Thrombolyse bei tiefer Venenthrombose? [Thrombolytic therapy in deep venous thrombosis?]

Sie sehen eine 45-jährige Patientin mit einem bläulich-zyanotischen rechten Bein. Vor fünf Tagen habe ein Spannungsschmerz in der Wade begonnen und sich zunehmend in den Oberschenkel hochgezogen. Die rechte Wade misst im Umfang 4 cm mehr als die linke. Die Anamnese ergibt keine familiäre oder persönliche Vorgeschichte einer thromboembolischen Erkrankung. Die Patientin ist übergewichtig ( BMI 35 kg/m2) und nimmt seit einigen Jahren eine Östrogen-Progesteron-Kombination. Der Ultraschall zeigt eine Thrombose der tiefen Beinvenen, die bis in die äussere Beckenvene reicht

Thrombose veineuse profonde : une thrombolyse est-elle efficace ? : revue cochrane pour le praticien

Scénario: Une patiente de 45 ans vous consulte car sa jambe droite est bleue, cyanosée, avec une tension dans le mollet depuis cinq jours, qui s'est étendue progressivement jusqu'au haut de la cuisse. La circonférence du mollet droit est 4 cm plus grande que celle du mollet gauche. La patiente est en surpoids (IMC à 35 kg/m2) et suit depuis quelques années un traitement oestro-progestatif. Elle n'a pas d'anamnèse familiale ou d'antécédent de maladie thromboembolique. Un ultrason montre une thrombose veineuse profonde (TVP) avec un thrombus s'étendant de la veine poplitée à la veine iliaque externe. Question: La patiente pourrait-elle bénéficier d'une thrombolyse? Contexte: Les complications de la TVP comprennent l'embolie pulmonaire et le syndrome post-thrombotique. Un syndrome post-thrombotique léger à modéré peut survenir chez 30-50% des patients malgré un traitement anticoagulant, qui prévient principalement l'embolie pulmonaire et la récidive de TVP. Cette mise à jour de revue systématique compare l'efficacité du traitement anticoagulant à celui combinant les anticoagulants et la thrombolyse (par streptokinase, urokinase ou activateur tissulaire du plasminogène)

Magnetodielectric coupling of a polar organic-inorganic hybrid Cr(II) phosphonate

Cr[(H(3)N-(CH(2))(2)-PO(3))(Cl)(H(2)O)] represents a rare example of a polar organic-inorganic hybrid material that exhibits a canted antiferromagnetic order below T(N)=5.5 K. The unusual coexistence of a polar crystal structure and magnetic order triggered our investigation of the magnetodielectric coupling. The coupling is evidenced by an anomaly in the temperature dependence of the dielectric constant epsilon below the Neel temperature. The magnetocapacitance is enhanced by one order of magnitude below T(N). The main characteristics of the magnetodielectic response are interpreted by Landau theoretical coupling terms

Investigating the high-frequency spectral features of SNRs Tycho, W44 and IC443 with the Sardinia Radio Telescope

The main characteristics in the radio continuum spectra of Supernova Remnants (SNRs) result from simple synchrotron emission. In addition, electron acceleration mechanisms can shape the spectra in specific ways, especially at high radio frequencies. These features are connected to the age and the peculiar conditions of the local interstellar medium interacting with the SNR. Whereas the bulk radio emission is expected at up to $20-50$ GHz, sensitive high-resolution images of SNRs above 10 GHz are lacking and are not easily achievable, especially in the confused regions of the Galactic Plane. In the framework of the early science observations with the Sardinia Radio Telescope in February-March 2016, we obtained high-resolution images of SNRs Tycho, W44 and IC443 that provided accurate integrated flux density measurements at 21.4 GHz: 8.8 $\pm$ 0.9 Jy for Tycho, 25 $\pm$ 3 Jy for W44 and 66 $\pm$ 7 Jy for IC443. We coupled the SRT measurements with radio data available in the literature in order to characterise the integrated and spatially-resolved spectra of these SNRs, and to find significant frequency- and region-dependent spectral slope variations. For the first time, we provide direct evidence of a spectral break in the radio spectral energy distribution of W44 at an exponential cutoff frequency of 15 $\pm$ 2 GHz. This result constrains the maximum energy of the accelerated electrons in the range $6-13$ GeV, in agreement with predictions indirectly derived from AGILE and \textit{Fermi}-LAT gamma-ray observations. With regard to IC443, our results confirm the noticeable presence of a bump in the integrated spectrum around $20-70$ GHz that could result from a spinning dust emission mechanism.Comment: 12 pages, 9 figure

A 20 GHz bright sample for {\delta} > +72{\deg}: I. Catalogue

During 2010-2011, the Medicina 32-m dish hosted the 7-feed 18-26.5 GHz receiver built for the Sardinia Radio Telescope, with the goal to perform its commissioning. This opportunity was exploited to carry out a pilot survey at 20 GHz over the area for {\delta} > + 72.3{\deg}. This paper describes all the phases of the observations, as they were performed using new hardware and software facilities. The map-making and source extraction procedures are illustrated. A customised data reduction tool was used during the follow-up phase, which produced a list of 73 confirmed sources down to a flux density of 115 mJy. The resulting catalogue, here presented, is complete above 200 mJy. Source counts are in agreement with those provided by the AT20G survey. This pilot activity paves the way to a larger project, the K-band Northern Wide Survey (KNoWS), whose final aim is to survey the whole Northern Hemisphere down to a flux limit of 50 mJy (5{\sigma}).Comment: 10 pages, 10 figures. Accepted by MNRA

Imaging of SNR IC443 and W44 with the Sardinia Radio Telescope at 1.5 GHz and 7 GHz

Observations of supernova remnants (SNRs) are a powerful tool for investigating the later stages of stellar evolution, the properties of the ambient interstellar medium, and the physics of particle acceleration and shocks. For a fraction of SNRs, multi-wavelength coverage from radio to ultra high-energies has been provided, constraining their contributions to the production of Galactic cosmic rays. Although radio emission is the most common identifier of SNRs and a prime probe for refining models, high-resolution images at frequencies above 5 GHz are surprisingly lacking, even for bright and well-known SNRs such as IC443 and W44. In the frameworks of the Astronomical Validation and Early Science Program with the 64-m single-dish Sardinia Radio Telescope, we provided, for the first time, single-dish deep imaging at 7 GHz of the IC443 and W44 complexes coupled with spatially-resolved spectra in the 1.5-7 GHz frequency range. Our images were obtained through on-the-fly mapping techniques, providing antenna beam oversampling and resulting in accurate continuum flux density measurements. The integrated flux densities associated with IC443 are S_1.5GHz = 134 +/- 4 Jy and S_7GHz = 67 +/- 3 Jy. For W44, we measured total flux densities of S_1.5GHz = 214 +/- 6 Jy and S_7GHz = 94 +/- 4 Jy. Spectral index maps provide evidence of a wide physical parameter scatter among different SNR regions: a flat spectrum is observed from the brightest SNR regions at the shock, while steeper spectral indices (up to 0.7) are observed in fainter cooling regions, disentangling in this way different populations and spectra of radio/gamma-ray-emitting electrons in these SNRs.Comment: 13 pages, 9 figures, accepted for publication to MNRAS on 18 May 201

Comparison of Cardiac and Non-Cardiac Biomarkers for Risk Stratification in Elderly Patients with Non-Massive Pulmonary Embolism.

Biomarkers unrelated to myocardial necrosis, such as cystatin C, copeptin, and mid-regional pro-adrenomedullin (MR-proADM), showed promise for cardiovascular risk prediction. Knowing whether they are comparable to cardiac biomarkers such as high-sensitive cardiac-troponin T (hs-cTnT) or N-terminal pro-Brain natriuretic peptide (NT-proBNP) in elderly patients with acute non-massive pulmonary embolism (NMPE) remains elusive. This study aims at comparing the prognostic accuracy of cardiac and non-cardiac biomarkers in patients with NMPE aged ≥65 years over time. In the context of the SWITCO65+ cohort, we evaluated 227 elderly patients with an available blood sample taken within one day from diagnosis. The primary study endpoint was defined as PE-related mortality and the secondary endpoint as PE-related complications. The biomarkers' predictive ability at 1, 3, 12 and 24 months was determined using C-statistics and Cox regression. For both study endpoints, C-statistics (95% confidence interval) were stable over time for all biomarkers, with the highest value for hs-cTnT, ranging between 0.84 (0.68-1.00) and 0.80 (0.70-0.90) for the primary endpoint, and between 0.74 (0.63-0.86) and 0.65 (0.57-0.73) for the secondary endpoint. For both study endpoints, cardiac biomarkers were found to be independently associated with risk, NT-proBNP displaying a negative predictive value of 100%. Among non-cardiac biomarkers, only copeptin and MR-proADM were independent predictors of PE-related mortality but they were not independent predictors of PE-related complications, and displayed lower negative predictive values. In elderly NMPE patients, cardiac biomarkers appear to be valuable prognostic to identify very low-risk individuals. ClinicalTrials.gov NCT00973596

Proyecto IRESUD: interconexión de sistemas fotovoltaicos a la red eléctrica en ambientes urbanos. estado de avance a julio de 2014 y primeras mediciones en sistemas piloto

En el marco de una convocatoria del Ministerio de Ciencia, Tecnología e Innovación Productiva, se conformó, en el año 2011, el consorcio público-privado IRESUD entre la Comisión Nacional de Energía Atómica (CNEA), la Universidad Nacional de San Martín (UNSAM) y 5 empresas privadas, para la ejecución del proyecto “Interconexión de Sistemas Fotovoltaicos a la Red Eléctrica en Ambientes Urbanos”. El principal objetivo del mismo es introducir en el país tecnologías asociadas con la interconexión a la red eléctrica, en áreas urbanas, de sistemas fotovoltaicos (FV), contemplando para ello cuestiones técnicas, económicas y regulatorias. En este trabajo, se presenta el grado de avance del proyecto en lo referente a las cuestiones regulatorias y a las instalaciones piloto realizadas o en ejecución en diferentes partes del país. Asimismo, se muestran las primeras mediciones de algunas de las instalaciones actualmente en operación y se analiza el comportamiento de un inversor FV de conexión a red.Fil: Durán, J. C.. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín; ArgentinaFil: Socolovsky, Hernan Pablo. Comisión Nacional de Energía Atómica; Argentina. Universidad Nacional de San Martín; ArgentinaFil: Raggio, D.. Comisión Nacional de Energía Atómica; ArgentinaFil: Godfrin, Elena María. Comisión Nacional de Energía Atómica; ArgentinaFil: Jakimczyk, J.. Universidad Tecnológica Nacional; ArgentinaFil: Martinez Bogado, Mónica Gladys. Universidad Nacional de San Martín; Argentina. Comisión Nacional de Energía Atómica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Diaz, F. J.. Universidad Nacional de La Plata. Facultad de Informática; ArgentinaFil: Castro, N. E.. Universidad Nacional de La Plata. Facultad de Informática; ArgentinaFil: Pedro, G.. Provincia del Neuquen. Ministerio de Hacienda Obras y Servivcios Publicos. Ente Provincial de Energia del Neuquen; ArgentinaFil: Sepúlveda, O.. Provincia del Neuquen. Ministerio de Hacienda Obras y Servivcios Publicos. Ente Provincial de Energia del Neuquen; ArgentinaFil: Argañaraz, C.. Provincia del Neuquen. Ministerio de Hacienda Obras y Servivcios Publicos. Ente Provincial de Energia del Neuquen; ArgentinaFil: Benítez, E.. Universidad Nacional de Luján; ArgentinaFil: Roldán, A.. Universidad Nacional de Luján; ArgentinaFil: Righini, R.. Universidad Nacional de Luján; Argentin

The Extreme Energy Events HECR array: status and perspectives

The Extreme Energy Events Project is a synchronous sparse array of 52 tracking detectors for studying High Energy Cosmic Rays (HECR) and Cosmic Rays-related phenomena. The observatory is also meant to address Long Distance Correlation (LDC) phenomena: the network is deployed over a broad area covering 10 degrees in latitude and 11 in longitude. An overview of a set of preliminary results is given, extending from the study of local muon flux dependance on solar activity to the investigation of the upward-going component of muon flux traversing the EEE stations; from the search for anisotropies at the sub-TeV scale to the hints for observations of km-scale Extensive Air Shower (EAS).Comment: XXV ECRS 2016 Proceedings - eConf C16-09-04.