Faunal behavior in response to near bottom water dynamics in a marine protected area (Cantabrian Sea, southern Bay of Biscay)

A set of lander deployments in a deep marine protected area (MPA; El Cachucho) combining environmental sensors and a baited camera provided insight on the relationship between faunal behavior and oceanographic dynamics. Landers were deployed at different depths, ranging from 500 to 960 m for a period of 24–26 h. A total of 10,989 photographs were downloaded and synchronized using a time code with all the environmental variables recorded (pressure, temperature, salinity, water current, and direction). Total richness accounted for 41 species of different taxonomic groups (21 fishes, 11 crustaceans, 6 echinoderms, and 3 molluscs). The most abundant species were Synaphobranchus kaupii, Mora moro, Phycis blennoides, Helicolenus dactylopterus, and Etmopterus spinax. Arrival times (Tarr) and maximum number of individuals (Nmax) greatly differed among stations. Cluster analysis showed two main faunal groups in relation to depth: those close to the top of the bank and those in the flanks. Species densities were estimated using Priede's equations and compared with those obtained in previous studies using trawl samplers. The relation of species with environmental variables showed high variability depending on the location of the station and the associated variables (depth, current, and water masses). Near-bottom dynamics were consistent with previously known oceanographic patterns at the bank, dominated by background anticyclonic recirculation along the flanks overlaid by strong tidal cycles. Current and hydrography tidally driven phases showed an evident effect in the arrival of species at some locations. Species appeared during specific periods matching the beginning of the flooding phase or end of the ebb phase. Movement rates (cm s−1) were estimated for some invertebrate species, such as crabs (Bathynectes maravigna, 0.66; Pagurus sp., 0.09), the gasteropod Colus gracilis (0.15), and echinoderms (Cidaris cidaris, 0.04; Araeosoma fenestratum, 0.23)

Bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer

Este artículo ha sido publicado en Oncology Basel. Esta versión tiene Licencia Creative Commons CC-BY-NC-ND No puedo enviar el postprint porque no lo tienen disponible o no quieren facilitarmelo, en su lugar he aportado en la descripción del envió dos e mail en los cuales la editorial me da permiso por escrito para su depósito como puede ver en los mimos Adjunto e mails, si tiene ustd alguna otra sugerencia para poder hacer deposito por favor hagamelo saber 2º e mail: Dear Alfonso, Our reply is the written permission to deposit the article in the university’s repository – please find it attached once again. Kind regards, Veronika 1º e mail Veronika Duhovnikova Key Account Manager, Academic & Research Markets +41 61 306 12 43 [email protected] Dear Alfonso, Thank you for your email. As to your query, we are pleased to inform you that Karger permits authors to archive their pre-prints (i.e. pre-peer review) or post-prints (i.e. accepted manuscript after peer review but before production) on their personal or their institution’s internal website. In addition, authors may post their accepted manuscripts in public Open Access repositories and scientific networks (e.g. ResearchGate or Mendeley) no earlier than 12 months following the publication of the publisher’s versions. For all self-archiving options, the posted manuscripts must be - used for non-commercial purposes only - linked to the final version on Karger Publishers - include the following statement: ‘This is the peer-reviewed but unedited manuscript version of the following article: [insert full citation, e.g. Oncology 1 December 2010; 79 (1-2): 98–104, (DOI: 10.1159/000320602)]. The final, published version is available at [https://karger.com/ocl/article-abstract/79/1-2/98/328844/Bevacizumab-plus-Low-Dose-Metronomic-Oral?redirectedFrom=fulltext].’ For papers published online first with a DOI number only, full citation details must be added as soon as the paper is published in its final version. This is important to ensure that citations can be credited to the article. It is the author’s responsibility to fulfil these requirements. Further information about Karger’s Self-Archiving Policy can be found on the Karger website https://karger.com/pages/rights-and-permissions ‘How can I share it?’ and on SherpaRomeo Welcome to Sherpa Romeo - v2.sherpa. Please feel free to contact us again, if you need any further information. Kind regards, Veronika Veronika Duhovnikova Key Account Manager, Academic & Research Markets +41 61 306 12 43 [email protected]: To retrospectively assess the efficacy and safety of bevacizumab plus low-dose metronomic oral cyclophosphamide in heavily pretreated patients with recurrent ovarian cancer. Patients and Methods: Patients with recurrent ovarian cancer and prior treatment with platinum- and taxanebased chemotherapy were included. Treatment consisted of bevacizumab 10 mg/kg intravenously every 2 weeks plus oral cyclophosphamide 50 mg daily until disease progression or unacceptable toxicity. Response rates (RR) were determined according to RECIST criteria and by monitoring the CA 125 serum tumor marker according to Rustin’s criteria.The endpoints were progression-free survival (PFS), RR, overall survival (OS), and safety. Results: Thirty-eight patients were treated; 79% were platinum resistant and 21% were platinum sensitive. The median number of previous treatments was 4 (range 1–8). Seventy-nine percent of patients had received more than 2 previous lines of treatment. Eightyone percent of patients had received gemcitabine, 76% liposomal doxorubicin, and 50% topotecan. A median of 8 (range 1–70) cycles of bevacizumab were administered. The overall RR was a complete response (CR) in 3 patients (8.1%), a partial response (PR) in 12 (32.4%), and stable disease (SD) 6 6 months in 3 (8.1%). The median PFS and OS were 4.5 and 10.7 months, respectively. Thirty-nine percent of patients were progression free for at least 6 months. In an exploratory analysis there was a significant relation of prior platinum response and performance status with the risk of progression.Grade 3–4 toxicities included anemia (1), hypertension (2), hematuria (1), arterial thrombosis in the leg (1), dyspnea (1), and intestinal fistulae (1). There were no cases of gastrointestinal perforation (GIP) or treatment-related deaths. Conclusion: The combination of bevacizumab and metronomic cyclophosphamide was active and well-tolerated in heavily pretreated patients with recurrent ovarian cancer

Twitter como herramienta de apoyo a la docencia

Memoria ID-0062. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2017-2018

Soybean protease inhibitors increase Bacillus thuringiensis subs. israelensis toxicity against Hypothenemus hampei

The coffee berry borer (Hypothenemus hampei Ferrari, CBB) is one of the most devastating pests on coffee plantations around the world. Although CBB is susceptible to the effect of δ–endotoxins of Bacillus thuringiensis subs. israelensis (Bti) at laboratory level, the efficacy of this control method is poor in the field, presumably due to the inactivation by digestive proteases different to those required for protoxin activation. Objective. To study whether the addition of a soybean flour extract enriched with protease inhibitors (PI), mixed with Bti crystals and spores (Bti-sc) in an artificial diet, could improve the toxicity of Bti against CBB. Materials and methods. This study was performed in San José, Costa Rica, between 2012 and 2013. A set of adult female CBB insects was exposed to a mixture containing different concentrations of a partially purified soybean meal extract with active PI and lyophilized Bti-sc, and were tested through a bioassay in artificial diet to estimate the sub-lethal concentration (LC50). The mortality results were validated by observing the dissected midgut, whose ultrastructure was analyzed by transmission electron microscopy. Results. The soybean extracts partially degraded the Bti-sc complex, it reduced its LC50 by almost four times (from 1.135 to 0.315 μg μl-1) and enhanced CBB mortality in a concentration-dependent manner. Histological analyses of the midgut confirmed this synergistic effect, since severe epithelial damage to the intestinal epithelium of CBB exposed to Bti-sc + PI was visualized compared to Bti-sc alone. Conclusions. The combination of a soybean extract enriched in PI and Bti-sc enhanced the mortality effect over CBB, which was confirmed by the midgut collapse. Soybean flour is a cost-effective supplement that could increase Bti effectiveness against CBB and delay the appearance of biological resistance.Universidad de Costa Rica/[801-A6-607]/UCR/Costa RicaUniversidad de Costa Rica/[801-A2-521]/UCR/Costa RicaAgroquímica Industrial RIMAC S.A./[]//Costa RicaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Biología Celular y Molecular (CIBCM)UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias de la Salud::Centro de Investigación en Enfermedades Tropicales (CIET)UCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Estructuras Microscópicas (CIEMIC)UCR::Vicerrectoría de Docencia::Salud::Facultad de Medicina::Escuela de MedicinaUCR::Vicerrectoría de Investigación::Unidades de Investigación::Ciencias Básicas::Centro de Investigación en Ciencia e Ingeniería de Materiales (CICIMA

General Microbiota of the Soft Tick Ornithodoros turicata Parasitizing the Bolson Tortoise (Gopherus flavomarginatus) in the Mapimi Biosphere Reserve, Mexico

The general bacterial microbiota of the soft tick Ornithodoros turicata found on Bolson tortoises (Gopherus flavomarginatus) were analyzed using next generation sequencing. The main aims of the study were to establish the relative abundance of bacterial taxa in the tick, and to document the presence of potentially pathogenic species for this tortoise, other animals, and humans. The study was carried-out in the Mapimi Biosphere Reserve in the northern-arid part of Mexico. Bolson tortoises (n = 45) were inspected for the presence of soft ticks, from which 11 tortoises (24.4%) had ticks in low loads (1–3 ticks per individual). Tick pools (five adult ticks each) were analyzed through 16S rRNA V3–V4 region amplification in a MiSeq Illumina, using EzBioCloud as a taxonomical reference. The operational taxonomic units (OTUs) revealed 28 phyla, 84 classes, 165 orders, 342 families, 1013 genera, and 1326 species. The high number of taxa registered for O. turicata may be the result of the variety of hosts that this tick parasitizes as they live inside G. flavomarginatus burrows. While the most abundant phyla were Proteobacteria, Actinobacteria, and Firmicutes, the most abundant species were two endosymbionts of ticks (Midichloria-like and Coxiella-like). Two bacteria documented as pathogenic to Gopherus spp. were registered (Mycoplasma spp. and Pasteurella testudinis). The bovine and ovine tick-borne pathogens A. marginale and A. ovis, respectively, were recorded, as well as the zoonotic bacteria A. phagocytophilum,Coxiella burnetii, and Neoehrlichia sp. Tortoises parasitized with O. turicata did not show evident signs of disease, which could indicate a possible ecological role as a reservoir that has yet to be demonstrated. In fact, the defense mechanisms of this tortoise against the microorganisms transmitted by ticks during their feeding process are still unknown. Future studies on soft ticks should expand our knowledge about what components of the microbiota are notable across multiple host–microbe dynamics. Likewise, studies are required to better understand the host competence of this tortoise, considered the largest terrestrial reptile in North America distributed throughout the Chihuahuan Desert since the late Pleistocene

2D-Tasks for Cognitive Rehabilitation

Neuropsychological Rehabilitation is a complex clinic process which tries to restore or compensate cognitive and behavioral disorders in people suffering from a central nervous system injury. Information and Communication Technologies (ICTs) in Biomedical Engineering play an essential role in this field, allowing improvement and expansion of present rehabilitation programs. This paper presents a set of cognitive rehabilitation 2D-Tasks for patients with Acquired Brain Injury (ABI). These tasks allow a high degree of personalization and individualization in therapies, based on the opportunities offered by new technologies

Perspectivas de la empresa y la economía mexicana frente a la reestructuración productiva

1 archivo PDF (404 páginas)Este texto se presenta una reflexión de investigadores de la UAM, así como de otras Instituciones de Educación Superior respecto al marco en el que se han desenvuelto las empresas mexicanas en los últimos años, así como del desarrollo en algunos de sus sistemas organizacionales. PALABRAS CLAVE: Mexico Economic policy 1970-1994