Videojuego para mejorar el proceso de aprendizaje de matemática de los estudiantes de primaria en la Institución Educativa Signos de Fe De La Salle Trujillo, 2022

La presente investigación consideró como objetivo general mejorar el proceso de aprendizaje matemático en la institución educativa Signos de Fe de la Salle de Trujillo en el año 2022. El tipo de investigación fue aplicada de grado experimental puro, para el desarrollo del videojuego se utilizó la metodología SUM, la cual cuenta con las siguientes fases: Concepto, Planificación, Elaboración, Beta y Cierre, complementando con la fase de Gestión de Riesgos. Los resultados obtenidos para el grupo experimental fueron, que existe un incremento significativo en el nivel de intervenciones en clase logrando un 40.67% de aumento en comparación a lo evidenciado en el grupo control, también se logró la reducción del tiempo promedio de resolución de problemas en un 63.24% después de la implementación del videojuego, por otro lado se tuvo un gran incremento en el promedio bimestral de los estudiantes en un 18% en comparación a lo evidenciado en el grupo control. Debido a que la muestra fueron los 30 registros relacionados con proceso de aprendizaje matemático en la institución educativa Signos de Fe de la Salle, se empleó la prueba de normalidad Shapiro Wilk para procesar los resultados del grupo control y grupo experimental, y con estos, se usó la prueba no paramétrica U de Mann Whitney y paramétrica T-Student para analizar los indicadores. La investigación se compone en introducción, marco teórico, metodología, resultados, discusión, conclusiones, recomendaciones y, por último, la metodología de desarrollo de videojuego, concluyendo que el uso de un videojuego si mejora el proceso de aprendizaje matemático en la institución educativa Signos de Fe de la Salle de Trujillo en el año 2022

Strategies for Systems Change: Lessons Learned from the Transforming Early Educator Lead Teacher Preparation Programs Through Multi-Partner Innovation Grant Program

In 2021–22, The Collaborative awarded eight grants in support of partnerships between institutions of higher education (IHEs) and states/territories/tribal nations to transform their preparation programs for early educators. To support our grantees in their work, The Collaborative engaged School Readiness Consulting (SRC) to develop a learning community to foster peer learning and collective problem-solving.Two years into this work, The Collaborative and SRC provided grantees with an opportunity to reflect on their experiences through the lens of an overarching question: How have the IHEs and their partners made meaningful, systemic changes to address barriers on their campuses, in their communities, and in the field at large?This report describes the strategies grantees used for systems change, as well as their reflections on next steps and sustainability.Key insights from the report include:Grantees readily leveraged policies, practices, and resources to create immediate and measurable impacts on their institutions and their students. Strategies include centering equity in student recruitment and retention, enhancing coursework offerings and strengthening classes related to culturally relevant practices, and investing in resources driven by the actual needs of their students.In addition, grantees identified strategies to create the conditions needed to maintain progress and enable further changes to best support their students. These strategies include strengthening and creating connections, shifting power dynamics, and changing mental models

Nivel de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad de la empresa Autonort Cajamarca S.A.C. año 2017

RESUMEN El principal objetivo de esta investigación es diagnosticar el nivel de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad de la empresa Autonort Cajamarca S.A.C. del año 2017, ubicada en el departamento de Cajamarca; este estudio se enmarca dentro de una investigación no experimental, transversal, correlacional simple. Por medio de la observación, investigación bibliográfica y la evaluación que se ha establecido la relación de las variables; los datos estadísticos que sostienen esta investigación, vienen de los resultados obtenidos por la aplicación de instrumentos de recolección de datos, como fueron fichas de observación sobre los niveles de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad de la empresa Autonort Cajamarca S.A.C., año 2017; así mismo, con la búsqueda de información y el procesamiento de los datos recopilados con los instrumentos mencionados, se logró verificar la hipótesis planteada. Al determinar el nivel de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad, se observó que el nivel de cumplimiento es regular con 40.59%. Se concluyó que el incumplimiento de los requisitos establecidos en cada uno de los procedimientos; influyen indirectamente en la morosidad de la empresa, esto debido a que si se mejora el nivel de cumplimiento, disminuirá la morosidad. En tal sentido, se recomienda mejorar el manejo de la evaluación de los créditos a los clientes, de acuerdo a sus procesos establecidos. Palabras Claves: Control Interno, Ventas al Crédito, Morosidad.ABSTRACT The main objective of this research is to diagnose the level of compliance of the processes of internal control of sales credit and its impact on the slowness of Autonort Cajamarca S.A.C. Company of the year 2017, located in the Department of Cajamarca; this study is part of a simple non-experimental, cross, correlational research. Through observation, bibliographic research and evaluation that has been established the relationship of the variables; statistical data supporting this research, come from the results obtained by the application of data collection instruments, as they were tokens of observation on the levels of compliance with internal control of sales processes to the credit and its impact on the slowness of Autonort Cajamarca S.A.C. company, year 2017; Likewise, with the search for information and the processing of data collected with the mentioned instruments, was accomplished to verify the hypothesis. To determine the level of compliance of the processes of internal control of sales credit and its impact on delinquency, it was observed that compliance level is regular with 40.59%. It was concluded that failure to comply with the requirements established by each of the procedures; they indirectly influence in non-performing loans of the company, because that improves the level of compliance will diminish late payment. In this regard, it is recommended to improve the management of evaluation of loans to customers, according to their established processes. Key words: Internal Control, sales to credit, non-performing loans

Nivel de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad de la empresa Autonort Cajamarca S.A.C. año 2017

RESUMEN El principal objetivo de esta investigación es diagnosticar el nivel de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad de la empresa Autonort Cajamarca S.A.C. del año 2017, ubicada en el departamento de Cajamarca; este estudio se enmarca dentro de una investigación no experimental, transversal, correlacional simple. Por medio de la observación, investigación bibliográfica y la evaluación que se ha establecido la relación de las variables; los datos estadísticos que sostienen esta investigación, vienen de los resultados obtenidos por la aplicación de instrumentos de recolección de datos, como fueron fichas de observación sobre los niveles de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad de la empresa Autonort Cajamarca S.A.C., año 2017; así mismo, con la búsqueda de información y el procesamiento de los datos recopilados con los instrumentos mencionados, se logró verificar la hipótesis planteada. Al determinar el nivel de cumplimiento de los procesos de control interno de las ventas al crédito y su incidencia en la morosidad, se observó que el nivel de cumplimiento es regular con 40.59%. Se concluyó que el incumplimiento de los requisitos establecidos en cada uno de los procedimientos; influyen indirectamente en la morosidad de la empresa, esto debido a que si se mejora el nivel de cumplimiento, disminuirá la morosidad. En tal sentido, se recomienda mejorar el manejo de la evaluación de los créditos a los clientes, de acuerdo a sus procesos establecidos. Palabras Claves: Control Interno, Ventas al Crédito, Morosidad.ABSTRACT The main objective of this research is to diagnose the level of compliance of the processes of internal control of sales credit and its impact on the slowness of Autonort Cajamarca S.A.C. Company of the year 2017, located in the Department of Cajamarca; this study is part of a simple non-experimental, cross, correlational research. Through observation, bibliographic research and evaluation that has been established the relationship of the variables; statistical data supporting this research, come from the results obtained by the application of data collection instruments, as they were tokens of observation on the levels of compliance with internal control of sales processes to the credit and its impact on the slowness of Autonort Cajamarca S.A.C. company, year 2017; Likewise, with the search for information and the processing of data collected with the mentioned instruments, was accomplished to verify the hypothesis. To determine the level of compliance of the processes of internal control of sales credit and its impact on delinquency, it was observed that compliance level is regular with 40.59%. It was concluded that failure to comply with the requirements established by each of the procedures; they indirectly influence in non-performing loans of the company, because that improves the level of compliance will diminish late payment. In this regard, it is recommended to improve the management of evaluation of loans to customers, according to their established processes. Key words: Internal Control, sales to credit, non-performing loans

Concert recording 2016-11-08

[Track 1]. Selve amiche / Antonio Caldara -- [Track 2]. Nuit d\u27étoiles / Claude Debussy -- [Track 3]. Silent noon / Ralph Vaughan Williams -- [Track 4]. Der Kuss / Ludwig van Beethoven -- [Track 5]. Dans un bois solitaire / Wolfgang Amadeus Mozart -- [Track 6]. Come ready and see me / Richard Hundley -- [Track 7]. Una donna a quindici anni from Cosi fan tutte / Mozart -- [Track 8]. Spring / Dominick Argento -- [Track 9]. O del mio amato ben / Stefano Donaudy -- [Track 10]. Quando me\u27n vo\u27 from La boheme / Giacomo Puccini -- [Track 11]. O quante volte from I Capuleti e i Montecchi / Vincenzo Bellini -- [Track 12]. Pierrot / Debussy -- [Track 13]. Frühlingstraum / Franz Schubert -- [Track 14]. The roadside fire / Vaughan Williams -- [Track 15]. Ich trage meine Minne / Richard Strauss -- [Track 16]. Fantoches / Debussy -- [Track 17]. Chanson triste / Henri Duparc -- [Track 18]. Auf dem See / Johannes Brahms -- [Track 19]. Abendempfindung / Mozart -- [Track 20]. Do not go, my love / Richard Hageman -- [Track 21]. Ah, love but a day / Amy Beach -- [Track 22]. Nixe binsefuss / Hugo Wolf -- [Track 23]. Der Engel / Richard Wagner -- [Track 24]. Dreaming / Lori Laitman

Concert recording 2016-11-08

[Track 1]. Selve amiche / Antonio Caldara -- [Track 2]. Nuit d\u27étoiles / Claude Debussy -- [Track 3]. Silent noon / Ralph Vaughan Williams -- [Track 4]. Der Kuss / Ludwig van Beethoven -- [Track 5]. Dans un bois solitaire / Wolfgang Amadeus Mozart -- [Track 6]. Come ready and see me / Richard Hundley -- [Track 7]. Una donna a quindici anni from Cosi fan tutte / Mozart -- [Track 8]. Spring / Dominick Argento -- [Track 9]. O del mio amato ben / Stefano Donaudy -- [Track 10]. Quando me\u27n vo\u27 from La boheme / Giacomo Puccini -- [Track 11]. O quante volte from I Capuleti e i Montecchi / Vincenzo Bellini -- [Track 12]. Pierrot / Debussy -- [Track 13]. Frühlingstraum / Franz Schubert -- [Track 14]. The roadside fire / Vaughan Williams -- [Track 15]. Ich trage meine Minne / Richard Strauss -- [Track 16]. Fantoches / Debussy -- [Track 17]. Chanson triste / Henri Duparc -- [Track 18]. Auf dem See / Johannes Brahms -- [Track 19]. Abendempfindung / Mozart -- [Track 20]. Do not go, my love / Richard Hageman -- [Track 21]. Ah, love but a day / Amy Beach -- [Track 22]. Nixe binsefuss / Hugo Wolf -- [Track 23]. Der Engel / Richard Wagner -- [Track 24]. Dreaming / Lori Laitman

Internalization pathways into cancer cells of gadolinium-based radiosensitizing nanoparticles

International audienceOver the last few decades, nanoparticles have been studied in theranostic field with the objective of exhibiting a long circulation time through the body coupled to major accumulation in tumor tissues, rapid elimination, therapeutic potential and contrast properties. In this context, we developed sub-5 nm gadolinium-based nanoparticles that possess in vitro efficient radiosensitizing effects at moderate concentration when incubated with head and neck squamous cell carcinoma cells (SQ20B). Two main cellular internalization mechanisms were evidenced and quantified: passive diffusion and macropinocytosis. Whereas the amount of particles internalized by passive diffusion is not sufficient to inducein vitro a significant radiosensitizing effect, the cellular uptake by macropinocytosis leads to a successful radiotherapy in a limited range of particles incubation concentration. Macropinocytosis processes in two steps: formation of agglomerates at vicinity of the cell followed by their collect via the lamellipodia (i.e. the "arms") of the cell. The first step is strongly dependent on the physicochemical characteristics of the particles, especially their zeta potential that determines the size of the agglomerates and their distance from the cell. These results should permit to control the quantity of particles internalized in the cell cytoplasm, promising ambitious opportunities towards a particle-assisted radiotherapy using lower radiation doses

Synergistic Cytotoxic Effect of Busulfan and the PARP Inhibitor Veliparib in Myeloproliferative Neoplasms

ABSTRACT Patients with high-risk myeloproliferative neoplasms (MPNs), and in particular myelofibrosis (MF), can be cured only with allogeneic hematopoietic stem cell transplantation (HSCT). Because MPNs and JAK2V617F-mutated cells show genomic instability, stalled replication forks, and baseline DNA double-strand breaks, DNA repair inhibition with poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors represents a potential novel therapy. Because the alkylating agent busulfan is integral in conditioning regimens for HSCT and leads to stalled replication forks through DNA strand cross-linking, we hypothesized that PARP inhibition with veliparib in combination with busulfan may lead to synergistic cytotoxicity in MPN cells. We first treated 2 MPN cell lines harboring the JAK2V617F mutation (SET2 and HEL) with veliparib at increasing concentrations and measured cell proliferation. SET2 and HEL cells were relatively sensitive to veliparib (IC50 of 11.3 μM and 74.2 μM, respectively). We next treated cells with increasing doses of busulfan in combination with 4 μM veliparib and found that the busulfan IC50 decreased from 27 μM to 4 μM in SET2 cells and from 45.1 μM to 28.1 μM in HEL cells. The mean combination index was .55 for SET2 cells and .40 for HEL cells. Combination treatment of SET2 cells caused G2M arrest in 53% of cells, compared with 30% with veliparib alone and 35% with busulfan alone. G2M arrest was associated with activation of the ATR-Chk1 pathway, as shown by an immunofluorescence assay for phosphorylated Chk1 (p-Chk1). We then tested in vivo the effect of combined low doses of busulfan and veliparib in a JAK2V617F MPN-AML xenotransplant model. Vehicle- and veliparib-treated mice had similar median survival of 39 and 40 days, respectively. Combination treatment increased median survival from 47 days (busulfan alone) to 50 days (P = .02). Finally, we tested the combined effect of busulfan and veliparib on CD34+ cells obtained from the bone marrow or peripheral blood of 5 patients with JAK2V617F-mutated and 2 patients with CALR-mutated MF. MF cells treated with the combination of veliparib and busulfan showed reduced colony formation compared with busulfan alone (87% versus 68%; P = .001). In contrast, treatment of normal CD34+ cells with veliparib did not affect colony growth. Here we show that in vivo confirmation that treatment with the PARP-1 inhibitor veliparib and busulfan results in synergistic cytotoxicity in MPN cells. Our data provide the rationale for testing novel pretransplantation conditioning regimens with combinations of PARP-1 inhibition and reduced doses of alkylators, such as busulfan and melphalan, for high-risk MPNs or MPN-derived acute myelogenous leukemia

Setae from the pine processionary moth (Thaumetopoea pityocampa) contain several relevant allergens

BACKGROUND: Pine processionary larvae produce urticating hairs (setae) that serve for protection against predators. Setae induce cutaneous reactions in animals and humans. The presence of toxic or allergic mechanisms is a matter of debate. OBJECTIVES: To detect the presence of allergens in setae and to characterize them. MATERIALS AND METHODS: Setae extracts were characterized by gel staining and immunoblot, with sera from patients with immediate reactions and positive prick test reactions, as well as a rabbit antiserum raised against setae. Setae proteins were fractionated by high-performance liquid chromatography. The most relevant allergen was analysed by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS), and its sequence was deduced from an expressed sequence tag bank. Results. Setae contained at least seven different allergens. The most intense detection corresponded to a protein of MW ~ 14,000 that was similar to thaumetopoein, a previously described protein with mast cell-degranulating properties. MALDI-MS-based de novo sequencing provided a partial amino acid sequence different from that of the previously described allergen Tha p 1, and it was named Tha p 2. This allergen was detected in 61% of patients, and it is therefore a new major caterpillar allergen. CONCLUSIONS: Penetration of the setae from the pine processionary caterpillar delivers their allergenic content in addition to causing mechanical or toxic injury.This work was supported by URTICLIM, a French project funded by the ‘Agence Nationale de la Recherche’ (ANR 07BDIV 013). Ana I. Rodriguez-Mahillo is a beneficiary of contract CA07/00046 from the Instituto de Salud Carlos III, Ministerio de Ciencia e Innovacion, Spain.S