255 research outputs found

    Interaction quantum quenches in the one-dimensional Fermi-Hubbard model with spin imbalance

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    Using the time-dependent density matrix renormalization group method and exact diagonalization, we study the non-equilibrium dynamics of the one-dimensional Fermi-Hubbard model following a quantum quench or a ramp of the onsite interaction strength. For quenches from the non-interacting to the attractive regime, we investigate the dynamical emergence of Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) correlations, which at finite spin polarizations are the dominant two-body correlations in the ground state, and their signatures in the pair quasi-momentum distribution function. We observe that the post-quench double occupancy exhibits a maximum as the interaction strength becomes of the order of the bandwidth. Finally, we study quenches and ramps from attractive to repulsive interactions, which imprint FFLO correlations onto repulsively bound pairs. We show that a quite short ramp time is sufficient to wipe out the characteristic FFLO features in the post-quench pair momentum distribution functions.Comment: 13 pages, 15 figures, minor revisions, version as publishe

    Optical beam guidance in monolithic polymer chips for miniaturized colorimetric assays

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    For the first time, we present a simple and robust optical concept to enable precise and sensitive read-out of colorimetric assays in flat lab-on-a-chip devices. The optical guidance of the probe beam through an incorporated measurement chamber to the detector is based on the total internal reflection at V-grooves in the polymer chip. This way, the optical path length through the flat measurement chamber and thus the performance of the measurements are massively enhanced compared to direct (perpendicular) beam incidence. This is demonstrated by a chip-based, colorimetric glucose-assay on serum. Outstanding features are an excellent reproducibility (CV= 1.91 %), a competitive lower limit of detection (cmin = 124 μM), and a high degree of linearity (R2 = 0.998) within a working range extending over nearly three orders of magnitude

    Stabilisation of river dykes with drainage elements

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    In recent times, enormous damage has been caused by dyke failures during and after river flood disasters throughout the world. Besides extreme meteorological conditions the reasons for these failures are inadequate design and the actual condition of affected dyke structures. <br><br> To minimize the occurrence of dyke failures in future, in a national BMBF research project (BMBF: German Federal Ministry of Education and Research) an alternative stabilisation technique has been investigated as an instrument for short term refurbishment and as an improvement to existing and endangered dyke structures. <br><br> It is intended to improve the stability of dyke structures by the mechanical installation of drainage devices, thus preventing dyke failure by controlling the seepage in the structure. <br><br> Within the scope of this paper selected results concerning stabilizing capability and feasibility of the stabilisation technique are presented in detail. Concerning feasibility the focus is placed on natural scale model tests to verify numerical calculations and to investigate the suitability of the adapted installation methods in situ

    Parallelization of chip-based fluorescence immuno-assays with quantum-dot labelled beads

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    This paper presents an optical concept for the read-out of a parallel, bead-based fluorescence immunoassay conducted on a lab-on-a-disk platform. The reusable part of the modular setup comprises a detection unit featuring a single LED as light source, two emission-filters, and a color CCD-camera as standard components together with a spinning drive as actuation unit. The miniaturized lab-on-a-disk is devised as a disposable. In the read-out process of the parallel assay, beads are first identified by the color of incorporated quantum dots (QDs). Next, the reaction-specific fluorescence signal is quantified with FluoSpheres-labeled detection anti-bodies. To enable a fast and automated read-out, suitable algorithms have been implemented in this work. Based on this concept, we successfully demonstrated a Hepatitis-A assay on our disk-based lab-on-a-chip

    Bispectral index monitoring during cardiopulmonary resuscitation repeated twice within 8 days in the same patient: a case report

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    Research on cardiac resuscitation has led to various changes in the techniques and drug administration involved in modern advanced life support. Besides improving primary cardiac survival, interest is increasingly focused on a favourable neurological outcome. However, until now there has been no on-site equipment to support the clinical observations of the cardiopulmonary resuscitation (CPR) team. Bispectral index (BIS) monitoring has been used for avoiding awareness during anaesthesia for many years. We report a case of a 68-year-old patient suffering twice from cardiac arrest due to thromboembolism within a few days. While the first cardiac resuscitation was survived without neurological consequences, the patient died after the second event. Both resuscitation events were monitored using the BIS. We discuss the course of BIS values and their possible contribution to the prediction of outcome

    Seasonal hydrologic buffer on continents : patterns, drivers and ecological benefits

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    This work has been supported by the Consejo Nacional de Investigaciones Científicas (CONICET) and the Agencia Nacional de Promoción Científica y Tecnológica of Argentina. GRACE land products are available at http://grace.jpl.nasa.gov, supported by the NASA MEaSUREs Program. ERAI/LAND precipitation and snowfall and ERA-Interim evaporation datasets are available from the Web Applications Server of the European Center for Medium Range Weather Forecasting (ECMWF), respectively at http://apps.ecmwf.int/datasets/data/interim-land/ and http://apps.ecmwf.int/datasets/data/interim-full-daily/, while potential evaporation of CRU TS3.23 can be retrieved from http://www.cru.uea.ac.uk/cru/data/hrg/cru_ts_3.23/. The SRTM data can be accessed through the Long Term Archive portal of USGS (https://lta.cr.usgs.gov/SRTM), the MODIS data was obtained using the REVERB data portal (http://reverb.echo.nasa.gov), and the ESA-CCI land cover data and the corresponding sub-setting/re-projecting/re-sampling tools are available on http://www.esa-landcover-cci.org. We thank two anonymous referees whose comments and suggestions significantly improved the analysis and the presentation of the material in this paper.Peer reviewedPostprintPostprintPublisher PD

    Atrial natriuretic factor

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    The discovery of the first well-defined natriuretic hormone, the Atrial Natriuretic Factor (ANF), has prompted research on its impact on volume regulation in health and disease. The natriuretic, diuretic, and smooth muscle-relaxing properties suggest an important role of this novel hormone in pathophysiological states with sodium or volume retention, such as congestive heart failure or cirrhosis of the liver. Investigations on the implications of ANF in liver disease have been performed for little more than 1 year, and results are still controversial in many respects. At present, it seems very likely that there is no absolute deficiency of plasma ANF in patients with cirrhosis. Moreover, elevated plasma levels in cirrhotics with ascites have been reported by several groups. However, as yet, a molecular characterization of this increased immunoreactivity is still lacking. There is disagreement on the reduced release of and renal response to ANF in subgroups of cirrhotics; however, stimulus-response-coupling might be impaired. Further studies are needed to elucidate the pathophysiological implications and therapeutical potential of ANF in patients with chronic liver disease

    Integrated acoustic immunoaffinity-capture (IAI) platform for detection of PSA from whole blood samples.

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    On-chip detection of low abundant protein biomarkers is of interest to enable point-of-care diagnostics. Using a simple form of integration, we have realized an integrated microfluidic platform for the detection of prostate specific antigen (PSA), directly in anti-coagulated whole blood. We combine acoustophoresis-based separation of plasma from undiluted whole blood with a miniaturized immunoassay system in a polymer manifold, demonstrating improved assay speed on our Integrated Acoustic Immunoaffinity-capture (IAI) platform. The IAI platform separates plasma from undiluted whole blood by means of acoustophoresis and provides cell free plasma of clinical quality at a rate of 10 uL/min for an online immunoaffinity-capture of PSA on a porous silicon antibody microarray. The whole blood input (hematocrit 38-40%) rate was 50 μl min(-1) giving a plasma volume fraction yield of ≈33%. PSA was immunoaffinity-captured directly from spiked female whole blood samples at clinically significant levels of 1.7-100 ng ml(-1) within 15 min and was subsequently detected via fluorescence readout, showing a linear response over the entire range with a coefficient of variation of 13%
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