Compressed Sensing for Monitoring of an Application

Generally, the present disclosure is directed to monitoring behavior of an application or other computing system or computing task. In particular, in some implementations, the systems and methods of the present disclosure can include or otherwise leverage one or more machine-learned models to predict behavior of an application or other computing system or computing task based on monitoring data

Do sample preparation techniques affect the relative abundance of Florisphaera profunda?

none6siWe investigated which method among smearing, settling, filtration, and random settling is the most accurate for determining the relative abundance of Florisphaera profunda. This species is included in paleoproductivity indices because it is one of the most important deep-water dwellers. Therefore, an accurate assessment of its relative abundance is key to monitoring variations in thermocline and nutricline depths. The low birefringence and flat polygonal shape of F. profunda may lead to inaccurate estimates of its relative abundance as it is poorly visible under light microscopy (LM), and different sample preparation may affect the number of specimens on each slide. We studied eight samples from the Ocean Drilling Program (ODP) Site 1209B (Shatsky Rise, NW Pacific) from the last 450 kyr. Each sample was prepared five times using each technique for a total of 160 slides. Through a rigorous analytical and statistical approach, we demonstrated the high reproducibility of each method and showed good agreement among techniques at low percentages of F. profunda. When the percentage of this species increases, the random settling technique differs from the others. Filtration and random settling preparation techniques were calibrated by spiking samples with microbeads. The ratio of microbeads observed in slides prepared using these two methods reflects bias due to loss of particles in the filtration technique. In addition, a hydrodynamic model for a fluttering and tumbling plate – such as F. profunda nannoliths – is proposed here along with calculated sinking velocities. These findings confirmed the efficiency of the long decantation time proposed for the random settling technique. The analysis of replicates, the validation with microbeads and the estimation of settling velocity of nannofossils in the tube convinced us that the higher relative abundance recorded by the random technique is not due to an imprecision of this method but, on the contrary, reflects the fact that it is more effective.openLupi, Claudia; Bordiga, Manuela; Sacchi, Roberto; Galinetto, Pietro; Beaufort, Luc; Cobianchi, MiriamLupi, Claudia; Bordiga, Manuela; Sacchi, Roberto; Galinetto, Pietro; Beaufort, Luc; Cobianchi, Miria

A role for autophagy in β-cell life and death.

Autophagy is a vacuolar, self-digesting mechanism responsible for the removal of organelles and defined regions of the cytoplams. This process has, in general, a beneficial role for the cell, since it regulates the turnover of aged proteins and eliminates damaged structures. However, cells that undergo altered autophagy may be triggered to die in a non-apoptotic manner. As a matter of fact, in recent years it has become clear that dysregulated autophagy may be implicated in several disorders, such as cancer, neurodegenerative diseases and hepatic encephalopathy. We have recently shown that β-cells of type 2 diabetic subjects show signs of autophagy associated death, which may contribute to the overall loss of β-cell mass in type 2 diabetes. In addition, studies with cell lines and rodent models have demonstrated the importance of autophagy in β-cell function and survival. Altogether, the available evidence supports the view that autophagy is implicated in β-cell pathophysiology, and suggests that addressing the molecular mechanisms involved in autophagic regulation might provide clues for preventing or treating β-cell damage in diabetes

An Automatic System for Modeling and Controlling Color Quality of Dyed Leathers in Tanneries

Abstract This paper presents an automatic system for modeling and controlling color quality of dyed leathers of an Italian tannery. The proposed software is implemented within the IT company system, and is fully integrated with the machineries of the finishing line, that is, a spraying cabin with a robotic carousel, and an electronic tintometer system. Suitable experimental tests according to the Design of Experiments (DoE) are firstly defined, executed and analyzed for a series of color tones of interest. In order to derive and validate a set of colorimetric models able to evaluate and predict the color rendering of painted leathers, a set of recipes of basic dye pigments and data of light reflection measured by a multispectral camera are used. Principal Component Analysis is applied for dimensionality reduction, and linear least squares regression is employed to identify these data-driven models, which are then used for color control purpose. A color correction feedback strategy is indeed developed in order to converge towards the various target formulations. The control algorithm aims at reaching the multispectral reading values of the reference, that is, the first sample of unknown color recipe starting from the most similar archive base and appropriately updating the recipe of pigments, by using the measurement of leather samples prepared from time to time by the finishing line machineries. A set of company data are used to successfully validate the identified colorimetric models and the proposed color correction strategy

Economic incentives and energy production from forest biomass in Argentina

Argentina faces a double challenge: on the one side, to support and strengthen the economic development process with the enlargement and enhancement of the energy matrix; and on the other side, the country adhered to the global trend of stimulating the development of renewable energies. It is there where the potential of non-conventional renewable energy (NCRE) especially stands out, and dendroenergy in particular. In order to stimulate bioenergy production from ad hoc forest plantations as well as by using forest by-products, it is essential to have a distributed generation regulatory and operational framework, or otherwise to work on a logistic profile that matches supply and demand (industrial and household) for energy, also considering power generation as well as preferrably cogeneration schemes. From a regulatory point of view, Argentina is already on its way towards such a system. The second item implies deeper planning policies, in a longer term. Even though a dynamic NCRE development has been seen for the past few years, dendroenergy projects in particular are below the identified potential. Drawing mainly on the INTA-FAO-Probiomasa consultancy (FAO, 2020a) precedent, this work discusses the identified areas with the greatest dendroenergy potential, the current institutional and regulatory incentives, and the necessary economic requirements for dendroenergy capacity growth.La Argentina enfrenta un doble desafío: por un lado debe acompañar y fortalecer el proceso de desarrollo económico con el crecimiento de la demanda y la complejización de la matriz energética; y por otro, el país adhirió a la tendencia mundial y se comprometió a favorecer el desarrollo de las energías renovables. Allí, se destaca especialmente el potencial de las no convencionales (ERNC) y, en particular, la dendroenergía. Para estimular la producción de bioenergía, tanto a partir de implantaciones boscosas ad hoc como mediante la utilización de residuos o subproductos forestales, resulta esencial contar con un régimen normativo y operativo de generación distribuida, o bien un perfil logístico que calce oferta con demanda, tanto industrial como domiciliaria, y tanto en generación eléctrica como preferentemente en esquemas de cogeneración. Desde el punto de vista normativo, la Argentina ya está transitando hacia un sistema acorde. El segundo elemento se inscribe en políticas de planificación más profundas, con un horizonte más largo. Si bien el desarrollo de ERNC en los últimos años se muestra dinámico, los proyectos de desarrollo dendroenergético en particular están por debajo del potencial identificado. Partiendo del antecedente de la consultoría INTA-FAO-Probiomasa, el presente trabajo expone las zonas con mayor potencial dendroenergético, los incentivos vigentes, y qué condiciones económicas son necesarias para lograr un crecimiento en la capacidad dendroenergética.Centro de investigación en Economía y ProspectivaFil: Olemberg, Demián Jeremías. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigación en Economía y Prospectiva (CIEP); ArgentinaFil: Egolf, Patricia. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigación en Economía y Prospectiva (CIEP); ArgentinaFil: Zaderenko, Constantino. Universidad Nacional de Misiones. Facultad de Ciencias Forestales; ArgentinaFil: Lupi, Ana Maria. Instituto Nacional de Tecnología Agropecuaria (INTA). Instituto de Suelos; ArgentinaFil: Fernandez, Roberto. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Montecarlo; ArgentinaFil: Casellas, Karina Susana. Instituto Nacional de Tecnología Agropecuaria (INTA). Centro de Investigación en Economía y Prospectiva (CIEP); Argentin

Constraints on the [C II] luminosity of a proto-globular cluster at z ∼ 6 obtained with ALMA

We report on ALMA observations of D1, a system at z 3c 6.15 with stellar mass M 17 3c 107M containing globular cluster (GC) precursors, strongly magnified by the galaxy cluster MACS J0416.1-2403. Since the discovery of GC progenitors at high redshift, ours is the first attempt to probe directly the physical properties of their neutral gas through infrared observations. A careful analysis of our dataset, performed with a suitable procedure designed to identify faint narrow lines and which can test various possible values for the unknown linewidth value, allowed us to identify a 4\u3c3 tentative detection of [CII] emission with intrinsic luminosity L[CII] = (2.9 \ub1 1.4) 106L, one of the lowest values ever detected at high redshift. This study offers a first insight on previously uncharted regions of the L[CII] 12 SF R relation. Despite large uncertainties affecting our measure of the star formation rate, if taken at face value our estimate lies more than 3c 1 dex below the values observed in local and high redshift systems. Our weak detection indicates a deficiency of [CII] emission, possibly ascribed to various explanations, such as a low-density gas and/or a strong radiation field caused by intense stellar feedback, and a low metal content. From the non-detection in the continuum we derive constraints on the dust mass, with 3 12 \u3c3 upper limit values as low as 3c a few 104 M, consistent with the values measured in local metal-poor galaxies

The diabetes-linked transcription factor Pax4 is expressed in human pancreatic islets and is activated by mitogens and GLP-1

We previously demonstrated that the transcription factor Pax4 is important for β-cell replication and survival in rat islets. Herein, we investigate Pax4 expression in islets of non-diabetic and diabetic donors, its regulation by mitogens, glucose and the incretin GLP-1 and evaluate its effect on human islet proliferation. Pax4 expression was increased in islets derived from Type 2 diabetic donors correlating with hyperglycaemia. In vitro studies on non diabetic islets demonstrated that glucose, betacellulin, activin A, GLP-1 and insulin increased Pax4 mRNA levels. Glucose-induced Pax4 expression was abolished by the inhibitors LY294002, PD98050 or H89. Surprisingly, increases in Pax4 expression did not prompt a surge in human islet cell replication. Furthermore, expression of the proliferation marker gene Id2 remained unaltered. Adenoviral-mediated expression of human Pax4 resulted in a small increase in Bcl-xL expression while Id2 transcript levels and cell replication were unchanged in human islets. In contrast, overexpression of mouse Pax4 induced human islet cell proliferation. Treatment of islets with 5-Aza-2′-deoxycytidine induced Pax4 without stimulating Bcl-xL and Id2 expression. Human Pax4 DNA binding activity was found to be lower than that of the mouse homologue. Thus, human pax4 gene expression is epigenetically regulated and induced by physiological stimuli through the concerted action of multiple signalling pathways. However, it is unable to initiate the transcriptional replication program likely due to post-translational modifications of the protein. The latter highlights fundamental differences between human and rodent islet physiology and emphasizes the importance of validating results obtained with animal models in human tissue

Glucagon-Like Peptide-1 Agonists Protect Pancreatic β-Cells From Lipotoxic Endoplasmic Reticulum Stress Through Upregulation of BiP and JunB

Chronic exposure of pancreatic beta-cells to saturated free fatty acids (FFAs) causes endoplasmic reticulum (ER) stress and apoptosis and may contribute to beta-cell loss in type 2 diabetes. Here, we evaluated the molecular mechanisms involved in the protection of beta-cells from lipotoxic ER stress by glucagon-like peptide (GLP)-1 agonists utilized in the treatment of type 2 diabetes.info:eu-repo/semantics/publishe

Analysis of multi-year near-surface ozone observations at the WMO/GAW "Concordia" station (75°06′S, 123°20′E, 3280 m a.s.l. – Antarctica)

Abstract This work focuses on the near-surface O3 variability over the eastern Antarctic Plateau. In particular, eight years (2006–2013) of continuous observations at the WMO/GAW contributing station "Concordia" (Dome C–DMC: 75°06′S, 123°20′E, 3280 m) are presented, in the framework of the Italian Antarctic Research Programme (PNRA). First, the characterization of seasonal and diurnal O3 variability at DMC is provided. Then, for the period of highest data coverage (2008–2013), we investigated the role of specific atmospheric processes in affecting near-surface summer O3 variability, when O3 enhancement events (OEEs) are systematically observed at DMC (average monthly frequency peaking up to 60% in December). As deduced by a statistical selection methodology, these OEEs are affected by a significant interannual variability, both in their average O3 values and in their frequency. To explain part of this variability, we analyzed OEEs as a function of specific atmospheric variables and processes: (i) total column of O3 (TCO) and UV-A irradiance, (ii) long-range transport of air masses over the Antarctic Plateau (by Lagrangian back-trajectory analysis – LAGRANTO), (iii) occurrence of "deep" stratospheric intrusion events (by using the Lagrangian tool STLEFLUX). The overall near-surface O3 variability at DMC is controlled by a day-to-day pattern, which strongly points towards a dominating influence of processes occurring at "synoptic" scales rather than "local" processes. Even if previous studies suggested an inverse relationship between OEEs and TCO, we found a slight tendency for the annual frequency of OEEs to be higher when TCO values are higher over DMC. The annual occurrence of OEEs at DMC seems related to the total time spent by air masses over the Antarctic plateau before their arrival to DMC, suggesting the accumulation of photochemically-produced O3 during the transport, rather than a more efficient local production. Moreover, the identification of recent (i.e., 4-day old) stratospheric intrusion events by STEFLUX suggested only a minor influence (up to 3% of the period, in November) of "deep" events on the variability of near-surface summer O3 at DMC

Efectos de diferentes prácticas de preparación del terreno y fertilización sobre el crecimiento inicial del Pinus spp en el NE argentino

Se presentan los resultados de crecimiento obtenidos, a los seis meses de efectuada la plantación, cuyos objetivos son evaluar la respuesta de Pinus taeda L. y de Pinus elliottii E. frente a diversas prácticas de establecimiento en el noreste de la provincia de Corrientes, Argentina. Sobre un Kandiudalf se evaluó la respuesta del Pinus taeda a la aplicación de 0, 22.5 y 45 g de N pl-1; 0, 45 y 90 g P2O5 pl-1 y 0, 36 y 72 g K2O pl-1 . Se observaron diferencias estadísticas entre las distintas dosis de N, de P y la interacción de NxK. La aplicación de fósforo se tradujo en un efecto positivo, mientras que la aplicación de nitrógeno muestra una tendencia inversa. También se evaluó la respuesta del Pinus taeda y Pinus elliottii, implantados en sitios con drenaje deficiente preparados mediante rastra y camellones, en los cuales fueron aplicados, además, 0, 100 y 200 g pl-1 de NPK 15-30-12. Los mayores crecimientos se presentaron cuando ambas especies fueron implantadas en camellones. Para el Pinus taeda se detectó una tendencia positiva ante la aplicación del fertilizante.Growth results of two experiments, obtained six months after plantation are presented. The objective was to evaluate the response of Pinus taeda L. and Pinus elliottii E. under different silvicultural treatments in Corrientes, northeastern Argentina. Response of Pinus taeda, applying 0, 22.5 and 45 g N pl-1; 0, 45 and 90 g P2O5 pl-1; also 0,36 and 72 g K2O pl-1, on Kandiudalf soil was evaluated. Statistical differences were observed between N, P and NxP interaction. P doses had a positive effect, while N doses presented a negative effect. Response of Pinus taeda and Pinus elliottii on deficient drainage sites prepared with disk ploughs or mounding with applications of NPK 15-30-12, at 0, 100 and 200 g pl-1 to both species was also evaluated. The best growth results were obtained when both species were planted on moundings. A positive trend was detected in Pinus taeda when fertilizer was applied.EEA MontecarloFil: Fernandez, Roberto Anibal. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Montecarlo; ArgentinaFil: Rodríguez Aspillaga, F. Productos Tissue S.A.; ArgentinaFil: Lupi, Ana María. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Montecarlo; ArgentinaFil: Hernández, A. Productos Tissue S.A.; ArgentinaFil: Reis, H. Instituto Nacional de Tecnología Agropecuaria (INTA). Estación Experimental Agropecuaria Montecarlo; Argentin