The XMM-Newton/INTEGRAL monitoring campaign of IGR J16318-4848

IGR J16318-4848 is the prototype and one of the more extreme examples of the new class of highly obscured Galactic X-ray sources discovered by INTEGRAL. A monitoring campaign on this source has been carried out by XMM-Newton and INTEGRAL, consisting in three simultaneous observations performed in February, March and August 2004. The long-term variability of the Compton-thick absorption and emission line complexes will be used to probe the properties of the circumstellar matter. A detailed timing and spectral analysis of the three observations is performed, along with the reanalysis of the XMM-Newton observation performed in February 2003. The results are compared with predictions from numerical radiative transfer simulations to derive the parameters of the circumstellar matter. Despite the large flux dynamic range observed (almost a factor 3 between observations performed a few months apart), the source remained bright (suggesting it is a persistent source) and Compton-thick (NH >1.2x10^24 cm-2). Large Equivalent Width (EW) emission lines from Fe Kalpha, Fe Kbeta and Ni Kalpha were present in all spectra. The addition of a Fe Kalpha Compton Shoulder improves the fits, especially in the 2004 observations. Sporadic occurrences of rapid X-ray flux risings were observed in three of the four observations. The Fe Kalpha light curve followed the continuum almost instantaneously, suggesting that the emission lines are produced by illumination of small-scale optically-thick matter around the high-energy continuum source. Using the iron line EW and Compton Shoulder as diagnostic of the geometry of the matter, we suggest that the obscuring matter is in a flattened configuration seen almost edge-on.Comment: accepted by Astronomy and Astrophysic

Local variation of hashtag spike trains and popularity in Twitter

We draw a parallel between hashtag time series and neuron spike trains. In each case, the process presents complex dynamic patterns including temporal correlations, burstiness, and all other types of nonstationarity. We propose the adoption of the so-called local variation in order to uncover salient dynamics, while properly detrending for the time-dependent features of a signal. The methodology is tested on both real and randomized hashtag spike trains, and identifies that popular hashtags present regular and so less bursty behavior, suggesting its potential use for predicting online popularity in social media.Comment: 7 pages, 7 figure

Reflection in Seyfert Galaxies and the Unified Model of AGN

We present a deep study of the average hard X-ray spectra of Seyfert galaxies. We analyzed all public INTEGRAL IBIS/ISGRI data available on all the 165 Seyfert galaxies detected at z<0.2. Our final sample consists of 44 Seyfert 1's, 29 Seyfert 1.5's, 78 Seyfert 2's, and 14 Narrow Line Seyfert 1's. We derived the average hard X-ray spectrum of each subsample in the 17-250keV energy range. All classes of Seyfert galaxies show on average the same nuclear continuum, as foreseen by the zeroth order unified model, with a cut-off energy of Ec>200keV, and a photon index of Gamma ~1.8. Compton-thin Seyfert 2's show a reflection component stronger than Seyfert 1's and Seyfert 1.5's. Most of this reflection is due to mildly obscured (10^23 cm^-2 < NH < 10^24 cm^-2) Seyfert 2's, which have a significantly stronger reflection component (R=2.2^{+4.5}_{-1.1}) than Seyfert 1's (R<=0.4), Seyfert 1.5's (R<= 0.4) and lightly obscured (NH < 10^23 cm^-2) Seyfert 2's (R<=0.5). This cannot be explained easily by the unified model. The absorber/reflector in mildly obscured Seyfert 2's might cover a large fraction of the X-ray source, and have clumps of Compton-thick material. The large reflection found in the spectrum of mildly obscured Seyfert 2's reduces the amount of Compton-thick objects needed to explain the peak of the cosmic X-ray background. Our results are consistent with the fraction of Compton-thick sources being ~10%. The spectra of Seyfert 2's with and without polarized broad lines do not show significant differences, the only difference between the two samples being the higher hard X-ray and bolometric luminosity of Seyfert 2's with polarized broad lines. The average hard X-ray spectrum of Narrow line Seyfert 1's is steeper than those of Seyfert 1's and Seyfert 1.5's, probably due to a lower energy of the cutoff.Comment: 19 pages, accepted for publication in Astronomy and Astrophysics, final versio

Unveiling the nature of INTEGRAL objects through optical spectroscopy. VIII. Identification of 44 newly detected hard X-ray sources

(abridged) Hard X-ray surveys performed by the INTEGRAL satellite have discovered a conspicuous fraction (up to 30%) of unidentified objects among the detected sources. Here we continue our identification program by selecting probable optical candidates using positional cross-correlation with soft X-ray, radio, and/or optical archives, and performing optical spectroscopy on them. As a result, we identified or more accurately characterized 44 counterparts of INTEGRAL sources: 32 active galactic nuclei, with redshift 0.019 < z < 0.6058, 6 cataclysmic variables (CVs), 5 high-mass X-ray binaries (2 of which in the Small Magellanic Cloud), and 1 low-mass X-ray binary. This was achieved by using 7 telescopes of various sizes and archival data from two online spectroscopic surveys. The main physical parameters of these hard X-ray sources were also determined using the available multiwavelength information. AGNs are the most abundant population among hard X-ray objects, and our results confirm this tendency when optical spectroscopy is used as an identification tool. The deeper sensitivity of recent INTEGRAL surveys enables one to begin detecting hard X-ray emission above 20 keV from sources such as LINER-type AGNs and non-magnetic CVs.Comment: 22 pages, 14 figures, 6 tables, accepted for publication on A&A, main journa

Unveiling the nature of INTEGRAL objects through optical spectroscopy. IX. 22 more identifications, and a glance into the far hard X-ray Universe

(Abridged) Since its launch in October 2002, the INTEGRAL satellite has revolutionized our knowledge of the hard X-ray sky thanks to its unprecedented imaging capabilities and source detection positional accuracy above 20 keV. Nevertheless, many of the newly-detected sources in the INTEGRAL sky surveys are of unknown nature. The combined use of available information at longer wavelengths (mainly soft X-rays and radio) and of optical spectroscopy on the putative counterparts of these new hard X-ray objects allows us to pinpoint their exact nature. Continuing our long-standing program that has been running since 2004, and using 6 different telescopes of various sizes, we report the classification through optical spectroscopy of 22 more unidentified or poorly studied high-energy sources detected with the IBIS instrument onboard INTEGRAL. We found that 16 of them are active galactic nuclei (AGNs), while the remaining 6 objects are within our Galaxy. Among the identified extragalactic sources, 14 are Type 1 AGNs; of these, 6 lie at redshift larger than 0.5 and one has z = 3.12, which makes it the second farthest object detected in the INTEGRAL surveys up to now. The remaining AGNs are of type 2, and one of them is a pair of interacting Seyfert 2 galaxies. The Galactic objects are identified as two cataclysmic variables, one high-mass X-ray binary, one symbiotic binary and two chromospherically active stars. We thus still find that AGNs are the most abundant population among hard X-ray objects identified through optical spectroscopy. Moreover, we note that the higher sensitivity of the more recent INTEGRAL surveys is now enabling the detection of high-redshift AGNs, thus allowing the exploration of the most distant hard X-ray emitting sources and possibly of the most extreme blazars.Comment: 18 pages, 9 figures, 8 tables, accepted for publication on Astronomy & Astrophysics, main journa

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Evolution of the use of corticosteroids for the treatment of hospitalised COVID-19 patients in Spain between March and November 2020: SEMI-COVID national registry

Objectives: Since the results of the RECOVERY trial, WHO recommendations about the use of corticosteroids (CTs) in COVID-19 have changed. The aim of the study is to analyse the evolutive use of CTs in Spain during the pandemic to assess the potential influence of new recommendations. Material and methods: A retrospective, descriptive, and observational study was conducted on adults hospitalised due to COVID-19 in Spain who were included in the SEMI-COVID- 19 Registry from March to November 2020. Results: CTs were used in 6053 (36.21%) of the included patients. The patients were older (mean (SD)) (69.6 (14.6) vs. 66.0 (16.8) years; p < 0.001), with hypertension (57.0% vs. 47.7%; p < 0.001), obesity (26.4% vs. 19.3%; p < 0.0001), and multimorbidity prevalence (20.6% vs. 16.1%; p < 0.001). These patients had higher values (mean (95% CI)) of C-reactive protein (CRP) (86 (32.7-160) vs. 49.3 (16-109) mg/dL; p < 0.001), ferritin (791 (393-1534) vs. 470 (236- 996) µg/dL; p < 0.001), D dimer (750 (430-1400) vs. 617 (345-1180) µg/dL; p < 0.001), and lower Sp02/Fi02 (266 (91.1) vs. 301 (101); p < 0.001). Since June 2020, there was an increment in the use of CTs (March vs. September; p < 0.001). Overall, 20% did not receive steroids, and 40% received less than 200 mg accumulated prednisone equivalent dose (APED). Severe patients are treated with higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%. Conclusions: Patients with greater comorbidity, severity, and inflammatory markers were those treated with CTs. In severe patients, there is a trend towards the use of higher doses. The mortality benefit was observed in patients with oxygen saturation </=90%

Numerical methods for the design and description of in vitro expansion processes of human mesenchymal stem cells

Human mesenchymal stem cells (hMSCs) are a valuable source of cells for clinical applications (e.g., treatment of acute myocardial infarction or inflammatory diseases), especially in the field of regenerative medicine. However, for autologous (patient-specific) and allogeneic (off-the-shelf) hMSC-based therapies, in vitro expansion is necessary prior to the clinical application in order to achieve the required cell numbers. Safe, reproducible, and economic in vitro expansion of hMSCs for autologous and allogeneic therapies can be problematic because the cell material is restricted and the cells are sensitive to environmental changes. It is beneficial to collect detailed information on the hydrodynamic conditions and cell growth behavior in a bioreactor system, in order to develop a so called “Digital Twin” of the cultivation system and expansion process. Numerical methods, such as Computational Fluid Dynamics (CFD) which has become widely used in the biotech industry for studying local characteristics within bioreactors or kinetic growth modelling, provide possible solutions for such tasks. In this review, we will present the current state-of-the-art for the in vitro expansion of hMSCs. Different numerical tools, including numerical fluid flow simulations and cell growth modelling approaches for hMSCs, will be presented. In addition, a case study demonstrating the applicability of CFD and kinetic growth modelling for the development of an microcarrier-based hMSC process will be shown

Nurses' perceptions of aids and obstacles to the provision of optimal end of life care in ICU

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