7 research outputs found
Phase III randomized trial of sunitinib versus capecitabine in patients with previously treated HER2-negative advanced breast cancer
- Author
- B Escudier
- Carlos H. Barrios
- DB Mendel
- DJ Slamon
- F Cardoso
- G Bianchi
- Hiroji Iwata
- HJ Burstein
- J Paulsson
- Jean-Marc Ferrero
- K Miller
- KD Miller
- Ke Zhang
- Kenjiro Aogi
- Kenneth A. Kern
- Laurence Vanlemmens
- MA Cobleigh
- Marla J. Brickman
- Mei-Ching Liu
- Miguel Martin
- Nadia Harbeck
- P Therasse
- Roberto Lugo-Quintana
- S Banerjee
- S George
- Soo Chin Lee
- T Jennison
- TJ Abrams
- Toshio Tabei
- Xavier Pivot
- Publication venue
- Springer US
- Publication date
- 01/01/2010
- Field of study
This multicenter, randomized, open-label phase III trial (planned enrollment: 700 patients) was conducted to test the hypothesis that single-agent sunitinib improves progression-free survival (PFS) compared with capecitabine as treatment for advanced breast cancer (ABC). Patients with HER2-negative ABC that recurred after anthracycline and taxane therapy were randomized (1:1) to sunitinib 37.5 mg/day or capecitabine 1,250 mg/m2 (1,000 mg/m2 in patients >65 years) BID on days 1–14 q3w. The independent data-monitoring committee (DMC) determined during the first interim analysis (238 patients randomized to sunitinib, 244 to capecitabine) that the trial be terminated due to futility in reaching the primary endpoint. No statistical evidence supported the hypothesis that sunitinib improved PFS compared with capecitabine (one-sided P = 0.999). The data indicated that PFS was shorter with sunitinib than capecitabine (median 2.8 vs. 4.2 months, respectively; HR, 1.47; 95% CI, 1.16–1.87; two-sided P = 0.002). Median overall survival (15.3 vs. 24.6 months; HR, 1.17; two-sided P = 0.350) and objective response rates (11 vs. 16%; odds ratio, 0.65; P = 0.109) were numerically inferior with sunitinib versus capecitabine. While no new or unexpected safety findings were reported, sunitinib treatment was associated with higher frequencies and greater severities of many common adverse events (AEs) compared with capecitabine, resulting in more temporary discontinuations due to AEs with sunitinib (66 vs. 51%). The relative dose intensity was lower with sunitinib than capecitabine (73 vs. 95%). Based on these efficacy and safety results, sunitinib should not be used as monotherapy for patients with ABC
Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries
- Author
- Abad-Motos Ane
- Abbas Ahmed M.
- Abbas Mostafa
- Abbasi Mujeeb
- Abbott Tom
- Abd Karim Muhammad Fairuz Shah
- Abdalaal Ibrahim
- Abdel-Galil Khalid
- Abdelemam Rania
- Abdelgawad Abdalrahman
- Abdelkarim Maryam
- Abdelkhalek Mohamed
- Abdelmageed Abdelfatah
- Abdelmawgoud Sherif
- Abdelmohsen Sarah
- Abdelrahman Ahmed Saber
- Abdelrahman Mostafa
- Abdelwahab Khaled
- Abdou Hossam
- Abdulai Darling Ramatu
- Abdulkhaleq Marwa
- Abdullah Bahiyah
- Abdulsalam Khalifa
- Abdulsalam Shuaib
- Abdur-Rahman Lukman
- Abdus-Salam Rukiyat
- Abdussalam Hameedat Opeyemi
- Abebrese John Tabiri
- Abeldaño Ariel
- Abou-Khalil Jad
- Abou-Taleb Hisham
- Abozid Anwaar
- Abozied Hesham
- Abrate Alberto
- Abu-Zaid Ahmed
- Abubakar Mohammed Kabir
- Abud Burçin
- Abuzaid Mohammed
- Adam Albushra Altayeb
- Adamina Michel
- Adamou Harissou
- Adamu Auwal
- Adamu Kabir Musa
- Adanu Kekeli
- Adebara Idowu
- Adebola Oluwaseyi
- Ademuyiwa Adesoji
- Adeniran Abiodun
- Adepiti Akinfolarin
- Aderogba Adeleke Akeem
- Adesunkanmi Abdulhafiz
- Adeyeye Ademola
- Adisa Adewale
- Adjeso Theophilus Justus Kofi
- Ads Adel Mohamed
- Ads Alaa Mohamed
- Adu-Aryee Nii Armah
- Adumah Collins
- Afzal Irrum
- Agapov Mikhail
- Agarwal Gaurav
- Agarwal Ravi
- Agbeko Anita Eseenam
- Agbeno Evans Kofi
- Agbonrofo Peter
- Agboola Oluseyi
- Aggarwal Gaurav
- Aghadi Ifeanyi
- Aghtarafi Natasha
- Agrawal Amit
- Agresta Ferdinando
- Aguado Héctor J.
- Aguilera-Arevalo Maria-Lorena
- Aherne Thomas
- Ahmad Aline
- Ahmad Maleeha
- Ahmad Misbahu
- Ahmad Sarwat
- Ahmad Shahzaib
- Ahmad Shoaib
- Ahmed Hayat Tarig Abdelhafiz
- Ahmed Khalid
- Ahmed Sharwany
- Ahmed Shima
- Ahmed Usama
- Aisuodionoe-Shadrach Oseremen
- Aitken Sarah
- Ajenifuja Kayode
- Ajiya Abdulrazak
- Akeel Nouf
- Akin Emrah
- Akinajo Opeyemi
- Akinyemi Tosin
- Akrida Ioanna
- Aktokmakyan Talar Vartanoglu
- Akwaisah Ayoub
- Al Bettar Osama
- Al-Badawi Ismail A.
- Al-Juaifari Maytham
- Al-Khyatt Waleed
- Al-Mallah Abdullah
- Al-Nusairi Ahmed
- Al-Saadi Nina
- Al-Sayaghi Khaled
- Al-Shaiji Tariq
- Al-Shehari Mohammed
- Al-Touny Aiman
- Al-Touny Shimaa A.
- Aladawi Omar
- Aladna Abdallah
- Alali Mahmoud
- Alam Mahmood
- Alam Mohammed Shadrul
- Alarabi Rehab
- Alawneh Yazan
- Alayande Barnabas
- Albanese Erminia
- Albayadi Eslam
- Albdour Maram
- Alconchel Felipe
- Alderazi Amer
- Alegbeleye Bamidele
- Alekberli Tural
- Alemu Misganaw Alemu Adimass
- Alexander Philip
- Alfieri Alex
- Algahtany Khaled
- Algarni Kamal
- Alhamad Ameen
- Alhamid Mohammad
- Alharmi Rawan A. Rahman
- Alharthi Mohammed
- Alhazmi Barrag
- Ali Mohamed Shafi Mahboob
- Ali Stephen
- Alibrahim Hidar
- Aljaaly Hattan
- Aljaiuossi Anas
- Aljanadi Firas
- Aljiffry Murad
- Aljirdabi Noof
- Alkahlan Mohammed
- Alkhalifa Elmustafa
- Alkhatib Sondos
- Alkhatieb Maram
- Allan Anna
- Almarshad Felwa
- Almgla Naser
- Almhimid Ali
- Almiqlash Bushray
- Almoshantaf Mohammad Badr
- Almutairi Abdulmjeed
- Alnsour Abed Alfattah Mahmoud
- Alobied Majd
- Alomar Osama
- Alonso Jesús Aarón Martínez
- Alonso Manuel Diez
- Alonso Nestor Fabian Pedraza
- Alonso Veronica
- Alqallaf Abdullah
- Alqaseer Asma
- Alrayes Bourhan
- Alsefri Maryam
- Alser Osaid
- Alsharif Mohammed
- Alsori Mohamed
- Altaf Abdulmalik
- Altinel Yuksel
- Altiner Saygin
- Altouny Ahmad
- Altun Demet
- Alvarez Natalia
- Alvarez-Lozada Luis Adrian
- Alvi Abdul
- Alwael Athari
- Alwash Mohammed
- Alyami Ziyad
- Alyousef Mohammed
- Alzahrani Saud
- Alzerwi Nasser
- Amin Shivang
- Amir Mohammed
- Ammar Ahmed Siddique
- Ammendola Michele
- Amores Remedios Revilla
- Amrayev Sultan
- Anastasiadou Sofia
- Ancans Guntis
- Anderson Caroline
- Andreani Lorenzo
- Andreotti Dario
- Andreuccetti Jacopo
- Andrianakis Alexandros
- Andro Christophe
- Anesi Alexandre
- Angamuthu Stephen
- Angeles Martina Aida
- Angelico Roberta
- Angelis Fragkiskos
- Angelou Dimitrios
- Angelou Kyveli
- Angulo Victor Pinto
- Anjum Arfa
- Anjum Muhammad Ayyub
- Annicchiarico Alfredo
- Anoldo Pietro
- Ansaloni Luca
- Anthoulakis Christos
- Antonelli Amedeo
- Anwar Mohamed
- Anwar Sumadi Lukman
- Anwer Mariyah
- Anyanwu Lofty-John
- Apostolou Christos
- Apostolou Konstantinos
- Appiah-Kubi Adu
- Aprea Giovanni
- Arbab Hana
- Archer James
- Ardura Francisco
- Aremu Muyiwa
- Arif Tahera
- Arkani Samara
- Armatura Giulia
- Armijos Daniel
- Arnaout Ali
- Arnaoutoglou Eleni
- Arnaud Alexis P.
- Arneja Jugpal
- Arrangoiz Rodrigo
- Arshad Muhammad
- Arthur Joshua
- Ashcroft James
- Ashford Bruce
- Ashraf Fariha
- Asiimwe Daniel
- Asirifi Samuel Amoako
- Asla Amir
- Aslam Ramisha
- Aspide Raffaele
- Ataya Karim
- Ateca Ibabe Villalabeitia
- Atici Semra Demirli
- Atis Gokhan
- Atkins William
- Atkinson Kate
- Attwood Joseph
- Auerkari Aino
- Augestad Knut Magne
- Augustin Goran
- Aujayeb Avinash
- Avella Pasquale
- Awad Ahmed K.
- Awad Hadeel
- Awad Rabih
- Awad Selmy
- Ayad Kusay
- Ayana Birhanu
- Aydin Yener
- Ayeni Funbi
- Aytac Erman
- Azab Ahmed
- Azami Rizwan
- Azize Diallo Abdoul
- Azzam Ahmed Y.
- Azzis Olivier
- Baba Yabasin Iddrisu
- Babis George
- Bacalbasa Nicolae
- Badiani Sarit
- Badran Saif
- Baduell Albert
- Baeesa Saleh
- Baertschiger Reto
- Bafaquh Mohammed
- Bahassan Omar Mohammed
- Bahrami-Hessari Michael
- Baia Marco
- Baidoo Ebikela Ivie
- Bailey Karen
- Baili Efstratia
- Bains Lovenish
- Baiocchi Gian Luca
- Baiocchi Glauco
- Baiyewu Lateef Ayodele
- Bajaj Ankur
- Bajunaid Khalid
- Balagobi Balasingam
- Balasubramanian Ishwarya
- Balduzzi Alberto
- Baldwin Alexander
- Balla Andrea
- Balogh Zsolt J.
- Balogun James A.
- Balogun Simon
- Baloyiannis Ioannis
- Ban Vin Shen
- Bandyopadhyay Samik Kumar
- Bandyopadhyay Soham
- Banerjee Sumit
- Banipal Gurpreet Singh
- Banky Balazs
- Bannone Elisa
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- Barmayehvar Behrad
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- Barra Fabio
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- Barugola Giuliano
- Basendowah Mohammed
- Bashir Mahmod
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- Bass Gary Alan
- Basu Somprakas
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- Bayhan Hüseyin
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- Beamish Andrew
- Beasley Nigel
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- Becerra Angel
- Bedada Alemayehu Ginbo
- Bedzhanyan Arkady
- Begum Farzana
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- Bello Usman Mohammed
- Bellés Ana Ciscar
- Belzile Etienne
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- Bence Matthew
- Benshetrit Guy
- Bensoltane Khadidja
- Bergkvist David Julià
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- Bernante Paolo
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- Bin Alhassan Baba Alhaji
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- BİŞGİN TAYFUN
- Blair James
- Blanco Jose
- Blencowe Natalie
- Bloemers Frank
- Board Timothy
- Bobak Peter
- Boccalatte Luis
- Boedo Maria Jesus Maroño
- Bohmer Rob
- Boira Mar Achalandabaso
- Boisson Matthieu
- Boligo Sofia
- Bolton William
- Bombardini Cristina
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- Bonci Eduard-Alexandru
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- Bonilla Antonio Ramos
- Bonsaana Gilbert Batieka
- Booth L.
- Borg Elaine
- Borges Miguel Fróis
- Borges Nuno
- Bork Ulrich
- Borselle Dominika
- Bortul Marina
- Botelho Pedro
- Bottari Andrea
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- Bowan Antoinette Bediako
- Bowen Joel
- Bozbiyik Osman
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- Brachini Gioia
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- Branagan Graham
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- Bravo Ana Maria Minaya
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- Bright Tim
- Brisinda Giuseppe
- Brodkin Edgar
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- Bruzzaniti Placido
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- Bua Emmanuel
- Budd Gabrielle
- Bukhari Syed Imran
- Bulian Dirk Rolf
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- Bàmbina Fabrizio
- Börner Nikolaus
- Böttcher Arne
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- Calabretto Francesca
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- Christodoulou Prokopis
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- Chu Michael Jen Jie
- Chukwu Isaac
- Chwat Carina
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- Cobianchi Lorenzo
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- Cockbain Andrew J.
- Cohnert Tina
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- Colombari Renan Carlo
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- Croghan Stefanie M.
- Cross George W. V.
- Cruz Ricardo Pedrini
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- Cullinane Carolyn
- Cullis Paul
- Cunha Miguel F.
- Cunningham Brian
- Currò Giuseppe
- Cuthbert Rory
- Cutmore Carina
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- Cáceres Freud
- D'Acapito Fabrizio
- D'Addino José Luis
- D'Amico Alessia
- D'Amore Anna
- D'Andrea Giancarlo
- D'Archi Sabatino
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- Das Sunit
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- Davidescu Mihnea
- Davies Jessica
- Davies Mark
- Davies Richard Justin
- Davis Amelia
- Dawson Amanda Caroline
- Dawson Jonathon
- Dbouk Samer
- De Alarcón Jaime Rodríguez
- De Andrés-Asenjo Beatriz
- De Bacco Marangon Gustavo
- De Campos Prado Caio Antonio
- De Cillia Michael
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- De Haro Joaquin
- De Jesus Labrador Hernandez Gregorio
- De La Infiesta García Carlos
- De La Medina Antonio Ramos
- De La Rosa-Estadella Marta
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- De Oliveira Gabriel Paiva
- De Pastena Matteo
- De Simone Veronica
- De Sousa Álvaro Francisco Lopes
- De Vega Sánchez Blanca
- De Virgilio Armando
- De Zuanni Marco
- Dean Yomna
- Degarege Dawit
- Degener Stephan
- Dejeu George
- Del Amo María Dolores Arribas
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K
- Demetriou Charis
- Demir Sebahattin
- Dennis Rory
- Deputy Mohammed
- Derilo Habtamu
- Des Déserts Marc Danguy
- Desai Chaitya
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- Dessalegn Megbar
- Devarakonda Sreekar
- Dewan Michael
- Dewan Varun
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- Diehl Thomas
- Dif Elmes Saoussene
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- Dimitrokallis Nikolaos
- Dincer Müserref Beril
- Dindyal Shiva
- Djama Zakarya
- Djedovic Gabriel
- Doerner Johannes
- Doherty Daniel
- Dolci Giampiero
- Domanin Maurizio
- Domingo Marta María Arroyo
- Dominguez-Rosado Ismael
- Don Cristine Pathirannehalage
- Donkin Ian
- Donmez Emin Erhan
- Donoghue Sophie
- Donovan Richard
- Dornseifer Mamun David
- Dorovinis Panagiotis
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- Doyle Alex
- Doǧan Lütfi
- Dragisic Vedran
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- Efremov Sergey
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- Ekwen Gerald
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- El Assaad Hadi
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- El-Boghdadly Kariem
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- Elagili Ahmed
- Elahi Zain
- Elbadawy Merihan A.
- Elbahnasawy Mohamed
- Elbe Peter
- Elboraei Rahma
- Eldabaa Mohamed
- Elebute Olumide
- Elfeki Hossam
- Elfiky Mahmoud
- Elgazar Amr
- Elghadban Hosam
- Elhadi Muhammed
- Elhassan Wael Atif Fadl
- Elkazaz Ahmed
- Ellafi Amera Ali Dakheel
- Elliot R.
- Elnour Moheyaldien Ahmed Elamin
- Elsadek Menan
- Elsahli Saifaleslam
- Elsalhawy Shady
- Elsayem Karam
- Elshahawy Mahmoud Abdelaziz Mohamed
- Elsherbiny Ahmed
- Eltayeb Momin
- Elzwai Suha
- Emara Moataz Maher
- Embarek Hussein
- Emile Sameh
- Emmanuel Muhawenimana
- Enciu Octavian
- English Camilla
- Enodien Bassey
- Enwerem Kenneth
- Erel Serap
- Ergenç Merve
- Ergenç Muhammer
- Erginöz Ergin
- Eroglu Atilla
- Escobar Pedro
- Escobedo Francisco Jose Barbosa
- Escrevente Ricardo
- Eskinazi Diego
- Esposito Sofia
- Eugene Muneza
- Ezanno Anne-Cecile
- Ezeanochie Michael
- Ezeme Constantine
- Ezenwa Ekene
- Ezomike Uchechukwu
- Fadalla Tarig
- Fadel Zahir T
- Fahim Margo Medhat Fouad
- Fahmy Ali
- Faiz Javaria
- Fajardo Rafael Torres
- Fakhradiyev Ildar
- Fallah Jean-Michel
- Familiari Pietro
- Fang Clarissa Ern Hui
- Faponle Folayemi
- Farhan-Alanie Muhamed
- Farid Shahzaib
- Farooq Muhammad
- Fatima Mishal
- Fayad Elsayed A.
- Federer Simon
- Federico Nicoletta Sveva Pipitone
- Feeney Kaylem
- Fehervari Matyas
- Fekaj Enver
- Fernandez Laura Gomez
- Fernández Julio Domenech
- Ferracci Federica
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- Ferrari Davide
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- Ferrer Antonio Perez
- Ferrer Ursula María Jariod
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- Flores S.L.
- Florian Ioan-Alexandru
- Flumignan Carolina Dutra Queiroz
- Flumignan Ronald
- Flórez Luis Joaquín García
- Foessleitner Philipp
- Fontalis Andreas
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- Forneris Agustin Albani
- Fortuna Laura
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- Fujimoto Yuki
- Furey Joseph
- Fusario Daniele
- Fusini Federico
- Futaba Kaori
- Függer Reinhold
- Gabr Abdullah
- Gada Parth
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- Meead Adullah
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- Nasser Sara
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- Shoukrie Shoukrie I. M.
- Shrestha Rashmit
- Siboe Mark
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- Sodhai Vivek
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- Sokolov Manol
- Solaini Leonardo
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- Sole-Sedeno Josep M.
- Soljic Martina
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- Soon Wai Cheong
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- Spartalis Michael
- Spellar Kayleigh
- Spiers Harry V. M.
- Spina Alfio
- Spriano Giuseppe
- Squiers John
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- Stamatakis Emmanouil
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- Starr Nichole
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- Stevens Sean
- Stevenson Andrew
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- Stijns Jasper
- Stogowski Piotr Tomasz
- Stoleriu Mircea Gabriel
- Stoyanov Vladislav
- Street John
- Strotmann Johanna Josefine
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- Su Yu-Xiong
- Suarez Sara Busto
- Subramani Yamini
- Subramaniam Sentilnathan
- Sue-Chue-Lam Colin
- Suer Muhammed Salih
- Sulaiman Bilal
- Sultania Mahesh
- Sundarraju Shalini
- Sungurtekin Hulya
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- Tejero-Pintor Francisco J.
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- Tsolakidis Alexandros
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- Tucker Olga
- Tuech Jean Jacques
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- Ubom Akaninyene Eseme
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- Ulas Ali Bilal
- Uldry Emilie
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- Ulkucu Attila
- Ulman Elif Akbas
- Ulman Hilmican
- Ulutaş Mehmet Eşref
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- Unsworth Richard
- Uprak Tevfik Kivilcim
- Urriza Pablo Vallés
- Usman Muhammad
- Usman Mustapha Ibrahim
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- Vaccara Vincenzo La
- Vagena Xanthoula
- Vagge Aldo
- Vailas Michail
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- Valadez Tania Abigail Cueto
- Valanci Sofia
- Valdespino Cristina Puentes
- Valeanu Liana
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- Valladares Sergio Chávez
- Vallve-Bernal Marc
- Van Acker Jill
- Van Den Eynde Jef
- Van Goor Harry
- Van Vliet Helen
- Van Wyk Naomi Natasha
- Vanni Camilla
- Vas Aurelia
- Vasarhelyi Edward
- Vaschetti Roberto
- Vassiliu Panteleimon
- Vatansever Dogan
- Vatish Jamie
- Vaughan-Shaw Peter G.
- Vaysburg Dennis
- Veglia Antonella
- Velten Markus
- Velázquez Maria Jose Martinez
- Venkatappa Sunil Kumar
- Venketeswaran Meenakshi
- Venskutonis Donatas
- Verbic Milena Senica
- Verdi Daunia
- Vergara-Fernandez Omar
- Verhoeff Kevin
- Veroux Massimiliano
- Verras Georgios-Ioannis
- Verre Luigi
- Vida Lucian
- Vidya Raghavan
- Viglietta Edoardo
- Vijay Vardhini
- Vijgen Guy
- Vilaró Blanca Capdevila
- Villanueva Julio
- Vilz Tim O.
- Vincent Elizabeth
- Vinci Danilo
- Viola Simona
- Violante Tommaso
- Vishnoi Jeewan Ram
- Vissapragada Ravi
- Vivancos Laura Guillamon
- Vives Josep Maria Muñoz
- Vizzielli Giuseppe
- Vohra Lubna
- Vokshi Ismail
- Vosinakis Christos
- Vásquez Javier Alberto Gutiérrez
- Vázquez Gil
- Vázquez Irene Ortega
- Vǎcǎraşu Andrei Bogdan
- Wade Ryckie
- Wafi Omar
- Wagner Gabriela
- Wallis Christopher
- Wanjara Samuel
- Waqar Shahzad Hussain
- Warden Claire
- Warner Christian
- Wasim D.
- Wason Shaun
- Wasserman Isaac
- Watcyn-Jones Tom
- Waterson Ben
- Watson David
- Watson Matthew
- Weber Clemens
- Wheatstone P.
- Wheeler James
- Wheldon Luke
- White Michelle
- White Stuart
- White William
- Wickramasinghe Dakshitha
- Widmer Lukas Werner
- Wiedemann Dominik
- Wiesinger Clemens Georg
- Wijekoon Naveen
- Wijenayake Wasantha
- Wijeyaratne Manuk
- Wijeysundera Duminda
- Wiles Matthew
- Wilkin Richard
- Wilkins Alex
- Wilkins James
- William Tinka George
- Williams Omolara Modupe
- Williams Shekinah
- Windsor John
- Winnand Philipp
- Wittmann Maria
- Wolde Amanuel
- Wolfenden John W. D.
- Wong Benjamin Ngie Xiong
- Wong Enoch
- Wong Evan G.
- Wong George Kwok Chu
- Wong Ho Ying Flora
- Wong Kai Yuen
- Wormald Justin
- Wright Deborah
- Wright Joshua
- Wu Fiona
- Wurm Markus
- Xenaki Sofia
- Yadev Ip
- Yahaya Ahmad Shuib
- Yakubu Mustapha
- Yang Wah
- Yanik Özge
- Yanowsky-Reyes Guillermo
- Yassin Abubaker
- Yates Elizabeth
- Yebes Alvaro
- Yenli Edwin Mwintiereh Ta-Ang
- Yeoh Tien
- Yeung Justin
- Yiallourou Anneza
- Yigit Banu
- Yildirim Asif
- Yim Guang
- Yiu Andrew
- Yonekura Hiroshi
- Yotsov Tsanko
- Younis Muhammad Umar
- Yunus Alif
- Yusefi Hossein
- Zabaleta Jon
- Zabkiewicz Catheriner
- Zaccaria Giulia
- Zacharia Bincy
- Zafar Syed Nabeel
- Zago Mauro
- Zaheen Zakia
- Zahid Zahra
- Zaimis Tilemachos
- Zakaria Andee Dzulkarnaen
- Zambon Martina
- Zamora Lindsey
- Zampogna Biagio
- Zancana Giuseppa
- Zani Augusto
- Zanin Luca
- Zanini Nicola
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarif Pierre
- Zaránd Attila
- Zehnder Philipp
- Zenger Serkan
- Zenha Horácio
- Zhu Michael Z. L.
- Ziemann Sebastian
- Zimak Danijela Mrazovac
- Zimak Zoran
- Zivkovic Dragana
- Zizzo Maurizio
- Zucker Benjamin
- Zwain Yasir
- Zyskowski Michael
- Ávila Clara Castro
- Älgå Andreas
- Çakici Mehmet Çaǧlar
- Çelik Enes
- Çelik Meryem Nur
- Özçay Necdet
- Şevik Hüsnü
- Šantak Goran
- Šimko Kristián
- Žatecký Jan
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2023
- Field of study
Abstract
Background
Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres.
Methods
This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries.
Results
In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia.
Conclusion
This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
- Author
- Abe Toshikazu
- Aboshady Abdelrhman
- Abrough Fekri
- Acampo-de Jong Melanie
- Acharya Subhash
- Acharya Subhash P
- Adderley Jane
- Adiguzel Nalan
- Agrawal Vijay Kumar
- Aguilar Gerardo
- Aguirre Gaston
- Aguirre-Bermeo Hernan
- Ahlström Björn
- Akbas Türkay
- Akker Mustafa
- Al Sadeh Ghamdan
- Alamri Sultan
- Algaba Angela
- Ali Muneeb
- Aliberti Anna
- Allegue Jose Manuel
- Alvarez Diana
- Amador Joaquin
- Amin Pravin
- Andersen Finn H
- Ansari Sharique
- Apichatbutr Yutthana
- Apostolopoulou Olympia
- Arabi Yaseen
- Arabi Yaseen
- Aragao Irene
- Aragao Irene
- Arellano Daniel
- Arica Mestanza
- Arikan Huseyin
- Arinaga Koichi
- Arnal Jean-Michel
- Asano Kengo
- Asín-Corrochano Marta
- Avalos Cabrera Jesus Milagrito
- Avila Fuentes Silvia
- Aydemir Semih
- Aygencel Gulbin
- Azevedo Luciano
- Bacakoglu Feza
- Badie Julio
- Baedorf Kassis Elias
- Bai Gabriela
- Balaraj Govindan
- Ballico Bruno
- Banner-Goodspeed Valerie
- Banwarie Preveen
- Barbieri Rosella
- Baronia Arvind
- Barrett Jonathan
- Barrot Loïc
- Barrueco-Francioni Jesus Emilio
- Barry Jeffrey
- Bauer Philippe
- Bauer Philippe
- Bawangade Harshal
- Beavis Sarah
- Beck Eduardo
- Beduneau Gaëtan
- Beduneau Gaëtan
- Beehre Nina
- Beitler Jeremy
- Belenguer Muncharaz Alberto
- Bellani Giacomo
- Bellani Giacomo
- Belliato Mirko
- Bellissima Agrippino
- Beltramelli Rodrigo
- Ben Souissi Asma
- Benitez-Cano Adela
- Benlamin Mohamed
- Benslama Abdellatif
- Bento Luis
- Benvenuti Daniela
- Berkius Johan
- Berkius Johan
- Bernabe Laura
- Bersten Andrew
- Berta Giacomo
- Bertini Pietro
- Bertram-Ralph Elliot
- Besbes Mohamed
- Bettini Lisandro Roberto
- Beuret Pascal
- Bewley Jeremy
- Bezzi Marco
- Bhakhtiani Lakshay
- Bhandary Rakesh
- Bhowmick Kaushik
- Bihari Shailesh
- Bissett Bernie
- Blythe David
- Bocher Simon
- Boedjawan Narain
- Bojanowski Christine M
- Boni Elisa
- Boraso Sabrina
- Borelli Massimo
- Borello Silvina
- Borislavova Margarita
- Bosma Karen J
- Bottiroli Maurizio
- Boyd Owen
- Bozbay Suha
- Briva Arturo
- Brochard Laurent
- Brochard Laurent
- Bruel Cédric
- Bruni Andrea
- Buehner Ulrike
- Bugedo Guillermo
- Bugedo Guillermo
- Bulpa Pierre
- Burt Karen
- Buscot Mathieu
- Buttera Stefania
- Cabrera Jorge
- Caccese Roberta
- Caironi Pietro
- Camporota Luigi
- Canchos Gutierrez Ivan
- Canedo Nancy
- Cani Alma
- Cappellini Iacopo
- Carazo Jesus
- Cardonnet Luis Pablo
- Carpio David
- Carriedo Demetrio
- Carrillo Ramón
- Carvalho João
- Caser Eliana
- Castelli Antonio
- Castillo Quintero Manuel
- Castro Heloisa
- Catorze Nuno
- Cengiz Melike
- Cereijo Enrique
- Cerny Vladimir
- Ceunen Helga
- Chaintoutis Christos
- Chang Youjin
- Chaparro Gustavogcha
- Chapman Carmel
- Chau Simon
- Chavez Cecilia Eugenia
- Chelazzi Cosimo
- Chelly Jonathan
- Chemouni Frank
- Chen Kai
- Chena Ariel
- Chiarandini Paolo
- Chilton Phil
- Chiumello Davide
- Cho Young-Jae
- Cho Young-Jae
- Chou-Lie Yvette
- Chudeau Nicolas
- Cinel Ismail
- Cinnella Gilda
- Clark Michele
- Clark Thomas
- Clarkson Kevin
- Clarkson Kevin
- Clementi Stefano
- Coaguila Luis
- Codecido Alexis Jaspe
- Collins Amy
- Colombo Riccardo
- Conde Juan
- Consales Guglielmo
- Cook Tim
- Coppadoro Andrea
- Cornejo Rodrigo
- Cortegiani Andrea
- Coxo Cristina
- Cracchiolo Andrea Neville
- Crespo Ramirez Mónica
- Crova Philippe
- Cruz José
- Cubattoli Lucia
- Curto Francesco
- Czempik Piotr
- D'Andrea Rocco
- da Silva Ramos Fernando
- Dangers Laurence
- Danguy des Déserts Marc
- Danin Pierre-Eric
- Dantas Fabianne
- Daubin Cédric
- Dawei Wu
- de Haro Candelaria
- de Jesus Montelongo Felipe
- De Mendoza Diego
- de Pablo Raúl
- De Pascale Gennaro
- De Rosa Silvia
- Decavèle Maxens
- Declercq Pierre-Louis
- Deicas Alberto
- del Carmen Campos Moreno María
- Dellamonica Jean
- Delmas Benjamin
- Demirkiran Hilmi
- Demirkiran Oktay
- Dendane Tarek
- di Mussi Rossella
- Diakaki Chrysi
- Diaz Anatilde
- Diaz Willy
- Dikmen Yalim
- Dimoula Aikaterini
- Doble Patricia
- Doha Nagwa
- Domingos Guilherme
- Dres Martin
- Dries David
- Duggal Abhijit
- Duke Graeme
- Dunts Pavel
- Dybwik Knut
- Dykyy Maksym
- Eckert Philippe
- Efe Serdar
- Elatrous Souheil
- Elay Gülseren
- Elmaryul Abubaker S
- Elsaadany Mohamed
- Elsayed Hany
- Elsayed Samar
- Emery Malo
- Ena Sébastien
- Eng Kevin
- Englert Joshua A
- Erdogan Elif
- Ergin Ozcan Perihan
- Eroglu Ege
- Escobar Miguel
- Esen Tekeli Arzu
- Esen Figen
- Esquivel Gallegos Helbert
- Esquivel Alejandro
- Estenssoro Elisa
- Ezzouine Hanane
- Facchini Alberto
- Faheem Mohammad
- Fanelli Vito
- Farina Maria Fernanda
- Fartoukh Muriel
- Fehrle Lutz
- Feng Feng
- Feng Yufeng
- Fernandez Borja
- Fernandez Irene
- Fernandez-Rodriguez Maria Lorena
- Ferrando Carlos
- Ferreira da Silva Maria João
- Ferreruela Mireia
- Ferrier Janet
- Flamm Zamorano Matias Jesús
- Flood Laura
- Floris Leda
- Fluckiger Martin
- Forteza Catalina
- Fortunato Antonella
- Frans Eric
- Frattari Antonella
- Fredes Sebastian
- Frenzel Tim
- Fumagalli Roberto
- Furche Mariano Andres
- Fusari Maurizio
- Fysh Edward
- Galeas-Lopez Juan Luis
- Galerneau Louis-Marie
- Garcia Olivares Pablo
- Garcia Analía
- Garcia Elisabet
- Garcia María Fernanda
- Garlicki Jaroslaw
- Garnero Aude
- Garofalo Eugenio
- Gautam Prabha
- Gazenkampf Andrey
- Gelinotte Stéphanie
- Gelormini Domenico
- Ghrenassia Etienne
- Giacomucci Angelo
- Giannoni Robert
- Gigante Andrea
- Glober Nancy
- Gnesin Paolo
- Goligher Ewan
- Goligher Ewan C
- Gollo Yari
- Gomaa Dina
- Gomero Paredes Rosita
- Gomes Rui
- Gomez Aroa
- Gomez Oscar
- Gomez Raúl Alejandro
- Gondim Louise
- Gonzalez Isabel
- Gonzalez Manuel
- Gonzalez-Castro Alejandro
- Gordillo Romero Orlando
- Gordo Federico
- Gouin Philippe
- Graf Santos Jerónimo
- Grainne Rooney
- Grando Matilde
- Granov Grabovica Sanja
- Grasselli Giacomo
- Grasselli Giacomo
- Grasselli Giacomo
- Grasso Rinaldo
- Grasso Salvatore
- Grimmer Lisa
- Grissom Colin
- Gritsan Alexey
- Gritsan Alexey
- Gu Qing
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- Terragni Pierpaolo
- Terzi Nicolas
- Thakur Anand
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- Thille Arnaud W
- Thomas Matt
- Thungtitigul Poungrat
- Thyrault Martial
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- van Haren Frank
- Van Haren Frank
- Van Haren Frank
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- Vargas-Ordoñez Mónica
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- Ventura Sara
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- von Seth Magnus
- Wajdi Maazouzi
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- Wang Shouhong
- Wardi Gabriel
- Ween-Velken Nils Christian
- Wei Bi-Lin
- Weller Dolf
- Welsh Deborah
- Welters Ingeborg
- Wert Michael
- Whiteley Simon
- Wilby Elizabeth
- Williams Erin
- Williams Karen
- Wilson Antoinette
- Wojtas Jadwiga
- Won Huh Jin
- Wrathall David
- Wright Christopher
- Wu Jian-Feng
- Wunsch Hannah
- Xi Guo
- Xing Zheng-Jiang
- Xu Hongyang
- Yamamoto Kotaro
- Yan Jie
- Yang Xiaobo
- Yates Elliot
- Yazicioglu Mocin Ozlem
- Ye Zhenglong
- Yildirim Fatma
- Yoshida Norifumi
- Yoshido Hector Higo Leon
- Young Lee Bo
- Yu Gong
- Yu Rongguo
- Yu Tao
- Yuan Boyun
- Yuangtrakul Nadwipa
- Yumoto Tetsuya
- Yun Xie
- Yáñez Julio
- Zakalik Graciela
- Zaki Ahmad
- Zalba-Etayo Begoña
- Zambon Massimo
- Zang Bin
- Zani Gianluca
- Zarka Jonathan
- Zeggwagh Amine Ali
- Zerbi Simone Maria
- Zerman Avsar
- Zetterquist Harald
- Zhang Guoxiu
- Zhang Hongwen
- Zhang Jiuzhi
- Zhang Wei
- Zhang Weixin
- Zhao Hongsheng
- Zheng Jia
- Zhu Bin
- Zumaran Ronald
- Çukurova Zafer
- Öveges Nándo
- Özyilmaz Ezgi
- Publication venue
- 'Elsevier BV'
- Publication date
- 21/01/2023
- Field of study
Background
Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation.
Methods
WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109.
Findings
Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2–6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital.
Interpretation
In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
- Author
- Abdelhamid Hachimi
- Abdellatif Benslama
- Abdelrhman Aboshady
- Abhijit Duggal
- Abidi Khalid
- Abubaker S Elmaryul
- Adela Benitez-Cano
- Adi Hadzibegovic
- Adrian Regli
- Agnes Sarkany
- Agnieszka Kubisz-Pudelko
- Agrippino Bellissima
- Agueda Ojados
- Ahmad Zaki
- Ahmed Rabie
- Aikaterini Dimoula
- Aiman Tulaimat
- Aitor Olmos
- Akihiro Takaba
- Akira Kuriyama
- Akram Khan
- Alastair Rose
- Alberto Belenguer Muncharaz
- Alberto Deicas
- Alberto Facchini
- Aldana Ruiz Robledo
- Alejandro Esquivel
- Alejandro Gonzalez-Castro
- Alejandro Risso Vazquez
- Alejandro Ubeda
- Alessandra Nasi
- Alex Martin
- Alexandre Molin
- Alexandre Tonnelier
- Alexey Gritsan
- Alexey Gritsan
- Alexis Jaspe Codecido
- Alfred Papali
- Alisha Van Axel
- Alistair Nichol
- Alma Cani
- Ameet Parekh
- Amine Ali Zeggwagh
- Amira Jamoussi
- Amy Collins
- Ana Raquel Lima
- Ana Vaz
- Ana Villagra
- Ana Vochin
- Anahita Rouze
- Anaid Manzano
- Analía Garcia
- Anand Thakur
- Anatilde Diaz
- Andrea Bruni
- Andrea Coppadoro
- Andrea Cortegiani
- Andrea Gabriela Peña Padilla
- Andrea Gigante
- Andrea Neville Cracchiolo
- Andrew Bersten
- Andrew Hermon
- Andrew McKown
- Andrew Seely
- Andrew Stapleton
- Andrey Gazenkampf
- Andrey Malyarchikov
- Angela Algaba
- Angela Rogers
- Angelo Giacomucci
- Angus Richardson
- Anil Hormis
- Anna Aliberti
- Anna Mattsson
- Antoinette Wilson
- Antonella Fortunato
- Antonella Frattari
- Antonia Vazquez-Sanchez
- Antonio Castelli
- Antonio Landaverde Lopez
- Antonio Luis Ruiz-Aguilar
- Anxela Vidal
- Aragao Irene
- Arantxa Mas
- Ariel Chena
- Arif Moghal
- Arnaud W Thille
- Aroa Gomez
- Arturo Briva
- Arvind Baronia
- Ary Serpa Neto
- Ary Serpa Neto
- Arzu Esen Tekeli
- Ashish K Khanna
- Ashish Rai
- Asim Shah
- Asisclo Villagomez
- Asisclo Villagomez
- Asma Ben Souissi
- Assem Abdel Razek
- Aude Garnero
- Aurélie Joret
- Avsar Zerman
- Ayca Gumus
- Ayse Nur Soyturk
- Banambar Ray
- Basanta Kumar Pati
- Beatriz Llorente
- Beduneau Gaëtan
- Begoña Zalba-Etayo
- Bellani Giacomo
- Benjamin Delmas
- Bernardo Panka
- Bernardo Panka
- Bernie Bissett
- Bertrand Sauneuf
- Betania Silva Sales
- Betty Tsuei
- Bhagyesh Shah
- Bi-Lin Wei
- Bin Zang
- Bin Zhu
- Björn Ahlström
- Bo Young Lee
- Bojan Jovanovic
- Bojan Jovanovic
- Borja Fernandez
- Boyun Yuan
- Brahim Housni
- Branislava Stefanovic
- Brit Ågot Sjøbø
- Brochard Laurent
- Bror Anders Johnstad
- Bruno Ballico
- Bruno Vilela Costa Pinto
- Candelaria de Haro
- Carla Santos
- Carlo Alberto Volta
- Carlo Oliveri
- Carlos Ferrando
- Carlos Munoz de Cabo
- Carlos Pellegrini
- Carmel Chapman
- Carmen Hernandez
- Caroline Kane
- Catalina Forteza
- Catherine Motherway
- Cecilia Eugenia Chavez
- Cenk Kirakli
- Ceri Lynch
- Cesar Perez Calvo
- Chen Jing
- Chen Shuhua
- Chengqing Mei
- Chenliang Sun
- Cherdkiat Karnjanarachata
- Christian Tomaszewski
- Christine M Bojanowski
- Christopher Tainter
- Christopher Wright
- Christos Chaintoutis
- Chrysi Diakaki
- Chuanyun Qian
- Clare Hammel
- Claude Guérin
- Claudia Elizabeth Lopez
- Claudia Lopez Nava
- Claudio Piras
- Colin Grissom
- Conchita Martínez-Fidalgo
- Cosimo Chelazzi
- Covadonga Rodriguez
- Cristina Coxo
- Cristina Martin Dal Gesso
- Cristina Villegas Succar
- Csaba Kopitko
- Cédric Bruel
- Cédric Daubin
- César Laborda
- Dagmar Holmquist
- Dahuan Li
- Daisuke Taniguchi
- Damien Roux
- Dan Lind
- Dana Tomescu
- Daniel Arellano
- Daniel Horner
- Daniel Moreno Torres
- Daniel Paul
- Daniel Rodriguez Gonzalez
- Daniel Silva
- Daniel Talmor
- Daniela Benvenuti
- Darshana Rathod
- David Blythe
- David Carpio
- David Dries
- David Perez-Torres
- David Slessor
- David Wrathall
- Davide Chiumello
- Deborah Welsh
- Deepak Jeswani
- Demetrio Carriedo
- Detajin Junhasavasdikul
- Diana Alvarez
- Dianne Hill
- Dick Nahar
- Didem Sozutek
- Diego De Mendoza
- Diego Rolando Morocho Tutillo
- Dieneke Kienhorst
- Dimitrios Matamis
- Dina Gomaa
- Dolf Weller
- Domenico Gelormini
- Don Walsh
- Doumiri Mouhssine
- Dácil Parrilla
- Edoardo Picetti
- Edoardo Piervincenzi
- Eduardo Beck
- Eduardo Labarca
- Edward Fysh
- Edward Litton
- Ege Eroglu
- Elena Nikolic
- Eleni Massa
- Eleni Mouloudi
- Eliana Caser
- Eliana Markman
- Elias Baedorf Kassis
- Elif Erdogan
- Elisa Boni
- Elisa Estenssoro
- Elisa Kam
- Elisabet Garcia
- Elisabeth Surlemont
- Elisabetta Pecci
- Elisabetta Pierucci
- Elizabeth Ramey
- Elizabeth Stevenson
- Elizabeth Wilby
- Elliot Bertram-Ralph
- Elliot Yates
- Elsa Sousa
- Eman Shebl
- Emanuele Sani
- Emilio Maseda
- Emmanuel Guerot
- Enrique Cereijo
- Enrique Paz
- Enrique Platas
- Eric Frans
- Erin Williams
- Estefania Prol-Silva
- Etienne Ghrenassia
- Ettore Vascotto
- Eugenio Garofalo
- Eugenio Luis Palazon Sanchez
- Ewan Goligher
- Ezgi Ozyilmaz
- Ezgi Özyilmaz
- Fabianne Dantas
- Fabio Guarracino
- Fabio Tarantino
- Faruk Seçkin Yücesoy
- Fatma Yildirim
- Faustine Reynaud
- Federica Vagginelli
- Federico Gordo
- Fekri Abrough
- Felipe de Jesus Montelongo
- Felipe Martinez
- Felix Martin
- Feng Feng
- Fernanda Kutchak
- Fernando da Silva Ramos
- Fernando Pachas Alvarado
- Fernando Rios
- Fernando Rios
- Ferran Roche-Campo
- Fethi Gül
- Feza Bacakoglu
- Figen Esen
- Filiep Soetens
- Finn H Andersen
- Francesca Lucchese
- Francesca Orsenigo
- Francesco Curto
- Francesco Mojoli
- Francis Schneider
- Francisco J Parrilla
- Frank Chemouni
- Frank Van Haren
- Frank Van Haren
- François Philippart
- Françoise Labat
- Frederik Seiler
- Frédérique Schortgen
- Gabriel Omar Heredia Orbegoso
- Gabriel Preda
- Gabriel Rodriguez
- Gabriel Wardi
- Gabriela Bai
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- Tamasato Tamasato
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- Terje Legernaes
- Tetsuya Yumoto
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- Tiago Pereira
- Tiehe Qin
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- Tommaso Tonetti
- Tomohito Sadahiro
- Toshikazu Abe
- Türkay Akbas
- Ulrike Buehner
- Valeria Lascari
- Valerie Banner-Goodspeed
- van Haren Frank
- Vanesa Alejandra Pavlotsky
- Venkat Sundaram
- Vera Pereira
- Victor Hugo Madrigal Robles
- Victoria McCredie
- Vijay Kumar Agrawal
- Vijayanand Palaniswamy
- Viratch Tangsujaritvijit
- Virginia Porta
- Virginie Lemiale
- Vito Fanelli
- Vitor Mendes
- Vladimir Cerny
- Volkan Inal
- Wang Ruilan
- Wei Zhang
- Weixin Zhang
- Wensen Pan
- Willy Diaz
- Willy Porras
- Wilson Oliveira Filho
- Wojciech Serednicki
- Won-Yeon Lee
- Wu Dawei
- Wunsch Hannah
- Xandra Yanina Rodriguez Tucto
- Xavier Souloy
- Xia Hongtao
- Xiang-Dong Guan
- Xiaobo Yang
- Xie Yun
- Yalim Dikmen
- Yari Gollo
- Yaseen Arabi
- Yaseen Arabi
- Yasemin Seker Tekdos
- Yazcitk Sandoval
- You Shang
- Youjin Chang
- Young Ju Lee
- Young-Jae Cho
- Young-Jae Cho
- Yuda Sutherasan
- Yufeng Feng
- Yukako Obata
- Yupeng Qi
- Yutthana Apichatbutr
- Yvette Chou-Lie
- Zafer Çukurova
- Zhang Minwei
- Zhanhong Tang
- Zheng-Jiang Xing
- Zhenglong Ye
- Zoltan Kulcsar
- Zsolt Molnar
- Zsolt Molnar
- Zsuzsanna Szabo
- Óscar Peñuelas
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2023
- Field of study
Background: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0-4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2-6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society
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- Ababneh Hazim
- Abad-Motos Ane
- Abbas Ferial Mohamed Ali
- Abbo Olivier
- Abbott Tom
- Abbott Tom
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdoun Meriem
- Abdur-Rahman Lukman
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala A.
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abuawad Carla
- Abukhalaf Sadi A.
- Abuleil Amro
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agarwal Ketan
- Agastra Ervis
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguilera-Arevalo Maria-Lorena
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmadi Navid
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Aiken Taylor
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Islam Ben Jouira Rayet
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Al-Naggar Hamza
- Al-Raimi Ibrahim
- Al-Sabbagh Yusra
- Al-Shehari Mohammed
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- AlAmeer Ehab
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Albared Sara Maa
- Albertsmeier Markus
- Albertsmeier Markus
- Alderazi Amer
- Aldlyami Ehab
- Aldressi Wafa
- Alecci Anna
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhassoun Turki
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Allemand Carola
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
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- Alqudah Majdi Ali
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- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Althumairi Azah
- Alvarado Carlos Eduardo Otiniano
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzate Juan Pablo
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Amor María Sol Crespi
- André Benoît
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aouabed Nesrine
- Aqeelah Ahmed
- Aqil Sabra
- Arancibia José Alfredo Calderón
- Arango Maria Clara Mendoza
- Arbane Gill
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
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- Asif Muhammad
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- Atnafu Bahru
- Aulerio Giuliana D.
- Aurora
- Awad Selmy
- Ayasra Faris
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Ayub Khurram
- Azevedo José
- Azevedo José
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
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- Berndtson Allison
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- Bescós Coro
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- Bhanderi Shivam
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- Bhat Dhananjaya
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- Bhende Vishal
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- Blanco-Colino Ruth
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- Boretto Jorge G.
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Botero Marcela Velez
- Bouaoud Souad
- Bouche Pierre-Alban
- Bouchenak Kamel
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- Boudou Rocio
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- Brown Wendy
- Brunaud Laurent
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- Glasbey James C.
- Glasbey James C.
- Glass Nina
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- Löffler Markus W.
- Lucchini Sergio Martin
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- Mayol Julio
- Mazingi Dennis
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- McDonnell Brendan
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- Mclean Kenneth A.
- Mclean Kenneth A.
- McNestry Catherine
- Meara John G.
- Meelad Ayman
- Mege Diane
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- Mengesha Mengistu G.
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- Olivos Maricarmen
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- Omar Omar M.
- Omari Rand Y.
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- Rida Ahmed Hossam Eldin Fouad
- Rio Javier
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- Ryan Éanna
- Saad Mahmoud M.
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- Schoneveld Martijn
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- Sigamoney Kohila
- Sikakulya Franck K.
- Silva Camilo Ortiz
- Silva Nelson
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- Simoes Joana Ff
- Simoes Joana Ff
- Simoes Joana Ff
- Sin MªPilar Canals
- Singh Harvinder
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- Srishankar Selvaratnam
- St-Germain Pascal
- Stadler Josef
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- Stavridis Sotir
- Stavrou Gregor A.
- Steinkamp Pieter
- Steinkamp Pieter
- Stephens Matthew
- Stevens Sean
- Stewart Grant D.
- Stewart Grant D.
- Stijns Jasper
- Stoleriu Mircea Gabriel
- Suarez Marcelo Moreno
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- Sultan Rizwan
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- Sumadi Adnan
- Sund Malin
- Surendran Arthika
- Suroy Atul
- Szakmany Tamas
- Sánchez Alberto Cabañero
- Sánchez Iran Irani Durán
- Sánchez-Cabús Santiago
- Tabiri Stephen
- Taboada María Victoria
- Tachella Sofia
- Tadesse Anteneh
- Talat Nabila
- Talib Ahmar Iftikhar
- Talwar Rishi
- Tamoos Khalil
- Tampaki Ekaterini Christina
- Tan Lorwai
- Tariq Aiman
- Tariq Muhammad
- Tarrado Xavier
- Taylor Elliott H.
- Teague Rebecca
- Teasdale Ella
- Tefera Teshome
- Tejero-Pintor Francisco J.
- Tendeng Jacques
- Teo Nan Zun
- Teresa Gavaldà Pellicé M.
- Testelin Sylvie
- Thakar Sumit
- Thereska Dariel
- Thereska Dariel
- Thies Cristina Ojeda
- Thyavihally Yuvaraja
- Tirapegui Sebastian
- Todorovic Lazar
- Tojal André
- Tolani Musliu Adetola
- Toma Elena Adelina
- Tornini Alejandra
- Toro Carlos Andres Marulanda
- Torres Martha Luz
- Toscano Marta Jimenez
- Totty Joshua
- Townend Philip
- Traeger Luke
- Traverso Rogelio
- Tripathi Manjul
- Trout Isobel M.
- Trujillo Lina María
- Tsegaye Bereket
- Tsoulfas Georgios
- Tudela Kiara
- Turinawe Gaston
- Turner Paul
- Turrado-Rodriguez Victor
- Uffelmann Constanza
- Ugarte-Sierra Bakarne
- Usang Usang
- Vaccaro Carlos
- Vagni Roberto
- Vaishnav Dhaivat
- Valcarcel Cristina Rey
- Valdez Pedro
- Valerio Ana Clara
- Vallam Karthik Chandra
- Vallve-Bernal Marc
- van Ramshorst Gabrielle
- van Ramshorst Gabrielle
- Vargas Lara
- Varghese Chris
- Varghese Chris
- Varghese Chris
- Varghese Chris
- Vartanian Jose Guilherme
- Vaughan-Shaw Peter
- Vayoth Sudheer Othiyil
- Vaysburg Dennis
- Vaysse Charlotte
- Velasco Jorge Caño
- Velasquez Enrique Jose Ruiz
- Venkatappa Sunil Kumar
- Venn Mary L.
- Verhaeghe Romain
- Verhaeghe Romain
- Vidal Rafael Perez
- Vidya Raghavan
- Vijayakumar Vijayakumar M.
- Villanueva Julio
- Vimalakanthan Thanusan
- Vita Diana Crego
- Vivancos Patricia Caja
- Viveiros Octavio
- Vives Inmaculada
- Vives Josep Maria Muñoz
- Vo Uyen Giao
- von Pusch Silke
- Vrapi Enxhi
- Vázquez Irene Ortega
- Wafi Omar
- Wagner Arthur
- Waissbluth Sofia
- Waqar Shahzad Hussain
- Watson David
- Watson Eleanor
- Watters David
- Weeraddana Prabuth Dulanjan
- Wells Cameron
- Welter Stefan
- Wettstein Dániel
- Wickramasinghe Dakshitha
- Wickramasinghe Dakshitha
- Wiegering Armin
- Wijeysundera Duminda
- Williams Emmanuel
- Williams Omolara
- Williams Omolara
- Wilson Michael
- Wolf Sebastian
- Wolfer Susanne
- Wong Enoch
- Wright Deborah
- Wright Deborah
- Wright Naomi
- Wuraola Funmilola
- Wuraola Funmilola
- Xaviour Okedi Francis
- Xu William
- Yadev I.
- Yagoub Ghozlan
- Yaqoob Eesha
- Yaqoob Hassan Nawaz
- Yasin Seid Mohammed
- Yazbek Guilherme
- Yebes Alvaro
- Yeung Justin
- Yip Sebastian Shu
- Youssef Mina
- Zabaleta Jon
- Zahid Imdad Ahmad
- Zanoni Gerardo
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarnescu Narcis Octavian
- Zarour Ahmad
- Zarour Ahmad
- Zarour Ahmad
- Zarratea Celeste Soledad
- Zegarra Sergio
- Zequi Stenio C.
- Zezular Damaris Idara Anabel
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zijaj Lorena
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Zohra Belabbes Fatima
- Publication venue
- HAL CCSD
- Publication date
- 01/11/2021
- Field of study
We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care. We aimed to determine the impact of pre-operative isolation on postoperative pulmonary complications after elective surgery during the global SARS-CoV-2 pandemic. We performed an international prospective cohort study including patients undergoing elective surgery in October 2020. Isolation was defined as the period before surgery during which patients did not leave their house or receive visitors from outside their household. The primary outcome was postoperative pulmonary complications, adjusted in multivariable models for measured confounders. Pre-defined sub-group analyses were performed for the primary outcome. A total of 96,454 patients from 114 countries were included and overall, 26,948 (27.9%) patients isolated before surgery. Postoperative pulmonary complications were recorded in 1947 (2.0%) patients of which 227 (11.7%) were associated with SARS-CoV-2 infection. Patients who isolated pre-operatively were older, had more respiratory comorbidities and were more commonly from areas of high SARS-CoV-2 incidence and high-income countries. Although the overall rates of postoperative pulmonary complications were similar in those that isolated and those that did not (2.1% vs 2.0%, respectively), isolation was associated with higher rates of postoperative pulmonary complications after adjustment (adjusted OR 1.20, 95%CI 1.05–1.36, p = 0.005). Sensitivity analyses revealed no further differences when patients were categorised by: pre-operative testing; use of COVID-19-free pathways; or community SARS-CoV-2 prevalence. The rate of postoperative pulmonary complications increased with periods of isolation longer than 3 days, with an OR (95%CI) at 4–7 days or ≥ 8 days of 1.25 (1.04–1.48), p = 0.015 and 1.31 (1.11–1.55), p = 0.001, respectively. Isolation before elective surgery might be associated with a small but clinically important increased risk of postoperative pulmonary complications. Longer periods of isolation showed no reduction in the risk of postoperative pulmonary complications. These findings have significant implications for global provision of elective surgical care
Effects of pre-operative isolation on postoperative pulmonary complications after elective surgery: an international prospective cohort study
- Author
- Ababneh Hazim
- Abad Gurumeta Alfredo
- Abad-Motos Ane
- Abbo Olivier
- Abbott Tom
- Abd Elwahab Sami
- Abdelkabir Mohammed
- Abdelkhalek Mohamed
- Abdur-Rahman Lukman
- Abebe Metasebia
- Aboazamazem Hajir
- Abou Chaar Mohamad K.
- Abou Chaar Mohamad K.
- Abouelnagah Galal
- Abozied Hesham
- Abu Salhiyeh Ala'a
- Abu-Ismail Luai
- Abu-Mehsen Marah
- Abukhalaf Sadi A.
- Abuleil Amro
- Achalandabaso Boira Mar
- Ackermann Travis
- Acquah Daniel Kwesi
- Adam Mohammed Elmujtba Adam Essa
- Adamina Michel
- Ademuyiwa Adesoji
- Adesanya Opeoluwa
- Adisa Adewale
- Afolabi Akinwale
- Agarwal Arnav
- Agarwal Gaurav
- Agastra Ervis
- Agbadebo Mouhamed
- Agbonrofo Peter
- Aguiar Junior Samuel
- Aguilera-Arevalo Maria-Lorena
- Ahmad Amer
- Ahmad Siddique
- Ahmed Waheed-Ul-Rahman
- Aigner Felix
- Akhavizadegan Hamed
- Akhbari Melika
- Akililu Yemisirach Bizuneh
- Akinmade Akinola
- Al Ameer Ahmed
- Al Amri Abdulrahman
- Al Balushi Zainab
- Al Maadany Faraj
- Al-Manaseer Balqees Mahmoud
- Al-Naggar Hamza
- Aladawi Omar
- Alajalen Amer
- Alalawi Yousef
- Alameer Ehab
- Alansari Arowa Hassan Abdulrahman
- Alawami Mohammed
- Alawneh Yazan
- Alayan Mohammed
- Alberdi San Roman Igor
- Albertsmeier Markus
- Alcaraz Fuentes Marta
- Alderazi Amer
- Aldressi Wafa
- Alexander Philip
- AlFakhri Abdullah
- Alharthi Mohammed
- Alhefdhi Amal
- Alkadeeki Ghadah
- Alkaseek Akram
- Alkhatib Ahmad
- Almabayev Ydyrys
- Almeida-Reis Rui
- Almiqlash Bushray
- Almoguera Jorge
- Almugaddami Ayman
- Almulhim Abddulrahman Saleh
- Alonso Mendoza Veronica
- Alqudah Majdi Ali
- Alrayes Bourhan
- Alsaadi Hayder
- Alser Osaid
- Alshaar Muhammad
- Alshahrani Mushabab
- Alshareef Khayriyah
- Alshehri Ameen
- Alshryda Sattar
- Alsibai Sareyah
- Alsunna Zaid
- Altaf Humera Naz
- Althumairi Azah
- Althumairi Azah
- Alyami Mohammad
- Alzahrani Abdulrahman
- Alzaidi Turki M.
- Alzerwi Nasser
- Amisi Nicolas
- Amnaina Mohamed
- Andre Benoit
- Andres Calvache Jose
- Angeles Martina Aida
- Anwer Mariyah
- Anyanwu Lofty-John
- Aqeelah Ahmed
- Aqil Sabra
- Arevalo Sandoval Danilo Alfonso
- Argus Leah
- Arias Claudia
- Arnalsteen Laurent
- Arnaud Alexis P.
- Asif Muhammad
- Assefa Melatework
- Ataide Gomes Gustavo Mendonca
- Atnafu Bahru
- Aviles Jimenez Pablo Mijahil
- Awad Selmy
- Ayasra Faris
- Ayoub Abdu
- Ayub Bushra
- Azevedo Jose
- Azevedo Jose
- Azevedo Pedro
- Aziz Aliya
- Azzam Ahmed Y.
- Bacalbasa Nicolae
- Badareesh L.
- Badenes Rafael
- Badiani Sarit
- Baia Catarina
- Bains Lovenish
- Baiocchi Glauco
- Bajaj Ankur
- Balanta-Melo Julian
- Baliarsing Lipika
- Ball Alasdair
- Ballouhey Quentin
- Bankhead-Kendall Brittany
- Barillas Sabrina
- Barker John
- Barrena Lopez Cristina
- Barros Aldo Vieira
- Basu Somprakas
- Batista Sylvia
- Behzadi Abdollah
- Bekele Kebebe
- Bele Uros
- Bele Uros
- Bella Romera Susana
- Ben Amer Anass
- Ben Jouira Rayet al Islam
- Benson Ruth
- Bergeat Damien
- Bertrand Marta
- Bescos Coro
- Betalleluz Pallardel Jenner
- Bezabih Yoseph Solomon
- Bhanderi Shivam
- Bhangu Aneel
- Bhat Dhananjaya
- Bhatti Abu Bakar Hafeez
- Bhende Vishal
- Biccard Bruce
- Blanco-Colino Ruth
- Boccalatte Luis
- Boisson Matthieu
- Bolatbekova Raikhan
- Bolger Jarlath
- Bolivar Saenz Dinimo
- Bonci Eduard-Alexandru
- Borda-Luque Giuliano
- Borges Filipe Castro
- Bork Ulrich
- Borowski David W.
- Bouche Pierre-Alban
- Boucher Sophie
- Bouhuwaish Ahmad
- Branquinho Rita
- Brar Amanpreet
- Breen Kerry
- Bright Tim
- Brown Wendy
- Brunaud Laurent
- Brunner Stefan M.
- Buarque Igor
- Buarque Igor Lima
- Bucyibaruta Georges
- Bukhari Syed Imran
- Burgan Dania
- Butyrskii Aleksandr
- Bwala Kefas
- Bywater Edward P.
- Cabanero Sanchez Alberto
- Caiado Andre
- Caicedo Lina
- Caja Vivancos Patricia
- Cal Fernando Bonilla
- Calderon Arancibia Jose Alfredo
- Calvo Espino Pablo
- Canals Sin Ma Pilar
- Canno Velasco Jorge
- Cappeliez Serge
- Cardenas Puiggros Laura
- Cardoso Paulo
- Carlos Bernal-Sprekelsen Juan
- Carpio Colmenares Yahaira Tatiana
- Carrasco Prats Milagros
- Carrera Jacqueline
- Carreras-Castaner Anna
- Caruana Edward
- Castell Gomez Jose Tomas
- Catala Bauset Juan Carlos
- Cerovac Anis
- Chadi Sami
- Chakrabortee Sohini
- Chapatwala Reema
- Charbonneau Helene
- Charles Shane
- Chaudhary Muhammad Hamid
- Chaudhry Daoud
- Chaudhry Navneet Kumar
- Chebaro Alexandre
- Chew Min Hoe
- Choong Peter
- Chowdappa Raghunandan Gorantlu
- Chowdhury Sharfuddin
- Christensen Peter
- Chuan Alwin
- Chwat Carina
- Clancy Cillian
- Colas-Ruiz Enrique
- Connelly Tara
- Connor Clare O.
- Corella Fernando
- Corripio-Sanchez Ramon
- Costa Luciana Cidade
- Costas-Chavarri Ainhoa
- Costea Radu
- Cox Daniel
- Creavin Ben
- Crego Vita Diana
- Cretolle Celia
- Cristina Rahy-Martin Aida
- Croghan Stefanie M.
- Cukier Moises
- Cullinane Carolyn
- Cunha Miguel F.
- D'Aulerio Giuliana
- Dajti Irida
- Daoud Hassan
- Davis Niall
- Dawson Amanda Caroline
- Dawson Brett E.
- De Andres-Asenjo Beatriz
- de Dieu Haragirimana Jean
- De Simone Belinda
- Degefa Eyueal
- Delgado Fernandez Juan
- Delibegovic Samir
- Delisau-Puig Olga
- Dell Angela
- Demetrashvili Zaza
- Demetriades Andreas K.
- Derilo Habtamu
- des Deserts Marc Danguy
- Desai Anant
- Deus Ana Claudia
- Dharap Satish
- Dhondt Bert
- Dhufera Hailu
- Di Martino Marcello
- Di Saverio Salomone
- Diaz Martinez Eneida
- Diaz-Feijoo Berta
- Diego Garcia Lucia
- Diez Alonso Manuel
- Dimofte Mihail-Gabriel
- Dione Sacdalan Marie
- do Amaral Campos Heloisa Galvao
- Doerner Johannes
- Domenech Julio
- Donlon Noel
- Drake Thomas
- Drasovean Radu
- Duarte Amalia Barrios
- Dube Surya Kumar
- Duchalais Emilie
- Dudi-Venkata Nagendra
- Duprat Neto Joao Pedreira
- Duran Sanchez Iran Irani
- Duran Irani
- Duro Agustin
- Dwaga Sumayya Essayah
- Dziakova Jana
- Earley Helen
- Eberbach Helge
- Edwards John
- Efetov Sergey
- Efetov Sergey
- Egoroff Natasha
- Ekenze Sebastian
- Ekiti Ido
- El-Boghdadly Kariem
- El-Hussuna Alaa
- Elhadi Muhammed
- Elhadi Muhammed
- Elhajdawe Fras
- Elliott Brodie
- Ellojli Ibrahim
- Emile Sameh
- Enjuto Diego
- Escudero Mario I.
- Eskander Antoine
- Espin-Basany Eloy
- Espinosa-Bravo Martin
- Estaire Gomez Mercedes
- Evans Jonathan
- Evelyn R Nissi
- Ezanno Anne-Cecile
- Fahadullah Muhammad
- Fahmy Mohamed
- Fakhradiyev Ildar
- Falcon Pacheco Glenda Marina
- Farfus Anthony
- Farik Shebani
- Farooq Umer
- Faustin Ntirenganya
- Fernandez Coimbra Felipe Jose
- Fernandez Martin Maria Teresa
- Fernandez Martinez Daniel
- Fernandez-Lopez Antonio-Jose
- Figueroa-Casanova Rafael
- Filipce Venko
- Filipescu Daniela
- Fiore Marco
- Fisseha Tigist
- Flamey Nicolas
- Fleming Christina
- Flexman Alana
- Fluegen Georg
- Flumignan Ronald
- Ford Samuel
- Forero-Torres Alexander
- Fotopoulou Christina
- Fowler Alexander
- Fredon Fabien
- Freiria Eiras Miguel Angel
- Fuentes Tyare
- Fujimoto Yuki
- Futaba Kaori
- Gahwagi Milad
- Gallo Gaetano
- Ganly Ian
- Garcia De Cortazar Unai
- Garcia Escudero Damian
- Garcia Laura Saura
- Garcia Soria Vanesa
- Garcia-Adamez Jorge
- Garcia-Montoya Oscar-Julian
- Gaujoux Sebastien
- Gavalda Pellice M. Teresa
- Gebreyohanes Mengistu
- Gempt Jens
- Ghazwani Salman
- Ghodke Rahul
- Ghosh Dhruva
- Ghosh Indranil
- Ghozy Sherief
- Ghunaim Mohammed
- Gialamas Eleftherios
- Gil-Sala Daniel
- Ginghina Octav
- Girard Edouard
- Girard Noemie
- Gjata Arben
- Glasbey James C.
- Glasbey James C.
- Glowka Tim R.
- Gohar Muhammad
- Gomez Fernandez Laura
- Gomez Perez Beatriz
- Gomez-Fernandez Hugo
- Gomez-Rosado Juan-Carlos
- Gonzalez-Suarez Susana
- Gourlay Ralph
- Gousias Konstantinos
- Gouvas Nikolaos
- Grama Florin
- Griffiths Ewen
- Gronchi Alessandro
- Groot Gary
- Gross Jefferson
- Gujjuri Rohan R.
- Gulla Aiste
- Gupta Anand
- Gupta Rahul
- Gut Anna Eleonora
- Gutierrez Perdomo Valentina
- Gutierrez Ruiz Alitza
- Ha Jeong
- Habumuremyi Sosthene
- Hadzibegovic Ana Danic
- Haidar Hanan
- Haider Fayza
- Hailu Samuel
- Hailu Samuel
- Hakami Ibrahim
- Hamad Faten Reyad Bani
- Hamdun Intisar Hisham Said
- Hameed B. M. Zeeshan
- Haran Cheyaanthan
- Harper Luke
- Harrison Ewen M.
- Hashimoto Daisuke
- Hassan Ramy A.
- Hecker Andreas
- Heredia Fernando
- Heriot Alexander
- Hervieux Erik
- Herzberg Jonas
- Hilmi Ahmed
- Hirschburger Markus
- Hodgson Russell
- Hoehn Philipp
- Hollington Paul
- Horch Raymund E.
- Horisberger Karoline
- Hossain Kamral
- Huang Abel
- Husain Shatha
- Hutchinson Peter
- Hyman Gabriella Yael
- Ikele Hilary
- Imanishimwe Alphonsine
- Incorvia Joseph
- Ingabire Jc Allen
- Ionescu Sebastian
- Isik Arda
- Iskander Othman
- Jain Kavitha
- Jain Ritu
- Jamal Mohammad
- James Harelimana Grace
- Javadpour Mohsen
- Javed Saad
- Jaworska Natalia
- Jayarajah Umesh
- Jeandel Clement
- Jenkinson Michael
- Jimaale Elmi Ahmed Mohamed
- Jimenez Toscano Marta
- Jimenez Raul
- Jimenez Virginia
- Jin-Young Jang
- Jira Moa
- Jlassi Haithem
- Jones Conor S.
- Jonker Pascal
- Jorda Sole Misericordia
- Jose Gonzalez-Gimeno Maria
- Jose Martinez Maria
- Jouffret Lionel
- Julia Bergkvist David
- Kaafarani Haytham
- Kabir Syed Mohammad Umar
- Kache Stephen
- Kacimi Salah Eddine Oussama
- Kaidarova Dilyara
- Kaiser Julia Christina
- Kaman Lileswar
- Kamarajah Sivesh K.
- Kamphues Carsten
- Kandevani Naser Yousefzadeh
- Kannaiyan Lavanya
- Kannan Ravi
- Karout Lina
- Karthigeyan Madhivanan
- Kassir Radwan
- Kauppila Joonas H.
- Kavalaka Alfie
- Keatley James M.
- Kembuan Gabriele
- Keppler Alexander M.
- Keppler Lena
- Kerawala Asad Ali
- Khalifa Houda
- Khamees Almu'atasim
- Khan Tabassum
- Khokhar Muhammad Imran
- Khosravi Mohammad Hossein
- Kieser David
- King Jasmin
- Kirov Mikhail
- Klat Jaroslav
- Knight Stephen Richard
- Kochetkov Viktor
- Koenigsrainer Alfred
- Koh Cherry
- Koh Frederick
- Kolias Angelos
- Komen Niels
- Konate Ibrahima
- Konrads Christian
- Kopetskyi Slava
- Kopjar Tomislav
- Kosir Jurij Ales
- Kowalski Luiz Paulo
- Kpangon Cyrille
- Kronberger E.
- Kronberger Irmgard Elisabeth
- Kroon Hidde M.
- Kruijff Schelto
- Kruijff Schelto
- Kudsk-Iversen Soren
- Kulimbet Mukhtar
- Kulkarni Amruta
- Kumar Aruna
- Kumar Ashwani
- Kuroda Naoto
- Kwan Tsun Yu
- Laban Simon
- Lakkis Zaher
- Landaluce-Olavarria Aitor
- Latif Haider
- Laudani Veronica
- Lawal Taiwo Akeem
- Lawani Ismail
- Lawday Samuel
- Le Bian Alban Zarzavadjian
- Lederhuber Hans
- Lekuya Herve Monka
- Leung Elaine
- Leventoglu Sezai
- Li Elizabeth
- Lidder Surjit
- Lincango-Naranjo Eddy
- Lindert Judith
- Linz Valerie Catherine
- Litvin Andrey
- Litvin Andrey
- Llaquet Bayo Heura
- Loaloa Mohamed Reda
- Loeffler Markus
- Loeffler Markus W.
- Lohsiriwat Varut
- Losada Manuel
- Lott Natalie
- Lou Wenhui
- Lowey Megan
- Lucia Portilla Ana
- Lugo Duarte Carolina
- Lule Herman
- Luna Joaquin
- Mabood Waleed
- Macchiavello Roberto
- MacKenzie Shawn
- Madabhavi Irappa
- Madkhali Tariq
- Mahakalkar Chandrashekhar
- Maimbo Mayaba
- Maji Suvendu
- Majid Haroon Javaid
- Major Piotr
- Makdissi Fabiana
- Makkai-Popa Silviu Tiberiu
- Maldonado-Marcos Eloy
- Maleki Esmaeil Rezghi
- Malik Muhammad Usman
- Manceau Gilles
- Mann Harvinder
- Manuel Morales-Puebla Jose
- Marcal Andre
- Maria Trujillo Lina
- Marquez Lucila
- Marson Ella J.
- Marta Modolo Maria
- Martin Lucchini Sergio
- Martin Sole Oriol
- Martin Janet
- Martin-Laez Ruben
- Martinez Alonso Jesus Aaron
- Martinez Laura
- Marulanda Toro Carlos Andres
- Mas Melendez Robinson
- Mashbari Hassan
- Massoud John George
- Matai Anil
- Mateo-Sierra Olga
- Mayol Julio
- Mazingi Dennis
- McDonnell Brendan
- McGuinness Matthew James
- McIntosh Nick
- McKay Siobhan
- Mclean Kenneth A.
- McNestry Catherine
- Meara John G.
- Meelad Ayman
- Mege Diane
- Megersa Abebe
- Mehraj Asif
- Mejia Dolores
- Melo Miguel Rocha
- Mendes Filipa
- Mendiola Gian
- Mendoza Arango Maria Clara
- Mengesha Mengistu G.
- Mersich Tamas
- Metallidis Symeon
- Migliorelli Federico
- Mihanovic Jakov
- Mihanovic Jakov
- Milan Peiman Brouki
- Mills Emily
- Mimica Ximena
- Minaya Bravo Ana Maria
- Minaya Bravo Ana Maria
- Mironescu Aurel
- Mishra Tushar
- Misra Sanjeev
- Misrai Vincent
- Mittal Rohin
- Mitul Ashrarur Rahman
- Modabber Ali
- Mohammed Alsnosy Abdullah Khalefa
- Mohan Helen
- Mohsen Mustafa Abo
- Mohyieldin Omar
- Molitvin Yegor
- Montenegro Emileth
- Montferrer Estruch Nuria
- Morales Palacios Nelson
- Moreno Suarez Marcelo
- Morsy Amr
- Moss Jana-Lee
- Mostafa Badr
- Motas Natalia
- Moug Susan
- Moya-Angeler Joaquin
- Mozafari Masoud
- Mozel Michelle
- Msherghi Ahmed
- Muheilan Muheilan
- Munoz Vives Josep Maria
- Munyaneza Emmanuel
- Munyika Akutu
- Muralidharan Vijayaragavan
- Muthu Sathish
- Nagar Manoj
- Nakagawa Suely
- Nappi Francesco
- Naseem Muhammad Yasir
- Nashidengo Pueya Rashid
- Nayen Alejandra
- Ncogoza Isaie
- Ndayishyigikiye Marcel Didier
- Ndong Abdourahmane
- Negoi Ionut
- Negoi Ionut
- Negussie Abraham
- Nepogodiev Dmitri
- Nepogodiev Dmitri
- Nessim Carolyn
- Ng-Kamstra Joshua
- Ngu James
- Niazi Sami Ullah
- Nidaw Melkamu
- Nieto Calvache Albaro Jose
- Nikolaieva Karine
- Niquen-Jimenez Milagros
- Nitschke Christine
- Nkembi Armande Subayi
- Nogueiro Jorge
- Noltes Milou
- Noltes Milou
- Norman Lisa
- Nouh Thamer
- Novysedlak Rene
- Nowak Kai
- Nunez Bernardo
- Nunez Jade
- Nunez Jorge
- Nurgozhin Talgat
- Nwegbu Chukwuemeka
- O'Brien Stephen
- Ofori Bernard
- Ojeda Thies Cristina
- Okereke Chukwuma
- Okunlola Abiodun
- Olaogun Julius
- Olaywah Noor
- Oliveira Joao
- Oliver Guillen Jose Ramon
- Olivos Maricarmen
- Olori Samson
- Omari Rand Y.
- Oosterlinck Wouter
- Ortega Vazquez Irene
- Ortiz Silva Camilo
- Osinaike Babatunde
- Otiniano Alvarado Carlos Eduardo
- Ots Riinu
- Outani Oumaima
- Outani Oumaima
- Pablo Alzate Juan
- Pacilli Maurizio
- Padmore Greg
- Palazon Bellver Pedro
- Pantoja Pachajoa Diana Alejandra
- Panyko Arpad
- Pata Francesco
- Pata Francesco
- Patel Akshay
- Paucar Urbina Arazzelly Del Pilar
- Pawar Pranay
- Pedraza Alonso Nestor Fabian
- Pedraza Salazar Ivana Ines
- Peiper Christian
- Pejkova Sofija
- Pellino Gianluca
- Pereira Rita Goncalves
- Perez Ferrer Antonio
- Perez-Bertolez Sonia
- Perez-Chrzanowska Hanna
- Perinotti Roberto
- Pfister Karin
- Phadnis Ashish
- Picciochi Maria
- Pigeolet Manon
- Plarre Philipp
- Pockney Peter
- Pockney Peter
- Police Andrea
- Porteiro Marino Lucia
- Porumb Vlad
- Prada Jorge
- Pramesh C. S.
- Prat-Ortells Jordi
- Prieto Mikel
- Putnis Soni
- Pykhteev Vadim
- Qasem Abdulrahman
- Qassem Faisal
- Qassem Mohamed
- Quante Markus
- Quintana-Villamandos Begona
- Qureshi Ahmad Uzair
- Ra'ed Hazim
- Radenkovic Dejan
- Raevskaya Marianna
- Rahbari Nuh
- Rai Lajpat
- Rajan Shiv
- Rajanbabu Anupama
- Ramallo-Solis Irene
- Rammohan Ashwin
- Ramos-De la Medina Antonio
- Ramos-Luengo Adolfo
- Ranganath N.
- Rasoaherinomenjanahary Fanjandrainy
- Rassweiler-Seyfried Marie-Claire
- Raut Monish
- Recinos Gustavo
- Regalo Guillermo
- Reim Daniel
- Reinhard Tobias
- Ren Dong-Lin
- Rennie Sarah
- Rennie Sarah
- Rey Valcarcel Cristina
- Riba Martinez Mireia
- Rice Henry E.
- Rida Ahmed Hossam Eldin Fouad
- Rio Javier
- Rios Chiuyari Jose
- Ripolles-Melchor Javier
- Rissmann Anke
- Rivera Lau Lorena Fuentes
- Rivera Carlos J-Perez
- Roberts Keith
- Rodas Alejandra
- Rodriguez Infante Antonio
- Rodriguez Juliana
- Rodriguez-Abreu Julia
- Rodriguez-Tesouro Ana
- Rojas Portilla Fabian
- Rokohl Alexander Christopher
- Roldon Golet Marta
- Roman Garcia de Leon Laura
- Ronellenfitsch Ulrich
- Rosa Ortiz Maria
- Roslani April Camilla
- Roth Andreas
- Rubio-Palau Josep
- Ruiz Velasquez Enrique Jose
- Ruiz-Marin Miguel
- Russell Crispin
- Rutegard Martin
- Ryan Eanna
- Saad Mahmoud M.
- Sacras Maria Luis
- Safieddine Najib
- Saier Tim
- Sale Danjuma
- Saleh Ismail Ali
- Salem Marwa
- Saliev Timur
- Sallam Asser
- Samadov Elgun
- Samaka Rehab
- Samantha Gonzalez Diana
- Samison Luc Herve
- Sampaio-Alves Mafalda
- Sanchez Fernandez Fatima
- Sanchez Lopez Anna
- Sanchez Mozo Ana
- Sanchez-Cabus Santiago
- Sancho-Muriel Jorge
- Santos Irene
- Santos-Costa Paulo
- Sanz-Gonzalez Rosa
- Sarjanoja Elise
- Sarwar Muhammad Zeeshan
- Satoi Sohei
- Sayyed Raza
- Scalabre Aurelien
- Schache Andrew
- Schlager Daniel
- Schmedding Andrea
- Schnitzbauer Andreas
- Schoneveld Martijn
- Seeliger Barbara
- Seguin-Givelet Agathe
- Sekar Arunkumar
- Serralheiro Pedro
- Serrano Gonzalez Javier
- Seyi-Olajide Justina
- Shah Rakesh
- Shanthanna Harsha
- Sharma Abhishek
- Sharma Rahul Deo
- Sharma Shilpa
- Shaw Catherine
- Shaw Richard
- Shehata Sameh
- Shehta Ahmed
- Sherif Ahmed Elshawadfy
- Shrestha Ashish Lal
- Shu Yip Sebastian
- Shu Sebastian
- Shumbash Kibruyisfaw
- Sieira-Gil Ramon
- Silva Nelson
- Silva-Igua Liliana
- Simoes Joana
- Simoes Joana F. F.
- Simoes Joana F. F.
- Singh Harvinder
- Sisay Silamlak
- Slavchev Mihail
- Slim Karem
- Smart Neil
- Smart Neil
- Soares Ana
- Sodhai Vivek
- Soni Rajesh
- Soto-Darias Ivan
- Spelsberg Fritz
- St-germain Pascal
- Stadler Josef
- Stavridis Sotir
- Stavrou Gregor A.
- Steinkamp Pieter
- Stephens Matthew
- Stevens Sean
- Stewart Grant D.
- Stijns Jasper
- Stoleriu Mircea Gabriel
- Subbian Anbukkani
- Suliaman Taha
- Sultan Rizwan
- Sumadi Adnan
- Sund Malin
- Suroy Atul
- Tabiri Stephen
- Tadesse Anteneh
- Talat Nabila
- Tamoos Khalil
- Tampaki Ekaterini Christina
- Tan Lorwai
- Tariq Aiman
- Tariq Muhammad
- Tarrado Xavier
- Taylor Elliott H.
- Teague Rebecca
- Teasdale Ella
- Tefera Teshome
- Tejero-Pintor Francisco J.
- Tendeng Jacques
- Teo Nan Zun
- Testelin Sylvie
- Thakar Sumit
- Thereska Dariel
- Thyavihally Yuvaraja
- Tobome Semevo Romaric
- Todorovic Lazar
- Tojal Andre
- Tolani Musliu Adetola
- Toma Elena Adelina
- Tormos Perez M. Pilar
- Torres Martha Luz
- Townend Philip
- Traeger Luke
- Tripathi Manjul
- Trout Isobel M.
- Tsegaye Bereket
- Tsoulfas Georgios
- Tudela Kiara
- Turrado-Rodriguez Victor
- Ugarte Oscco Regina Amparo
- Ugarte-Sierra Bakarne
- Usang Usang
- Vaishnav Dhaivat
- Valderrabano Gonzalez Santiago
- Vallam Karthik Chandra
- Vallve-Bernal Marc
- van Ramshorst Gabrielle
- Varghese Chris
- Varghese Chris
- Varghese Christopher
- Vartanian Jose Guilherme
- Vasquez Ojeda Ximena Paola
- Vaughan-Shaw Peter
- Vayoth Sudheer Othiyil
- Vaysse Charlotte
- Vazquez Melero Alba
- Velez Botero Marcela
- Venkatappa Sunil Kumar
- Venn Mary L.
- Verhaeghe Romain
- Vidya Raghavan
- Vijayakumar M. Vijayakumar
- Villanueva Julio
- Viveiros Octavio
- Vives Inmaculada
- Vo Uyen Giao
- von Pusch Silke
- Wafi Omar
- Wagner Arthur
- Waissbluth Sofia
- Waqar Shahzad Hussain
- Watson David
- Watson Eleanor
- Watters David
- Wells Cameron
- Welter Stefan
- Wettstein Daniel
- Wickramasinghe Dakshitha
- Wiegering Armin
- Wijeysundera Duminda
- Williams Emmanuel
- Williams Omolara
- Wolf Sebastian
- Wolfer Susanne
- Wong Enoch
- Wright Deborah
- Wright Naomi
- Wuraola Funmilola
- Xu William
- Yadev I.
- Yagoub Ghozlan
- Yaqoob Eesha
- Yaqoob Hassan Nawaz
- Yasin Seid Mohammed
- Yazbek Guilherme
- Yebes Alvaro
- Yeung Justin
- Zabaleta Jon
- Zahid Imdad Ahmad
- Zapardiel Ignacio
- Zapata Carlos Shiraishi
- Zarnescu Narcis Octavian
- Zarour Ahmad
- Zarour Ahmad
- Zegarra Sergio
- Zequi Stenio C.
- Zhou Xuanyu
- Zhussupov Baurzhan
- Zimmelman Natalie
- Zmora Oded
- Zmora Oded
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Weaning from mechanical ventilation in intensive care units across 50 countries (WEAN SAFE): a multicentre, prospective, observational cohort study
- Author
- Abe T.
- Aboshady Abdelrhman
- Abrough Fekri
- Acampo-de Jong Melanie J.
- Acharya S.
- Acharya Subhash P.
- Adderley Jane
- Adiguzel N.
- Agrawal V.K.
- Aguilar G.
- Aguirre Gaston
- Aguirre-Bermeo Hernán
- Ahlström B.
- Akbas Türkay
- Akker M.
- Al Sadeh G.
- Alamri S.
- Algaba Ángela
- Ali M.
- Aliberti A.
- Allegue J.M.
- Alvarez Diana
- Amador J.
- Amin P.
- Andersen F.H.
- Ansari S.
- Apichatbutr Yutthana
- Apostolopoulou Olympia
- Arabi Y.
- Aragao Irene César
- Arellano D.
- Arica Mestanza
- Arikan Huseyin
- Arinaga K.
- Arnal J.-M.
- Asano Kengo
- Asín-Corrochano M.
- Avalos Cabrera J.M.
- Avila Fuentes S.
- Aydemir Semih
- Aygencel Gulbin
- Azevedo L.
- Bacakoglu Feza
- Badie Julio C.
- Baedorf Kassis E.
- Bai Gabriela
- Balaraj Govindan
- Ballico B.
- Banner-Goodspeed Valerie M.
- Banwarie Preveen
- Barbieri R.
- Baronia Arvind Kumar
- Barrett Jonathan A.
- Barrot L.
- Barrueco-Francioni Jesus Emilio
- Barry Jeffrey
- Bauer Philippe R.
- Bawangade H.
- Beavis Sarah
- Beck E.
- Beduneau G.
- Beehre N.
- Beitler J.
- Belenguer Muncharaz Alberto
- Bellani Giacomo
- Belliato M.
- Bellissima A.
- Beltramelli Rodrigo
- Ben Souissi Asma
- Benitez-Cano A.
- Benlamin Mohamed
- Benslama Abdellatif
- Bento Luís Í.
- Benvenuti Daniela
- Berkius J.
- Bernabe Laura
- Bersten Andrew D.
- Berta G.
- Bertini P.
- Bertram-Ralph Elliott
- Besbes M.
- Bettini L.R.
- Beuret P.
- Bewley Jeremy S.
- Bezzi M.
- Bhakhtiani L.
- Bhandary R.
- Bhowmick Kaushik
- Bihari S.
- Bissett B.
- Blythe D.
- Bocher Simon
- Boedjawan N.
- Bojanowski C.M.
- Boni E.
- Boraso Sabrina
- Borelli M.
- Borello S.
- Borislavova M.
- Bosma Karen J.
- Bottiroli M. A.
- Boyd Owen F.
- Bozbay S.
- Briva A.
- Brochard L.
- Bruel C.
- Bruni Andrea
- Buehner Ulrike
- Bugedo G.
- Bulpa P.
- Burt Karen
- Buscot Matthieu
- Buttera S.
- Cabrera Jorge
- Caccese Roberta
- Caironi P.
- Camporota Luigi
- Canchos Gutierrez Ivan
- Canedo N.
- Cani A.
- Cappellini I.
- Carazo Jesus
- Cardonnet Luis Pablo
- Carpio D.
- Carriedo Demetrio
- Carrillo Ramón
- Carvalho J.
- Caser Eliana Bernardete
- Castelli A.
- Castillo Quintero M.
- Castro H.
- Catorze Nuno T.
- Cengiz Melike
- Cereijo E.
- Cerny V.
- Ceunen H.
- Chaintoutis Christos
- Chang Youjin
- Chaparro G.
- Chapman Carmel
- Chau Simon K.
- Chavez C.E.
- Chelazzi Cosimo
- Chelly J.
- Chemouni F.
- Chen Kai
- Chena Ariel
- Chiarandini P.
- Chilton Phil
- Chiumello D.
- Cho Y.-J.
- Chou-Lie Y.
- Chudeau N.
- Cinel İsmail Hakkı
- Cinnella G.
- Clark Michele
- Clark Thomas
- Clarkson Kevin P.
- Clementi S.
- Coaguila Luis
- Codecido Alexis Jaspe
- Collins A.
- Colombo R.
- Conde Juan
- Consales G.
- Cook T.
- Coppadoro A.
- Cornejo Rodrigo A.
- Cortegiani Andrea
- Coxo Cristina M.
- Cracchiolo Andrea Neville
- Crespo Ramirez M.
- Crova P.
- Cruz José David
- Cubattoli L.
- Curto F.
- Czempik Piotr Filip
- d'Andrea R.
- da Silva Ramos F.
- Dangers L.
- Danguy Des Déserts Marc
- Danin P.-E.
- Dantas F.
- Daubin Cédric
- Dawei Wu
- de Haro C.
- de Jesus Montelongo Felipe
- de Mendoza Diego
- de Pablo Raúl
- de Pascale Gennaro D.
- de Rosa Silvia
- Decavèle Maxens
- Declercq P.-L.
- Deicas Alberto
- del Carmen Campos Moreno M.
- Dellamonica J.
- Delmas B.
- Demirkiran Hilmi
- Demirkiran Oktay
- Dendane T.
- Di Mussi Rosa
- Diakaki C.
- Diaz A.
- Diaz W.
- Dikmen Yalim
- Dimoula Aikaterini
- Doble P.
- Doha Nagwa M.
- Domingos G.
- Dres M.
- Dries D.
- Duggal Abhijit
- Duke Graeme J.
- Dunts Pavel V.
- Dybwik Knut
- Dykyy M.
- Eckert Philippe
- Efe Serdar
- Elatrous S.
- Elay Gülseren
- Elmaryul Abubaker S.
- Elsaadany M.
- Elsayed Hany
- Elsayed Samar
- Emery M.
- Ena S.
- Eng Kevin
- Englert Joshua A.
- Erdogan E.
- Ergin Ozcan P.
- Eroglu Ege
- Escobar M.
- Esen Tekeli Arzu
- Esen F.
- Esquivel Gallegos H.
- Esquivel Alejandro
- Estenssoro Elisa
- Ezzouine H.
- Facchini Alberto
- Faheem Mohammad
- Fanelli V.
- Farina Maria Fernanda
- Fartoukh Muriel Sarah
- Fehrle Lutz
- Feng Feng
- Feng Yufeng
- Fernandez B.
- Fernandez Irene
- Fernandez-Rodriguez M.L.
- Ferrando Carlos
- Ferreira da Silva Maria João
- Ferreruela Mireia
- Ferrier Janet
- Flamm Zamorano Matias Jesús
- Flood Laura
- Floris L.
- Fluckiger M.
- Forteza Catalina
- Fortunato A.
- Frans E.
- Frattari A.
- Fredes Sebastián
- Frenzel Tim
- Fumagalli R.
- Furche M.A.
- Fusari Maurizio
- Fysh E.
- Galeas-Lopez J.L.
- Galerneau L.-M.
- Garcia Olivares P.
- Garcia Analía
- Garcia E.
- Garcia M.F.
- Garlicki Jarosław B.
- Garnero Aude
- Garofalo E.
- Gautam Prabha
- Gazenkampf A.
- Gelinotte S.
- Gelormini Domenico
- Ghrenassia Étienne
- Giacomucci Angelo
- Giannoni Roberto
- Gigante A.
- Glober Nancy King
- Gnesin Paolo
- Goligher E.
- Goligher E.C.
- Gollo Y.
- Gomaa Dina
- Gomero Paredes Rosita
- Gomes R.
- Gomez A.
- Gomez Oscar
- Gomez Raúl Alejandro
- Gondim Louise Aline Romão
- Gonzalez I.
- Gonzalez Manuel E.
- Gonzalez-Castro A.
- Gordillo Romero Orlando
- Gordo Federico
- Gouin Philippe
- Graf Santos J.
- Grainne R.
- Grando Matilde
- Granov Grabovica S.
- Grasselli Giacomo
- Grasso R.
- Grasso S.
- Grimmer Lisa
- Grissom Colin K.
- Gritsan Alexey I.
- Gu Qing
- Guan X.-D.
- Guarracino F.
- Guasch N.
- Guatteri Luca
- Gueret Renaud M.
- Guerot Emmanuel
- Guitard P.-G.
- Gumus Ayça
- Gurjar M.
- Gutierrez Patricia
- Guérin Claude
- Gül Fethi
- Hachimi Abdelhamid
- Hadzibegovic A.
- Hagan Samantha J.
- Hammel Clare
- Han Song J.
- Hanlon Gabrielle C.
- Hashemian Seyed Mohammad Reza
- Heines Serge J.H.Jan Hubert
- Henriksson J.
- Herbrecht Jean Étienne
- Heredia Orbegoso G.O.
- Hermans Greet M.
- Hermon A.
- Hernandez C.
- Hernandez R.
- Herrera Luis
- Herrera-Gutierrez M.
- Heunks Leo M.A.
- Heunks Leo M.A.
- Hidalgo J.
- Hill Dianne
- Holmquist D.
- Homez M.
- Hongtao Xia
- Hormis Anil P.
- Horner D.
- Hornos Micaela Carmen
- Hou M.
- House S.
- Housni B.
- Hugill Keith
- Humbert L.
- Humphreys Sally K.
- Hunter Stephanie
- Hwa Young Lee
- Iezzi N.
- Ilutovich Santiago
- Inal V.
- Innes R.
- Ioannides Panagiotis
- Iotti Giorgio Antonio
- Ippolito Mariachiara
- Irie Hiromasa
- Iriyama H.
- Itagaki T.
- Izura Javier J.
- Izza Santiago
- Jabeen R.
- Jamaati Hamidreza
- Jamadarkhana Sunil
- Jamoussi Amira
- Jankowski Milosz
- Jaramillo L.A.
- Jeon K.
- Jeong Lee Seok
- Jeswani Deepak
- Jha S.
- Jiang Liangyan
- Jing C.
- Jochmans S.
- Johnstad B.A.
- Jongmin Jongmin
- Joret A.
- Jovanovic B.
- Junhasavasdikul D.
- Jurado Maria Teresa
- Kam E.
- Kamohara H.
- Kane C.
- Kara Iskender
- Karakurt Sait
- Karnjanarachata C.
- Kataoka Jun
- Katayama Shinshu
- Kaushik S.
- Kelebek Girgin Nermin
- Kerr Kathryn
- Kerslake I.
- Khairnar Prakash
- Khalid Abidi
- Khan A.
- Khanna A.K.
- Khorasanee Reza
- Kienhorst Dieneke
- Kirakli C.
- Knafelj Rihard
- Kol Mark R.
- Kongpolprom N.
- Kopitko Csaba
- Korkmaz Ekren P.
- Kubisz-Pudelko A.
- Kulcsar Z.
- Kumasawa Junji
- Kurahashi Kiyoyasu
- Kuriyama Akira
- Kutchak F.
- Laake J.H.
- Labarca Eduardo F.
- Labat F.
- Laborda C.
- Laca Barrera M.A.
- Laffey J.G.
- Lagache Laurie
- Landaverde Lopez Antonio
- Lanspa M.
- Lascari Valeria
- Le Meur M.
- Lee J.
- Lee Jinwoo
- Lee S.H.
- Lee W.-Y.
- Lee Y.J.
- Legernaes T.
- Leiner Tamaas
- Lemiale Virginie
- Leonor T.
- Lepper Philipp Moritz
- Li D.
- Li H.
- Li O.
- Lima Ana Raquel
- Lind D.
- Litton E.
- Liu Jialin
- Liu Ling
- Liu N.
- Llitjos J.-F.
- Llorente Beatriz
- Lopez Nava C.
- Lopez C.E.
- Lopez R.
- Lovazzano Pablo
- Lu M.
- Lucchese F.
- Lugano M.
- Lugo Goytia Gustavo
- Luo H.
- Lynch C.
- Macheda Sebastiano
- Madotto F.
- Madrigal Robles V.H.
- Maggiore S.M.
- Magret Iglesias M.
- Malaga P.
- Mallapura Maheswarappa Harish
- Malpartida G.
- Malyarchikov A.
- Mancebo J.
- Mansson Helena Holm
- Manzano Anaid
- Marey I.
- Marin María
- Marin N.
- Markman E.
- Martin Dal Gesso Cristina
- Martin Alex
- Martin F.
- Martin-Loeches I.
- Martinez F.
- Martínez-Fidalgo Conchita
- Mas A.
- Masaaki S.
- Maseda Emilio
- Massa Eleni V.
- Matamis Dimitrios
- Mattsson Anna
- Maugeri Jessica Giuseppina
- Mccredie Victoria A.
- Mccullough J.
- Mcguinness S.
- Mckown A.
- Medve László
- Mei C.
- Mellado Artigas R.
- Mendes V.
- Mervat Mohamed Khalaf Ebraheim
- Michaux I.
- Mikhaeil M.
- Milagros O.
- Milet Igor
- Millan M.T.
- Minwei Z.
- Mirabella Lucia
- Mishra Sanghamitra
- Mistraletti G.
- Mochizuki Katsunori
- Moerer Onnen
- Moghal Arif
- Mojoli F.
- Molin Alexandre
- Molnar Z.
- Montiel R.
- Montini L.
- Monza G.
- Mora Aznar María
- Morakul Sunthiti
- Morales M.
- Moreno Torres Daniel
- Morocho Tutillo Diego Rolando
- Motherway C.
- Mouhssine Doumiri
- Mouloudi Eleni K.
- Munoz de Cabo Carlos
- Mustafa Mohamed
- Muthuchellappan R.
- Muthukrishnan M.
- Muttini Stefano
- Muñoz T.
- Nagata Isao
- Nahar Dick
- Nakanishi Misuzu
- Nakayama I.
- Namendys-Silva Silvio A.
- Nanchal R.
- Nandakumar S.
- Nasi Alessandra
- Nasir Kamal
- Navalesi P.
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- Nichol A.
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- Nikolic Elena
- Nitta Kenichi
- Noc M.
- Nonas Stephanie A.
- Nseir Saad
- Nur Soyturk Ayşe
- Obata Y.
- Oeckler R.
- Oguchi Moe
- Ohshimo Shinichiro
- Oikonomou M.
- Ojados Agueda
- Oliveira Filho W.
- Oliveira M.T.
- Oliveri C.
- Olmos Aitor
- Omura K.
- Orlandi M.C.
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- Ortiz-Ruiz de Gordoa Laura
- Ota Kei
- Ovalle Olmos R.
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- Ozkan Kuscu O.
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- Pachas Alvarado F.
- Pagella Gonzalo
- Palaniswamy Vijayanand
- Palazon Sanchez E.L.
- Palmese Salvatore
- Pan Guojun
- Pan W.
- Panka Bernardo Amisa
- Papali A.
- Papanikolaou Metaxia N.
- Papavasilopoulou Theonymfi G.
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- Parke R.
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- Pavesi Maurizio
- Pavlotsky V.A.
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- Perez Maita Ronald
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- Persona P.
- Pesenti A.
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- Petrova Marina V.
- Peña Padilla Andrea Gabriela
- Peñuelas O.
- Peñuelas Ó.
- Pham Tài
- Pham Tài
- Philippart François
- Picetti Edoardo
- Pierucci Elisabetta
- Piervincenzi E.
- Pinciroli Riccardo
- Pintado M.-C.
- Piquilloud Lise
- Piraino T.
- Piras Cláudio
- Piras Stephanie
- Pirompanich P.
- Pisani Luigi
- Platas Enrique
- Plotnikow G.
- Porras Willy
- Porta Virginia
- Portilla M.
- Portugal J.
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- Prat G.
- Pratto R.
- Preda Gabriel
- Prieto Isidro J.
- Prol-Silva E.
- Pugh Richard
- Pérez-Araos Rodrigo A.
- Qi Yupeng
- Qian C.
- Qin Tiehe
- Qiu Haibo
- Qu Hongping
- Quintana T.
- Quispe Sierra Rosari
- Quispe Soto Rocio
- Rabbani R.
- Rabee Mohamed A.
- Rabie Ahmed
- Rahe Pereira M.A.
- Rai A.
- Raj Ashok Sundar
- Rajab Mostafa
- Ramdhani N.
- Ramey Elizabeth
- Ranieri V. Marco
- Rathod Darshana S.
- Ray B.
- Razek Assem Abdel
- Redwanul Huq S.M.
- Regli Adrian
- Reina Rosa
- Resano Sarmiento N.
- Reynaud Faustine
- Rialp G.
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- Richardson Angus
- Rieder M.
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- Rios F.
- Risso Vazquez Alejandro
- Rittayamai N.
- Riva I.
- Rivette M.
- Roca O.
- Roche-Campo Ferrán
- Rodriguez Gonzalez Daniel
- Rodriguez Tucto Xandra Yanina
- Rodriguez Covadonga
- Rodriguez G.
- Rogers A.
- Roldan R.
- Romano María Elena
- Rose Alastair
- Roux Damien
- Rouze A.
- Rubatto Birri Paolo Nahuel
- Ruilan Wang
- Ruiz Robledo A.
- Ruiz-Aguilar Antonio Luis
- Rørtveit Linda
- Sadahiro Tomohito
- Saez I.
- Sagardia Judith
- Saha R.
- Saha Rajnish
- Saiphoklang Narongkorn
- Saito Shigeki
- Salem Maie
- Sales Gabriele
- Salgado P.
- Samavedam Srinivas
- Sami Mebazaa Mhamed
- Samuelsson L.
- San Juan Roman Nandyelly
- Sanchez Patricia
- Sanchez-Ballesteros J.
- Sandoval Yazcitk
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- Short J.
- Shuhua Chen
- Siddiqui Sughrat
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- Silva Sales Betania
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- Simons K.
- Sjøbø Brit Å.
- Slessor Dave
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- Smischney N.
- Smith M.
- Smith Paul J.
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- Snape S.
- Snyman Lindi
- Soetens F.
- Sook Hong K.
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- Soto Giovanna Leonardo
- Souloy Xavier
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- van Axel A.
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- Vermeijden J.W.
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- Villagomez A.
- Villagra Ana
- Villegas Succar Cristina
- Vinorum O.G.
- Vitale G.
- Vj Ramesh
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- von Seth M.
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- Wang S.
- Wardi G.
- Ween-Velken Nils Christian
- Wei Bilin
- Weller D.
- Welsh Deborah
- Welters Ingeborg Dorothea M.
- Wert M.
- Whiteley Simon M.
- Wilby E.
- Williams E.
- Williams K.
- Wilson Antoinette
- Wojtas Jadwiga
- Won Huh J.
- Wrathall David Wayne
- Wright Christopher
- Wu J.-F.
- Wunsch H.
- Xi Guo
- Xing Zhengjiang
- Xu H.
- Yamamoto K.
- Yan Jie
- Yang X.
- Yates E.
- Yazicioglu Mocin Özlem
- Ye Zhenglong
- Yildirim F.
- Yoshida Norifumi
- Yoshido Hector Higo Leon
- Young Lee B.
- Yu Gong
- Yu R.
- Yu T.
- Yuan B.
- Yuangtrakul N.
- Yumoto Tetsuya
- Yun Xie
- Yáñez J.
- Zakalik G.
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zambon Massimo
- Zang Bin
- Zani G.
- Zarka Jonathan
- Zeggwagh A.A.
- Zerbi S.M.
- Zerman A.
- Zetterquist H.
- Zhang Guoxiu
- Zhang Hongwen
- Zhang Jiuzhi
- Zhang W.
- Zhang Weixin
- Zhao H.
- Zheng Jia
- Zhu Bin
- Zumaran R.
- Çukurova Z.
- Öveges Nándo
- Publication venue
- Elsevier
- Publication date
- 01/01/2023
- Field of study
International audienceBackground: Current management practices and outcomes in weaning from invasive mechanical ventilation are poorly understood. We aimed to describe the epidemiology, management, timings, risk for failure, and outcomes of weaning in patients requiring at least 2 days of invasive mechanical ventilation. Methods: WEAN SAFE was an international, multicentre, prospective, observational cohort study done in 481 intensive care units in 50 countries. Eligible participants were older than 16 years, admitted to a participating intensive care unit, and receiving mechanical ventilation for 2 calendar days or longer. We defined weaning initiation as the first attempt to separate a patient from the ventilator, successful weaning as no reintubation or death within 7 days of extubation, and weaning eligibility criteria based on positive end-expiratory pressure, fractional concentration of oxygen in inspired air, and vasopressors. The primary outcome was the proportion of patients successfully weaned at 90 days. Key secondary outcomes included weaning duration, timing of weaning events, factors associated with weaning delay and weaning failure, and hospital outcomes. This study is registered with ClinicalTrials.gov, NCT03255109. Findings: Between Oct 4, 2017, and June 25, 2018, 10 232 patients were screened for eligibility, of whom 5869 were enrolled. 4523 (77·1%) patients underwent at least one separation attempt and 3817 (65·0%) patients were successfully weaned from ventilation at day 90. 237 (4·0%) patients were transferred before any separation attempt, 153 (2·6%) were transferred after at least one separation attempt and not successfully weaned, and 1662 (28·3%) died while invasively ventilated. The median time from fulfilling weaning eligibility criteria to first separation attempt was 1 day (IQR 0–4), and 1013 (22·4%) patients had a delay in initiating first separation of 5 or more days. Of the 4523 (77·1%) patients with separation attempts, 2927 (64·7%) had a short wean (≤1 day), 457 (10·1%) had intermediate weaning (2–6 days), 433 (9·6%) required prolonged weaning (≥7 days), and 706 (15·6%) had weaning failure. Higher sedation scores were independently associated with delayed initiation of weaning. Delayed initiation of weaning and higher sedation scores were independently associated with weaning failure. 1742 (31·8%) of 5479 patients died in the intensive care unit and 2095 (38·3%) of 5465 patients died in hospital. Interpretation: In critically ill patients receiving at least 2 days of invasive mechanical ventilation, only 65% were weaned at 90 days. A better understanding of factors that delay the weaning process, such as delays in weaning initiation or excessive sedation levels, might improve weaning success rates. Funding: European Society of Intensive Care Medicine, European Respiratory Society