Desarrollo de la Medicina Regenerativa Periodontal con células madre y hemocomponentes

Cuba, es uno de los países con una notable aplicación de la medicina celular regenerativa, en especialidades médicas y estomatológicas, Santiago de Cuba, ha contribuido a su desarrollo, en los últimos años. Se realiza una investigación con carácter histórico, el objetivo de esta es describir la introducción y el desarrollo alcanzado por la especialidad, con células madre y hemocomponentes, en la especialidad de periodoncia, cuando se realiza la primera aplicación con plasma rico en plaquetas, luego del surgimiento de la Consulta de Medicina Celular Regenerativa, hasta la actualidad. Se evidencia el incremento del número de pacientes, con defectos óseos periodontales, beneficiados con esta terapéutica y el marcado beneficio social de salud, económico, político e institucional que se deriva de esta y propicia un servicio sanitario de calidad a la población

Development of Periodontal Regenerative Medicine with Mother Cells and hemocomponents

Cuba, es uno de los países con una notable aplicación de la medicina celular regenerativa, en especialidades médicas y estomatológicas, Santiago de Cuba, ha contribuido a su desarrollo, en los últimos años. Se realiza una investigación con carácter histórico, el objetivo de esta es describir la introducción y el desarrollo alcanzado por la especialidad, con células madre y hemocomponentes, en la especialidad de periodoncia, cuando se realiza la primera aplicación con plasma rico en plaquetas, luego del surgimiento de la Consulta de Medicina Celular Regenerativa, hasta la actualidad. Se evidencia el incremento del número de pacientes, con defectos óseos periodontales, beneficiados con esta terapéutica y el marcado beneficio social de salud, económico, político e institucional que se deriva de esta y propicia un servicio sanitario de calidad a la población.Cuba is one of the countries with a notable application of cell regenerative medicine in   medical and dental specialties, Santiago de Cuba has contributed to its development in the last years. A  historical research has been carried out , the objective is to describe the introduction and the reached development by the specialty, with mother cells and hemocomponents, in the specialty of Periodontics, when it was performed the first  application with plasma rich in platelets, after the after starting the Consult of Cellular Regenerative Medicine, until the present. There is evidence of the increasing of the number of patients, with bone periodontal defects, favored by this therapeutic and the obvious social, health, economic, politic and institutional benefit that has been derived.  It provides a qualified sanitary service to the population.

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3 - Meeting Abstracts - Antwerp, Belgium. 15–20 July 2017

This work was produced as part of the activities of FAPESP Research,\ud Disseminations and Innovation Center for Neuromathematics (grant\ud 2013/07699-0, S. Paulo Research Foundation). NLK is supported by a\ud FAPESP postdoctoral fellowship (grant 2016/03855-5). ACR is partially\ud supported by a CNPq fellowship (grant 306251/2014-0)

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Bioestimulación capilar con plasma rico en plaquetas contra la caída del cabello

Se describe el caso clínico de una paciente de 69 años de edad, quien acudió a la consulta de medicina regenerativa por presentar estrés mantenido y pérdida del cabello, para lo cual se decidió aplicar la bioestimulación con plasma rico en plaquetas lisado como terapia regenerativa, con plaquetas alogénicas en forma tópica, puesto que es un tratamiento inocuo y carente de complicaciones. Se obtuvo un incremento de los cabellos, espesamiento de la zona alopécica y la paciente recuperó su aparienci

Demography of degenerative arthropathy and regenerative medicine in santiaguero sport

This research uses regenerative medicine in degenerative arthropathy for sport, intending to demographically evaluate this population, general variables, and individuals of interest were assessed. In the percentage statistical analysis for the interpretation of results was obtained from the general variables, the predominance for males in the group of former athletes in the age range of 41 to 50 years, grade II of knee ostearthrosis as the region of anatomical location, and the most affected degree, the time of manifestation of the disease the eldest of the year of evolution, the over-use as an incidence factor for the onset of injury in the group of most affected sports treated, and as a treatment of implanted regenerative medicine most employed platelet-rich plasma (PRP). In particular variables of interest, the predominance in training, and the training cycle for the occurrence of the injury, and the competitive stage for athletes, and the general stage for former athletes, was obtained from the location for the occurrence of the injury

Perfeccionamiento de la microbiología y parasitología médicas mediante un enfoque interdisciplinario

En busca de novedosos enfoques metodológicos para la resolución de problemas, el objetivo de este trabajo consistió en mostrar los resultados de la labor interdisciplinaria del profesorado de Microbiología y Parasitología médicas en ese sentido, basada en la creación de los siguientes materiales didácticos: Manual de respuesta inmune a los agentes biológicos para estudiantes de medicina, Sistema de habilidades para el perfeccionamiento de la asignatura y Guía didáctica de los agentes biológicos que agreden al ser humano, entre otros. El claustro de profesores estableció una nueva relación entre estudiante y docente, derivada de profundos cambios en el método de enseñanza para cumplir la exigencia interdisciplinaria en la formación académica de los educandos y contribuir a la integración de la asignatur