Evolution of ecosystem services in the frame of pastoral functional categories A study case in Swedish Lapland

International audienceEcosystem services represent a useful tool to manage human – environment systems, (Vihervaara, Kumpula et al., 2010). In polar environments where global warming has stronger effects on socioecosystems (ACIA, 2004; WG1, IPCC, 2014), taking account of local knowledge, culture and productionrepresent an urgent matter (WG2, IPCC, 2014; Maynard, Oskal et al. in Gutman, Reissell (eds), 2010). In northern Europe, reindeer (Rangifer tarandus tarandus L.) is a keystone specie, particularly important for landscapes ecological functioning, structure, and for pastoral systems resilience (Forbes,Kumpula, 2009). The aims of the study are both methodological and thematic: by re-using the classification of ecosystem services that Vihervaara, Kumpula et al. (2010) proposed, we seek firstly to map ecosystem services (supporting, provisioning, regulating, cultural services), as some could be named in thenorthern Saami language. Secondly we survey how ecosystem services of the Gabna reindeer herders’ community (roughly stretching between Riksgränsen and Kiruna, ~150 km, Norrbotten county, Sweden) evolved along time (from 1990, 2000 to 2017).Using literature (Klein, 1990, Inga, 2006, 2007, Roturier et al., 2009, Lavrillier (ed) 2017) and field information (mainly floristic surveys), we use saami pastoral categories of vegetation according to their provisioning or cultural ecosystem services. Landsat imagery is processed all along the study (landcover classification using saami terminologies and comparatively the EUNIS habitat classification), as well as floristic datasets (physiognomy, floristic communities) to create a supervised terrain classification with remote sensing techniques.First results show that slight differences (in surface units) are noticed between saami terminologies and EUNIS habitat classification to express ecosystem services. Results stay scale-dependent according to the spatial unit (entire community, seasonal pastures…). A progressive, but important decrease in ecosystem services within the Gabna community borders is recorded, explainable by (a) forestry intensification for winter pastures (b) mining and touristic activities intensification (c) loss of palatable vegetation in summer / effects of plant competition.The use of local terminologies in the frame of pastoralist landscape conservation applied to a survey in environmental sciences opened to a holistic integration. This raised the importance of local stakeholders (herders, law makers, scientists) as co-researchers in nature conservation studies

Effect of Flow Rate and Viscosity on Complex Fracture Development in UFM Model

A recently developed unconventional fracture model (UFM*) is able to simulate complex fracture networks propagation in a formation with pre-existing natural fractures. Multiple fracture branches can propagate at the same time and crisscross each other. The behaviour of a hydraulic fracture when it intersects a natural fracture, whether being arrested, crossing, creating an offset, or dilating the natural fracture, plays a key role in predicting the resulting fracture footprint, microseismicity, and improving production evaluation. It is therefore critical to properly model the fracture interaction in a complex fracture model such as UFM

Ascites and resistance to immune checkpoint inhibition in dMMR/MSI-H metastatic colorectal and gastric cancers

Gastrointestinal neoplasms; Immunotherapy; Tumor biomarkersNeoplasias gastrointestinales; Inmunoterapia; Biomarcadores tumoralesNeoplàsies gastrointestinals; Immunoteràpia; Biomarcadors tumoralsBackground Despite unprecedented benefit from immune checkpoint inhibitors (ICIs) in patients with mismatch repair deficient (dMMR)/microsatellite instability high (MSI-H) advanced gastrointestinal cancers, a relevant proportion of patients shows primary resistance or short-term disease control. Since malignant effusions represent an immune-suppressed niche, we investigated whether peritoneal involvement with or without ascites is a poor prognostic factor in patients with dMMR/MSI-H metastatic colorectal cancer (mCRC) and gastric cancer (mGC) receiving ICIs. Methods We conducted a global multicohort study at Tertiary Cancer Centers and collected clinic-pathological data from a cohort of patients with dMMR/MSI-H mCRC treated with anti-PD-(L)1 ±anti-CTLA-4 agents at 12 institutions (developing set). A cohort of patients with dMMR/MSI-high mGC treated with anti-PD-1 agents±chemotherapy at five institutions was used as validating dataset. Results The mCRC cohort included 502 patients. After a median follow-up of 31.2 months, patients without peritoneal metastases and those with peritoneal metastases and no ascites had similar outcomes (adjusted HR (aHR) 1.15, 95% CI 0.85 to 1.56 for progression-free survival (PFS); aHR 0.96, 95% CI 0.65 to 1.42 for overall survival (OS)), whereas inferior outcomes were observed in patients with peritoneal metastases and ascites (aHR 2.90, 95% CI 1.70 to 4.94; aHR 3.33, 95% CI 1.88 to 5.91) compared with patients without peritoneal involvement. The mGC cohort included 59 patients. After a median follow-up of 17.4 months, inferior PFS and OS were reported in patients with peritoneal metastases and ascites (aHR 3.83, 95% CI 1.68 to 8.72; aHR 3.44, 95% CI 1.39 to 8.53, respectively), but not in patients with only peritoneal metastases (aHR 1.87, 95% CI 0.64 to 5.46; aHR 2.15, 95% CI 0.64 to 7.27) when compared with patients without peritoneal involvement. Conclusions Patients with dMMR/MSI-H gastrointestinal cancers with peritoneal metastases and ascites should be considered as a peculiar subgroup with highly unfavorable outcomes to current ICI-based therapies. Novel strategies to target the immune-suppressive niche in malignant effusions should be investigated, as well as next-generation ICIs or intraperitoneal approaches

Rubus idaeus extract improves symptoms in knee osteoarthritis patients: results from a phase II double-blind randomized controlled trial.

peer reviewed[en] BACKGROUND: Osteoarthritis (OA) is the most frequent cause of disability in elderly people. In daily practice, the main objective of the physician is to reduce patient symptoms using treatments without adverse effects. However, the most prescribed treatment to manage OA symptoms remains nonsteroidal anti-inflammatory drugs which are associated with severe adverse effects. Therefore, we need a safe alternative to managing OA. One candidate is Rubus idaeus leaf extracts known to inhibit inflammatory responses. OBJECTIVE: This study aimed to evaluate the effects of a 12-weeks intervention with an ethanolic extract from Rubus idaeus leaf on symptoms of knee osteoarthritis. METHOD: The study was a randomized, double-blind, placebo-controlled, monocentric trial of 198 participants with femorotibial osteoarthritis. Participants were randomized equally to receive one daily during 3 months either 1 capsule of Rubus idaeus leaf extract 400 mg, 1 capsule of Rubus idaeus leaf extract 200 mg, or 1 capsule of placebo. The participants were assessed at baseline and after one and three months of treatment. The primary endpoint was an absolute change of the Western Ontario McMaster osteoarthritis index (WOMAC) pain subscale. The secondary endpoints were WOMAC global score, stiffness and function sub-scales, knee pain VAS score at walking, the Short Form (SF)-36, the Short Physical Performance Battery (SPPB), the 20-m walk test, and the International Physical Activity Questionnaire (IPAQ) and Outcome Measures in Rheumatology Clinical Trials and Osteoarthritis Research Society International (OMERACT-OARSI) responders rate. Statistical analyses were conducted on the intent-to-treat (ITT) population. RESULTS: In the Intention-to-treat population, WOMAC pain was not significantly modified by Rubus idaeus leaf extract compared to placebo. In contrast, Rubus idaeus leaf extract 400 mg after 12 weeks of treatment significantly reduced pain measured by the VAS. The mean pain decrease induced by Rubus ideaus leaf extract was over -7 mm which is clinically relevant and reached a clinically statistical difference compared to placebo with the highest dose. Rubus Ideaus was not significantly more efficient than the placebo on WOMAC global score, stiffness, and physical function subscores, IPAQ, SF-36, walking distance in treadmill test, SPPB, and evaluation of associated treatments needed to manage OA. CONCLUSION: Rubus idaeus leaf extract was well tolerated and effective to relieve pain in a patient with knee osteoarthritis. TRIAL REGISTRATION: NCT03703024  (11/10/2018)

Simplicial simple-homotopy of flag complexes in terms of graphs

International audienceA flag complex can be defined as a simplicial complex whose simplices correspond to complete subgraphs of its 1-skeleton taken as a graph. In this article, by introducing the notion of s-dismantlability, we shall define the s-homotopy type of a graph and show in particular that two finite graphs have the same s-homotopy type if, and only if, the two flag complexes determined by these graphs have the same simplicial simple-homotopy type. This result is closely related to similar results established by Barmak and Minian [J.A. Barmak, E.G. Minian, Simple homotopy types and finite spaces, Adv. Math. 218 (1) (2008) 87-104. doi:10.1016/j.aim.2007.11.019] in the framework of posets and we give the relation between the two approaches. We conclude with a question about the relation between the s-homotopy and the graph homotopy defined in [B. Chen, S.-T. Yau, Y.-N. Yeh, Graph homotopy and Graham homotopy, Selected papers in honor of Helge Tverberg, Discrete Math. 241 (1-3) (2001) 153-170. doi:10.1016/S0012-365X(01)00115-7.

Statistical learning occurs during practice while high-order rule learning during rest period

Knowing when the brain learns is crucial for both the comprehension of memory formation and consolidation and for developing new training and neurorehabilitation strategies in healthy and patient populations. Recently, a rapid form of offline learning developing during short rest periods has been shown to account for most of procedural learning, leading to the hypothesis that the brain mainly learns during rest between practice periods. Nonetheless, procedural learning has several subcomponents not disentangled in previous studies investigating learning dynamics, such as acquiring the statistical regularities of the task, or else the high-order rules that regulate its organization. Here we analyzed 506 behavioral sessions of implicit visuomotor deterministic and probabilistic sequence learning tasks, allowing the distinction between general skill learning, statistical learning, and high-order rule learning. Our results show that the temporal dynamics of apparently simultaneous learning processes differ. While high-order rule learning is acquired offline, statistical learning is evidenced online. These findings open new avenues on the short-scale temporal dynamics of learning and memory consolidation and reveal a fundamental distinction between statistical and high-order rule learning, the former benefiting from online evidence accumulation and the latter requiring short rest periods for rapid consolidation

Pressure promoted low-temperature melting of metal–organic frameworks

International audienceMetal–organic frameworks (MOFs) are microporous materials with huge potential for chemical processes. Structural collapse at high pressure, and transitions to liquid states at high temperature, have recently been observed in the zeolitic imidazolate framework (ZIF) family of MOFs. Here, we show that simultaneous high-pressure and high-temperature conditions result in complex behaviour in ZIF-62 and ZIF-4, with distinct high- and low-density amorphous phases occurring over different regions of the pressure–temperature phase diagram. In situ powder X-ray diffraction, Raman spectroscopy and optical microscopy reveal that the stability of the liquid MOF state expands substantially towards lower temperatures at intermediate, industrially achievable pressures and first-principles molecular dynamics show that softening of the framework coordination with pressure makes melting thermodynamically easier. Furthermore, the MOF glass formed by melt quenching the high-temperature liquid possesses permanent, accessible porosity. Our results thus imply a route to the synthesis of functional MOF glasses at low temperatures, avoiding decomposition on heating at ambient pressure

Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease

Background: Myelin oligodendrocyte glycoprotein antibodies (MOG-Ab) are related to several acquired demyelinating syndromes in adults, but the therapeutic approach is currently unclear. We aimed to describe the response to different therapeutic strategies in adult patients with relapsing MOG-Ab-associated disease. Methods: This is a retrospective study conducted in France and Spain including 125 relapsing MOG-Ab patients aged ≥ 18 years. First, we performed a survival analysis to investigate the relapse risk between treated and non-treated patients, performing a propensity score method based on the inverse probability of treatment weighting. Second, we assessed the annualised relapse rates (ARR), Expanded Disability Status Scale (EDSS) and visual acuity pre-treatment and on/end-treatment. Results: Median age at onset was 34.1 years (range 18.0-67.1), the female to male ratio was 1.2:1, and 96% were Caucasian. At 5 years, 84% (95% confidence interval [CI], 77.1-89.8) patients relapsed. At the last follow-up, 66 (52.8%) received maintenance therapy. Patients initiating immunosuppressants (azathioprine, mycophenolate mophetil [MMF], rituximab) were at lower risk of new relapse in comparison to non-treated patients (HR, 0.41; 95CI%, 0.20-0.82; p = 0.011). Mean ARR (standard deviation) was reduced from 1.05(1.20) to 0.43(0.79) with azathioprine (n = 11; p = 0.041), from 1.20(1.11) to 0.23(0.60) with MMF (n = 11; p = 0.033), and from 1.08(0.98) to 0.43(0.89) with rituximab (n = 26; p = 0.012). Other immunosuppressants (methotrexate/mitoxantrone/cyclophosphamide; n = 5), or multiple sclerosis disease-modifying drugs (MS-DMD; n = 9), were not associated with significantly reduced ARR. Higher rates of freedom of EDSS progression were observed with azathioprine, MMF or rituximab. Conclusion: In adults with relapsing MOG-Ab-associated disease, immunosuppressant therapy (azathioprine, MMF and rituximab) is associated with reduced risk of relapse and better disability outcomes. Such an effect was not found in the few patients treated with MS-DMD