1,176 research outputs found
Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).
BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule. We demonstrate the effectiveness of this schedule in a noncontrolled, multinational drug-utilization study. METHODS: A total of 2020 patients with late-stage HAT were treated with the 10-day melarsoprol schedule in 16 centers in 7 African countries. We assessed outcome on the basis of major adverse events and the cure rate after treatment and during 2 years of follow-up. RESULTS: The cure rate 24 h after treatment was 93.9%; 2 years later, it was 86.2%. However, 49.3% of patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular eruptions was 0.8% and 6.8%, respectively. CONCLUSIONS: The 10-day treatment schedule was well implemented in the field and was effective. It reduces treatment duration, drug amount, and hospitalization costs per patient, and it increases treatment-center capacity. The shorter protocol has been recommended by the International Scientific Council for Trypanosomiasis Research and Control for the treatment of late-stage HAT caused by Trypanosoma brucei gambiense
Phase transitions in a gas of anyons
We continue our numerical Monte Carlo simulation of a gas of closed loops on
a 3 dimensional lattice, however now in the presence of a topological term
added to the action corresponding to the total linking number between the
loops. We compute the linking number using certain notions from knot theory.
Adding the topological term converts the particles into anyons. Using the
correspondence that the model is an effective theory that describes the
2+1-dimensional Abelian Higgs model in the asymptotic strong coupling regime,
the topological linking number simply corresponds to the addition to the action
of the Chern-Simons term. We find the following new results. The system
continues to exhibit a phase transition as a function of the anyon mass as it
becomes small \cite{mnp}, although the phases do not change the manifestation
of the symmetry. The Chern-Simons term has no effect on the Wilson loop, but it
does affect the {\rm '}t Hooft loop. For a given configuration it adds the
linking number of the 't Hooft loop with all of the dynamical vortex loops to
the action. We find that both the Wilson loop and the 't Hooft loop exhibit a
perimeter law even though there are no massless particles in the theory, which
is unexpected.Comment: 6 pages, 5 figure
Deep near-IR observations of the Globular Cluster M4: Hunting for Brown Dwarfs
We present an analysis of deep HST/WFC3 near-IR (NIR) imaging data of the
globular cluster M4. The best-photometry NIR colour-magnitude diagram (CMD)
clearly shows the main sequence extending towards the expected end of the
Hydrogen-burning limit and going beyond this point towards fainter sources. The
white dwarf sequence can be identified. As such, this is the deepest NIR CMD of
a globular cluster to date. Archival HST optical data were used for
proper-motion cleaning of the CMD and for distinguishing the white dwarfs (WDs)
from brown dwarf (BD) candidates. Detection limits in the NIR are around F110W
approx 26.5 mag and F160W approx27 mag, and in the optical around F775W approx
28 mag. Comparing our observed CMDs with theoretical models, we conclude that
we have reached beyond the H-burning limit in our NIR CMD and are probably just
above or around this limit in our optical-NIR CMDs. Thus, any faint NIR sources
that have no optical counterpart are potential BD candidates, since the optical
data are not deep enough to detect them. We visually inspected the positions of
NIR sources which are fainter than the H-burning limit in F110W and for which
the optical photometry did not return a counterpart. We found in total five
sources for which we did not get an optical measurement. For four of these five
sources, a faint optical counterpart could be visually identified, and an upper
optical magnitude was estimated. Based on these upper optical magnitude limits,
we conclude that one source is likely a WD, one source could either be a WD or
BD candidate, and the remaining two sources agree with being BD candidates. For
only one source no optical counterpart could be detected, which makes this
source a good BD candidate. We conclude that we found in total four good BD
candidates.Comment: ApJ accepted, 28 pages including 16 figure
Early Huntington's disease affects movements in transformed sensorimotor mappings
This study examined the effect of transformed visual feedback on movement control in Huntington’s disease (HD). Patients in the early stages of HD and controls performed aiming movements towards peripheral targets on a digitizing tablet using an indirect visual control of movement through a monitor and emphasizing precision. In a baseline condition, HD patients were slower but showed few precision problems in aiming. When visual feedback was inverted in both vertical and horizontal axes, patients showed problems in initial and terminal phases of movement where feedback is most critical. When visual feedback was inverted along a single axis as in a mirror-inversion, HD patients showed large deviations and over-corrections before adaptation. Adaptation was similar in both groups. These results suggest that HD impairs on-line error correction in novel movements
Models of Metal Poor Stars with Gravitational Settling and Radiative Accelerations: I. Evolution and Abundance Anomalies
Evolutionary models have been calculated for Pop II stars of 0.5 to
1.0 from the pre-main-sequence to the lower part of the giant branch.
Rosseland opacities and radiative accelerations were calculated taking into
account the concentration variations of 28 chemical species, including all
species contributing to Rosseland opacities in the OPAL tables. The effects of
radiative accelerations, thermal diffusion and gravitational settling are
included. While models were calculated both for Z=0.00017 and 0.0017, we
concentrate on models with Z=0.00017 in this paper. These are the first Pop II
models calculated taking radiative acceleration into account. It is shown that,
at least in a 0.8 star, it is a better approximation not to let Fe
diffuse than to calculate its gravitational settling without including the
effects of . In the absence of any turbulence outside of
convection zones, the effects of atomic diffusion are large mainly for stars
more massive than 0.7. Overabundances are expected in some stars with
\teff \ge 6000K. Most chemical species heavier than CNO are affected. At 12
Gyr, overabundance factors may reach 10 in some cases (e.g. for Al or Ni) while
others are limited to 3 (e.g. for Fe). The calculated surface abundances are
compared to recent observations of abundances in globular clusters as well as
to observations of Li in halo stars. It is shown that, as in the case of Pop I
stars, additional turbulence appears to be present.Comment: 40 pages, 17 color figures, to appear in The Astrophysical Journal,
April 2002 (paper with original high resolution figures can be found at
http://www.cerca.umontreal.ca/~richer/Fichiersps/popII_1.ps
A {\mu}-TPC detector for the characterization of low energy neutron fields
The AMANDE facility produces monoenergetic neutron fields from 2 keV to 20
MeV for metrological purposes. To be considered as a reference facility,
fluence and energy distributions of neutron fields have to be determined by
primary measurement standards. For this purpose, a micro Time Projection
Chamber is being developed to be dedicated to measure neutron fields with
energy ranging from 8 keV up to 1 MeV. In this work we present simulations
showing that such a detector, which allows the measurement of the ionization
energy and the 3D reconstruction of the recoil nucleus, provides the
determination of neutron energy and fluence of these neutron fields
Stellar Evolution in NGC 6791: Mass Loss on the Red Giant Branch and the Formation of Low Mass White Dwarfs
We present the first detailed study of the properties (temperatures,
gravities, and masses) of the NGC 6791 white dwarf population. This unique
stellar system is both one of the oldest (8 Gyr) and most metal-rich ([Fe/H] ~
0.4) open clusters in our Galaxy, and has a color-magnitude diagram (CMD) that
exhibits both a red giant clump and a much hotter extreme horizontal branch.
Fitting the Balmer lines of the white dwarfs in the cluster, using Keck/LRIS
spectra, suggests that most of these stars are undermassive, = 0.43 +/-
0.06 Msun, and therefore could not have formed from canonical stellar evolution
involving the helium flash at the tip of the red giant branch. We show that at
least 40% of NGC 6791's evolved stars must have lost enough mass on the red
giant branch to avoid the flash, and therefore did not convert helium into
carbon-oxygen in their core. Such increased mass loss in the evolution of the
progenitors of these stars is consistent with the presence of the extreme
horizontal branch in the CMD. This unique stellar evolutionary channel also
naturally explains the recent finding of a very young age (2.4 Gyr) for NGC
6791 from white dwarf cooling theory; helium core white dwarfs in this cluster
will cool ~3 times slower than carbon-oxygen core stars and therefore the
corrected white dwarf cooling age is in fact ~7 Gyr, consistent with the well
measured main-sequence turnoff age. These results provide direct empirical
evidence that mass loss is much more efficient in high metallicity environments
and therefore may be critical in interpreting the ultraviolet upturn in
elliptical galaxies.Comment: 15 pages, 9 figures, 2 tables. Accepted for publication in Astrophys.
J. Very minor changes from first versio
A trio of new Local Group galaxies with extreme properties
We report on the discovery of three new dwarf galaxies in the Local Group.
These galaxies are found in new CFHT/MegaPrime g,i imaging of the south-western
quadrant of M31, extending our extant survey area to include the majority of
the southern hemisphere of M31's halo out to 150 kpc. All these galaxies have
stellar populations which appear typical of dwarf spheroidal (dSph) systems.
The first of these galaxies, Andromeda XVIII, is the most distant Local Group
dwarf discovered in recent years, at ~1.4 Mpc from the Milky Way (~ 600 kpc
from M31). The second galaxy, Andromeda XIX, a satellite of M31, is the most
extended dwarf galaxy known in the Local Group, with a half-light radius of r_h
~ 1.7 kpc. This is approximately an order of magnitude larger than the typical
half-light radius of many Milky Way dSphs, and reinforces the difference in
scale sizes seen between the Milky Way and M31 dSphs (such that the M31 dwarfs
are generally more extended than their Milky Way counterparts). The third
galaxy, Andromeda XX, is one of the faintest galaxies so far discovered in the
vicinity of M31, with an absolute magnitude of order M_V ~ -6.3. Andromeda
XVIII, XIX and XX highlight different aspects of, and raise important questions
regarding, the formation and evolution of galaxies at the extreme faint-end of
the luminosity function. These findings indicate that we have not yet sampled
the full parameter space occupied by dwarf galaxies, although this is an
essential pre-requisite for successfully and consistently linking these systems
to the predicted cosmological dark matter sub-structure.Comment: 32 pages, 7 figures (ApJ preprint format). Accepted for publication
in Ap
The ionization mechanism of NGC 185: how to fake a Seyfert galaxy?
NGC 185 is a dwarf spheroidal satellite of the Andromeda galaxy. From
mid-1990s onwards it was revealed that dwarf spheroidals often display a varied
and in some cases complex star formation history. In an optical survey of
bright nearby galaxies, NGC 185 was classified as a Seyfert galaxy based on its
emission line ratios. However, although the emission lines in this object
formally place it in the category of Seyferts, it is probable that this galaxy
does not contain a genuine active nucleus. NGC 185 was not detected in radio
surveys either in 6 or 20 cm, or X-ray observations, which means that the
Seyfert-like line ratios may be produced by stellar processes. In this work, we
try to identify the possible ionization mechanisms for this galaxy. We
discussed the possibility of the line emissions being produced by planetary
nebulae (PNe), using deep spectroscopy observations obtained with GMOS-N, at
Gemini. Although the fluxes of the PNe are high enough to explain the
integrated spectrum, the line ratios are very far from the values for the
Seyfert classification. We then proposed that a mixture of supernova remnants
and PNe could be the source of the ionization, and we show that a composition
of these two objects do mimic Seyfert-like line ratios. We used chemical
evolution models to predict the supernova rates and to support the idea that
these supernova remnants should be present in the galaxy.Comment: 9 pages, 7 figures, accepted for publication in MNRA
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