1,428 research outputs found
Interconnect Challenges in Highly Integrated MEMS/ASIC Subsystems
Micromechanical devices like accelerometers or rotation sensors form an
increasing segment beneath the devices supplying the consumer market. A hybrid
integration approach to build smart sensor clusters for the precise detection
of movements in all spatial dimensions requires a large toolbox of interconnect
technologies, each with its own constraints regarding the total process
integration. Specific challenges described in this paper are post-CMOS
feedthroughs, front-to-front die contact arrays, vacuum-compliant lateral
interconnect and fine-pitch solder balling to finally form a Chip-Scale
System-in-Package (CSSiP).Comment: Submitted on behalf of EDA Publishing Association
(http://irevues.inist.fr/EDA-Publishing
Transmission of grapevine yellows by Oncopsis alni (Schrank) (Auchenorrhyncha: Macropsinae)
Research Not
An exact mathematical programming approach to multiple RNA sequence-structure alignment
One of the main tasks in computational biology is the computation of
alignments of genomic sequences to reveal their commonalities. In case of DNA
or protein sequences, sequence information alone is usually sufficient to
compute reliable alignments. RNA molecules, however, build spatial
conformations—the secondary structure—that are more conserved than the actual
sequence. Hence, computing reliable alignments of RNA molecules has to take
into account the secondary structure. We present a novel framework for the
computation of exact multiple sequence-structure alignments: We give a graph-
theoretic representation of the sequence-structure alignment problem and
phrase it as an integer linear program. We identify a class of constraints
that make the problem easier to solve and relax the original integer linear
program in a Lagrangian manner. Experiments on a recently published benchmark
show that our algorithms has a comparable performance than more costly dynamic
programming algorithms, and outperforms all other approaches in terms of
solution quality with an increasing number of input sequences
Accurate multiple sequence-structure alignment of RNA sequences using combinatorial optimization
Background: The discovery of functional non-coding RNA sequences has led to an increasing interest in algorithms related to RNA analysis. Traditional sequence alignment algorithms, however, fail at computing reliable alignments of low-homology RNA sequences. The spatial conformation of RNA sequences largely determines their function, and therefore RNA alignment algorithms have to take structural information into account. Results: We present a graph-based representation for sequence-structure alignments, which we model as an integer linear program (ILP). We sketch how we compute an optimal or near-optimal solution to the ILP using methods from combinatorial optimization, and present results on a recently published benchmark set for RNA alignments. Conclusions: The implementation of our algorithm yields better alignments in terms of two published scores than the other programs that we tested: This is especially the case with an increasing number of inpu
Antilope - A Lagrangian Relaxation Approach to the de novo Peptide Sequencing Problem
Peptide sequencing from mass spectrometry data is a key step in proteome
research. Especially de novo sequencing, the identification of a peptide from
its spectrum alone, is still a challenge even for state-of-the-art algorithmic
approaches. In this paper we present Antilope, a new fast and flexible approach
based on mathematical programming. It builds on the spectrum graph model and
works with a variety of scoring schemes. Antilope combines Lagrangian
relaxation for solving an integer linear programming formulation with an
adaptation of Yen's k shortest paths algorithm. It shows a significant
improvement in running time compared to mixed integer optimization and performs
at the same speed like other state-of-the-art tools. We also implemented a
generic probabilistic scoring scheme that can be trained automatically for a
dataset of annotated spectra and is independent of the mass spectrometer type.
Evaluations on benchmark data show that Antilope is competitive to the popular
state-of-the-art programs PepNovo and NovoHMM both in terms of run time and
accuracy. Furthermore, it offers increased flexibility in the number of
considered ion types. Antilope will be freely available as part of the open
source proteomics library OpenMS
High Resolution Photoemission Study on Low-T_K Ce Systems: Kondo Resonance, Crystal Field Structures, and their Temperature Dependence
We present a high-resolution photoemission study on the strongly correlated
Ce-compounds CeCu_6, CeCu_2Si_2, CeRu_2Si_2, CeNi_2Ge_2, and CeSi_2. Using a
normalization procedure based on a division by the Fermi-Dirac distribution we
get access to the spectral density of states up to an energy of 5 k_BT above
the Fermi energy E_F. Thus we can resolve the Kondo resonance and the crystal
field (CF) fine-structure for different temperatures above and around the Kondo
temperature T_K. The CF peaks are identified with multiple Kondo resonances
within the multiorbital Anderson impurity model. Our theoretical 4f spectra,
calculated from an extended non-crossing approximation (NCA), describe
consistently the observed photoemission features and their temperature
dependence. By fitting the NCA spectra to the experimental data and
extrapolating the former to low temperatures, T_K can be extracted
quantitatively. The resulting values for T_K and the crystal field energies are
in excellent agreement with the results from bulk sensitive measurements, e.g.
inelastic neutron scattering.Comment: 16 two-column pages, 10 figure
Local electronic structure of the peptide bond probed by resonant inelastic soft X-ray scattering.
The local valence orbital structure of solid glycine, diglycine, and triglycine is studied using soft X-ray emission spectroscopy (XES), resonant inelastic soft X-ray scattering (RIXS) maps, and spectra calculations based on density-functional theory. Using a building block approach, the contributions of the different functional groups of the peptides are separated. Cuts through the RIXS maps furthermore allow monitoring selective excitations of the amino and peptide functional units, leading to a modification of the currently established assignment of spectral contributions. The results thus paint a new-and-improved picture of the peptide bond, enhance the understanding of larger molecules with peptide bonds, and simplify the investigation of such molecules in aqueous environment
Социально-философский анализ процессов модернизации в Китайской Народной Республике
Проанализированы основные изменения, произошедшие в обществе, в политической системе Китая в связи с началом реформ и модернизации после прихода к власти Дэн Сяопина. Дан анализ основных положений программы модернизации, предложенной руководством КНР. Освещены теоретико-методологические предпосылки модернизации КНР. Выделены основные мировоззренческие и методологические элементы теории социализма с китайской специфики
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