Centre de Formentera: els inicis en qüestió de dependència

Fins ara l’atenció i els serveis sociosanitaris específics per a la tercera edat i els malalts crònics han estat gairebé inexistents a Formentera; el tipus d’assistència que s’ha donat ha estat majoritàriament d’ajuda o de suport mitjançant el curador informal. És un fet que els trets particulars que presenta Formentera plantegen unes necessitats especials; així, cal un esforç per aconseguir una equiparació en les prestacions i els serveis existents a la resta d’illes. La construcció d’un centre de dia suposa un pas important per superar aquesta mancança de recursos, i alhora és un projecte necessari i esperat a l’illa. Segons les dades demogràfiques, la de Formentera serà una població envellida; aquest centre garantirà a la població una millor qualitat d’atenció i de vida, donant resposta i cobertura a les necessitats de les persones dependents, amb serveis que, d’altra banda, són de primera necessitat. Aquest projecte suposa un repte tant institucional com professional. Les característiques de Formentera fan que el centre estigui plantejat per donar assistència als tres col·lectius més vulnerables i desprotegits: persones grans dependents, persones amb algun tipus de discapacitat i persones amb malaltia mental; d’aquesta manera ens trobam davant tres centres dins una mateixa instal·lació. Així, el Programa Bàsic del Centre s’inscriu dins una estratègia institucional dirigida a oferir un marc terapèutic que faciliti confiança i seguretat a l’usuari i que mitjançant el suport i l’ensenyament permeti treballar les capacitats conservades, millorant l’autonomia i alentint el procés de dependència. Cal destacar la novetat del recurs per als habitants de Formentera, juntament amb un factor cultural molt arrelat a l’illa, que estableix la cura de les persones grans a casa i sota la figura d’algun familiar. Malgrat això, les actuals previsions indiquen un debilitament d’aquesta xarxa de cures, circumstància que ve provocada per diversos factors: el canvi en el rol social de la dona, l’envelliment i augment de la fragilitat dels cuidadors, així com l’estrès del cuidador / la cuidadora, habitualment generat per una situació de cures llarga i intensa —i sovint difícil— en absència d’un suport adequat.Hasta ahora la atención y los servicios sociosanitarios específicos para la tercera edad y los enfermos crónicos han sido casi inexistentes en Formentera; el tipo de asistencia dirigida ha sido mayoritariamente de ayuda o apoyo mediante el cuidador informal. Es un hecho que las particulares condiciones que presenta la isla plantean unas necesidades especiales, así hace falta un esfuerzo para conseguir una equiparación en las prestaciones y servicios existentes en el resto de islas y donde la construcción de un centro de día en Formentera supone un paso importante para superar la carencia de recursos o estructuras sociosanitarias. Este Centro de día es un proyecto necesario y esperado en la isla, que prevé paliar el déficit sociosanitario existente hasta ahora. Según los datos demográficos, Formentera, en un futuro, será una población envejecida; este centro garantizará a la población una mejor calidad de atención y de vida, dando respuesta y cobertura a las necesidades de las persones dependientes con servicios que, por otro lado, son de primera necesidad. La puesta en marcha de este proyecto supone un reto tanto a nivel institucional como profesional. Las características de Formentera (tamaño, población, aislamiento, etc.), hacen que el proyecto de centro de día esté planteado para dar asistencia a los tres colectivos más vulnerables y desprotegidos: personas mayores dependientes, personas con algún tipo de discapacidad y personas con enfermedad mental, de este modo nos encontramos ante tres centros de día dentro de una misma instalación. Así, el Programa Básico del Centro se inscribe dentro de una estrategia institucional dirigida a ofrecer un marco terapéutico que facilite confianza y seguridad al usuario y que, a través del apoyo y la enseñanza, permita trabajar sobre las capacidades conservadas mejorando la autonomía y ralentizando el proceso de dependencia. También se tiene que destacar la novedad del recurso para los habitantes de la isla y un factor cultural muy arraigado en la población de Formentera que establece el cuidado de los mayores en casa y bajo la figura de algún familiar. Sin embargo, las actuales previsiones indican un debilitamiento de esta red de apoyo, circunstancia que viene provocada por varios factores: el cambio en el rol social de la mujer, el envejecimiento y aumento de la fragilidad de los cuidadores, así como el estrés del cuidador/a habitualmente generado por una situación de curas larga e intensa —y a menudo difícil— en ausencia de un apoyo adecuado

Gel-free/label-free analysis to study the proteome of botrytis cinerea

Comunicaciones a congreso

Acute stress assessment using infrared thermography in fattening rabbits reacting to handling under winter and summer conditions

Aim of study: This study assesses acute stress by measuring, through infrared thermography in summer and winter, the temperature of the eye, outer ear, inner ear and nose in 40 fattening rabbits before and after handling.Area of study: Seville (Spain).Material and methods: Body thermographic temperatures were recorded during a 38-day fattening period twice weekly and twice a day, before and after the handler held the rabbits in their arms for one minute. Ambient temperature and relative humidity were also recorded, and their influence on body temperatures was assessed. For each anatomical part, the variation of the temperature between the handled and undisturbed rabbit, and the differential temperature between the anatomical part in the undisturbed rabbit and the ambient temperature were calculated.Main results: The variation in temperatures between handled and undisturbed rabbits ranged from 0.25±0.041 ºC for eye to 3.09±0.221 ºC for outer ear in summer and -0.41±0.182 ºC for nose to 2.09±0.178 ºC for outer ear in winter. The day of the fattening period influenced all the temperature traits during summer and winter, except for the inner ear in winter. In summer, unlike winter, the temperature variation at the end of fattening period between handled and undisturbed rabbits was lower than at weaning (-0.04 to 1.94 ºC vs. 0.54 to 5.52 ºC, respectively). The temperatures in undisturbed rabbits were correlated with ambient temperature.Research highlights: Measuring body temperature with infrared thermography is a useful tool to evaluate acute stress in handled rabbits, with the inner ear and eye the most reliable body parts for measuring it

Analysis of the holm oak (Quercu Ilex subs ballota) pollen proteome by using NLC-MS/MS

Comunicaciones a congreso

COPD is a clear risk factor for increased use of resources and adverse outcomes in patients undergoing intervention for colorectal cancer: a nationwide study in Spain

We hypothesized that patients undergoing surgery for colorectal cancer (CRC) with COPD as a comorbidity would consume more resources and have worse in-hospital outcomes than similar patients without COPD. Therefore, we compared different aspects of the care process and short-term outcomes in patients undergoing surgery for CRC, with and without COPD. This was a prospective study and it included patients from 22 hospitals located in Spain - 472 patients with COPD and 2,276 patients without COPD undergoing surgery for CRC. Clinical variables, postintervention intensive care unit (ICU) admission, use of invasive mechanical ventilation, and postintervention antibiotic treatment or blood transfusion were compared between the two groups. The reintervention rate, presence and type of complications, length of stay, and in-hospital mortality were also estimated. Hazard ratio (HR) for hospital mortality was estimated by Cox regression models. COPD was associated with higher rates of in-hospital complications, ICU admission, antibiotic treatment, reinterventions, and mortality. Moreover, after adjusting for other factors, COPD remained clearly associated with higher and earlier in-hospital mortality. To reduce in-hospital morbidity and mortality in patients undergoing surgery for CRC and with COPD as a comorbidity, several aspects of perioperative management should be optimized and attention should be given to the usual comorbidities in these patients

A thermophysical study of the melting process in alkyl chain metal n-alkanoates: The thallium (I) series

The peculiar thermal behavior of the thallium(I) n-alkanoates series (consisting in several transitions between polymorphic and mesomorphic phases) in comparison with other metallic n-alkanoates series is stated. The allowance of highly accurate adiabatic heat capacity data permits a study of the CH2CH2 contributions to the lattice heat capacity curve at low temperature. Moreover, in this series an anomalous gradual enhancement of the lattice heat capacity has been interpreted from vibrational spectroscopy results as a noncooperative effect due to the internal hindered rotation of the alkyl chain (formation of gauche defects, even in the solid state). The thermodynamics of the “stepwise melting process” from the totally ordered solid at low temperature to the isotropic liquid is based on a revised lattice heat-capacity curve. This was used to evaluate the energy and entropy not only of the clear first order transitions present in the series but also of the described noncooperative effect. The CH2CH2 enthalpy and entropy contribution for this series is estimated and a comparison with the published values for other series is carried out. Moreover, the texture of the mesophases is revealed by polarized light microscopy. © 1999 American Institute of Physics.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/69602/2/JCPSA6-111-8-3590-1.pd

Mitochondrial toxicity and caspase activation in HIV pregnant women.

To assess the impact of HIV-infection and highly active anti-retroviral treatment in mitochondria and apoptotic activation of caspases during pregnancy and their association with adverse perinatal outcome. Changes of mitochondrial parameters and apoptotic caspase activation in maternal peripheral blood mononuclear cells were compared at first trimester of pregnancy and delivery in 27 HIV-infected and -treated pregnant women versus 24 uninfected pregnant controls. We correlated immunovirological, therapeutic and perinatal outcome with experimental findings: mitochondrial DNA (mtDNA) content, mitochondrial protein synthesis, mitochondrial function and apoptotic caspase activation. The HIV pregnancies showed increased adverse perinatal outcome (OR: 4.81 [1.14-20.16]; P < 0.05) and decreased mtDNA content (42.66 ± 5.94%, P < 0.01) compared to controls, even higher in naïve participants. This depletion caused a correlated decrease in mitochondrial protein synthesis (12.82 ± 5.73%, P < 0.01) and function (20.50 ± 10.14%, P < 0.001), not observed in controls. Along pregnancy, apoptotic caspase-3 activation increased 63.64 ± 45.45% in controls (P < 0.001) and 100.00 ± 47.37% in HIV-pregnancies (P < 0.001), in correlation with longer exposure to nucleoside analogues. HIV-infected women showed increased obstetric problems and declined genetic and functional mitochondrial parameters during pregnancy, especially those firstly exposed to anti-retrovirals. The apoptotic activation of caspases along pregnancy is emphasized in HIV pregnancies promoted by nucleoside analogues. However, we could not demonstrate direct mitochondrial or apoptotic implication in adverse obstetric outcome probably because of the reduced sample size

INRISCO: INcident monitoRing in Smart COmmunities

Major advances in information and communication technologies (ICTs) make citizens to be considered as sensors in motion. Carrying their mobile devices, moving in their connected vehicles or actively participating in social networks, citizens provide a wealth of information that, after properly processing, can support numerous applications for the benefit of the community. In the context of smart communities, the INRISCO [1] proposal intends for (i) the early detection of abnormal situations in cities (i.e., incidents), (ii) the analysis of whether, according to their impact, those incidents are really adverse for the community; and (iii) the automatic actuation by dissemination of appropriate information to citizens and authorities. Thus, INRISCO will identify and report on incidents in traffic (jam, accident) or public infrastructure (e.g., works, street cut), the occurrence of specific events that affect other citizens' life (e.g., demonstrations, concerts), or environmental problems (e.g., pollution, bad weather). It is of particular interest to this proposal the identification of incidents with a social and economic impact, which affects the quality of life of citizens.This work was supported in part by the Spanish Government through the projects INRISCO under Grant TEC2014-54335-C4-1-R, Grant TEC2014-54335-C4-2-R, Grant TEC2014-54335-C4-3-R, and Grant TEC2014-54335-C4-4-R, in part by the MAGOS under Grant TEC2017-84197-C4-1-R, Grant TEC2017-84197-C4-2-R, and Grant TEC2017-84197-C4-3-R, in part by the European Regional Development Fund (ERDF), and in part by the Galician Regional Government under agreement for funding the Atlantic Research Center for Information and Communication Technologies (AtlantTIC)

Nivolumab and sunitinib combination in advanced soft tissue sarcomas : A multicenter, single-arm, phase Ib/II trial

Sarcomas exhibit low expression of factors related to immune response, which could explain the modest activity of PD-1 inhibitors. A potential strategy to convert a cold into an inflamed microenvironment lies on a combination therapy. As tumor angiogenesis promotes immunosuppression, we designed a phase Ib/II trial to test the double inhibition of angiogenesis (sunitinib) and PD-1/PD-L1 axis (nivolumab). This single-arm, phase Ib/II trial enrolled adult patients with selected subtypes of sarcoma. Phase Ib established two dose levels: level 0 with sunitinib 37.5 mg daily from day 1, plus nivolumab 3 mg/kg intravenously on day 15, and then every 2 weeks; and level-1 with sunitinib 37.5 mg on the first 14 days (induction) and then 25 mg per day plus nivolumab on the same schedule. The primary endpoint was to determine the recommended dose for phase II (phase I) and the 6-month progression-free survival rate, according to Response Evaluation Criteria in Solid Tumors 1.1 (phase II). From May 2017 to April 2019, 68 patients were enrolled: 16 in phase Ib and 52 in phase II. The recommended dose of sunitinib for phase II was 37.5 mg as induction and then 25 mg in combination with nivolumab. After a median follow-up of 17 months (4-26), the 6-month progression-free survival rate was 48% (95% CI 41% to 55%). The most common grade 3-4 adverse events included transaminitis (17.3%) and neutropenia (11.5%). Sunitinib plus nivolumab is an active scheme with manageable toxicity in the treatment of selected patients with advanced soft tissue sarcoma, with almost half of patients free of progression at 6 months

Stochastic Approximation to Understand Simple Simulation Models

This paper illustrates how a deterministic approximation of a stochastic process can be usefully applied to analyse the dynamics of many simple simulation models. To demonstrate the type of results that can be obtained using this approximation, we present two illustrative examples which are meant to serve as methodological references for researchers exploring this area. Finally, we prove some convergence results for simulations of a family of evolutionary games, namely, intra-population imitation models in n-player games with arbitrary payoffs.Ministerio de Educación (JC2009- 00263), Ministerio de Ciencia e Innovación (CONSOLIDER-INGENIO 2010: CSD2010-00034, DPI2010-16920