Redes semánticas sobre felicidad en docentes de la UNAD - Zona Sur

En la presente investigación se realizó la construcción de significados psicológicos sobre felicidad, partiendo del sujeto común no experto en la materia. Para ello se utilizó la técnica de Redes Semánticas Naturales Modificadas (RSNM), la cual se caracteriza por ser una técnica cualitativa que explora la riqueza del lenguaje del participante para describir y aportar a la construcción de significados sobre un tema de interés, en este caso felicidad, desde el conocimiento adquirido por la experiencia de vida y su interactuar con la cultura y sociedad. Esto en el contexto de la UNAD Zona Sur, específicamente con el cuerpo docente de las diferentes escuelas académicas, excepto los que pertenecen al programa de psicología, esto con el objetivo de descartar influencia disciplinaria en la construcción del concepto de interés. Dando como resultado una diferencia no significativa entre docentes psicólogos y docentes de otras disciplinas. El significado psicológico de felicidad tiene entonces una configuración más sociocultural que académica.In the present investigation the construction of psychological meanings on happiness was carried out, starting from the common subject not expert in the matter. For this, the technique of Modified Natural Semantic Networks (RSNM) was used, which is characterized by being a qualitative technique that explores the richness of the participant's language to describe and contribute to the construction of meanings on a topic of interest, in this case happiness, from the knowledge acquired by the experience of life and its interaction with culture and society. This in the context of the UNAD South Zone, specifically with the teaching staff of the different academic schools, except those belonging to the psychology program, this with the objective of ruling out disciplinary influence in the construction of the concept of interest. Resulting in a non-significant difference between teacher’s psychologists and teachers of other disciplines. The psychological meaning of happiness then has a more sociocultural than academic configuration

Diseño del sistema de control interno administrativo “Caron shoes”

Nuestro trabajo de investigación se lllevo a cabo en la empresa con nombre comercial Caron Shoes y razón social Sport 14 CR Y CIA LTDA. En el presente trabajo se plantea la implementación del diseño del sistema de Control Interno Administrativo para una Pyme perteneciente al sector de Calzado, en el cual el manejo que se da a los controles internos va en contravía de las exigencias que esta requiere y que a partir de su análisis sirva como una herramienta para fortalecer el buen funcionamiento del ente económico y así brindar un sistema que permita el fortalecimiento integral de la empresa. Una de las características más importantes que se evidencia en este grupo de empresas, es la poca importancia que se le da a la gestión de un buen Sistema de Control Interno Administrativo y las ventajas que este puede brindar.PregradoCONTADOR(A) PÚBLIC

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN

Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL maps are derived through computational staining using a convolutional neural network trained to classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and correlation with overall survival. TIL map structural patterns were grouped using standard histopathological parameters. These patterns are enriched in particular T cell subpopulations derived from molecular measures. TIL densities and spatial structure were differentially enriched among tumor types, immune subtypes, and tumor molecular subtypes, implying that spatial infiltrate state could reflect particular tumor cell aberration states. Obtaining spatial lymphocytic patterns linked to the rich genomic characterization of TCGA samples demonstrates one use for the TCGA image archives with insights into the tumor-immune microenvironment

Tapping into non-English-language science for the conservation of global biodiversity.

The widely held assumption that any important scientific information would be available in English underlies the underuse of non-English-language science across disciplines. However, non-English-language science is expected to bring unique and valuable scientific information, especially in disciplines where the evidence is patchy, and for emergent issues where synthesising available evidence is an urgent challenge. Yet such contribution of non-English-language science to scientific communities and the application of science is rarely quantified. Here, we show that non-English-language studies provide crucial evidence for informing global biodiversity conservation. By screening 419,679 peer-reviewed papers in 16 languages, we identified 1,234 non-English-language studies providing evidence on the effectiveness of biodiversity conservation interventions, compared to 4,412 English-language studies identified with the same criteria. Relevant non-English-language studies are being published at an increasing rate in 6 out of the 12 languages where there were a sufficient number of relevant studies. Incorporating non-English-language studies can expand the geographical coverage (i.e., the number of 2° × 2° grid cells with relevant studies) of English-language evidence by 12% to 25%, especially in biodiverse regions, and taxonomic coverage (i.e., the number of species covered by the relevant studies) by 5% to 32%, although they do tend to be based on less robust study designs. Our results show that synthesising non-English-language studies is key to overcoming the widespread lack of local, context-dependent evidence and facilitating evidence-based conservation globally. We urge wider disciplines to rigorously reassess the untapped potential of non-English-language science in informing decisions to address other global challenges. Please see the Supporting information files for Alternative Language Abstracts