Estrés percibido y habilidades sociales en docentes del nivel inicial del Callao – 2015

La presente investigación tuvo como objetivo general determinar la relación del estrés percibido y habilidades sociales en docentes del nivel inicial red 10 del Callao – 2015. Problema general ¿Cuál es la relación entre estrés percibido y habilidades sociales en docentes del nivel inicial de la Red Nº10 del Callao -2015? El método empleado en la investigación fue el hipotético-deductivo. Esta investigación utilizó para su propósito el diseño no experimental de nivel correlacional de corte transversal. La muestra es probabilística aleatoria simple que asciende a 100 docentes. Se aplicaron los instrumentos: cuestionario de Estrés percibido de Cohen, Kamarak y Mermelstein (1983). Adaptación: González y Landero (2004), dividido en las dimensiones internalidad, resilencia y ajuste psicológico. El cuestionario de Habilidades Sociales de Elena Gismero Gonzáles (201 0), consta de seis dimensiones. Al realizar el procesamiento estadístico, Se obtuvo un coeficiente de correlación negativa y muy baja de r= -,187 con una p=0.062 (p > .05), con el cual se acepta la hipótesis nula y se rechaza la hipótesis alterna. Por lo tanto, se puede afirmar que no existe una correlación directa y significativa entre estrés percibido y habilidades sociales; es decir que las variables varían sin ninguna relación sistemática entre sí

Nurses Alumni Association Bulletin, Fall 1987

Alumni Calendar Officers and Committee Chairmen The President\u27s Message Treasurer\u27s Report Nurses\u27 Relief Fund Scholarship Fund School Nurses- Ahead of Their Time Remember? Happy Ending Florence Nightingale End of an Era Little Jeff - As I Remember It Happy Retirement Peg Distinguished Career Ends Special Achievement Award Fiftieth Anniversary 1986 Alumni Directory Happy Birthday Resume of Minutes of Alumni Association Meetings Bequests Alumni Office News Committee Reports Bulletin Scholarship Satellite Social Finance Luncheon Pictures In Memoriam, Names of Deceased Graduates Class News Caps, Pins, Transcripts, Class Address Lists Change of Address Form Relief Fund Application Scholarship Fund Application Membership Applicatio

Does Seasonal Reproductive State Affect the Neuroendocrine Response of the Ewe to a Long-Day Pattern of Melatonin?

This study examined whether or not the reproductive response of female sheep to photoperiod varies with seasonal reproductive state. The specific objective was to test the hypothesis that the reproductive response to a long-day pattern of melatonin varies with the reproductive state of the ewe. The response examined was the synchronization of reproductive neuroendocrine induction (rise in serum luteinizing hormone, or LH) following nocturnal infusion of melatonin into pinealectomized ewes for 35 consecutive nights. This infusion restored a pattern of circulating melatonin similar to that in pineal-intact ewes maintained in a long photoperiod (LD 16:8). The ewes had been pinealectomized and without melatonin replacement for 16-25 months prior to the study. They were in differing reproductive states at the start of the infusion, as their endogenous reproductive rhythm had become desynchronized among individuals and with respect to time of year. Noninfused pinealectomized ewes served as controls. Regardless of the reproductive state at the start of the 35-day infusion of the long-day pattern of melatonin, all treated ewes exhibited the same reproductive neuroendocrine response after the infusion was ended. This consisted of a synchronized rise in LH some 6-8 weeks after the infusion was terminated, the maintenance of a high level of serum LH for some 15 weeks, and a subsequent precipitous fall in LH to a very low level. These results provide evidence that a long-day pattern of melatonin can synchronize reproductive neuroendocrine induction in the ewe, regardless of reproductive condition, and thus do not support the hypothesis that this response differs with seasonal reproductive state.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/66625/2/10.1177_074873049200700101.pd

Torus and AGN properties of nearby Seyfert galaxies: Results from fitting IR spectral energy distributions and spectroscopy

We used the CLUMPY torus models and a Bayesian approach to fit the infrared spectral energy distributions (SEDs) and ground-based high-angular resolution mid-infrared spectroscopy of 13 nearby Seyfert galaxies. This allowed us to put tight constraints on torus model parameters such as the viewing angle, the radial thickness of the torus Y, the angular size of the cloud distribution sigma_torus, and the average number of clouds along radial equatorial rays N_0. The viewing angle is not the only parameter controlling the classification of a galaxy into a type 1 or a type 2. In principle type 2s could be viewed at any viewing angle as long as there is one cloud along the line of sight. A more relevant quantity for clumpy media is the probability for an AGN photon to escape unabsorbed. In our sample, type 1s have relatively high escape probabilities, while in type 2s, as expected, tend to be low. Our fits also confirmed that the tori of Seyfert galaxies are compact with torus model radii in the range 1-6pc. The scaling of the models to the data also provided the AGN bolometric luminosities, which were found to be in good agreement with estimates from the literature. When we combined our sample of Seyfert galaxies with a sample of PG quasars from the literature to span a range of L_bol(AGN)~10^{43}-10^{47}erg/s, we found plausible evidence of the receding torus. That is, there is a tendency for the torus geometrical covering factor to be lower at high AGN luminosities than at low AGN luminosities. This is because at low AGN luminosities the tori appear to have wider angular sizes and more clouds along radial equatorial rays. We cannot, however rule out the possibility that this is due to contamination by extended dust structures not associated with the dusty torus at low AGN luminosities, since most of these in our sample are hosted in highly inclined galaxies. (Abridged)Comment: Accepted for publication in Ap

Torus and Active Galactic Nucleus Properties of Nearby Seyfert Galaxies: Results from Fitting Infrared Spectral Energy Distributions and Spectroscopy

We used the CLUMPY torus models and a Bayesian approach to fit the infrared spectral energy distributions and ground-based high angular resolution mid-infrared spectroscopy of 13 nearby Seyfert galaxies. This allowed us to put tight constraints on torus model parameters such as the viewing angle i, the radial thickness of the torus Y, the angular size of the cloud distribution σtorus, and the average number of clouds along radial equatorial rays N0. We found that the viewing angle i is not the only parameter controlling the classification of a galaxy into type 1 or type 2. In principle, type 2s could be viewed at any viewing angle i as long as there is one cloud along the line of sight. A more relevant quantity for clumpy media is the probability for an active galactic nucleus (AGN) photon to escape unabsorbed. In our sample, type 1s have relatively high escape probabilities, Pesc ~ 12%-44%, while type 2s, as expected, tend to have very low escape probabilities. Our fits also confirmed that the tori of Seyfert galaxies are compact with torus model radii in the range 1-6 pc. The scaling of the models to the data also provided the AGN bolometric luminosities Lbol(AGN), which were found to be in good agreement with estimates from the literature. When we combined our sample of Seyfert galaxies with a sample of PG quasars from the literature to span a range of Lbol(AGN) ~ 1043-1047 erg s-1, we found plausible evidence of the receding torus. That is, there is a tendency for the torus geometrical covering factor to be lower (f2 ~ 0.1-0.3) at high AGN luminosities than at low AGN luminosities (f2 ~ 0.9-1 at ~{}1043-1044 erg s-1). This is because at low AGN luminosities the tori appear to have wider angular sizes (larger σtorus) and more clouds along radial equatorial rays. We cannot, however, rule out the possibility that this is due to contamination by extended dust structures not associated with the dusty torus at low AGN luminosities, since most of these in our sample are hosted in highly inclined galaxies

Infrared Emission of Normal Galaxies from 2.5 to 12 Microns: ISO Spectra, Near-Infrared Continuum and Mid-Infrared Emission Features

We present ISO-PHOT spectra of the regions 2.5-4.9um and 5.8-11.6um for a sample of 45 disk galaxies from the U.S. ISO Key Project on Normal Galaxies. The spectra can be decomposed into three spectral components: (1) continuum emission from stellar photospheres, which dominates the near-infrared (2.5- 4.9um; NIR) spectral region; (2) a weak NIR excess continuum, which has a color temperature of ~ 1000K, carries a luminosity of a few percent of the total far-infrared luminosity L(FIR), and most likely arises from the ISM; and (3) the well-known broad emission features at 6.2, 7.7, 8.6 and 11.3 um, which are generally attributed to aromatic carbon particles. These aromatic features in emission (AFEs) dominate the mid-infrared (5.8-11.6 um; MIR) part of the spectrum, and resemble the so-called Type-A spectra observed in many non-stellar sources and the diffuse ISM in our own Galaxy. The relative strengths of the AFEs vary by 15-25% among the galaxies. However, little correlation is seen between these variations and either IRAS 60um-to-100um flux density ratio R(60/100) or the FIR-to-blue luminosity ratio L(FIR)/L(B), suggesting that the observed variations are not a direct consequence of the radiation field differences among the galaxies. We demonstrate that the NIR excess continuum and AFE emission are correlated, suggesting that they are produced by similar mechanisms and similar (or the same) material. On the other hand, as the current star-formation activity increases, the overall strengths of the AFEs and the NIR excess continuum drop significantly with respect to that of the far-infrared emission from large dust grains. This is likely a consequence of the preferential destruction in intense radiation fields of the small carriers responsible for the NIR/AFE emission.Comment: With 8 tables and 12 figures; to appear in the Astrophysical Journa

Development of the chronic obstructive pulmonary disease morning symptom diary (COPD-MSD).

BACKGROUND: The morning tends to be the most difficult time of day for many patients with chronic obstructive pulmonary disease (COPD) when symptoms can limit one's ability to perform even simple activities. Morning symptoms have been linked to higher levels of work absenteeism, thereby increasing the already substantial economic burden associated with COPD. A validated patient-reported outcome (PRO) instrument designed to capture morning symptoms will allow for a more comprehensive approach to the evaluation of treatment benefit in COPD clinical trials. METHODS: A qualitative interview study was conducted among a sample of symptomatic adults with COPD. Concept elicitation interviews (n = 35) were conducted to identify COPD morning symptoms, followed by cognitive interviews (n = 21) to ensure patient comprehension of the items, instructions and response options of the draft COPD Morning Symptom Diary (COPD-MSD). All interview transcript data were coded using ATLAS.ti software for content analysis. RESULTS: Mean age of the concept elicitation and cognitive interview sample was 65.0 years (±7.5) and 62.3 years (±8.3), respectively. The study sample represented the full range of COPD severity (Global Initiative for Chronic Lung Disease [GOLD] classifications I-IV) and included a mix of racial backgrounds, employment status and educational achievement. During the concept elicitation interviews, the three most frequently reported morning symptoms were shortness of breath (n = 35/35; 100 %), phlegm/mucus (n = 31/35; 88.6 %), and cough (n = 30/35; 85.7 %). A group of clinical and instrument development experts convened to review the concept elicitation data and develop the initial 32-item draft COPD-MSD. Cognitive interviews indicated subjects found the draft COPD-MSD to be comprehensive, clear, and easy to understand. The COPD-MSD underwent minor editorial revisions and streamlining based on cognitive interviews and input from the experts to yield the final 19-item daily diary. CONCLUSIONS: This study supports the content validity of the new COPD-MSD and positions the diary for quantitative psychometric testing

Perspective:Dietary Biomarkers of Intake and Exposure - Exploration with Omics Approaches

While conventional nutrition research has yielded biomarkers such as doubly labeled water for energy metabolism and 24-h urinary nitrogen for protein intake, a critical need exists for additional, equally robust biomarkers that allow for objective assessment of specific food intake and dietary exposure. Recent advances in high-throughput MS combined with improved metabolomics techniques and bioinformatic tools provide new opportunities for dietary biomarker development. In September 2018, the NIH organized a 2-d workshop to engage nutrition and omics researchers and explore the potential of multiomics approaches in nutritional biomarker research. The current Perspective summarizes key gaps and challenges identified, as well as the recommendations from the workshop that could serve as a guide for scientists interested in dietary biomarkers research. Topics addressed included study designs for biomarker development, analytical and bioinformatic considerations, and integration of dietary biomarkers with other omics techniques. Several clear needs were identified, including larger controlled feeding studies, testing a variety of foods and dietary patterns across diverse populations, improved reporting standards to support study replication, more chemical standards covering a broader range of food constituents and human metabolites, standardized approaches for biomarker validation, comprehensive and accessible food composition databases, a common ontology for dietary biomarker literature, and methodologic work on statistical procedures for intake biomarker discovery. Multidisciplinary research teams with appropriate expertise are critical to moving forward the field of dietary biomarkers and producing robust, reproducible biomarkers that can be used in public health and clinical research

Role of Abl Kinase and the Wave2 Signaling Complex in HIV-1 Entry at a Post-Hemifusion Step

Entry of human immunodeficiency virus type 1 (HIV-1) commences with binding of the envelope glycoprotein (Env) to the receptor CD4, and one of two coreceptors, CXCR4 or CCR5. Env-mediated signaling through coreceptor results in Gαq-mediated Rac activation and actin cytoskeleton rearrangements necessary for fusion. Guanine nucleotide exchange factors (GEFs) activate Rac and regulate its downstream protein effectors. In this study we show that Env-induced Rac activation is mediated by the Rac GEF Tiam-1, which associates with the adaptor protein IRSp53 to link Rac to the Wave2 complex. Rac and the tyrosine kinase Abl then activate the Wave2 complex and promote Arp2/3-dependent actin polymerization. Env-mediated cell-cell fusion, virus-cell fusion and HIV-1 infection are dependent on Tiam-1, Abl, IRSp53, Wave2, and Arp3 as shown by attenuation of fusion and infection in cells expressing siRNA targeted to these signaling components. HIV-1 Env-dependent cell-cell fusion, virus-cell fusion and infection were also inhibited by Abl kinase inhibitors, imatinib, nilotinib, and dasatinib. Treatment of cells with Abl kinase inhibitors did not affect cell viability or surface expression of CD4 and CCR5. Similar results with inhibitors and siRNAs were obtained when Env-dependent cell-cell fusion, virus-cell fusion or infection was measured, and when cell lines or primary cells were the target. Using membrane curving agents and fluorescence microscopy, we showed that inhibition of Abl kinase activity arrests fusion at the hemifusion (lipid mixing) step, suggesting a role for Abl-mediated actin remodeling in pore formation and expansion. These results suggest a potential utility of Abl kinase inhibitors to treat HIV-1 infected patients

Constitutive Activation of PrfA Tilts the Balance of Listeria monocytogenes Fitness Towards Life within the Host versus Environmental Survival

PrfA is a key regulator of Listeria monocytogenes pathogenesis and induces the expression of multiple virulence factors within the infected host. PrfA is post-translationally regulated such that the protein becomes activated upon bacterial entry into the cell cytosol. The signal that triggers PrfA activation remains unknown, however mutations have been identified (prfA* mutations) that lock the protein into a high activity state. In this report we examine the consequences of constitutive PrfA activation on L. monocytogenes fitness both in vitro and in vivo. Whereas prfA* mutants were hyper-virulent during animal infection, the mutants were compromised for fitness in broth culture and under conditions of stress. Broth culture prfA*-associated fitness defects were alleviated when glycerol was provided as the principal carbon source; under these conditions prfA* mutants exhibited a competitive advantage over wild type strains. Glycerol and other three carbon sugars have been reported to serve as primary carbon sources for L. monocytogenes during cytosolic growth, thus prfA* mutants are metabolically-primed for replication within eukaryotic cells. These results indicate the critical need for environment-appropriate regulation of PrfA activity to enable L. monocytogenes to optimize bacterial fitness inside and outside of host cells