Hybrid confinement of optical and mechanical modes in a bullseye optomechanical resonator

Optomechanical cavities have proven to be an exceptional tool to explore fundamental and technological aspects of the interaction between mechanical and optical waves. Such interactions strongly benefit from cavities with large optomechanical coupling, high mechanical and optical quality factors, and mechanical frequencies larger than the optical mode linewidth, the so called resolved sideband limit. Here we demonstrate a novel optomechanical cavity based on a disk with a radial mechanical bandgap. This design confines light and mechanical waves through distinct physical mechanisms which allows for independent control of the mechanical and optical properties. Our device design is not limited by unique material properties and could be easily adapted to allow large optomechanical coupling and high mechanical quality factors with other promising materials. Finally, our demonstration is based on devices fabricated on a commercial silicon photonics facility, demonstrating that our approach can be easily scalable.Comment: 16 pages, 11 figure

Topsy-Turvy Neo-Developmentalism: An Analysis of the Current Brazilian Model of Development*

A B S T R AC T | The paper discusses the similarities and differences between neo-developmentalism and neo-extractivism. The evaluation compares Brazil with nine other Latin American countries and is based on a framework that considers both economic policies and their outcomes. On the policy side, it looks at income, monetary, international trade, industrial and mineral resource policies; on the outcome side, it observes the composition of both exports and the Gross Domestic Product. In the end, we argue that neo-developmentalism and neo-extractivism are actually variations of the same development route and may face similar challenges in the long term. Neodesarrolismo al revés: un análisis del actual modelo brasileño de desarrollo R E S U M E N | El artículo analiza las similitudes y diferencias entre el neodesarrollismo y el neoextractivismo. Esta revisión compara Brasil con otros nueve países de América Latina y utiliza como base un modelo que considera las políticas económicas y sus resultados. Por el lado de la política, considera la política económica, industrial, de comercio internacional, ingresos y recursos minerales. Por el lado de los resultados, observa la composición de las exportaciones y el PIB. Por último, se argumenta que el neodesarrollismo y neoextractivismo en realidad son variaciones de la misma vía de desarrollo y tienden a enfrentar los mismos desafíos en el largo plazo. PA L A B R A S C L AV E | Neodesarrollismo, neoextractivismo, desarrollo, América Latina. Neodesenvolvimento ao contrário: uma análise do atual modelo brasileiro de desenvolvimento R E S U M O | Este artigo analisa as semelhanças e as diferenças entre o neodesenvolvimentismo e o neoextrativismo. Esta revisão compara o Brasil com outros nove países da América Latina e utiliza como base um modelo que considera as políticas econômicas e seus resultados. No que se refere à política, considera as políticas de renda, monetária, de comércio internacional, industrial e de recursos minerais. Quanto aos resultados, observa a composição das exportações e o PIB. Por último, argumenta-se que o neodesenvolvimentismo e o neoextrativismo em realidade são variações da mesma via de desenvolvimento e tendem a enfrentar os mesmos desafios em longo prazo

Topsy-Turvy Neo-Developmentalism: An Analysis of the Current Brazilian Model of Development*

A B S T R AC T | The paper discusses the similarities and differences between neo-developmentalism and neo-extractivism. The evaluation compares Brazil with nine other Latin American countries and is based on a framework that considers both economic policies and their outcomes. On the policy side, it looks at income, monetary, international trade, industrial and mineral resource policies; on the outcome side, it observes the composition of both exports and the Gross Domestic Product. In the end, we argue that neo-developmentalism and neo-extractivism are actually variations of the same development route and may face similar challenges in the long term. Neodesarrolismo al revés: un análisis del actual modelo brasileño de desarrollo R E S U M E N | El artículo analiza las similitudes y diferencias entre el neodesarrollismo y el neoextractivismo. Esta revisión compara Brasil con otros nueve países de América Latina y utiliza como base un modelo que considera las políticas económicas y sus resultados. Por el lado de la política, considera la política económica, industrial, de comercio internacional, ingresos y recursos minerales. Por el lado de los resultados, observa la composición de las exportaciones y el PIB. Por último, se argumenta que el neodesarrollismo y neoextractivismo en realidad son variaciones de la misma vía de desarrollo y tienden a enfrentar los mismos desafíos en el largo plazo. PA L A B R A S C L AV E | Neodesarrollismo, neoextractivismo, desarrollo, América Latina. Neodesenvolvimento ao contrário: uma análise do atual modelo brasileiro de desenvolvimento R E S U M O | Este artigo analisa as semelhanças e as diferenças entre o neodesenvolvimentismo e o neoextrativismo. Esta revisão compara o Brasil com outros nove países da América Latina e utiliza como base um modelo que considera as políticas econômicas e seus resultados. No que se refere à política, considera as políticas de renda, monetária, de comércio internacional, industrial e de recursos minerais. Quanto aos resultados, observa a composição das exportações e o PIB. Por último, argumenta-se que o neodesenvolvimentismo e o neoextrativismo em realidade são variações da mesma via de desenvolvimento e tendem a enfrentar os mesmos desafios em longo prazo

Efficient anchor loss suppression in coupled near-field optomechanical resonators

FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQElastic dissipation through radiation towards the substrate is a major loss channel in micro-and nanomechanical resonators. Engineering the coupling of these resonators with optical cavities further complicates and constrains the design of low-loss optomechanical devices. In this work we rely on the coherent cancellation of mechanical radiation to demonstrate material and surface absorption limited silicon near-field optomechanical resonators oscillating at tens of MHz. The effectiveness of our dissipation suppression scheme is investigated at room and cryogenic temperatures. While at room temperature we can reach a maximum quality factor of 7.61k (fQ-product of the order of 10(11) Hz), at 22 K the quality factor increases to 37k, resulting in a fQ-product of 2 x 10(12) Hz.25253134731361FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQ2008/57857-22012/17610-32012/17765-7153044/2013-

Epithelium and stroma from nasal polyp mucosa exhibits inverse expression of TGF- beta(1) as compared with healthy nasal mucosa

Objective: To evaluate TGF-beta(1) expression in polypoid mucosa (epithelium and stroma) of patients with chronic rhinosinusitis with nasal polyposis (CRSwNP).Methods: Cross-sectional study with two groups: 17 patients with nasal polyposis and 11 controls. Polyps and normal nasal mucosa were processed by immunohistochemical methods for TGF-beta 1 visualization. Then, the percentage of TGF-beta 1 expression in stroma and epithelium was objectively quantified using UT Morph software.Results: A lower percentage of positive expression was found in the epithelium of CRSwNP patients (32.44%) versus normal controls (55.91%) (p < 0.05), and a higher percentage of positive expression in the stroma of CRSwNP patients (23.24%) versus controls (5.88%) (p < 0.05).Conclusion: the lower percentage of TGF-beta(1) expression in the nasal epithelium of CRSwNP patients may have an impact on epithelium-directed topical treatments employed in this patient population.Universidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, BrazilUniv Ghent, Ghent Univ Hosp, Dept Otorhinolaryngol, Upper Airway Res Lab, B-9000 Ghent, BelgiumUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Otolaryngol Head & Neck Surg, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, São Paulo, BrazilWeb of Scienc

An orally active formulation of angiotensin-(1-7) produces an antithrombotic effect

INTRODUCTION AND OBJECTIVE: The heptapeptide angiotensin-(1-7) is a component of the renin-angiotensin system, which promotes many beneficial cardiovascular effects, including antithrombotic activity. We have recently shown that the antithrombotic effect of angiotensin-(1-7) involves receptor Mas-mediated NO-release from platelets. Here, we describe an orally active formulation based on angiotensin-(1-7) inclusion in cyclodextrin [Ang-(1-7)- CyD] as an antithrombotic agent. Cyclodextrins are pharmaceutical tools that are used to enhance drug stability, absorption across biological barriers and gastric protection. METHOD: To test the antithrombotic effect of Ang-(1-7)-CyD, thrombus formation was induced in the abdominal vena cava of spontaneously hypertensive rats that were pretreated either acutely or chronically with Ang-(1-7)-CyD. Male Mas-knockout and wild-type mice were used to verify the role of the Mas receptor on the effect of Ang-(1-7)-CyD. RESULTS: Acute or chronic oral treatment with Ang-(1-7)-CyD promoted an antithrombotic effect (measured by thrombus weight; all values are, respectively, untreated vs. treated animals) in spontaneously hypertensive rats (acute: 2.86 + 0.43 mg vs. 1.14 + 0.40 mg; chronic: 4.27 + 1.03 mg vs. 1.39 + 0.68 mg). This effect was abolished in Mas-knockout mice (thrombus weight in Mas wild-type: 0.76 + 0.10 mg vs. 0.37 + 0.02 mg; thrombus weight in Mas-knockout: 0.96 + 0.11 mg vs. 0.87 + 0.14 mg). Furthermore, the antithrombotic effect of Ang-(1-7)-CyD was associated with an increase in the plasma level of Angiotensin-(1-7). CONCLUSION: These results show for the first time that the oral formulation Ang-(1-7)-CyD has biological activity and produces a Mas-dependent antithrombotic effect

Performance and plasma urea nitrogen of immunocastrated males pigs of medium genetic potential

ABSTRACT Objective. A study was carried out to evaluate the performance and the plasma urea nitrogen (PUN) of male pigs of medium genetic potential for lean meat deposition in carcass, which underwent immunocastration. Materials and methods. Forty-five seventy-days old Large White x Landrace crossbred were used. The pigs were distributed in a randomized design in three treatments: castrated males, females and immunocastrated males. Each treatment group was replicated three times with five pigs per replicate. The trial period was of 70 days, divided into phases of growing (70 to 110 days old) and finishing (111 to 140 days old). The pigs were weighed four times: at the beginning of the trial, at the first immunocastration vaccine dose (80 days old), at the second immunocastration vaccine dose (110 days old) and just before slaughter (140 days old). Blood samples were taken on the same day that the animals were weighed. Results. Between 80 and 110 days old, there was an increase in PUN value, only for castrated males and females. No differences were found in weight gain between the studied groups within the periods. Immunocastrated males had lower feed intake than females and these had a lower feed intake than castrated males. To 110 days old, immunocastrated animals showed feed conversion ratio similar to females and better than castrated males. However, after the second dose of the vaccine, feed conversion was similar between groups. Conclusions. The benefits of immunocastration are prominent in animals with low to medium genetic potential. RESUMEN Objetivo. Se realizó un estudio para evaluar el rendimiento y la concentración de urea en plasma (PUN) de los cerdos machos de medio potencial genético de carne magra en la canal sometidos a la inmunocastración. Materiales y métodos. Se utilizaron 45 cerdos de 70 días de edad Landrace x Large White. Los animales se distribuyeron en un diseño completamente al azar con tres tratamientos: machos castrados, hembras y machos inmunocastrados. Cada tratamiento consistió en tres repeticiones, con cinco animales por réplica. El período experimental fue de 70 días, divididos en las etapas de crecimiento (70 a 110 días de edad) y terminación (111 a 140 días de edad). Los cerdos fueron pesados cuatro veces: al inicio del experimento, en la primera dosis de vacuna de inmunocastración (80 días de edad), en la segunda dosis de la vacuna de inmunocastración (110 días de edad) y antes de el sacrificio (140 días de edad). Las muestras de sangre se recogieron en el mismo día en que se pesaron los animales. Resultados. Entre 80 y 110 días de edad, hubo un aumento en la cantidad de PUN, sólo para machos castrados y hembras. No hubo diferencias en la ganancia de peso entre los grupos en ninguno de los períodos estudiados. Machos inmunocastrados tuvieron menor consumo de alimento que las hembras y éstas mostraron un menor consumo que los machos castrados. En 110 días de edad, los animales inmunocastrados mostraron la conversión de alimento similar a las hembras y mejor que los machos castrados. Sin embargo, después de la segunda dosis de la vacuna, la conversión alimenticia fue similar entre los grupos. Conclusiones. Los beneficios de inmunocastración son prominentes en animales con bajo a médio potencial genético.

Resumen de la Tarea de Análisis de Sentimientos Basado en Aspectos en Portugués (ABSAPT) en IberLEF 2022

Este artículo presenta la Tarea sobre Análisis de Sentimientos basado en Aspectos en Portugués (ABSAPT), realizada en el IberLEF 2022. Les pedimos a los participantes que desarrollaran sistemas capaces de identificar aspectos (AE) y extraer la polaridad (ASC) en textos escritos en portugués. Doce equipos se inscribieron en la tarea, entre los cuales cinco presentaron predicciones e informes técnicos. El sistema con mejor rendimiento logró un valor de precisión (Acc) de 0,67 para la subtarea de AE (Equipo Deep Learning Brasil) y un valor de precisión equilibrada (Bacc) de 0,82 para la subtarea de ASC (Equipo Deep Learning Brasil).This paper presents the task on Aspect-Based Sentiment Analysis in Portuguese (ABSAPT), held within Iberian Languages Evaluation Forum (IberLEF 2022). We asked the participants to develop systems capable of extracting aspects (AE) and classifying sentiment of aspects (ASC) in texts. We created one corpora containing reviews about hotels. Twelve teams registered to the task, among which five submitted predictions and technical reports. The best performing system achieved an Accuracy (Acc) value of 0.67 in AE sub-task (Team Deep Learning Brasil) and a Balanced Accuracy (Bacc) value of 0.82 in ASC sub-task (Team Deep Learning Brasil).This work was financed in part by the following Brazilian research agencies: CAPES and CNPq

Intensity modulated radiotherapy for localized prostate cancer: rigid compliance to dose-volume constraints as a warranty of acceptable toxicity?

BACKGROUND: To report the toxicity after intensity modulated radiotherapy (IMRT) for patients with localized prostate cancer, as a sole treatment or after radical prostatectomy. METHODS: Between August 2001 and December 2003, 132 patients with prostate cancer were treated with IMRT and 125 were evaluable to acute and late toxicity analysis, after a minimum follow-up time of one year. Clinical and treatment data, including normal tissue dose-volume histogram (DVH) constraints, were reviewed. Gastro-intestinal (GI) and genito-urinary (GU) signs and symptoms were evaluated according to the Radiation Therapy Oncology Group (RTOG) toxicity scales. Median prescribed dose was 76 Gy. Median follow-up time was of 26.1 months. RESULTS: From the 125 patients, 73 (58.4%) presented acute Grade 1 or Grade 2 GI and 97 (77.2%) presented acute Grade 1 or Grade 2 GU toxicity. Grade 3 GI acute toxicity occurred in only 2 patients (1.6%) and Grade 3 GU acute toxicity in only 3 patients (2.4%). Regarding Grade 1 and 2 late toxicity, 26 patients (20.8%) and 21 patients (16.8%) presented GI and GU toxicity, respectively. Grade 2 GI late toxicity occurred in 6 patients (4.8%) and Grade 2 GU late toxicity in 4 patients (3.2%). None patient presented any Grade 3 or higher late toxicity. Non-conformity to DVH constraints occurred in only 11.2% of treatment plans. On univariate analysis, no significant risk factor was identified for Grade 2 GI late toxicity, but mean dose delivered to the PTV was associated to higher Grade 2 GU late toxicity (p = 0.042). CONCLUSION: IMRT is a well tolerable technique for routine treatment of localized prostate cancer, with short and medium-term acceptable toxicity profiles. According to the data presented here, rigid compliance to DHV constraints might prevent higher incidences of normal tissue complication