The chronology and rotational kinematics in the South-Eastern Jaca Basin (Southern Pyrenees) : Las Bellostas section

Acknowledgement. This paper represents our modest tribute to Pep Serra-Kiel for his inspiring work, his sharp intelligence, his working tenacity, his always fruitful discussions and his camaraderie and friendship. This work was financed by the Sobrarbe County Research fellow-UNESCO Global Geopark (ARP) and by some projects from the Spanish Science National Plan (UKRIA4D- PID2019--I00/CTA, DR3AM. CGL2014 54118-C2-2-R and MAGIBER-II. CGL2017-90632-REDT). We are also very grateful to the laboratories of the universities of Burgos (Juanjo Villalaín) and Zaragoza (Teresa Román and Sylvia Gracia), Sergio Arruej Gil for the field support and Pablo Calvin and Vicky Burriel for the Burgos logistic support. Very warm acknowledged is given to Alejandro and Pablo from "Casa Molinero" in Las Bellostas for their hospitality, friendship and human warmth during all these years. Finally, we sincerely acknowledge the thorough and constructive reviews done by Miguel Garcés, Josep Tosquella and the editor Carles Martín-Closas.Despite the large number of magnetostratigraphic studies in the South Pyrenean Basin aiming to calibrate the basin chronostratigraphy and the biostratigraphic scales, the South Eastern Jaca Basin remains unexplored from this perspective, and its relation with the Ainsa Basin is not fully understood. In this work we contribute with new magnetostratigraphic data from the 950m thick Las Bellostas section, located in the northern hinge of the Balzes anticline. Well-proven primary signal (positive fold test and two pseudo-antiparallel polarities) supported by numerous primary data in the surroundings allow us building a reliable local polarity sequence of eight magnetozones (from R1 to N4). Additionally, seven new biostratigraphic samples (Nummulites and Assilina) in the lower part of the section (marine environment) allows tightening the section to the Geomagnetic Polarity Time Scale (GPTS) and proposing a refined age model for the southeastern Jaca Basin. The section starts in the Boltaña Fm., of Cuisian age (Shallow Benthic Zone, SBZ11), is followed by a sedimentary gap from C22n to C20n as witnessed by biostratigraphic data (SBZ11 underneath the hiatus and SBZ16 just atop). The deltaic Sobrarbe Fm can be tracked until the C19n (Late Lutetian). From this point (200m) until the top of the section (950m), at least, the entire C18n chron can be recognized within the molassic Campodarbe Fm (C18n.2n-C18n.1r and C18n.1n) (Bartonian) equivalent to the West to the prodeltaic Arguis marls Fm. The Middle Cusian (SBZ11) to Middle Lutetian (SBZ15) stratigraphic hiatus is, in part, enhanced by the structural position at the hinge of the Balzes anticline. These new chronostratigraphic constraints help refining the W-E and N-S stratigraphic relationships in the eastern Jaca Basin and in the Ainsa Basin. This section also allows us to accurately refine the kinematics of the rotational activity in the eastern External Sierras. The significant difference in magnetic declination along the section and neighboring paleomagnetic data from the Balzes anticline (from ≈70º clockwise at the base of the stratigraphic section to non-significant at the top) together with the new age model for the Eastern Jaca Basin help characterizing the rotational activity of the Balzes thrust sheet. The rotation took place between chrons C20r (Middle Lutetian; 45Ma) and C17 (Lower Priabonian 37-38Ma) in agreement to nearby structures (Boltaña, Pico del Aguila anticlines) but clearly diachronic to western ones (Santo Domingo anticline). Besides, the rotational activity seems to follow a linear and continuous pattern (velocity 9-11º/Ma, R: 0.83-0.96) in contrast to closer structures that show two distinct rotational velocities (i.e. Boltaña). These new data still let open the debate on the rotational kinematics along the South Pyrenean basal thrust

EL USO DE LAS TIC´S EN TRÁMITES DE ADJUDICACIÓN DE APOYO Y CONCILIACIÓN FRENTE AL COVID-19

Con el fin de indagar acerca de los mecanismos alternativos de solución de conflictos, en especial la conciliación, que son instrumentos diseñados para descongestionar el sistema judicial colombiano a través de la Ley 640 de 2001, se pretende desarrollar el mecanismo de la conciliación en específico y su actual importancia con la implementación de la Ley 1996 de 2019, la cual busca regular la capacidad de los colombianos que presentan alguna condición de discapacidad, eliminado el antiguo proceso de interdicción y reemplazándolo por los trámites de adjudicación de apoyos, los cuales pueden realizarse por los centros de conciliación. Se busca realizar el estudio de la respectiva aplicación de esta, teniendo en cuenta el obstáculo que generó la actual pandemia causada por COVID-19, por medio del método cualitativo descriptivo, con el fin de descubrir las problemáticas presentadas en el acceso a la justicia para la población que presenta alguna condición de discapacidad y brindar posibles soluciones desde el ámbito académico

Virtualización de materiales de aprendizaje sobre evaluación. Experiencia de conocimiento abierto a través de un MOOC

Memoria ID-203. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Mejora de la orientación profesional desde el proyecto profesional: vinculación del Grado de Pedagogía y el Máster de Profesorado mediante recursos b-learning

Memoria ID-062. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2018-2019

Low nadir CD4+ T-cell counts predict gut dysbiosis in HIV-1 infection

Human immunodeficiency virus (HIV)-1 infection causes severe gut and systemic immune damage, but its effects on the gut microbiome remain unclear. Previous shotgun metagenomic studies in HIV-negative subjects linked low-microbial gene counts (LGC) to gut dysbiosis in diseases featuring intestinal inflammation. Using a similar approach in 156 subjects with different HIV-1 phenotypes, we found a strong, independent, dose-effect association between nadir CD4+ T-cell counts and LGC. As in other diseases involving intestinal inflammation, the gut microbiomes of subjects with LGC were enriched in gram-negative Bacteroides, acetogenic bacteria and Proteobacteria, which are able to metabolize reactive oxygen and nitrogen species; and were depleted in oxygen-sensitive methanogenic archaea and sulfate-reducing bacteria. Interestingly, subjects with LGC also showed increased butyrate levels in direct fecal measurements, consistent with enrichment in Roseburia intestinalis despite reductions in other butyrate producers. The microbiomes of subjects with LGC were also enriched in bacterial virulence factors, as well as in genes associated with beta-lactam, lincosamide, tetracycline, and macrolide resistance. Thus, low nadir CD4+ T-cell counts, rather than HIV-1 serostatus per se, predict the presence of gut dysbiosis in HIV-1 infected subjects. Such dysbiosis does not display obvious HIV-specific features; instead, it shares many similarities with other diseases featuring gut inflammation

Cytokine and microbiota profiles in obesity-related hypertension patients

BackgroundSystemic arterial hypertension is linked to a heightened risk of cardiovascular diseases on a global scale. In Mexico, nearly half of adults in vulnerable conditions experience hypertension. Imbalance in the oral and intestinal microbiota composition has been observed in patients with hypertension, documented by a decrease of bacteria producing short-chain fatty acids, which play a critical role in blood pressure regulation.AimTo examine the cytokines’ profile and assess the characteristics of oral and gut microbiota in obesity-related hypertension in Mexican patients.MethodsA cross-sectional, observational, and analytical study was carried out. Twenty-two patients were categorized by their body mass index (BMI) as overweight and obese, and the diagnosis of primary hypertension. DNA from supragingival dental plaque and feces samples was used to carry out 16S rRNA sequencing. Additionally, 13 cytokines were quantified.ResultsIn the oral microbiota, Kluyvera was found to be significantly enriched in obese compared to overweight patients. Instead, the gut microbiota was dominated by Firmicutes. However, the correlation between certain genera and proinflammatory cytokines was noted.ConclusionThis exploratory study provides insights into the complex relationship between the oral and gut microbiota and their association with systemic inflammation in obesity-related hypertension

Caso piloto : prospectiva sector agroindustrial con énfasis en biotecnología prospectiva sectorial

El documento presenta los resultados del primer piloto de prospectiva sectorial en el marco del proyecto prospectiva sectorial enfocado en biotecnología aplicada a la agroindustria y su desarrollo en la región Pacifico, realizado por el Centro de Biotecnología Industrial CBI Palmira, con el apoyo de los Centros de las Regionales Valle, Cauca y Nariño, se describe la metodología empleada, las etapas de pre-prospectiva, prospectiva y post-prospectiva así como la identificación de escenarios y estrategias futuras a abordar por parte del SENAThe document presents the results of the first sectoral foresight pilot in the framework of the prospective sectoral project focused on biotechnology applied to agroindustry and its development in the Pacific region, carried out by the CBI Palmira Industrial Biotechnology Center, with the support of the The Regional Valleys, Cauca and Nariño, describes the methodology used, the pre-prospective, prospective and post-prospection stages, as well as the identification of future scenarios and strategies to be addressed by SENAfase I: pre–prospectiva -- fase II: prospectiva -- fase III: pos–prospectiva -- Conclusiones para la toma de decisiones estratégicasnaDocumento creado en colaboración del Sistema de Investigación, Desarrollo Tecnológico e Innovación (SENNOVA), Centro de Biotecnología Industrial (CBI), Centro Nacional de Asistencia Técnica a la Industria (ASTIN), Centro Internacional de Producción Limpia (LOPE) y el Instituto de Prospectiva de la Universidad del Valle87 página

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio