137 research outputs found
Physical soil quality indicators for monitoring British soils
The condition or quality of soils determines its ability to deliver a range of functions that support ecosystem services, human health and wellbeing. The increasing policy imperative to implement successful soil monitoring programmes has resulted in the demand for reliable soil quality indicators (SQIs) for physical, biological and chemical soil properties. The selection of these indicators needs to ensure that they are sensitive and responsive to pressure and change e.g. they change across space and time in relation to natural perturbations and land management practices. Using a logical sieve approach based on key policy-related soil functions, this research assessed whether physical soil properties can be used to indicate the quality of British soils in terms of its capacity to deliver ecosystem goods and services. The resultant prioritised list of physical SQIs were tested for robustness, spatial and temporal variability and expected rate of change using statistical analysis and modelling. Six SQIs were prioritised; packing density, soil water retention characteristics, aggregate stability, rate of erosion, depth of soil and soil sealing. These all have direct relevance to current and likely future soil and environmental policy and are appropriate for implementation in soil monitoring programs
Indicators of soil quality - Physical properties (SP1611). Final report to Defra
The condition of soil determines its ability to carry out diverse and essential functions that support human health and wellbeing. These functions (or ecosystem goods and services) include producing food, storing water, carbon and nutrients, protecting our buried cultural heritage and providing a habitat for flora and fauna. Therefore, it is important to know the condition or quality of soil and how this changes over space and time in response to natural factors (such as changing weather patterns) or to land management practices. Meaningful soil quality indicators (SQIs), based on physical, biological or chemical soil properties are needed for the successful implementation of a soil monitoring programme in England and Wales. Soil monitoring can provide decision makers with important data to target, implement and evaluate policies aimed at safeguarding UK soil resources. Indeed, the absence of agreed and well-defined SQIs is likely to be a barrier to the development of soil protection policy and its subsequent implementation. This project assessed whether physical soil properties can be used to indicate the quality of soil in terms of its capacity to deliver ecosystem goods and services. The 22 direct (e.g. bulk density) and 4 indirect (e.g. catchment hydrograph) physical SQIs defined by Loveland and Thompson (2002) and subsequently evaluated by Merrington et al. (2006), were re-visited in the light of new scientific evidence, recent policy drivers and developments in sampling techniques and monitoring methodologies (Work Package 1). The culmination of these efforts resulted in 38 direct and 4 indirect soil physical properties being identified as potential SQIs. Based on the gathered evidence, a ‘logical sieve’ was used to assess the relative strengths, weaknesses and suitability of each potential physical SQI for national scale soil monitoring. Each soil physical property was scored in terms of: soil function – does the candidate SQI reflect all soil function(s)? land use - does the candidate SQI apply to all land uses found nationally? soil degradation - can the candidate SQI express soil degradation processes? does the candidate SQI meet the challenge criteria used by Merrington et al. (2006)?This approach enabled a consistent synthesis of available information and the semi-objective, semi-quantitative and transparent assessment of indicators against a series of scientific and technical criteria (Ritz et al., 2009; Black et al., 2008). The logical sieve was shown to be a flexible decision-support tool to assist a range of stakeholders with different agenda in formulating a prioritised list of potential physical SQIs. This was explored further by members of the soil science and soils policy community at a project workshop. By emphasising the current key policy-related soil functions (i.e. provisioning and regulating), the logical sieve was used to generate scores which were then ranked to identify the most qualified SQIs. The process selected 18 candidate physical SQIs. This list was further filtered to move from the ‘narrative’ to a more ‘numerical’ approach, in order to test the robustness of the candidate SQIs through statistical analysis and modelling (Work Package 2). The remaining 7 physical SQIs were: depth of soil; soil water retention characteristics; packing density; visual soil assessment / evaluation; rate of erosion; sealing; and aggregate stability. For these SQIs to be included in a robust national soil monitoring programme, we investigated the uncertainty in their measurement; the spatial and temporal variability in the indicator as given by observed distributions; and the expected rate of change in the indicator. Whilst a baseline is needed (i.e. the current state of soil), it is the rate of change in soil properties and the implications of that change in terms of soil processes and functioning that are key to effective soil monitoring. Where empirical evidence was available, power analysis was used to understand the variability of indicators as given by the observed distributions. This process determines the ability to detect a particular change in the SQI at a particular confidence level, given the ‘noise’ or variability in the data (i.e. a particular power to detect a change of ‘X’ at a confidence level of ‘Y%’ would require ‘N’ samples). However, the evidence base for analysing the candidate SQIs is poor: data are limited in spatial and temporal extent for England and Wales, in terms of a) the degree (magnitude) of change in the SQI which significantly affects soil processes and functions (i.e. ‘meaningful change’), and b) the change in the SQI that is detectable (i.e. what sample size is needed to detect the meaningful signal from the variability or noise in the signal). This constrains the design and implementation of a scientifically and statistically rigorous and reliable soil monitoring programme. Evidence that is available suggests that what constitutes meaningful change will depend on soil type, current soil state, land use and the soil function under consideration. However, when we tested this by analysing detectable changes in packing density and soil depth (because data were available for these SQIs) over different land covers and soil types, no relationships were found. Schipper and Sparling (2000) identify the challenge: “a standardised methodology may not be appropriate to apply across contrasting soils and land uses. However, it is not practical to optimise sampling and analytical techniques for each soil and land use for extensive sampling on a national scale”. Despite the paucity in data, all seven SQIs have direct relevance to current and likely future soil and environmental policy, because they can be related (qualitatively) to soil processes, soil functions and delivery of ecosystem goods and services. Even so, meaningful and detectable changes in physical SQIs may be out of time with any soil policy change and it is not usually possible to link particular changes in SQIs to particular policy activities. This presents challenges in ascertaining trends that can feed into policy development or be used to gauge the effectiveness of soil protection policies (Work Package 3). Of the seven candidate physical SQIs identified, soil depth and surface sealing are regarded by many as indicators of soil quantity rather than quality. Visual soil evaluation is currently not suited to soil monitoring in the strictest sense, as its semi-qualitative basis cannot be analysed statistically. Also, few data exist on how visual evaluation scores relate to soil functions. However, some studies have begun to investigate how VSE might be moved to a more quantified scale and the method has some potential as a low cost field technique to assess soil condition. Packing density requires data on bulk density and clay content, both of which are highly variable, so compounding the error term associated with this physical SQI. More evidence is needed to show how ‘meaningful’ change in aggregate stability affects soil processes and thus soil functions (for example, using the limited data available, an equivocal relationship was found with water regulation / runoff generation). The analysis of available data has given promising results regarding the prediction of soil water retention characteristics and packing density from relatively easy to measure soil properties (bulk density, texture and organic C) using pedotransfer functions. Expanding the evidence base is possible with the development of rapid, cost-effective techniques such as NIR sensors to measure soil properties. Defra project SP1303 (Brazier et al., 2012) used power analyses to estimate the number of monitoring locations required to detect a statistically significant change in soil erosion rate on cultivated land. However, what constitutes a meaningful change in erosion rates still requires data on the impacts of erosion on soil functions. Priority cannot be given amongst the seven SQIs, because the evidence base for each varies in its robustness and extent. Lack of data (including uncertainty in measurement and variability in observed distributions) applies to individual SQIs; attempts at integrating more than one SQI (including physical, biological and chemical SQIs) to improve associations between soil properties and processes / functions are only likely to propagate errors. Whether existing monitoring programmes can be adapted to incorporate additional measurement of physical SQIs was explored. We considered options where one or more of the candidate physical SQIs might be implemented into soil monitoring programmes (e.g. as a new national monitoring scheme; as part of the Countryside Survey; and as part of the National Soil Inventory). The challenge is to decide whether carrying out soil monitoring that is not statistically robust is still valuable in answering questions regarding current and future soil quality. The relationship between physical (and other) SQIs, soil processes and soil functions is complex, as is how this influences ecosystem services’ delivery. Important gaps remain in even the realisation of a conceptual model for these inter-relationships, let alone their quantification. There is also a question of whether individual quantitative SQIs can be related to ecosystem services, given the number of variables
Multi-ancestry genome-wide association study of gestational diabetes mellitus highlights genetic links with type 2 diabetes
Gestational diabetes mellitus (GDM) is associated with increased risk of pregnancy complications and adverse perinatal outcomes. GDM often reoccurs and is associated with increased risk of subsequent diagnosis of type 2 diabetes (T2D). To improve our understanding of the aetiological factors and molecular processes driving the occurrence of GDM, including the extent to which these overlap with T2D pathophysiology, the GENetics of Diabetes In Pregnancy Consortium assembled genome-wide association studies of diverse ancestry in a total of 5485 women with GDM and 347 856 without GDM. Through multi-ancestry meta-analysis, we identified five loci with genome-wide significant association (P < 5 x 10(-8)) with GDM, mapping to/near MTNR1B (P = 4.3 x 10(-54)), TCF7L2 (P = 4.0 x 10(-16)), CDKAL1 (P = 1.6 x 10(-4)), CDKN2A-CDKN2B (P = 4.1 x 10(-9)) and HKDC1 (P = 2.9 x 10(-8)). Multiple lines of evidence pointed to the shared pathophysiology of GDM and T2D: (i) four of the five GDM loci (not HKDC1) have been previously reported at genome-wide significance for T2D; (ii) significant enrichment for associations with GDM at previously reported T2D loci; (iii) strong genetic correlation between GDM and T2D and (iv) enrichment of GDM associations mapping to genomic annotations in diabetes-relevant tissues and transcription factor binding sites. Mendelian randomization analyses demonstrated significant causal association (5% false discovery rate) of higher body mass index on increased GDM risk. Our results provide support for the hypothesis that GDM and T2D are part of the same underlying pathology but that, as exemplified by the HKDC1 locus, there are genetic determinants of GDM that are specific to glucose regulation in pregnancy.Peer reviewe
EPHA2 Is Associated with Age-Related Cortical Cataract in Mice and Humans
Age-related cataract is a major cause of blindness worldwide, and cortical cataract is the second most prevalent type of age-related cataract. Although a significant fraction of age-related cataract is heritable, the genetic basis remains to be elucidated. We report that homozygous deletion of Epha2 in two independent strains of mice developed progressive cortical cataract. Retroillumination revealed development of cortical vacuoles at one month of age; visible cataract appeared around three months, which progressed to mature cataract by six months. EPHA2 protein expression in the lens is spatially and temporally regulated. It is low in anterior epithelial cells, upregulated as the cells enter differentiation at the equator, strongly expressed in the cortical fiber cells, but absent in the nuclei. Deletion of Epha2 caused a significant increase in the expression of HSP25 (murine homologue of human HSP27) before the onset of cataract. The overexpressed HSP25 was in an underphosphorylated form, indicating excessive cellular stress and protein misfolding. The orthologous human EPHA2 gene on chromosome 1p36 was tested in three independent worldwide Caucasian populations for allelic association with cortical cataract. Common variants in EPHA2 were found that showed significant association with cortical cataract, and rs6678616 was the most significant in meta-analyses. In addition, we sequenced exons of EPHA2 in linked families and identified a new missense mutation, Arg721Gln, in the protein kinase domain that significantly alters EPHA2 functions in cellular and biochemical assays. Thus, converging evidence from humans and mice suggests that EPHA2 is important in maintaining lens clarity with age
Why do banks promise to pay par on demand?
We survey the theories of why banks promise to pay par on demand and examine evidence about
the conditions under which banks have promised to pay the par value of deposits and banknotes on
demand when holding only fractional reserves. The theoretical literature can be broadly divided into four
strands: liquidity provision, asymmetric information, legal restrictions, and a medium of exchange. We
assume that it is not zero cost to make a promise to redeem a liability at par value on demand. If so, then
the conditions in the theories that result in par redemption are possible explanations of why banks
promise to pay par on demand. If the explanation based on customers’ demand for liquidity is correct,
payment of deposits at par will be promised when banks hold assets that are illiquid in the short run. If
the asymmetric-information explanation based on the difficulty of valuing assets is correct, the
marketability of banks’ assets determines whether banks promise to pay par. If the legal restrictions
explanation of par redemption is correct, banks will not promise to pay par if they are not required to do
so. If the transaction explanation is correct, banks will promise to pay par value only if the deposits are
used in transactions. After the survey of the theoretical literature, we examine the history of banking in
several countries in different eras: fourth-century Athens, medieval Italy, Japan, and free banking and
money market mutual funds in the United States. We find that all of the theories can explain some of the
observed banking arrangements, and none explain all of them
Loci influencing blood pressure identified using a cardiovascular gene-centric array
Blood pressure (BP) is a heritable determinant of risk for cardiovascular disease (CVD). To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP) and pulse pressure (PP), we genotyped 50 000 single-nucleotide polymorphisms (SNPs) that capture variation in 2100 candidate genes for cardiovascular phenotypes in 61 619 individuals of European ancestry from cohort studies in the USA and Europe. We identified novel associations between rs347591 and SBP (chromosome 3p25.3, in an intron of HRH1) and between rs2169137 and DBP (chromosome1q32.1 in an intron of MDM4) and between rs2014408 and SBP (chromosome 11p15 in an intron of SOX6), previously reported to be associated with MAP. We also confirmed 10 previously known loci associated with SBP, DBP, MAP or PP (ADRB1, ATP2B1, SH2B3/ATXN2, CSK, CYP17A1, FURIN, HFE, LSP1, MTHFR, SOX6) at array-wide significance (P 2.4 10(6)). We then replicated these associations in an independent set of 65 886 individuals of European ancestry. The findings from expression QTL (eQTL) analysis showed associations of SNPs in the MDM4 region with MDM4 expression. We did not find any evidence of association of the two novel SNPs in MDM4 and HRH1 with sequelae of high BP including coronary artery disease (CAD), left ventricular hypertrophy (LVH) or stroke. In summary, we identified two novel loci associated with BP and confirmed multiple previously reported associations. Our findings extend our understanding of genes involved in BP regulation, some of which may eventually provide new targets for therapeutic intervention.</p
Diving into the vertical dimension of elasmobranch movement ecology
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
Diving into the vertical dimension of elasmobranch movement ecology
Knowledge of the three-dimensional movement patterns of elasmobranchs is vital to understand their ecological roles and exposure to anthropogenic pressures. To date, comparative studies among species at global scales have mostly focused on horizontal movements. Our study addresses the knowledge gap of vertical movements by compiling the first global synthesis of vertical habitat use by elasmobranchs from data obtained by deployment of 989 biotelemetry tags on 38 elasmobranch species. Elasmobranchs displayed high intra- and interspecific variability in vertical movement patterns. Substantial vertical overlap was observed for many epipelagic elasmobranchs, indicating an increased likelihood to display spatial overlap, biologically interact, and share similar risk to anthropogenic threats that vary on a vertical gradient. We highlight the critical next steps toward incorporating vertical movement into global management and monitoring strategies for elasmobranchs, emphasizing the need to address geographic and taxonomic biases in deployments and to concurrently consider both horizontal and vertical movements
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