Personal Agenda-Public Agenda Congruency: A Contingent Condition for Agenda-setting Effects

This paper focuses on the concept of the impact area as the intersection between the common issues of the personal agenda and the public agenda. Expanding the concept of agenda-setting effects, which focuses mainly on the relation between the public and media agendas, we have examined the congruity of the public agenda and the personal agenda as a contingent condition for the strength of these effects. The concept also distinguishes between the top-priority issues of the public and personal agendas, setting out that the general public’s search for information about these top-priority issues highlights the need for orientation. We used data from Spain to focus on the national elections (2011, 2015 and 2019), plus the beginning of the pandemic (2020). The study includes a content analysis of the El País daily newspaper for the four periods and a variety of surveys and representative electoral barometers. To those data we have added an analysis of the main search topics on Google Trends for each of the four years. The results reveal that variations in the relationship between the public and personal agendas are linked to the strength of the agenda-setting effect between the media and public agendas

The Palaeocene Cerro Munro tonalite intrusion (Chubut Province, Argentina): A plutonic remnant of explosive volcanism?

The Cerro Munro sub-volcanic intrusion is emplaced in the back-arc (400 km from the trench) as small sub-circular tonalite-granodiorite plutons with abundant radial porphyritic dikes. U-Pb zircon SHRIMP data give an age of crystallization of 57 Ma ± 1.4 Ma. It is located to the east of the North Patagonian Batholith (NPB) that shows a protracted and episodic magmatic history from Cretaceous to Miocene time. The NPB Palaeogene episode is characterized by the lack of magmatic activity at the arc axis, as small plutonic emplacements move to the fore-arc and back-arc. This Palaeogene tectono-magmatic episode is ruled by the detachment of the Aluk plate during the Aluk-Farallon-SAM triple junction, active at that time along northern Patagonia active margin, changing the Cretaceous ?NPB orogenic? setting to a Palaeogene ?Munro transitional? tectono-magmatic setting. Near the contacts, the tonalite contains abundant enclaves of igneous appearance and variable size from several cm to dm, described as autoliths. The study of autoliths and host tonalite reveals interesting results on the processes of fractionation in a thermally zoned magma chamber. Autoliths, and in a large extent the host tonalite, represent disguised cumulates from which a hydrous silicic liquid was extracted. Barometry calculations from mineral chemistry in both autoliths and tonalites record a shallow pressure of emplacement of 0.5 kbar. Rhyolite-dacite flows and ignimbrites, surrounding the northern contact of the Cerro Munro tonalite, may represent the exsolved liquid from the plutonic cumulates. The study by cathodoluminiscence and electron backscattered diffraction techniques from a rhyolite-hosted quartz supports this protracted history of the Cerro Munro magma chamber.Facultad de Ciencias Naturales y MuseoCentro de Investigaciones GeológicasConsejo Nacional de Investigaciones Científicas y Técnica

The Palaeocene Cerro Munro tonalite intrusion (Chubut Province, Argentina): A plutonic remnant of explosive volcanism?

The Cerro Munro sub-volcanic intrusion is emplaced in the back-arc (400 km from the trench) as small sub-circular tonalite-granodiorite plutons with abundant radial porphyritic dikes. U-Pb zircon SHRIMP data give an age of crystallization of 57 Ma ± 1.4 Ma. It is located to the east of the North Patagonian Batholith (NPB) that shows a protracted and episodic magmatic history from Cretaceous to Miocene time. The NPB Palaeogene episode is characterized by the lack of magmatic activity at the arc axis, as small plutonic emplacements move to the fore-arc and back-arc. This Palaeogene tectono-magmatic episode is ruled by the detachment of the Aluk plate during the Aluk-Farallon-SAM triple junction, active at that time along northern Patagonia active margin, changing the Cretaceous ?NPB orogenic? setting to a Palaeogene ?Munro transitional? tectono-magmatic setting. Near the contacts, the tonalite contains abundant enclaves of igneous appearance and variable size from several cm to dm, described as autoliths. The study of autoliths and host tonalite reveals interesting results on the processes of fractionation in a thermally zoned magma chamber. Autoliths, and in a large extent the host tonalite, represent disguised cumulates from which a hydrous silicic liquid was extracted. Barometry calculations from mineral chemistry in both autoliths and tonalites record a shallow pressure of emplacement of 0.5 kbar. Rhyolite-dacite flows and ignimbrites, surrounding the northern contact of the Cerro Munro tonalite, may represent the exsolved liquid from the plutonic cumulates. The study by cathodoluminiscence and electron backscattered diffraction techniques from a rhyolite-hosted quartz supports this protracted history of the Cerro Munro magma chamber.Facultad de Ciencias Naturales y MuseoCentro de Investigaciones GeológicasConsejo Nacional de Investigaciones Científicas y Técnica

The Spanish Institute of Oceanography Observing System around N and NW Iberia

In the late 80's, the Spanish Institute of Oceanography (IEO) began some ambitious programs of monitoring around the Iberian Peninsula. The coastal observing system core structure was the Radiales program, a series of transects nearby most coastal IEO laboratories where a minimum set of hydrographical, chemical and biological parameters is sampled monthly. The sections are designed to be completed in one-day journeys so the system is supported by quite small vessels, mainly covering the continental shelf with the noteworthy exception of the Santander Section, where the proximity of the shelf-break allows sampling deep waters monthly. During the last 20 years the program has supported many specific scientific research projects and has created a detailed description of seasonal to interannual variability in the coastal ecosystem that serves as a baseline to explore long-term changes or trends...Versión de auto

A genome-wide association study follow-up suggests a possible role for PPARG in systemic sclerosis susceptibility

Introduction: A recent genome-wide association study (GWAS) comprising a French cohort of systemic sclerosis (SSc) reported several non-HLA single-nucleotide polymorphisms (SNPs) showing a nominal association in the discovery phase. We aimed to identify previously overlooked susceptibility variants by using a follow-up strategy.<p></p> Methods: Sixty-six non-HLA SNPs showing a P value <10-4 in the discovery phase of the French SSc GWAS were analyzed in the first step of this study, performing a meta-analysis that combined data from the two published SSc GWASs. A total of 2,921 SSc patients and 6,963 healthy controls were included in this first phase. Two SNPs, PPARG rs310746 and CHRNA9 rs6832151, were selected for genotyping in the replication cohort (1,068 SSc patients and 6,762 healthy controls) based on the results of the first step. Genotyping was performed by using TaqMan SNP genotyping assays. Results: We observed nominal associations for both PPARG rs310746 (PMH = 1.90 × 10-6, OR, 1.28) and CHRNA9 rs6832151 (PMH = 4.30 × 10-6, OR, 1.17) genetic variants with SSc in the first step of our study. In the replication phase, we observed a trend of association for PPARG rs310746 (P value = 0.066; OR, 1.17). The combined overall Mantel-Haenszel meta-analysis of all the cohorts included in the present study revealed that PPARG rs310746 remained associated with SSc with a nominal non-genome-wide significant P value (PMH = 5.00 × 10-7; OR, 1.25). No evidence of association was observed for CHRNA9 rs6832151 either in the replication phase or in the overall pooled analysis.<p></p> Conclusion: Our results suggest a role of PPARG gene in the development of SSc

The syndrome of central hypothyroidism and macroorchidism: IGSF1 controls TRHR and FSHB expression by differential modulation of pituitary TGFβ and Activin pathways

IGSF1 (Immunoglobulin Superfamily 1) gene defects cause central hypothyroidism and macroorchidism. However, the pathogenic mechanisms of the disease remain unclear. Based on a patient with a full deletion of IGSF1 clinically followed from neonate to adulthood, we investigated a common pituitary origin for hypothyroidism and macroorchidism, and the role of IGSF1 as regulator of pituitary hormone secretion. The patient showed congenital central hypothyroidism with reduced TSH biopotency, over-secretion of FSH at neonatal minipuberty and macroorchidism from 3 years of age. His markedly elevated inhibin B was unable to inhibit FSH secretion, indicating a status of pituitary inhibin B resistance. We show here that IGSF1 is expressed both in thyrotropes and gonadotropes of the pituitary and in Leydig and germ cells in the testes, but at very low levels in Sertoli cells. Furthermore, IGSF1 stimulates transcription of the thyrotropin-releasing hormone receptor (TRHR) by negative modulation of the TGFβ1-Smad signaling pathway, and enhances the synthesis and biopotency of TSH, the hormone secreted by thyrotropes. By contrast, IGSF1 strongly down-regulates the activin-Smad pathway, leading to reduced expression of FSHB, the hormone secreted by gonadotropes. In conclusion, two relevant molecular mechanisms linked to central hypothyroidism and macroorchidism in IGSF1 deficiency are identified, revealing IGSF1 as an important regulator of TGFβ/Activin pathways in the pituitary

MAPPING COMMUNITY INTEREST HABITATS IN THE COLUMBRETES ARCHIPELAGO, AN EXTRAORDINARY HOT SPOT OF BIODIVERSITY

The Columbretes Archipelago and their submerged surroundings are part of an unusual, Pleistocene volcanic field located in the Western Mediterranean designated as a Site of Community Importance (SCI) of the Natura 2000 Network. In the present study, 4 benthic habitats of community interest (1110, 1170, 1180 and 8330) have been identified by analyzing several sources of information. Generalized additive models (GAMs) have been used to model the potential distribution of reefs (1170) and maërl beds (1110). Our results highlight the diversity and extent of these habitats and allow comparisons to other marine SCIs of Spain. This can be attributed to the variability of the environment of this site. The Columbretes Islands combine a relatively shallow environment with volcanic structures, hydrothermalism with active degassing, current-driven sedimentary lobes and the influence of inland flows. Understanding high biodiversity spots is crucial as they offer natural laboratories to describe how ecosystems respond to the effects of global change. The knowledge obtained will be of paramount importance for the conservation of species and habitats. Furthermore, it will establish a baseline for future monitoring and assist in the development of effective management plans

Actualizando la base de datos de fallas activas en el Cuaternario de Iberia a la versión 4 (QAFI v.4): cambios en la forma y en el fondo

Reunión Ibérica sobre Fallas Activas y Paleosismología (3ª. 2018. Alicante). - Texto en español con resumen y palabras claves en inglés y españolSe presentan a la comunidad científica los principales cambios que conllevará la actualización a la versión 4 de la base de datos QAFI. El nombre de la base de datos se modifica pasando a ser “Quaternary-Active Faults…”. Se sustituye el término “segment” por “section”. Se omiten las estimaciones automáticas de magnitud máxima y recurrencia. Se amplía la extensión de la base de datos al margen norteafricano. Se creará una nueva base de datos con aquellas fallas cuya actividad en el cuaternario ha quedado descartada en base a evidencias geológicas publicadas. También se exponen diversas mejoras en relación con la visualización de las fallas en la aplicación web, y se solicita colaboración para mejorar la parte de asociaciones con la sismicidad. Finalmente, se prospectan futuras aplicaciones de la QAFI: la clasificación de falla activa del Eurocódigo-8 y una base de datos de fuentes sismogénicas tipo falla. = We present to the scientific community the main changes that would affect the QAFI database in the process of updating to version 4. The name of the database changes, being now: “Quaternary-Active Faults…”. The term fault “segment” is substituted by “section”. Version 4 will not include automatic estimations of maximum magnitude nor recurrence interval. The spatial coverage of the database is extended to the north of Africa. A new complementary database with faults with proof of no Quaternary activity will be created. We also describe foreseen improvements in the visualization of the fault traces in the web application, and we ask for collaboration to improve the fault relationships with seismicity. Finally, we prospect about future uses of the QAFI database: active fault definition in Eurocode-8 and a seismogenic fault-sources database.Instituto Geológico y Minero de España, EspañaDepartamento de Geología y Geoquímica, Universidad Autónoma de Madrid, EspañaDepartamento de Geodinámica, Universidad Complutense de Madrid, EspañaGrupo RISKNAT, Departament de Dinàmica de la Terra i de l’Oceà, Universitat de Barcelona, EspañaGeosciences Research Division, Scripps Institution of Oceanography, University of California, Estados UnidosInstituto de Ciencias del Mar, EspañaDepartamento de Ciencias de la Tierra, Universidad de Zaragoza, EspañaDepartamento de Biología y Geología, Física y Química Inorgánica, Universidad Rey Juan Carlos, EspañaDepartamento de Ciencias de la Tierra y el Medio Ambiente, Universidad de Alicante, EspañaDepartamento de Geodinámica, Universidad de Granada, EspañaGNS Science, Nueva ZelandaDepartamento de Geologia, Universidade de Lisboa, PortugalUnidade de Geologia, Hidrogeologia e Geologia Costeira, Laboratório Nacional de Energia e Geologia, Portuga

Association of a non-synonymous functional variant of the ITGAM gene with systemic sclerosis.

Systemic sclerosis (SSc) is a chronic fibrotic autoimmune disease of complex aetiology which shares genetic similarities with systemic lupus erythematosus (SLE).1 2 One of the novel risk loci that have been recently associated with SLE is the integrin α M (ITGAM) gene, which encodes the α subunit of the αMβ2-integrin.3 4 The most likely causal polymorphism that best explains this association is a non-synonymous single-nucleotide polymorphism (SNP) at the exon 3, rs1143679, which changes the 77th amino acid residue arginine to histidine (R77H). This functional SNP represents one of the highest associated signals with SLE and is predicted to alter the structure and function of the integrin.4 5 To determine whether ITGAM rs1143679 is also associated with SSc susceptibility and clinical manifestations, we genotyped a total of 3735 SSc patients and 3930 matched healthy individuals from seven independent European cohorts of Caucasian origin (Spain, Germany, The Netherlands, Italy, Norway, Sweden and UK) using a predesigned TaqMan® assay (ID: C___2847895_1_) in an ABI 7900HT (both from Applied Biosystems, Foster City, California, USA). Case …Peer Reviewe