Influence of Olfactory Epithelium on Mitral/Tufted Cell Dendritic Outgrowth

Stereotypical connections between olfactory sensory neuron axons and mitral cell dendrites in the olfactory bulb establish the first synaptic relay for olfactory perception. While mechanisms of olfactory sensory axon targeting are reported, molecular regulation of mitral cell dendritic growth and refinement are unclear. During embryonic development, mitral cell dendritic distribution overlaps with olfactory sensory axon terminals in the olfactory bulb. In this study, we investigate whether olfactory sensory neurons in the olfactory epithelium influence mitral cell dendritic outgrowth in vitro. We report a soluble trophic activity in the olfactory epithelium conditioned medium which promotes mitral/tufted cell neurite outgrowth. While the trophic activity is present in both embryonic and postnatal olfactory epithelia, only embryonic but not postnatal mitral/tufted cells respond to this activity. We show that BMP2, 5 and 7 promote mitral/tufted cells neurite outgrowth. However, the BMP antagonist, Noggin, fails to neutralize the olfactory epithelium derived neurite growth promoting activity. We provide evidence that olfactory epithelium derived activity is a protein factor with molecular weight between 50–100 kD. We also observed that Follistatin can effectively neutralize the olfactory epithelium derived activity, suggesting that TGF-beta family proteins are involved to promote mitral/tufted dendritic elaboration

SKIM, a candidate satellite mission exploring global ocean currents and waves

The Sea surface KInematics Multiscale monitoring (SKIM) satellite mission is designed to explore ocean surface current and waves. This includes tropical currents, notably the poorly known patterns of divergence and their impact on the ocean heat budget, and monitoring of the emerging Arctic up to 82.5°N. SKIM will also make unprecedented direct measurements of strong currents, from boundary currents to the Antarctic circumpolar current, and their interaction with ocean waves with expected impacts on air-sea fluxes and extreme waves. For the first time, SKIM will directly measure the ocean surface current vector from space. The main instrument on SKIM is a Ka-band conically scanning, multi-beam Doppler radar altimeter/wave scatterometer that includes a state-of-the-art nadir beam comparable to the Poseidon-4 instrument on Sentinel 6. The well proven Doppler pulse-pair technique will give a surface drift velocity representative of the top meter of the ocean, after subtracting a large wave-induced contribution. Horizontal velocity components will be obtained with an accuracy better than 7 cm/s for horizontal wavelengths larger than 80 km and time resolutions larger than 15 days, with a mean revisit time of 4 days for of 99% of the global oceans. This will provide unique and innovative measurements that will further our understanding of the transports in the upper ocean layer, permanently distributing heat, carbon, plankton, and plastics. SKIM will also benefit from co-located measurements of water vapor, rain rate, sea ice concentration, and wind vectors provided by the European operational satellite MetOp-SG(B), allowing many joint analyses. SKIM is one of the two candidate satellite missions under development for ESA Earth Explorer 9. The other candidate is the Far infrared Radiation Understanding and Monitoring (FORUM). The final selection will be announced by September 2019, for a launch in the coming decade

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure

AN EXAMINATION OF BELIEF AND ATTITUDE BASED REPUTATION AND ITS IMPACT ON BEHAVIORAL CONSEQUENCES

The objective of this research is to ground the reputation construct in theory and to explore the formation of reputation through beliefs about the university and attitude toward the university. Additionally, it will allow for analysis of the consequences of reputation, specifically behavioral intentions, which has received limited attention in the extant literature. This study seeks a better understanding of the construct of reputation. Much of the existing literature on reputation has focused on measuring reputation. Earlier work identified reputation from a strategic perspective and more recently, studies have identified the importance of also understanding reputation from the stakeholder perspective. However, very few of either types of research have identified the theoretical foundation for the formation of reputation (Caruana, Cohen, & Krentler, 2006). There is also a paucity of research that examines the consequences or outcomes of reputation. This study will specifically examine the impact of university reputation on the behavioral consequences of prospective students. This study utilizes the theory of planned behavior (Fishbein & Ajzen, 1975) to identify how reputation is formed through beliefs about and attitude toward the organization that results in behavioral intentions. The proposed model for this study is an adaptation of the Fishbein and Ajzen (1975) model and the model presented by Money and Hillenbrand (2006). Respondents to the survey were prospective students at two universities in the southeastern United States. Results support the hypothesis that beliefs about the organization and attitude toward the organization are related. Multiple regression identified that emotional appeal, social and environmental responsibility and financial performance of the university were significant predictors for a student‟s likelihood of enrolling in the university

Assessing the Impact of University Reputation on Stakeholder Intentions

This article explores the concept of university reputation and its impact on stakeholder intentions. The authors seek a greater understanding of how different stakeholders perceive the reputation of universities. The literature dealing with identity, image and reputation is explored, as well as stakeholder theory, the measurement of reputation and various models of university reputation. The article concludes with a proposed model for testing the reputation of a university. A list of attributes that should be used to test stakeholder perceptions of university reputation is presented