Effectiveness of a 10-day melarsoprol schedule for the treatment of late-stage human African trypanosomiasis: confirmation from a multinational study (IMPAMEL II).

BACKGROUND: Treatment of late-stage human African trypanosomiasis (HAT) with melarsoprol can be improved by shortening the regimen. A previous trial demonstrated the safety and efficacy of a 10-day treatment schedule. We demonstrate the effectiveness of this schedule in a noncontrolled, multinational drug-utilization study. METHODS: A total of 2020 patients with late-stage HAT were treated with the 10-day melarsoprol schedule in 16 centers in 7 African countries. We assessed outcome on the basis of major adverse events and the cure rate after treatment and during 2 years of follow-up. RESULTS: The cure rate 24 h after treatment was 93.9%; 2 years later, it was 86.2%. However, 49.3% of patients were lost to follow-up. The overall fatality rate was 5.9%. Of treated patients, 8.7% had an encephalopathic syndrome that was fatal 45.5% of the time. The rate of severe bullous and maculopapular eruptions was 0.8% and 6.8%, respectively. CONCLUSIONS: The 10-day treatment schedule was well implemented in the field and was effective. It reduces treatment duration, drug amount, and hospitalization costs per patient, and it increases treatment-center capacity. The shorter protocol has been recommended by the International Scientific Council for Trypanosomiasis Research and Control for the treatment of late-stage HAT caused by Trypanosoma brucei gambiense

Phase transitions in a gas of anyons

We continue our numerical Monte Carlo simulation of a gas of closed loops on a 3 dimensional lattice, however now in the presence of a topological term added to the action corresponding to the total linking number between the loops. We compute the linking number using certain notions from knot theory. Adding the topological term converts the particles into anyons. Using the correspondence that the model is an effective theory that describes the 2+1-dimensional Abelian Higgs model in the asymptotic strong coupling regime, the topological linking number simply corresponds to the addition to the action of the Chern-Simons term. We find the following new results. The system continues to exhibit a phase transition as a function of the anyon mass as it becomes small \cite{mnp}, although the phases do not change the manifestation of the symmetry. The Chern-Simons term has no effect on the Wilson loop, but it does affect the {\rm '}t Hooft loop. For a given configuration it adds the linking number of the 't Hooft loop with all of the dynamical vortex loops to the action. We find that both the Wilson loop and the 't Hooft loop exhibit a perimeter law even though there are no massless particles in the theory, which is unexpected.Comment: 6 pages, 5 figure

Deep near-IR observations of the Globular Cluster M4: Hunting for Brown Dwarfs

We present an analysis of deep HST/WFC3 near-IR (NIR) imaging data of the globular cluster M4. The best-photometry NIR colour-magnitude diagram (CMD) clearly shows the main sequence extending towards the expected end of the Hydrogen-burning limit and going beyond this point towards fainter sources. The white dwarf sequence can be identified. As such, this is the deepest NIR CMD of a globular cluster to date. Archival HST optical data were used for proper-motion cleaning of the CMD and for distinguishing the white dwarfs (WDs) from brown dwarf (BD) candidates. Detection limits in the NIR are around F110W approx 26.5 mag and F160W approx27 mag, and in the optical around F775W approx 28 mag. Comparing our observed CMDs with theoretical models, we conclude that we have reached beyond the H-burning limit in our NIR CMD and are probably just above or around this limit in our optical-NIR CMDs. Thus, any faint NIR sources that have no optical counterpart are potential BD candidates, since the optical data are not deep enough to detect them. We visually inspected the positions of NIR sources which are fainter than the H-burning limit in F110W and for which the optical photometry did not return a counterpart. We found in total five sources for which we did not get an optical measurement. For four of these five sources, a faint optical counterpart could be visually identified, and an upper optical magnitude was estimated. Based on these upper optical magnitude limits, we conclude that one source is likely a WD, one source could either be a WD or BD candidate, and the remaining two sources agree with being BD candidates. For only one source no optical counterpart could be detected, which makes this source a good BD candidate. We conclude that we found in total four good BD candidates.Comment: ApJ accepted, 28 pages including 16 figure

Early Huntington's disease affects movements in transformed sensorimotor mappings

This study examined the effect of transformed visual feedback on movement control in Huntington’s disease (HD). Patients in the early stages of HD and controls performed aiming movements towards peripheral targets on a digitizing tablet using an indirect visual control of movement through a monitor and emphasizing precision. In a baseline condition, HD patients were slower but showed few precision problems in aiming. When visual feedback was inverted in both vertical and horizontal axes, patients showed problems in initial and terminal phases of movement where feedback is most critical. When visual feedback was inverted along a single axis as in a mirror-inversion, HD patients showed large deviations and over-corrections before adaptation. Adaptation was similar in both groups. These results suggest that HD impairs on-line error correction in novel movements

Models of Metal Poor Stars with Gravitational Settling and Radiative Accelerations: I. Evolution and Abundance Anomalies

Evolutionary models have been calculated for Pop II stars of 0.5 to 1.0$M_\odot$ from the pre-main-sequence to the lower part of the giant branch. Rosseland opacities and radiative accelerations were calculated taking into account the concentration variations of 28 chemical species, including all species contributing to Rosseland opacities in the OPAL tables. The effects of radiative accelerations, thermal diffusion and gravitational settling are included. While models were calculated both for Z=0.00017 and 0.0017, we concentrate on models with Z=0.00017 in this paper. These are the first Pop II models calculated taking radiative acceleration into account. It is shown that, at least in a 0.8$M_\odot$ star, it is a better approximation not to let Fe diffuse than to calculate its gravitational settling without including the effects of $g_{rad}(Fe)$. In the absence of any turbulence outside of convection zones, the effects of atomic diffusion are large mainly for stars more massive than 0.7$M_\odot$. Overabundances are expected in some stars with \teff \ge 6000K. Most chemical species heavier than CNO are affected. At 12 Gyr, overabundance factors may reach 10 in some cases (e.g. for Al or Ni) while others are limited to 3 (e.g. for Fe). The calculated surface abundances are compared to recent observations of abundances in globular clusters as well as to observations of Li in halo stars. It is shown that, as in the case of Pop I stars, additional turbulence appears to be present.Comment: 40 pages, 17 color figures, to appear in The Astrophysical Journal, April 2002 (paper with original high resolution figures can be found at http://www.cerca.umontreal.ca/~richer/Fichiersps/popII_1.ps

A {\mu}-TPC detector for the characterization of low energy neutron fields

The AMANDE facility produces monoenergetic neutron fields from 2 keV to 20 MeV for metrological purposes. To be considered as a reference facility, fluence and energy distributions of neutron fields have to be determined by primary measurement standards. For this purpose, a micro Time Projection Chamber is being developed to be dedicated to measure neutron fields with energy ranging from 8 keV up to 1 MeV. In this work we present simulations showing that such a detector, which allows the measurement of the ionization energy and the 3D reconstruction of the recoil nucleus, provides the determination of neutron energy and fluence of these neutron fields

Stellar Evolution in NGC 6791: Mass Loss on the Red Giant Branch and the Formation of Low Mass White Dwarfs

We present the first detailed study of the properties (temperatures, gravities, and masses) of the NGC 6791 white dwarf population. This unique stellar system is both one of the oldest (8 Gyr) and most metal-rich ([Fe/H] ~ 0.4) open clusters in our Galaxy, and has a color-magnitude diagram (CMD) that exhibits both a red giant clump and a much hotter extreme horizontal branch. Fitting the Balmer lines of the white dwarfs in the cluster, using Keck/LRIS spectra, suggests that most of these stars are undermassive, = 0.43 +/- 0.06 Msun, and therefore could not have formed from canonical stellar evolution involving the helium flash at the tip of the red giant branch. We show that at least 40% of NGC 6791's evolved stars must have lost enough mass on the red giant branch to avoid the flash, and therefore did not convert helium into carbon-oxygen in their core. Such increased mass loss in the evolution of the progenitors of these stars is consistent with the presence of the extreme horizontal branch in the CMD. This unique stellar evolutionary channel also naturally explains the recent finding of a very young age (2.4 Gyr) for NGC 6791 from white dwarf cooling theory; helium core white dwarfs in this cluster will cool ~3 times slower than carbon-oxygen core stars and therefore the corrected white dwarf cooling age is in fact ~7 Gyr, consistent with the well measured main-sequence turnoff age. These results provide direct empirical evidence that mass loss is much more efficient in high metallicity environments and therefore may be critical in interpreting the ultraviolet upturn in elliptical galaxies.Comment: 15 pages, 9 figures, 2 tables. Accepted for publication in Astrophys. J. Very minor changes from first versio

A trio of new Local Group galaxies with extreme properties

We report on the discovery of three new dwarf galaxies in the Local Group. These galaxies are found in new CFHT/MegaPrime g,i imaging of the south-western quadrant of M31, extending our extant survey area to include the majority of the southern hemisphere of M31's halo out to 150 kpc. All these galaxies have stellar populations which appear typical of dwarf spheroidal (dSph) systems. The first of these galaxies, Andromeda XVIII, is the most distant Local Group dwarf discovered in recent years, at ~1.4 Mpc from the Milky Way (~ 600 kpc from M31). The second galaxy, Andromeda XIX, a satellite of M31, is the most extended dwarf galaxy known in the Local Group, with a half-light radius of r_h ~ 1.7 kpc. This is approximately an order of magnitude larger than the typical half-light radius of many Milky Way dSphs, and reinforces the difference in scale sizes seen between the Milky Way and M31 dSphs (such that the M31 dwarfs are generally more extended than their Milky Way counterparts). The third galaxy, Andromeda XX, is one of the faintest galaxies so far discovered in the vicinity of M31, with an absolute magnitude of order M_V ~ -6.3. Andromeda XVIII, XIX and XX highlight different aspects of, and raise important questions regarding, the formation and evolution of galaxies at the extreme faint-end of the luminosity function. These findings indicate that we have not yet sampled the full parameter space occupied by dwarf galaxies, although this is an essential pre-requisite for successfully and consistently linking these systems to the predicted cosmological dark matter sub-structure.Comment: 32 pages, 7 figures (ApJ preprint format). Accepted for publication in Ap

The ionization mechanism of NGC 185: how to fake a Seyfert galaxy?

NGC 185 is a dwarf spheroidal satellite of the Andromeda galaxy. From mid-1990s onwards it was revealed that dwarf spheroidals often display a varied and in some cases complex star formation history. In an optical survey of bright nearby galaxies, NGC 185 was classified as a Seyfert galaxy based on its emission line ratios. However, although the emission lines in this object formally place it in the category of Seyferts, it is probable that this galaxy does not contain a genuine active nucleus. NGC 185 was not detected in radio surveys either in 6 or 20 cm, or X-ray observations, which means that the Seyfert-like line ratios may be produced by stellar processes. In this work, we try to identify the possible ionization mechanisms for this galaxy. We discussed the possibility of the line emissions being produced by planetary nebulae (PNe), using deep spectroscopy observations obtained with GMOS-N, at Gemini. Although the fluxes of the PNe are high enough to explain the integrated spectrum, the line ratios are very far from the values for the Seyfert classification. We then proposed that a mixture of supernova remnants and PNe could be the source of the ionization, and we show that a composition of these two objects do mimic Seyfert-like line ratios. We used chemical evolution models to predict the supernova rates and to support the idea that these supernova remnants should be present in the galaxy.Comment: 9 pages, 7 figures, accepted for publication in MNRA