{1,1′-[(2,2-Dimethyl­propane-1,3-di­yl)bis­(nitrilo­methyl­idyne)]di-2-naphthol­ato}dioxidomolybdenum(VI) dichloro­methane 1.75-solvate

In the crystal structure of the title compound, [Mo(C27H24N2O2)O2]·1.75CH2Cl2, the MoVI ion is coordinated by two oxide O atoms and by two O and two N atoms of the tetra­dentate 1,1′-[(2,2-dimethyl­propane-1,3-di­yl)bis­(nitrilo­methyl­idyne)]di-2-naphtholate Schiff base ligand in a distorted octa­hedral configuration. The compound crystallizes with 1.75 mol­ecules of dichloro­methane per complex mol­ecule. In the crystal, symmetry-related mol­ecules are linked by a number of C—H⋯O inter­actions involving both the Schiff base ligand and the partly disordered dichloro­methane solvent mol­ecules, leading to the formation of a two-dimensional network extending parallel to (101)

Methano­ldioxido{1-[(2RS)-(2-oxidoprop­yl)iminometh­yl]-2-naphtholato}molybdenium(VI)

Crystals of the title compound, [Mo(C14H13NO2)O2(CH4O)], were obtained by recrystallization from methanol. The MoVI atom is coordinated by two oxide O atoms and by two O atoms and one N atom of the tridentate 1-[(2-oxidoprop­yl)iminometh­yl]-2-naphtholate Schiff base ligand. The coordination sphere is completed by the O atom of a methanol mol­ecule, yielding a distorted octa­hedron. O—H⋯O hydrogen bonding yields centrosymmetric dimers

Temperature and pH-responsive nano-hydrogel drug delivery system based on lysine-modified poly (vinylcaprolactam).

BACKGROUND: Smart materials capable of responding to external stimuli are noteworthy candidates in designing drug delivery systems. In many of the recent research, temperature and pH have been recognized as the main stimulating factors in designing systems for anti-cancer drugs delivery systems. PURPOSE: In this study, thermo and pH-responsive character of a nano-carrier drug delivery platform based on lysine modified poly (vinylcaprolactam) hydrogel conjugated with doxorubicin was assessed. METHODS: Poly (vinylcaprolactam) cross-linked with poly (ethyleneglycol) diacrylate was prepared via RAFT polymerization, and the prepared structure was linked with lysine through ring-opening. The anti-cancer drug doxorubicin, was linked to lysine moiety of the prepared structure via Schiff-base reaction. The prepared platform was characterized by 1HNMR and FT-IR, while molecular weight characterization was performed by size exclusion chromatography. The temperature-responsive activity was evaluated using differential scanning calorimetry and dynamic light scattering. In vitro release pattern in simulated physiologic pH at 37°C was compared with acidic pH attributed to tumor site and elevated temperature. The anticancer efficiency of the drug-conjugated structure was evaluated in breast cancer cell line MCF-7 in 24 and 48 h, and cell uptake assay was performed on the same cell line. CONCLUSION: According to the results, well-structure defined smart pH and temperature responsive nano-hydrogel was prepared. The enhanced release rates are observed at acidic pH and elevated temperature. We have concluded that the doxorubicin-conjugated nanoparticle results in higher cellular uptakes and more cytotoxicity

N-Hydroxyphthalimide Anchored on Diamond Nanoparticles as a Selective Heterogeneous Metal-free Oxidation Catalyst of Benzylic Hydrocarbons and Cyclic Alkenes by Molecular O2

This is the peer reviewed version of the following article: Blandez, Juan F., Navalón Oltra, Sergio, Alvaro Rodríguez, Maria Mercedes, García Gómez, Hermenegildo. (2018). N-Hydroxyphthalimide Anchored on Diamond Nanoparticles as a Selective Heterogeneous Metal-free Oxidation Catalyst of Benzylic Hydrocarbons and Cyclic Alkenes by Molecular O2.ChemCatChem, 10, 1, 198-205. DOI: 10.1002/cctc.201700886 , which has been published in final form at http://doi.org/10.1002/cctc.201700886. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.[EN] N-hydroxyphthalimide (NHPI) derived from trimellitic anhydride has been covalently anchored (4wt%) through ester bonds to the surface of commercial diamond nanoparticles previously functionalized by chemical and thermal treatments (DH). IR spectroscopy of the NHPI/DH solid shows the presence of a characteristic peak at 1735cm(-1) attributable to the ester bond, while solid-state MAS (CNMR)-C-13 spectroscopy shows two broad bands corresponding to carbon atoms of carbonyl groups (167ppm) and aromatic carbons (127ppm). NHPI/DH promotes autoxidation of isobutylbenzene involving superoxide (O-2(.-)) and hydroperoxide (HOO) radicals; NHPI/DH can be reused at least three times and reach a minimum turnover number as high as 20600, which is probably due to the inertness of the diamond surface, allowing free diffusion of reactive oxygen species. Analogous materials in which NHPI was anchored on activated carbon and multiwall carbon nanotubes were inefficient as autoxidation catalysts. NHPI/DH is able to promote also selective aerobic oxidation of other benzylic hydrocarbons and cycloalkenes.Financial support by the Spanish Ministry of Economy and Competitiveness (Severo Ochoa and CTQ2015-69153-CO2-R1 and CTQ2014-53292-R and Generalitat Valenciana (Prometeo 2013/14) and is grateful acknowledged. S.N. is thankful for financial support by Fundacion Ramon Areces (XVIII Concurso Nacional, Ciencias de la Vida y de la Materia, Energia renovable: materiales y procesos 2016).Blandez, JF.; Navalón Oltra, S.; Alvaro Rodríguez, MM.; García Gómez, H. (2018). N-Hydroxyphthalimide Anchored on Diamond Nanoparticles as a Selective Heterogeneous Metal-free Oxidation Catalyst of Benzylic Hydrocarbons and Cyclic Alkenes by Molecular O2. ChemCatChem. 10(1):198-205. https://doi.org/10.1002/cctc.201700886S19820510