CoRoT\,102699796, the first metal-poor Herbig Ae pulsator: a hybrid δ\delta Sct-γ\gamma Dor variable?

We present the analysis of the time series observations of CoRoT\,102699796 obtained by the CoRoT satellite that show the presence of five independent oscillation frequencies in the range 3.6-5 c/d. Using spectra acquired with FLAMES@VLT, we derive the following stellar parameters: spectral type F1V, T$_{\rm eff}$=7000$\pm$200 K, log(g)=$3.8\pm0.4$, [M/H]=$-1.1\pm0.2$, $v$sin$i$=$50\pm5$ km/s, L/L$_{\odot}$=21$^{+21}_{-11}$. Thus, for the first time we report the existence of a metal poor, intermediate-mass PMS pulsating star. Ground-based and satellite data are used to derive the spectral energy distribution of CoRoT\,102699796 extending from the optical to mid-infrared wavelengths. The SED shows a significant IR excess at wavelengths greater than $\sim5 \mu$. We conclude that CoRoT\,102699796 is a young Herbig Ae (F1Ve) star with a transitional disk, likely associated to the HII region [FT96]213.1-2.2. The pulsation frequencies have been interpreted in the light of the non-radial pulsation theory, using the LOSC code in conjunction with static and rotational evolutionary tracks. A minimization algorithm was used to find the best-fit model with M=1.84 M$_{\odot}$, T$_{\rm eff}$=6900 K which imply an isochronal age of t$\sim$2.5 Myr. This result is based on the interpretation of the detected frequencies as $g$-modes of low-moderate $n$-value. To our knowledge, this is the first time that such modes are identified in a intermediate-mass PMS pulsating star. Since CoRoT\,102699796 lies in the region of the HR diagram where the $\delta$ Sct and $\gamma$ Dor instability strips intersect, we argue that the observed pulsation characteristics are intermediate between these classes of variables, i.e. CoRoT\,102699796 is likely the first PMS hybrid $\gamma$ Dor-$\delta$ Sct pulsator ever studied.Comment: 13 pages, 7 figures. Accepted for publication in Monthly Notices of the RA

Influence of acute kidney injury on short- and long-term outcomes in patients undergoing cardiac surgery: risk factors and prognostic value of a modified RIFLE classification

Introduction: The development of acute kidney injury (AKI) is associated with poor outcome. The modified RIFLE (risk, injury, failure, loss of kidney function, and end-stage renal failure) classification for AKI, which classifies patients with renal replacement therapy needs according to RIFLE failure class, improves the predictive value of AKI in patients undergoing cardiac surgery. Our aim was to assess risk factors for post-operative AKI and the impact of renal function on short- and long-term survival among all AKI subgroups using the modified RIFLE classification. Methods: We prospectively studied 2,940 consecutive cardiosurgical patients between January 2004 and July 2009. AKI was defined according to the modified RIFLE system. Pre-operative, operative and post-operative variables usually measured on and during admission, which included main outcomes, were recorded together with cardiac surgery scores and ICU scores. These data were evaluated for association with AKI and staging in the different RIFLE groups by means of multivariable analyses. Survival was analyzed via Kaplan-Meier and a risk-adjusted Cox proportional hazards regression model. A complete follow-up (mean 6.9 ± 4.3 years) was performed in 2,840 patients up to April 2013. Results: Of those patients studied, 14% (n = 409) were diagnosed with AKI. We identified one intra-operative (higher cardiopulmonary bypass time) and two post-operative (a longer need for vasoactive drugs and higher arterial lactate 24 hours after admission) predictors of AKI. The worst outcomes, including in-hospital mortality, were associated with the worst RIFLE class. Kaplan-Meier analysis showed survival of 74.9% in the RIFLE risk group, 42.9% in the RIFLE injury group and 22.3% in the RIFLE failure group (P <0.001). Classification at RIFLE injury (Hazard ratio (HR) = 2.347, 95% confidence interval (CI) 1.122 to 4.907, P = 0.023) and RIFLE failure (HR = 3.093, 95% CI 1.460 to 6.550, P = 0.003) were independent predictors for long-term patient mortality. Conclusions: AKI development after cardiac surgery is associated mainly with post-operative variables, which ultimately could lead to a worst RIFLE class. Staging at the RIFLE injury and RIFLE failure class is associated with higher short- and long-term mortality in our population

Caracterización fisicoquímica del agua de la laguna La Vega Escondida, Tampico, Tamaulipas-México - Physicochemical water characterization of La Vega Escondida Lake, Tampico, Tamaulipas-México

La laguna La Vega Escondida se ubica al Noroeste del municipio de Tampico, Tamaulipas. Es un área natural protegida, que colinda con la zona conurbada de Tampico, Madero y Altamira, que además del beneficio ecológico,es una fuente de abastecimiento de agua potable para la ciudad de Tampico. Por lo cual es importante conocer la composición fisicoquímica del agua de esta laguna, con el fin de proteger tanto el ecosistema como la salud humana. Este estudio, evaluó la concentración de los parámetros fisicoquímicos del agua (pH, conductividad eléctrica, sólidos totales, temperatura, cloruros, dureza, alcalinidad, sulfatos, demanda química de oxígeno y oxígeno disuelto), así como la distribución espacial de éstos dentro de la laguna. Los resultados obtenidos, se compararon con los criterios ecológicos de la calidad del agua (CE-CCA-001-SEMARNAT, 1989) y con la Norma Oficial Mexicana (NOM-127-SSA1-1994), obteniéndose que en los parámetros analizados el agua cumple con la calidad requerida para mantener la vida acuática y captación para consumo humano, excepto en el parámetro de sólidos suspendidos totales (SST). Se observó además que los patrones de distribución espacial de los parámetros fisicoquímicos son heterogéneos y que hay diferencias significativas en el parámetro OD (profundidades), así como en el pH y la CE (puntos de muestreo), al nivel de significancia del 5 %

The Influence of Body Mass Index on Outcomes in Patients Undergoing Cardiac Surgery: Does the Obesity Paradox Really Exist?

Purpose: Obesity influences risk stratification in cardiac surgery in everyday practice. However, some studies have reported better outcomes in patients with a high body mass index (BMI): this is known as the obesity paradox. The aim of this study was to quantify the effect of diverse degrees of high BMI on clinical outcomes after cardiac surgery, and to assess the existence of an obesity paradox in our patients. Methods: A total of 2,499 consecutive patients requiring all types of cardiac surgery with cardiopulmonary bypass between January 2004 and February 2009 were prospectively studied at our institution. Patients were divided into four groups based on BMI: normal weight (18.524.9 kg∙m−2; n = 523; 21.4%), overweight (2529.9kg∙m−2; n = 1150; 47%), obese (≥30≤34.9kg∙m−2; n = 624; 25.5%) and morbidly obese (≥35kg∙m−2; n = 152; 6.2%). Follow-up was performed in 2,379 patients during the first year. Results: After adjusting for confounding factors, patients with higher BMI presented worse oxygenation and better nutritional status, reflected by lower PaO2/FiO2 at 24h and higher albumin levels 48h after admission respectively. Obese patients showed a higher risk for Perioperative Myocardial Infarction (OR: 1.768; 95% CI: 1.0353.022; p = 0.037) and septicaemia (OR: 1.489; 95% CI: 1.2821.997; p = 0.005). In-hospital mortality was 4.8% (n = 118) and 1-year mortality was 10.1% (n = 252). No differences were found regarding in-hospital mortality between BMI groups. The overweight group showed better 1-year survival than normal weight patients (91.2% vs. 87.6%; Log Rank: p = 0.029. HR: 1.496; 95% CI: 1.0622.108; p = 0.021). Conclusions: In our population, obesity increases Perioperative Myocardial Infarction and septicaemia after cardiac surgery, but does not influence in-hospital mortality. Although we found better 1-year survival in overweight patients, our results do not support any protective effect of obesity in patients undergoing cardiac surgery

Evaluation of the PaO2/FiO2 ratio after cardiac surgery as a predictor of outcome during hospital stay

Background: the arterial partial pressure of O2 and the fraction of inspired oxygen (PaO2/FiO2) ratio is widely used in ICUs as an indicator of oxygenation status. Although cardiac surgery and ICU scores can predict mortality, during the first hours after cardiac surgery few instruments are available to assess outcome. The aim of this study was to evaluate the usefulness of PaO2/FIO2 ratio to predict mortality in patients immediately after cardiac surgery. Methods: we prospectively studied 2725 consecutive cardiac surgery patients between 2004 and 2009. PaO2/FiO2 ratio was measured on admission and at 3 h, 6 h, 12 h and 24 h after ICU admission, together with clinical data and outcomes. Results: all PaO2/FIO2 ratio measurements differed between survivors and non-survivors (p  242; Group 2, with PaO2/FIO2 from 202 to 242; and Group 3, with PaO2/FIO2 < 202. Group 3 showed higher in-ICU mortality and ICU length of stay and Groups 2 and 3 also showed higher respiratory complication rates. The presence of a PaO2/FIO2 ratio < 202 at 3 h after admission was shown to be a predictor of in-ICU mortality (OR:1.364; 95% CI:1.212-1.625, p < 0.001) and of worse long-term survival (88.8% vs. 95.8%; Log rank p = 0.002. Adjusted Hazard ratio: 1.48; 95% CI:1.293-1.786; p = 0.004). Conclusions: a simple determination of PaO2/FIO2 at 3 h after ICU admission may be useful to identify patients at risk immediately after cardiac surgery

Immune Profiling of Peripheral Blood Mononuclear Cells at Pancreas Acute Rejection Episodes in Kidney-Pancreas Transplant Recipients

Profiling of circulating immune cells provides valuable insight to the pathophysiology of acute rejection in organ transplantation. Herein we characterized the peripheral blood mononuclear cells in simultaneous kidney-pancreas transplant recipients. We conducted a retrospective analysis in a biopsy-matched cohort (n = 67) and compared patients with biopsy proven acute rejection (BPAR; 41%) to those without rejection (No-AR). We observed that CD3+ T cells, both CD8+ and CD4+, as well as CD19+ B cells were increased in patients with BPAR, particularly in biopsies performed in the early post-transplant period (<3 months). During this period immune subsets presented a good discriminative ability (CD4+ AUC 0.79; CD8+ AUC 0.80; B cells AUC 0.86; p < 0.05) and outperformed lipase (AUC 0.62; p = 0.12) for the diagnosis of acute rejection. We further evaluated whether this could be explained by differences in frequencies prior to transplantation. Patients presenting with early post-transplant rejection (<3 months) had a significant increase in T-cell frequencies pre-transplant, both CD4+ T cells and CD8+ T cells (p < 0.01), which were associated with a significant inferior rejection-free graft survival. T cell frequencies in peripheral blood correlated with pancreas acute rejection episodes, and variations prior to transplantation were associated with pancreas early acute rejection.Copyright © 2022 Rovira, Ramirez-Bajo, Bañón-Maneus, Hierro-Garcia, Lazo-Rodriguez, Piñeiro, Montagud-Marrahi, Cucchiari, Revuelta, Cuatrecasas, Campistol, Ricart, Diekmann, Garcia-Criado and Ventura-Aguiar

Evaluation of uncertainty sources in the determination of testosterone in urine by calibration-based and isotope dilution quantification using ultra high performance liquid chromatography tandem mass spectrometry

Three quantification methodologies, namely calibration with internal standard (Cal-IS, non-weighted), weighted calibration with internal standard (wCal-IS) and isotope pattern deconvolution (IPD) have been used for the determination of testosterone in urine by LC-MS/MS. Uncertainty has been calculated and compared for the three methodologies through intra- and inter-laboratory reproducibility assays. IPD showed the best performance for the intra-laboratory reproducibility, with RSD and combined uncertainty values below 4% and 9% respectively. wCal-IS showed similar performance, while Cal-IS where not constant and clearly worse at the lowest concentration assayed (2 ng/mL) reaching RSD values up to 16%. The inter-laboratory assay indicated similar results although wCal-IS RSD (20%) was higher than IPD (10%) and Cal-IS get worse with RSD higher than 40% for the lowest concentration level. Uncertainty budgets calculated for the three procedures revealed that intercept and slope were the most important factors contributing to uncertainty for Cal-IS. The main factors for wCal-IS and IPD were the volumes of sample and/or standard measured.The authors acknowledge financial support from the Generalitat Valenciana (Research group of excellence Prometeo II 2014/023 and Collaborative Research on Environment and Food Safety ISIC/2012/016), as well as University Jaume I for project PB1-1B2013-55. Finally, the authors are grateful to the Serveis Centrals d'Instrumentació Científica (SCIC) of University Jaume I for using Acquity and TQD instruments