked first in this set of tools when considering Paleoceanography, a science that has grown up proportionally to their use since now more than half a century. Planktonic foraminifera (PF) actually constitute the key material for paleoceanographers as a basic tool for stratigraphical and paleoecological reconstructions, both often based on coupled geochemical and micropaleontological approaches. Since the late ninety’s, the modern calibration of the PF proxy has taken growing importance, challenging the principle of uniformitarianism, especially in response to questions introduced by the molecular biology. This calibration can rely on two approaches: the first implies repetitive surveys of modern populations (throughout plankton tows or sediment traps) and the other one directly targets the analysis of recently fossilized populations in the topmost oceanic sediments in order to implement regional databases and develop the statistical approach of transfer functions sensu lato. This paper reviews the strengths and weaknesses of the latter approach, focusing on the North Atlantic Ocean (and its border seas), which up to now counts the largest existing set of data concerning planktonic foraminifera population

Sequence stratigraphy architecture and variations of aeolian deposits preservation in a coastal environment (Permian Cutler Group, SE Utah, USA).

International audienc

Late Permian to Late Triassic basin evolution of North Vietnam:geodynamic implications for the South China and Indochina blocks

International audienceThe core of South East Asia is composed of a mosaic of continental blocks, among which the Indochina and theSouth China blocks (present day northern Vietnam), amalgamated during the Permian and/or the Triassic. LatePermian to Late Triassic geodynamic evolution of these two blocks remains controversial. The main discussionpoints concern the existence and the closure of an oceanic domain separating the Indochina and the South Chinablocks during this period. Especially, the polarity and the timing of the subduction zone that led to the collisionbetween the blocks as well as the present location of the suture delimiting them are a matter of debate. Despite thevaluable information they can provide, the sedimentary basins from northern Vietnam have been neglected in theprevious studies dealing with the geodynamic evolution of South East Asia.To determine the geodynamic evolution of the area, the basins of Sam Nua and Song Da, presently locatedin North Vietnam, have been investigated using a combined approach involving sedimentology, geochronology(U-Pb/zircon) and geochemistry (whole-rock major and trace elements composition of both volcanic and volcaniclasticrocks). The palaeoenvironment evolution, the main unconformities, their age and the tectonic affinitiesof the interbedded volcanic and volcaniclastics series have been characterized for these two basins. Our resultsdemonstrate (i) that the Song Da Basin exhibits a palaeogeographic affinity with the South China block, (ii) theoccurrence of extensive calk-alkaline volcanism and associated volcaniclastic deposits in the Sam Nua Basin,related to the existence of an active magmatic arc during the Early and the lower Middle Triassic, (iii) a Southdipping (present day coordinate) oceanic lithosphere beneath the Indochina block, deduced from the location ofthe magmatic arc south of the potential suture zones, (iv) that an angular unconformity postdates the lower MiddleTriassic volcaniclastic deposits in the Sam Nua basin. This unconformity, crosscutting the subduction relateddeposits, is interpreted as the result of the collision between the Indochina and the South China blocks

Geodynamic evolution of the Minas Basin, southern S?o Francisco craton (Brazil), during the early paleoproterozoic : climate or tectonic?

Like many other cratons around the world, the S?o Francisco Craton is characterized by an early Paleoproterozoic (2.5?2.1 Ga) unconformity that is reported worldwide as the result of global glacial events leading to a major sea-level drop. To document the duration and the cause(s) of the stratigraphic hiatus in the S?o Francisco Craton, this study provides U?Pb dates obtained on detrital zircon grains from the Piracicaba Group, which directly overlies the unconformity. Our results show that this sedimentary unit is younger than 2333 ? 11 Ma and consequently deposited during the late Siderian or the early Rhaycian. This maximum depositional age demonstrates that the early Paleoproterozoic stratigraphic gap lasted for at least 60 Ma. Based on quantitative analyses of the age distribution of the Piracicaba Group, we evidence a major shift in sedimentary provenance between the sedimentary units located below and above the unconformity. This change is interpreted to be directly related to the development of a subduction system along the southern and eastern margins of the S?o Francisco proto-craton. Our results indicate that regional geodynamic events, and not only global glacial events and their consequences, must be accounted for in Earth system models for the early Paleoproterozoic