La calidad del servicio educativo resultados preliminares en la Universidad Fidélitas

The investigation addressed the quality of the educational service at the Fidélitas University, during the year 2017, perceived by undergraduate students. The object of study was analyzed in the two venues of the University, and in the different class schedules. The objective on the one hand was to construct in a participatory way the quality assessment instrument, and on the other to determine the factors that explain the quality of the service received. To this end, the Student Teaching Evaluation Questionnaire was built collaboratively with students, academic and administrative directors through focus groups and in-depth interviews. Subsequently, a stratified probabilistic sampling of the questionnaires was carried out. The instrument was validated according to Alpha de Cronbach. The Kruskall-Wallis test was used to find differences in campus and schedules, and the Spearman Rho correlation to identify the variables associated with the teacher's performance. A Teacher's Net Promote Score of 51,42 % was found, with small differences per campus, and a better recommendation during daytime hours. Seven key factors were identified, that explain largely the student's satisfaction with their teacher, emphasizing attitudinal as the key to the perception of quality.La investigación abordó la calidad del servicio educativo en la Universidad Fidélitas, durante el año 2017, percibido por los estudiantes de grado. El objeto de estudio fue analizado en las dos sedes de la Universidad, y en los diferentes horarios de clase. El objetivo por un lado fue construir de manera participativa el instrumento de evaluación de la calidad, y por otro determinar los factores que explican la calidad del servicio percibido. Para ello se construyó el Cuestionario de Evaluación Docente Estudiantil de manera colaborativa con estudiantes, directivos académicos y administrativos mediante grupos focales y entrevistas en profundidad. Posteriormente se realizó un muestreo probabilístico estratificado de los cuestionarios. El instrumento se validó según Alpha de Cronbach. Se utilizó la prueba de Kruskall-Wallis pare encontrar diferencias entre sedes y horarios y la correlación de Spearman Rho, para identificar las variables asociadas al desempeño del profesor. Se encontró un Net Promote Score del profesor de 51,42 %, con pequeñas diferencias entre sedes y una mejor recomendación en horarios diurnos. Se identificaron siete factores clave que explican en mayor medida la satisfacción del estudiante con su profesor, destacándose los actitudinales como claves de la percepción de la calidad

Propuesta de intervención en Educación Física para trabajar el bloque de contenido de salud en la última década

Observar los resultados de los programas de intervención en Educación Física orientada a la Salud con el objetivo de ver su influencia en los adolescentes y el poder que ejercen sobre ellos para seguir con los buenos hábitos adquiridos de forma responsable en el tiempo. Se revisaron artículos originales sólo en español publicados en las bases de datos de Csic-Issoc, Scopus, Sportdiscus, Eric, Pubmed, Dialnet y en revistas digitales tales como Apunts, Investigacion en la Escuela, Revista Profesorado, Cuaderno de Pedagogia, Habilidad Motriz, motricidad, Nutricion Hospitalaria y Revista Española de Pedagogia desde enero de 2001 a diciembre de 2011. Se analizaron un total de 10 artículos que cumplieron con los criterios de inclusión para esta revisión. Todos cuasi experimentales y llevados a cabo en España.Observe the results of the intervention programs in Physical Education oriented to Health in order to see their influence on adolescents and the power they exercise over them to continue with the good habits acquired in a responsible manner over time. We reviewed original articles only in Spanish published in the databases of Csic-Issoc, Scopus, Sportdiscus, Eric, Pubmed, Dialnet and in digital journals such as Apunts, Research at School, Faculty Journal, Pedagogy Notebook, Motor Skill, motor, Hospital Nutrition and Spanish Journal of Pedagogy from January 2001 to December 2011. A total of 10 articles that met the inclusion criteria for this review were analyzed. All quasi-experimental and carried out in Spain

PREVALENCIA DE FACTORES DE RIESGO CARDIOVASCULAR EN PACIENTES HOSPITALIZADOS EN UN HOSPITAL DE LIMA: PREVALENCE OF CARDIOVASCULAR RISK FACTORS IN HOSPITALIZED PATIENTS IN A LIMA HOSPITAL

Objective: To determine the factors associated with cardiovascular risk in patients of the HSEB Department of Medicine. Methods: Prospective, cross-sectional, descriptive and observational study, included 83 probabilistically chosen patients from a universe of 105 hospitalized from the HSEB Department of Medicine. For the calculation, OpenEpi version 3 and Microsoft Excel 2010 were used and in the analysis and interpretation of the data, graphs and tables of relative and absolute frequencies were used. Results:53% were women and the average age was 54.5 years. The frequency of main risk factors was: Overweight 30.1%, obesity 13.3%, the Ci / Ca index very high in women 54.2%, family history of AMI 38.5% and HTA 34.6%, DM2 65.5%, High Cholesterol 34.4% , HTA 21.7% of these 73.9% were controlled, classified and were optimal 21.7% and Normal-High 34.8, also sedentary lifestyle 50%, carbohydrate consumption 56.6%, lipids 32.5%, fast food 44.6% and as a degree of Anxiety less than 54.2% and greater than 32.5%. Conclusion:There is a higher risk of a coronary event more in women over 50 years of age than in men, having as main cardiovascular risk factors diet, sedentary lifestyle, overweight, normal-high pressures, minor anxiety, andcomorbidities Associated such as diabetes and high cholesterol.Objetivo: Determinar los factores asociados a riesgo cardiovascular en pacientes del Departamento de Medicina del Hospital Sergio E. Bernales (HSEB). Métodos: Estudio transversal, descriptivo y observacional, incluyo 83 pacientes elegidos probabilísticamente de una población de 105 hospitalizados del Departamento de Medicina del HSEB. En el análisis e interpretación de los datos se utilizaron gráficos y tablas de frecuencias relativas y absolutas. Resultados: El 53% fueron mujeres y la edad promedio fue 54,5 años. La frecuencia de factores de riesgo principales fue: El sobrepeso 30,1%, la obesidad 13,3%, el Índice Ci/Ca muy alto en mujeres 54,2%, antecedente familiar de IAM 38,5% e HTA 34,6%, DM2 65,5%, Colesterol Alto 34,4%, HTA 21.7%, según su tipo se tuvo que el 73.9% estaban controladas; y al clasificarla, fueron optimas el 21,7% y Normal-Alta 34,8, asimismo se observó también sedentarismo 50%, consumo carbohidratos 56.6%, lípidos 32.5%, comida rápida 44,6% y como grado de Ansiedad menor un 54.2% y mayor el 32,5%. Conclusión: Un mayor riesgo de evento coronario afecta más a las mujeres mayores de 50 años que en los varones, teniendo como factores de riesgo cardiovascular principales la dieta, el sedentarismo, el sobrepeso, las presiones normal- alta, la ansiedad menor, y comorbilidades asociadas como la diabetes y colesterol alto

Hollow Gold Nanoparticles Produced by Femtosecond Laser Irradiation

[EN] Metallic hollow nanoparticles exhibit interesting optical properties that can be controlled by geometrical parameters. Irradiation with femtosecond laser pulses has emerged recently as a valuable tool for reshaping and size modification of plasmonic metal nanoparticles, thereby enabling the synthesis of nanostructures with unique morphologies. In this Letter, we use classical molecular dynamics simulations to investigate the solid-to-hollow conversion of gold nanoparticles upon femtosecond laser irradiation. Here, we suggest an efficient method for producing hollow nanoparticles under certain specific conditions, namely that the particles should be heated to a maximum temperature between 2500 and 3500 K, followed by a fast quenching to room temperature, with cooling rates lower than 120 ps. Therefore, we describe the experimental conditions for efficiently producing hollow nanoparticles, opening a broad range of possibilities for applications in key areas, such as energy storage and catalysis.This work has been funded by the Spanish Ministry of Science, Innovation and Universities (MICIU) (Grants RTI2018-095844-B-I00, PGC2018-096444-B-I00, and MAT2017-86659-R), the EUROfusion Consortium through Project ENR-IFE19.CCFE-01, and the Madrid Regional Government (Grants P2018/NMT-4389 and P2018/EMT-4437). A.P. is thankful for the support of FONDECYT under Grants 3190123 and 11180557, as well as from Financiamiento Basal para Centros Cientificos y Tecnologicos de Excelencia FB-0807. K.L. acknowledges the support of the Russian Science Foundation (Project 19-19-00683). The authors acknowledge the computer resources and technical assistance provided by the Centro de Supercomputacion y Visualizacion de Madrid (CeSViMa) and the supercomputing infrastructure of the NLHPC (ECM-02). This Letter is based upon work from COST Action TUMIEE (CA17126)Castro-Palacio, JC.; Ladutenko, K.; Prada, A.; Gonzalez-Rubio, G.; Diaz-Nunez, P.; Guerrero-Martinez, A.; Fernández De Córdoba, P.... (2020). Hollow Gold Nanoparticles Produced by Femtosecond Laser Irradiation. The Journal of Physical Chemistry Letters. 11(13):5108-5114. https://doi.org/10.1021/acs.jpclett.0c01233S51085114111

NKG2D-CAR memory T cells target pediatric T-cell acute lymphoblastic leukemia in vitro and n vivo but fail to eliminate leukemiai nitiating cells

[Introduction]: Refractory/relapsed pediatric acute leukemia are still clinically challenging and new therapeutic strategies are needed. Interactions between Natural Killer Group 2D (NKG2D) receptor, expressed in cytotoxic immune cells, and its ligands (NKG2DL), which are upregulated in leukemic blasts, are important for anti-leukemia immunosurveillance. Nevertheless, leukemia cells may develop immunoescape strategies as NKG2DL shedding and/or downregulation. [Methods]: In this report, we analyzed the anti-leukemia activity of NKG2D chimeric antigen receptor (CAR) redirected memory (CD45RA-) T cells in vitro and in a murine model of T-cell acute lymphoblastic leukemia (T-ALL). We also explored in vitro how soluble NKG2DL (sNKG2DL) affected NKG2D-CAR T cells’ cytotoxicity and the impact of NKG2D-CAR T cells on Jurkat cells gene expression and in vivo functionality. [Results]: In vitro, we found NKG2D-CAR T cells targeted leukemia cells and showed resistance to the immunosuppressive effects exerted by sNKG2DL. In vivo, NKG2D-CAR T cells controlled T cell leukemia burden and increased survival of the treated mice but failed to cure the animals. After CAR T cell treatment, Jurkat cells upregulated genes related to proliferation, survival and stemness, and in vivo, they exhibited functional properties of leukemia initiating cells. [Discussion]: The data here presented suggest, that, in combination with other therapeutic approaches, NKG2D-CAR T cells could be a novel treatment for pediatric T-ALL.This work was supported by a grant from the Instituto de Salud Carlos III to LF PI21/01049, the II and V awards from UNOENTRECIENMIL Foundation, and a grant from CRIS FOUNDATION to Beat Cancer as part of the projects “Cell therapy based on NKG2D-CAR for pediatric leukemia” and “NKG2D-CAR as treatment for pediatric patients suffering from acute leukemia and juvenile myelomonocytic leukemia”. AF, MI-N, AN-Z and CF have been supported by Personnel research grants from CRIS Foundation to beat cancer. CM has been supported by Personnel PhD student grants from the Instituto de Salud Carlos III (ISCIII), PFIS (FI19/00176). MVG is funded by grant PID2021-123795OB-I00 from the Spanish Ministry of Science and Innovation [Ministerio de Ciencia e Innovación (MCIN)/Agencia Estatal de Investigación (AEI) / 10.13039/501100011033 and European Regional Development Fund (ERDF)-A way of making Europe] and belongs to cancer-Hub CSIC. MI lab is funded by grant PID2020-114148RB-I00 from the Spanish Ministry of Science and Innovation MCIN/AEI/10.13039/501100011033,which was in part granted with FEDER funding (EC)

Plasma β-III tubulin, neurofilament light chain and glial fibrillary acidic protein are associated with neurodegeneration and progression in schizophrenia

Schizophrenia is a progressive disorder characterized by multiple psychotic relapses. After every relapse, patients may not fully recover, and this may lead to a progressive loss of functionality. Pharmacological treatment represents a key factor to minimize the biological, psychological and psychosocial impact of the disorder. The number of relapses and the duration of psychotic episodes induce a potential neuronal damage and subsequently, neurodegenerative processes. Thus, a comparative study was performed, including forty healthy controls and forty-two SZ patients divided into first-episode psychosis (FEP) and chronic SZ (CSZ) subgroups, where the CSZ sub group was subdivided by antipsychotic treatment. In order to measure the potential neuronal damage, plasma levels of β-III tubulin, neurofilament light chain (Nf-L), and glial fibrillary acidic protein (GFAP) were performed. The results revealed that the levels of these proteins were increased in the SZ group compared to the control group (P < 0.05). Moreover, multiple comparison analysis showed highly significant levels of β-III tubulin (P = 0.0002), Nf-L (P = 0.0403) and GFAP (P < 0.015) in the subgroup of CSZ clozapine-treated. In conclusion, β-III tubulin, Nf-L and GFAP proteins may be potential biomarkers of neurodegeneration and progression in SZFundação para a Ciência e a Tecnologia | Ref. SFRH/BD/135623/20Instituto de Salud Carlos III | Ref. P16/00405Ministerio de Sanidad, Igualdad y Política Social | Ref. 2017I054Agencia del Conocimiento en Salud | Ref. PRIS2-17Xunta de Galicia | Ref. IN607C-2017/02Xunta de Galicia | Ref. IN607B 2018/1

Integrated GWAS and Gene Expression Suggest ORM1 as a Potential Regulator of Plasma Levels of Cell-Free DNA and Thrombosis Risk

Plasma cell-free DNA (cfDNA) is a surrogate marker of neutrophil extracellular traps (NETs) that contribute to immunothrombosis. There is growing interest about the mechanisms underlying NET formation and elevated cfDNA, but little is known about the factors involved. We aimed to identify genes involved in the regulation of cfDNA levels using data from the Genetic Analysis of Idiopathic Thrombophilia (GAIT-2) Project. Imputed genotypes, whole blood RNA-Seq data, and plasma cfDNA quantification were available for 935 of the GAIT-2 participants from 35 families with idiopathic thrombophilia. We performed heritability and GWAS analysis for cfDNA. The heritability of cfDNA was 0.26 ( p  = 3.7 × 10 (−6) ), while the GWAS identified a significant association (rs1687391, p  = 3.55 × 10 (−10) ) near the ORM1 gene, on chromosome 9. An eQTL (expression quantitative trait loci) analysis revealed a significant association between the lead GWAS variant and the expression of ORM1 in whole blood ( p  = 6.14 × 10 (−9) ). Additionally, ORM1 expression correlated with levels of cfDNA ( p  = 4.38 × 10 (−4) ). Finally, genetic correlation analysis between cfDNA and thrombosis identified a suggestive association ( ρ (g)  = 0.43, p  = 0.089). All in all, we show evidence of the role of ORM1 in regulating cfDNA levels in plasma, which might contribute to the susceptibility to thrombosis through mechanisms of immunothrombosis

Fuego en los ecosistemas argentinos

La sociedad usualmente concibe a los incendios como catástrofes naturales, con efectos negativos para los organismos y los ambientes. Esta visión, favorecida por el sensacionalismo de los medios de comunicación, quizás tiene sus bases en percibir al fuego como un disturbio aislado en el tiempo y en el espacio, que elimina la totalidad de los organismos vivos, dejando solo cenizas y suelos estériles. Sin embargo, los incendios forman parte de la naturaleza, modelando la distribución de los ecosistemas terrestres y generando biodiversidad. El estudio del régimen de fuego, es decir las características de los incendios en una región determinada incluyendo su variabilidad temporal y espacial, es una concepción más holística que permite entender mejor la compleja relación entre el fuego y los ecosistemas. Existen regímenes de incendios que son sostenibles desde el punto de vista ecológico, por ejemplo los incendios de pastizales en los Parques Nacionales El Palmar o Quebrada del Condorito. Sin embargo, los actuales cambios globales producidos por la especie humana, traducidos en el cambio climático y los cambios en el uso de la tierra, están produciendo incendios en ecosistemas sensibles al fuego (como el Amazonas, las Yungas o la selva misionera) o están alterando los patrones históricos de incendios en regiones donde normalmente el fuego estaba presente. Por lo tanto, es imprescindible y urgente entender la relación entre los cambios en los regímenes de fuego producidos por las actividades humanas y la respuesta de los ambientes para desarrollar una visión crítica y planificar acciones con el objetivo de mitigar efectos ecológicos insostenibles. Una de las preguntas más comunes que la sociedad se plantea es si los incendios son buenos o malos, y en qué medida. En este artículo trataremos de responder varios aspectos desde la Ecología del Fuego. Para ello, organizamos el contenido en relación a cómo el régimen de fuego afecta a las propiedades de los ecosistemas, a los organismos que forman parte del mismo, y a las interacciones bióticasFil: Carbone, Lucas Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Tavella, Julia Rita. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Naval Fernández, Maria Cecilia. Comision Nacional de Actividades Espaciales. Instituto de Altos Estudios Espaciales "Mario Gulich"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Bianchi, Maria Martha. Secretaría de Cultura de la Nación. Dirección Nacional de Cultura y Museos. Instituto Nacional de Antropología y Pensamiento Latinoamericano; ArgentinaFil: Rodriguez, Juan Manuel. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones Biológicas y Tecnológicas. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas, Físicas y Naturales. Instituto de Investigaciones Biológicas y Tecnológicas; ArgentinaFil: Marcora, Paula Inés. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Longo, Maria Silvana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Urcelay, Roberto Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Jaureguiberry, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto Multidisciplinario de Biología Vegetal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto Multidisciplinario de Biología Vegetal; ArgentinaFil: Landi, Marcos Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Diversidad y Ecología Animal. Universidad Nacional de Córdoba. Facultad de Ciencias Exactas Físicas y Naturales. Instituto de Diversidad y Ecología Animal; ArgentinaFil: Bravo, Sandra. Universidad Nacional de Santiago del Estero. Facultad de Cs.forestales. Instituto de Protección Forestal; ArgentinaFil: Blackhall, Melisa. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Biodiversidad y Medioambiente. Universidad Nacional del Comahue. Centro Regional Universidad Bariloche. Instituto de Investigaciones en Biodiversidad y Medioambiente; Argentin

Molecular phenomics of a high-calorie diet-induced porcine model of prepubertal obesity

As obesity incidence is alarmingly rising among young individuals, we aimed to characterize an experimental model of this situation, considering the similarity between human and porcine physiology. For this reason, we fed prepubertal (63 days old) Duroc breed females (n=21) either with a standard growth diet (3800 kcal/day) or one with a high-calorie content (5200 kcal/day) during 70 days. Computerized tomography, mass-spectrometry-based metabolomics and lipidomics, as well as peripheral blood mononuclear cell transcriptomics, were applied to define traits linked to high-calorie intake. Samples from a human cohort confirmed potential lipidomic markers. Compared to those fed a standard growth diet, pigs fed a high-calorie diet showed an increased weight gain (13%), much higher adiposity (53%), hypertriacylglyceridemia and hypercholesterolemia in parallel to insulin resistance. This diet induced marked changes in the circulating lipidome, particularly in phosphatidylethanolamine-type molecules. Also, circulating specific diacylglycerol and monoacylglycerol contents correlated with visceral fat and intrahepatic triacylglycerol concentrations. Specific lipids associated with obesity in swine (mainly belonging to glycerophospholipid, triacylglyceride and sterol classes) were also linked with obesity traits in the human cohort, reinforcing the usefulness of the chosen approach. Interestingly, no overt inflammation in plasma or adipose tissue was evident in this model. The presented model is useful as a preclinical surrogate of prepubertal obesity in order to ascertain the pathophysiology interactions between energy intake and obesity development.Supported by Centro para el Desarrollo Tecnológico e Industrial, Spain, Project reference: IPT-20111008, and Generalitat de Catalunya grants 2017SGR1719 and 2017SGR696. MJ is a "Serra Hunter" program fellow. Supported by Instituto de Salud Carlos III, Spain, Project reference: 17-00134, co-financed by FEDER Funds A way to make Europe