Historical setting and neuropathology of lathyrism: insights from the neglected 1944 report by Oliveras de la Riva

Lathyrism is a central motor system disorder recognized since antiquity resulting from prolonged dietary dependence on the grasspea (Lathyrus sativus). The neuropathology underlying the characteristic spastic paraparesis of lathyrism is sketchy. Described here is a landmark but little-known Spanish-language neuropathological study of two patients with lathyrism of recent onset. Due to erroneous interpretations of Filimonov's influential work in 1926, it was assumed that spastic paraparesis of lathyrism was explained by destruction of Betz's pyramidal cells in the motor cortex. Contrary to present understanding, Betz cells and anterior horn cells were preserved, and pathological findings dominated by myelin loss were largely limited to pyramidal tracts in the lumbar cord. Thickening of the adventitia of capillaries and arterioles, together with proliferation of perivascular astrocytes, was found along the length of the spinal cord. Oliveras de la Riva proposed that the segmental spinal pathology arose because distal regions of elongate pyramidal tract axons are distant from their trophic center in the motor cortex, a view not far from the current distal axonopathy concept of lathyrism. In addition, we review the historical circumstances of Filimonov's work in Russia, a summary of the epidemic of lathyrism in Spain following its Civil War (1936-1939), and some historical aspects of the Cajal Institute in Madrid, where Oliveras de la Riva's work was carried out under the supervision of Fernando de Castro, one of Cajal's favorite students

Documento de trabajo. El impacto en el desarrollo local de las políticas educativas en el municipio de medellín entre 2004 – 2011.

This study is inspired by determining the scope of the public policy of the city of Medellín in the education component and its impact on the index of quality of life of its citizens. Progress identified in the local development of the city taking as a reference the policies implemented in municipal administrations 2004 - 2007 and 2008 - 2011 investment in education through observation initially mentioned index

El sistema metrocable línea k y su impacto en la calidad de vida de la población de la comuna uno en la ciudad de Medellín entre los años 2004-2008 : Análisis de percepción

La calidad de vida medida a través del sistema de transporte de una región se convierte en una variable significativa en el desarrollo de las personas, que como conjunto reflejan el desarrollo de una localidad. La motivación de esta investigación se enfoca en la importancia del sistema de transporte Metro Cable Linea K y los impactos generados en la comuna uno de la ciudad de Medellín durante el periodo (2004-2008), comuna caracterizada por la alta vulnerabilidad económica, social y una alta densidad poblacional con respecto a otras comunas de la ciudad. Se busca entonces observar como para este caso especifico de la ciudad de Medellín, la nueva infraestructura de transporte potencializa el desarrollo de la movilidad, buscando generar un efecto positivo sobre el acceso al centro de la ciudad, el ahorro de tiempo en los desplazamientos, descongestión del tráfico vehicular, cuidado del medio ambiente e impacto sobre el ingreso disponible.Facultad de Humanidades y Ciencias de la Educació

Documento de trabajo. El sistema metrocable linea k y su impacto en la calidad de vida de la población de la comuna uno en la ciudad de medellín entre los años 2004-2008

Quality of life measured by the transportation system of a region becomes a significant variable in the development of individuals, which as a whole reflect the development of a locality. The motivation of this research focuses on the importance of the transport system Metro Cable Line K and impacts generated in the commune 1 of Medellin during the period (2004-2008), a town characterized by high economic, social vulnerability and high population density relative to other districts of the city. It is the city of Medellín, one of the main urban centers of Colombia, where the importance of efficient management of transport management and mobility, thought from the welfare and urban competitiveness, as part of a process of globalization is recognized growing and challenging in terms of market liberalization, the development of its citizens and business development dynamics of the investment community. In the context of competitiveness is then seeks potentiate the different territories in Medellín, through the development of mobility, seeking to generate a positive effect on access to downtown, saving time in commuting, congestion of vehicular traffic, environmental stewardship by reducing gases, safety mobilization and redistribution of disposable income. This is how the Metrocable K line system positively affects the aforementioned variables to generate progress in local development of the commune One - Popular

Documento de trabajo. El impacto en el desarrollo local de las políticas educativas en el municipio de medellín entre 2004 – 2011.

This study is inspired by determining the scope of the public policy of the city of Medellín in the education component and its impact on the index of quality of life of its citizens. Progress identified in the local development of the city taking as a reference the policies implemented in municipal administrations 2004 - 2007 and 2008 - 2011 investment in education through observation initially mentioned index

The effects of modifying contact, duration, and teaching strategies in awareness interventions on attitudes towards inclusion in physical education

This quasi-experimental study analyses the effects of an awareness intervention programme with five different branches designed to improve the attitudes of physical education (PE) students towards the inclusion of classmates with disabilities. The contact (yes/no) and its frequency (×1 vs. ×3) with para-athletes, the duration of the programme (1 vs. 6/7 sessions), and the provision of teaching strategies and materials (yes/no) were manipulated. The study involved 603 students aged 14‒19 from five public educational centres in southern Spain. Attitudes were assessed pre- and post-intervention with the Spanish version of the Children's Attitude towards Integrated Physical Education (general and specific subscales) and the Scale of Attitudes towards Students with Disabilities in PE. The three groups having contact with para-athletes during the interventions improved in the three attitude variables (p < 0.05; −0.20 < d < −0.24). Pairwise comparisons of the improvement ratios also revealed several positive effects of the intervention duration and provision of teaching strategies (p < 0.05; −0.07 < d < 0.18). These findings could assist PE teachers in educating students to improve their knowledge and attitudes towards people with disabilities, having different strategies and resources to conduct awareness interventions based on para-sports in their regular PE classes

Neurophysiological development of newborn pigs: effect of the sow’s parity number in eutocic farrowings

The objective of the present study was to determine the effect of sow parity on neonatal piglet health and vitality at birth. We evaluated 1505 neonate piglets, which were born of York–Landrace sows with the following parity distribution: primiparous (n = 202), second (n = 207), third (n = 211), fourth (n = 222), fifth (n = 225), sixth (n = 218) and seventh parity (n = 220). Piglets born to primiparous and seventh-parity sows had the lowest and highest birthweights respectively, and showed the most marked imbalances in blood gas exchanges, acid–base balance and energy profiles, as well as the highest percentage of severe meconium staining of the skin and the lowest vitality scores (P < 0.05). In contrast, the neonates from the fourth-parity sows had the highest vitality scores, required less time to reach the mother’s teat, and had the highest percentage of adhered umbilical cords and newborns with dyspnoea, apnoea and abnormal heartbeat (P < 0.05). The results of this study suggest that during eutocic farrowings, the sow’s parity number has the following effects on newborn piglets: reduced vigour and longer latencies to begin breathing, stand and take the teat. These effects are due to the presence of imbalances in gas exchanges, the acid–base balance and energy profiles that occurred when the mother was a primiparous or older sow. These signs indicate that the newborn piglet survived a process of intrapartum asphyxia.info:eu-repo/semantics/acceptedVersio

El cohecho pasivo específico y su relación con el tráfico de influencias negativo en el proceso de investigación preparatoria en la Corte Superior de Justicia de Lima Sur-2019

La presente tesis tiene como objetivo principal establecer la relación que existe entre el delito de cohecho pasivo específico y el tráfico de influencias negativo en los procesos de investigación preparatoria en la Corte superior de Justicia de Lima Sur ocurrida en el año 2019, conocer las causas de su problemática considerando dentro de sus objetivos específicos analizando la correlación entre los elementos normativos, los sujetos y la jurisprudencia del delito de cohecho especifico y el tráfico de influencias. El tipo de investigación es pura o básica con nivel Descriptivo-Correlacional, de diseño no experimental-transeccional y enfoque cuantitativo, se realizó este estudio considerando como población a operadores jurídicos conformando muestreo en encuestas a magistrados, fiscales, personal jurisdiccional y abogados litigantes de derecho penal cuya función fue medir variables de la tesis permitiendo lograr los objetivos planteados de la investigación, teniendo como resultado la relación significativa entre el delito de cohecho especifico y el tráfico de influencias en un proceso de investigación preparatoria en la Corte Superior de Justicia de Lima Sur, demostrando la necesidad de cambios importantes en la legislación penal que realmente luchen y prohíban taxativamente estos ilícitos que denigran la administración pública nacional

Diseño de un sistema de seguridad y salud en el trabajo en comercializadora Hidro Frio S.A.S.

El trabajo de investigación “Diseño de un sistema de seguridad y salud en el trabajo (SGSST) en comercializadora Hidro Frio SAS” busca identificar las condiciones actuales que presenta la empresa de acuerdo a los parámetros establecidos en el decreto 1072 del 2015 y resolución 1111 del 2017, buscando brindar ambientes sanos de trabajo, minimizando así el riesgo a los que se encuentran expuestos sus trabajadores.Resumen Título de Investigación Planteamiento del Problema Descripción del problema Pregunta problema Objetivo General Objetivos específicos Justificación Identificación de la empresa. Delimitación del problema. Estado del Arte Marco Teórico Planeación estratégica Marco Legal Diseño Metodológico Fases del Estudio Desarrollo Resultados Cumplimiento de objetivos Glosario Priorización del riesgo Análisis costo beneficio Conclusiones Recomendaciones ReferenciasEspecializaciónEspecialista en Gerencia de la Seguridad y Salud en el TrabajoEspecialización en Gerencia de la Seguridad y Salud en el Trabaj