Moderns Emphasize Health

Sleep is a first essential in collegiate happiness, say Adelaide Richardson

Veishea Presents a Study in Modernity

Adelaide Richardson checks up on departmental open house plan

The Iowa Homemaker vol.19, no.6

The Home, page 1 Streamlining in Local Fashion, page 2 From Simpleton to Smartie, page 3 Pretty as a Valentine, page 4 Playing House in College, page 6 Through Pre-School Days, page 7 What’s New in Home Economics, page 8 Home Fires of Mount Vernon, page 10 From Journalistic Spindles, page 11 The Journalistic Touch, page 12 Alums in the News, page 13 Behind Bright Jackets, page 14 Inquisitive Intellect, page 15 Biography of a Home Economist, page 1

Huntingtin associates with the actin cytoskeleton and alpha-actinin isoforms to influence stimulus dependent morphology changes

One response of cells to growth factor stimulus involves changes in morphology driven by the actin cytoskeleton and actin associated proteins which regulate functions such as cell adhesion, motility and in neurons, synaptic plasticity. Previous studies suggest that Huntingtin may be involved in regulating morphology however, there has been limited evidence linking endogenous Huntingtin localization or function with cytoplasmic actin in cells. We found that depletion of Huntingtin in human fibroblasts reduced adhesion and altered morphology and these phenotypes were made worse with growth factor stimulation, whereas the presence of the Huntington\u27s Disease mutation inhibited growth factor induced changes in morphology and increased numbers of vinculin-positive focal adhesions. Huntingtin immunoreactivity localized to actin stress fibers, vinculin-positive adhesion contacts and membrane ruffles in fibroblasts. Interactome data from others has shown that Huntingtin can associate with alpha-actinin isoforms which bind actin filaments. Mapping studies using a cDNA encoding alpha-actinin-2 showed that it interacts within Huntingtin aa 399-969. Double-label immunofluorescence showed Huntingtin and alpha-actinin-1 co-localized to stress fibers, membrane ruffles and lamellar protrusions in fibroblasts. Proximity ligation assays confirmed a close molecular interaction between Huntingtin and alpha-actinin-1 in human fibroblasts and neurons. Huntingtin silencing with siRNA in fibroblasts blocked the recruitment of alpha-actinin-1 to membrane foci. These studies support the idea that Huntingtin is involved in regulating adhesion and actin dependent functions including those involving alpha-actinin

The Iowa Homemaker vol.19, no.2

Dedication, page 1 Personality and Popularity, page 2 Herbs – the Secret of Foreign Contries, page 3 Dear Sis, page 4 Home Economics Women Take the Air, page 5 Sally’s Predictions, page 6 Iowa State’s Honoraries, page 8 The Carillon, page 9 What’s New in Home Economics, page 10 Moderns Emphasize Health, page 12 A Book Lover’s Boon, page 13 Behind Bright Jackets, page 14 Alums in the News, page 15 Dreams of a Dorm Room, page 16 A Worthy Phi U Project, page 18 From Journalistic Spindles, page 19 Biography of a Home Economist, page 2

The Iowa Homemaker vol.20, no.1

Recreation that Recreates, Editor, page 1 Dual Personalities, Catherine Raymond, page 2 Married Right Out of College, Mary Ellen Lynch Brown, page 3 Sally Bows to Summer’s Sun, Kathryn Cooley, page 4 Selling Yourself, Kathryn Monson, page 6 I Want a Cotton Dress, Marcia E. Turner, page 7 Playtime Pays Dividends, Jane Wiley, page 8 Behind Closed Doors, Margaret Kumlien, page 9 Sunshine Sports, Jeanette Woodward, page 10 Packing the Convention Bag, Shirley Ambrose, page 11 What’s New in Home Economics, page 12 Veishea Presents, Adelaide Richardson, page 14 Picnic Basket, Dorothy Jo Weber, page 16 Alums in the News, Bette Simpson, page 17 Make Room for Music, Nancy Mason, page 18 Behind Bright Jackets, Betty Bice, page 20 Journalistic Spindles, Dorothy Anne Roost, page 23 Biography of a Home Economist, Eleanor White, page 2

Phage Therapy and Photodynamic Therapy: Low Environmental Impact Approaches to Inactivate Microorganisms in Fish Farming Plants

Owing to the increasing importance of aquaculture to compensate for the progressive worldwide reduction of natural fish and to the fact that several fish farming plants often suffer from heavy financial losses due to the development of infections caused by microbial pathogens, including multidrug resistant bacteria, more environmentally-friendly strategies to control fish infections are urgently needed to make the aquaculture industry more sustainable. The aim of this review is to briefly present the typical fish farming diseases and their threats and discuss the present state of chemotherapy to inactivate microorganisms in fish farming plants as well as to examine the new environmentally friendly approaches to control fish infection namely phage therapy and photodynamic antimicrobial therapy

Veishea Presents a Study in Modernity

Adelaide Richardson checks up on departmental open house plans</p

Streamlining in Local Fashion

Adelaide Richardson brings the newest in household conveniences from a trip through Ames homes.</p