Fluid technologies: The Bush Pump, the LifeStraw ® and microworlds of humanitarian design

Over the past decade, many ingenious, small-scale gadgets have appeared in response to problems of disaster and extreme poverty. Focusing on the LifeStraw ® , a water filtration device invented by the company Vestergaard Frandsen, I situate this wave of humanitarian design relative to Marianne de Laet and Annemarie Mol’s classic article on the Zimbabwe Bush Pump. The LifeStraw shares the Bush Pump’s principle of technical minimalism, as well as its ethical desire to improve the lives of communities. Unlike the pump, however, the straw defines itself through rather than against market logic, accepting the premise that one can ‘do well while doing good’. Moreover, it does not share the assumed framework of de Laet and Mol’s Zimbabwean socio-technical landscape: a postcolonial state happily en route to national self-definition. Nonetheless, it clearly embodies moral affect, if in the idiom of humanitarian concern rather than development. My aim is to open up three interrelated lines of inquiry for discussion. First, I consider aspects of a postcolonial condition at the micro-level of immediate needs, including assumptions about nation-state politics and markets. Second, I emphasize science and technology in the form of infrastructure, the material frontline of norms. Third, I return reflexively to love, and the complicated allure of engagement in academic work

Spectral analysis of 3D MHD models of coronal structures

We study extreme-ultraviolet emission line spectra derived from three-dimensional magnetohydrodynamic models of structures in the corona. In order to investigate the effects of increased magnetic activity at photospheric levels in a numerical experiment, a much higher magnetic flux density is applied at photospheric levels as compared to the Sun. Thus, we can expect our results to highlight the differences between the Sun and more active, but still solar-like stars. We discuss signatures seen in extreme-ultraviolet emission lines synthesized from these models and compare them to signatures found in the spatial distribution and temporal evolution of Doppler shifts in lines formed in the transition region and corona. This is of major interest to test the quality of the underlying magnetohydrodynamic model to heat the corona, i.e. currents in the corona driven by photospheric motions (flux braiding).Comment: 10 pages, 3 figure

Protein phosphatase 5 regulates titin phosphorylation and function at a sarcomere-associated mechanosensor complex in cardiomyocytes.

Serine/threonine protein phosphatase 5 (PP5) is ubiquitously expressed in eukaryotic cells; however, its function in cardiomyocytes is unknown. Under basal conditions, PP5 is autoinhibited, but enzymatic activity rises upon binding of specific factors, such as the chaperone Hsp90. Here we show that PP5 binds and dephosphorylates the elastic N2B-unique sequence (N2Bus) of titin in cardiomyocytes. Using various binding and phosphorylation tests, cell-culture manipulation, and transgenic mouse hearts, we demonstrate that PP5 associates with N2Bus in vitro and in sarcomeres and is antagonistic to several protein kinases, which phosphorylate N2Bus and lower titin-based passive tension. PP5 is pathologically elevated and likely contributes to hypo-phosphorylation of N2Bus in failing human hearts. Furthermore, Hsp90-activated PP5 interacts with components of a sarcomeric, N2Bus-associated, mechanosensor complex, and blocks mitogen-activated protein-kinase signaling in this complex. Our work establishes PP5 as a compartmentalized, well-controlled phosphatase in cardiomyocytes, which regulates titin properties and kinase signaling at the myofilaments

Ultraviolet Spectroscopy of Rapidly-Rotating Solar-Mass Stars: Emission Line Redshifts as a Test of the Solar-Stellar Connection

We compare high-resolution ultraviolet spectra of the Sun and thirteen solarmass main sequence stars with different rotational periods that serve as proxies for their different ages and magnetic field structures. In this the second paper in the series, we study the dependence of ultraviolet emission-line centroid velocities on stellar rotation period, as rotation rates decrease from that of the Pleiades star HII314 (Prot = 1.47 days) to Alpha Cen A (Prot = 28 days). Our stellar sample of F9 V to G5 V stars consists of six stars observed with the Cosmic Origins 1Guest Observer, NASA/ESA Hubble Space Telescope and User of the Data Archive at the Space Telescope Science Institute. Spectrograph on HST and eight stars observed with the Space Telescope Imaging Spectrograph on HST. We find a systematic trend of increasing redshift with more rapid rotation (decreasing rotation period) that is similar to the increase in line red shift between quiet and plage regions on the Sun. The fastest-rotating solar-mass star in our study, HII314, shows significantly enhanced redshifts at all temperatures above log T = 4.6, including the corona, which is very different from the redshift pattern observed in the more slowly-rotating stars. This difference in the redshift pattern suggests that a qualitative change in the magnetic-heating process occurs near Prot = 2 days. We propose that HII314 is an example of a solar-mass star with a magnetic heating rate too large for the physical processes responsible for the redshift pattern to operate in the same way as for the more slowly rotating stars. HII314 may therefore lie above the high activity end of the set of solar-like phenomena that is often called the "solar-stellar connection".Comment: 36 pages, 7 figures, 6 tables, to appear in the Astrophysical Journal July 201

The open question

The open question: Medical anthropology and open acces

Effect of Oral Iron Repletion on Exercise Capacity in Patients With Heart Failure With Reduced Ejection Fraction and Iron Deficiency: The IRONOUT HF Randomized Clinical Trial.

Importance: Iron deficiency is present in approximately 50% of patients with heart failure with reduced left ventricular ejection fraction (HFrEF) and is an independent predictor of reduced functional capacity and mortality. However, the efficacy of inexpensive readily available oral iron supplementation in heart failure is unknown. Objective: To test whether therapy with oral iron improves peak exercise capacity in patients with HFrEF and iron deficiency. Design, Setting, and Participants: Phase 2, double-blind, placebo-controlled randomized clinical trial of patients with HFrEF ( Interventions: Oral iron polysaccharide (n = 111) or placebo (n = 114), 150 mg twice daily for 16 weeks. Main Outcomes and Measures: The primary end point was a change in peak oxygen uptake (V̇o2) from baseline to 16 weeks. Secondary end points were change in 6-minute walk distance, plasma N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels, and health status as assessed by Kansas City Cardiomyopathy Questionnaire (KCCQ, range 0-100, higher scores reflect better quality of life). Results: Among 225 randomized participants (median age, 63 years; 36% women) 203 completed the study. The median baseline peak V̇o2 was 1196 mL/min (interquartile range [IQR], 887-1448 mL/min) in the oral iron group and 1167 mL/min (IQR, 887-1449 mL/min) in the placebo group. The primary end point, change in peak V̇o2 at 16 weeks, did not significantly differ between the oral iron and placebo groups (+23 mL/min vs -2 mL/min; difference, 21 mL/min [95% CI, -34 to +76 mL/min]; P = .46). Similarly, at 16 weeks, there were no significant differences between treatment groups in changes in 6-minute walk distance (-13 m; 95% CI, -32 to 6 m), NT-proBNP levels (159; 95% CI, -280 to 599 pg/mL), or KCCQ score (1; 95% CI, -2.4 to 4.4), all P \u3e .05. Conclusions and Relevance: Among participants with HFrEF with iron deficiency, high-dose oral iron did not improve exercise capacity over 16 weeks. These results do not support use of oral iron supplementation in patients with HFrEF. Trial Registration: clinicaltrials.gov Identifier: NCT02188784

Cosmic ray transport and anisotropies

We show that the large-scale cosmic ray anisotropy at ~10 TeV can be explained by a modified Compton-Getting effect in the magnetized flow field of old supernova remnants. This approach suggests an optimum energy scale for detecting the anisotropy. Two key assumptions are that propagation is based on turbulence following a Kolmogorov law and that cosmic ray interactions are dominated by transport through stellar winds of the exploding stars. A prediction is that the amplitude is smaller at lower energies due to incomplete sampling of the velocity field and also smaller at larger energies due to smearing.Comment: 6 pages, 1 figur

Driven Tunneling Dynamics: Bloch-Redfield Theory versus Path Integral Approach

In the regime of weak bath coupling and low temperature we demonstrate numerically for the spin-boson dynamics the equivalence between two widely used but seemingly different roads of approximation, namely the path integral approach and the Bloch-Redfield theory. The excellent agreement between these two methods is corroborated by a novel efficient analytical high-frequency approach: it well approximates the decay of quantum coherence via a series of damped coherent oscillations. Moreover, a suitably tuned control field can selectively enhance or suppress quantum coherence.Comment: 4 pages including 3 figures, submitted for publicatio

Spin conductance, dynamic spin stiffness and spin diffusion in itinerant magnets

We discuss analogies between the charge- and spin response functions of itinerant magnets. We show that the spin-analog of the charge stiffness is not given by the usual spin stiffness rho_s, but by the dynamic spin stiffness D_s, which is obtained from the dynamic spin conductance G_s (omega) in the limit of vanishing frequency omega. The low-frequency behavior of G_s (omega) is used to define ideal spin conductors, normal spin conductors, and spin insulators. Assuming diffusive spin dynamics, we show that the spin diffusion coefficient is proportional to lim_{omega rightarrow 0} {Re} {G}_s (omega). We exploit this fact to develop a new extrapolation scheme for the spin diffusion coefficient in the paramagnetic phase of the Hubbard model.Comment: Discussion of gauge invariance and difference between transverse and longitudinal response added. Accepted for publication in Phys. Rev.

Net community production in the North Atlantic Ocean derived from Volunteer Observing Ship data

The magnitude of marine plankton net community production (NCP) is indicative of both the biologically driven exchange of carbon dioxide between the atmosphere and the surface ocean and the export of organic carbon from the surface ocean to the ocean interior. In this study the seasonal variability in the NCP of five biogeochemical regions in the North Atlantic was determined from measurements of surface water dissolved oxygen and dissolved inorganic carbon (DIC) sampled from a Volunteer Observing Ship (VOS). The magnitude of NCP derived from dissolved oxygen measurements (NCPinline image) was consistent with previous geochemical estimates of NCP in the North Atlantic, with an average annual NCPinline image of 9.5 ± 6.5 mmol O2 m−2 d−1. Annual NCPinline image did not vary significantly over 35° of latitude and was not significantly different from NCP derived from DIC measurements (NCPDIC). The relatively simple method described here is applicable to any VOS route on which surface water dissolved oxygen concentrations can be accurately measured, thus providing estimates of NCP at higher spatial and temporal resolution than currently achieved