Определение расходных характеристик в технологических процессах с контролируемым давлением

Assessment of the environmental and economic performance of a safety valve requires information about the flow of the substance through the valve when it is actuated. The goal of this paper was to determine the flow rate of the discharged substance and the mass flow rate of the substance entering the safety valve when it is actuated. Proposed a mathematical model to describe the processes occurring in the valve. The model includes a system of differential equations describing the physical laws of conservation in the internal volume of the valve and differential equations, which link the value of gas flow through the valve with the pressure and the amount of movement of the shut-off disk. Used a modified method by S.K. Godunov to solve gasdynamic equations. Established that the determination of the flow and power characteristics of the valve requires the preliminary construction of a mathematical model of the safety valve operation. Based on this, proposed a method for determining the flow rate of the discharged substance and the mass rate of the substance entering the safety valve when it is actuated. Obtained the flow characteristics of the valves under review and the dynamics of movement of the shutoff disc of the valve, as well as the dependence of the pressure change on the opening time of the valve. Comparison of the calculated values with available experimental data gives good agreement of results (no more than 5.6 % for a gas flow rate, under 10 % for the movement of the valve and change the arrival of gas in time using the standard deviation function of the flow characteristics of 0.6 %), confirms the correctness of the defined mathematical model, used numerical schemes and algorithms, as well as the proposed method and recoverability of the arrival of gas in a pressure–time curve

Определение расходных характеристик в технологических процессах с контролируемым давлением

Assessment of the environmental and economic performance of a safety valve requires information about the flow of the substance through the valve when it is actuated. The goal of this paper was to determine the flow rate of the discharged substance and the mass flow rate of the substance entering the safety valve when it is actuated.Proposed a mathematical model to describe the processes occurring in the valve. The model includes a system of differential equations describing the physical laws of conservation in the internal volume of the valve and differential equations, which link the value of gas flow through the valve with the pressure and the amount of movement of the shut-off disk. Used a modified method by S.K. Godunov to solve gasdynamic equations.Established that the determination of the flow and power characteristics of the valve requires the preliminary construction of a mathematical model of the safety valve operation. Based on this, proposed a method for determining the flow rate of the discharged substance and the mass rate of the substance entering the safety valve when it is actuated.Obtained the flow characteristics of the valves under review and the dynamics of movement of the shutoff disc of the valve, as well as the dependence of the pressure change on the opening time of the valve. Comparison of the calculated values with available experimental data gives good agreement of results (no more than 5.6 % for a gas flow rate, under 10 % for the movement of the valve and change the arrival of gas in time using the standard deviation function of the flow characteristics of 0.6 %), confirms the correctness of the defined mathematical model, used numerical schemes and algorithms, as well as the proposed method and recoverability of the arrival of gas in a pressure–time curve.Оценка экологичности и экономичности работы предохранительного клапана требует информации о расходе вещества через клапан при его срабатывании. Целью данной работы являлось определение величины расхода сбрасываемого вещества и массовой скорости поступления вещества в предохранительный клапан при его срабатывании.Для описания процессов, протекающих в клапане, предложена математическая модель, включающая систему дифференциальных уравнений, описывающих физические законы сохранения во внутреннем объёме клапана и дифференциальные уравнения, связывающие величину расхода газа через клапан с давлением и величиной перемещения запорного диска. Для решения газодинамических уравнений применялся модифицированный метод С.К. Годунова.Установлено, что определение расходной и силовой характеристик клапана требует предварительного построения математической модели функционирования предохранительного клапана. На основании чего предложена методика определения величины расхода сбрасываемого вещества и массовой скорости поступления вещества в предохранительный клапан при его срабатывании.Получены расходные характеристики рассматриваемых клапанов и динамика перемещения запорного диска клапана, а также зависимость изменения давления от времени открытия клапана. Сопоставление расчётных значений с имеющимися экспериментальными данными даёт хорошее совпадение (не более 5,6 % для расхода газа, менее 10 % для перемещения клапана и изменения прихода газа во времени при среднеквадратичных отклонениях функции расходных характеристик 0,6 %) результатов, подтверждает корректность сформулированной математической модели, используемых численных схем и алгоритмов, предложенной методики и возможность восстановления прихода газа по кривой давление – время

EUV spectra of highly-charged ions W54+^{54+}-W63+^{63+} relevant to ITER diagnostics

We report the first measurements and detailed analysis of extreme ultraviolet (EUV) spectra (4 nm to 20 nm) of highly-charged tungsten ions W$^{54+}$ to W$^{63+}$ obtained with an electron beam ion trap (EBIT). Collisional-radiative modelling is used to identify strong electric-dipole and magnetic-dipole transitions in all ionization stages. These lines can be used for impurity transport studies and temperature diagnostics in fusion reactors, such as ITER. Identifications of prominent lines from several W ions were confirmed by measurement of isoelectronic EUV spectra of Hf, Ta, and Au. We also discuss the importance of charge exchange recombination for correct description of ionization balance in the EBIT plasma.Comment: 11 pages, 4 figure

Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells

The repertoire of extratranslational functions of components of the protein synthesis apparatus is expanding to include control of key cell signaling networks. However, very little is known about noncanonical functions of members of the protein synthesis machinery in regulating cellular mechanics. We demonstrate that the eukaryotic initiation factor 6 (eIF6) modulates cellular mechanobiology. eIF6-depleted endothelial cells, under basal conditions, exhibit unchanged nascent protein synthesis, polysome profiles, and cytoskeleton protein expression, with minimal effects on ribosomal biogenesis. In contrast, using traction force and atomic force microscopy, we show that loss of eIF6 leads to reduced stiffness and force generation accompanied by cytoskeletal and focal adhesion defects. Mechanistically, we show that eIF6 is required for the correct spatial mechanoactivation of ERK1/2 via stabilization of an eIF6-RACK1-ERK1/2-FAK mechanocomplex, which is necessary for force-induced remodeling. These results reveal an extratranslational function for eIF6 and a novel paradigm for how mechanotransduction, the cellular cytoskeleton, and protein translation constituents are linked

Understanding decisions about antibiotic prescribing in ICU: an application of the Necessity Concerns Framework

Background: Antibiotics are extensively prescribed in intensive care units (ICUs), yet little is known about how antibiotic-related decisions are made in this setting. We explored how beliefs, perceptions and contextual factors influenced ICU clinicians’ antibiotic prescribing. / Methods: We conducted 4 focus groups and 34 semistructured interviews with clinicians involved in antibiotic prescribing in four English ICUs. Focus groups explored factors influencing prescribing, whereas interviews examined decision-making processes using two clinical vignettes. Data were analysed using thematic analysis, applying the Necessity Concerns Framework. / Results: Clinicians’ antibiotic decisions were influenced by their judgement of the necessity for prescribing/not prescribing, relative to their concerns about potential adverse consequences. Antibiotic necessity perceptions were strongly influenced by beliefs that antibiotics would protect patients from deterioration and themselves from the ethical and legal consequences of undertreatment. Clinicians also reported concerns about prescribing antibiotics. These generally centred on antimicrobial resistance; however, protecting the individual patient was prioritised over these societal concerns. Few participants identified antibiotic toxicity concerns as a key influencer. Clinical uncertainty often complicated balancing antibiotic necessity against concerns. Decisions to start or continue antibiotics often represented ‘erring on the side of caution’ as a protective response in uncertainty. This approach was reinforced by previous experiences of negative consequences (‘being burnt’) which motivated prescribing ‘just in case’ of an infection. Prescribing decisions were also context-dependent, exemplified by a lower perceived threshold to prescribe antibiotics out-of-hours, input from external team members and local prescribing norms. / Conclusion: Efforts to improve antibiotic stewardship should consider clinicians’ desire to protect with a prescription. Rapid molecular microbiology, with appropriate communication, may diminish clinicians’ fears of not prescribing or of using narrower-spectrum antibiotics

Oscillator strengths with pseudopotentials

The time-dependent local-density approximation (TDLDA) is shown to remain accurate in describing the atomic response of IB elements under the additional approximation of using pseudopotentials to treat the effects of core electrons. This extends the work of Zangwill and Soven who showed the utility of the all-electron TDLDA in the atomic response problem.Comment: 13 pages including 3 Postscript figure

Social network analysis shows direct evidence for social transmission of tool use in wild chimpanzees

The authors are grateful to the Royal Zoological Society of Scotland for providing core funding for the Budongo Conservation Field Station. The fieldwork of CH was funded by the Leverhulme Trust, the Lucie Burgers Stichting, and the British Academy. TP was funded by the Canadian Research Chair in Continental Ecosystem Ecology, and received computational support from the Theoretical Ecosystem Ecology group at UQAR. The research leading to these results has received funding from the People Programme (Marie Curie Actions) and from the European Research Council under the European Union's Seventh Framework Programme (FP7/2007–2013) REA grant agreement n°329197 awarded to TG, ERC grant agreement n° 283871 awarded to KZ. WH was funded by a BBSRC grant (BB/I007997/1).Social network analysis methods have made it possible to test whether novel behaviors in animals spread through individual or social learning. To date, however, social network analysis of wild populations has been limited to static models that cannot precisely reflect the dynamics of learning, for instance, the impact of multiple observations across time. Here, we present a novel dynamic version of network analysis that is capable of capturing temporal aspects of acquisition-that is, how successive observations by an individual influence its acquisition of the novel behavior. We apply this model to studying the spread of two novel tool-use variants, "moss-sponging'' and "leaf-sponge re-use,'' in the Sonso chimpanzee community of Budongo Forest, Uganda. Chimpanzees are widely considered the most "cultural'' of all animal species, with 39 behaviors suspected as socially acquired, most of them in the domain of tool-use. The cultural hypothesis is supported by experimental data from captive chimpanzees and a range of observational data. However, for wild groups, there is still no direct experimental evidence for social learning, nor has there been any direct observation of social diffusion of behavioral innovations. Here, we tested both a static and a dynamic network model and found strong evidence that diffusion patterns of moss-sponging, but not leaf-sponge re-use, were significantly better explained by social than individual learning. The most conservative estimate of social transmission accounted for 85% of observed events, with an estimated 15-fold increase in learning rate for each time a novice observed an informed individual moss-sponging. We conclude that group-specific behavioral variants in wild chimpanzees can be socially learned, adding to the evidence that this prerequisite for culture originated in a common ancestor of great apes and humans, long before the advent of modern humans.Publisher PDFPeer reviewe

Theory and applications of atomic and ionic polarizabilities

Atomic polarization phenomena impinge upon a number of areas and processes in physics. The dielectric constant and refractive index of any gas are examples of macroscopic properties that are largely determined by the dipole polarizability. When it comes to microscopic phenomena, the existence of alkaline-earth anions and the recently discovered ability of positrons to bind to many atoms are predominantly due to the polarization interaction. An imperfect knowledge of atomic polarizabilities is presently looming as the largest source of uncertainty in the new generation of optical frequency standards. Accurate polarizabilities for the group I and II atoms and ions of the periodic table have recently become available by a variety of techniques. These include refined many-body perturbation theory and coupled-cluster calculations sometimes combined with precise experimental data for selected transitions, microwave spectroscopy of Rydberg atoms and ions, refractive index measurements in microwave cavities, ab initio calculations of atomic structures using explicitly correlated wave functions, interferometry with atom beams, and velocity changes of laser cooled atoms induced by an electric field. This review examines existing theoretical methods of determining atomic and ionic polarizabilities, and discusses their relevance to various applications with particular emphasis on cold-atom physics and the metrology of atomic frequency standards.Comment: Review paper, 44 page

CHIANTI - an Atomic Database for Emission Lines. Paper VI: Proton Rates and Other Improvements

The CHIANTI atomic database contains atomic energy levels, wavelengths, radiative transition probabilities and electron excitation data for a large number of ions of astrophysical interest. Version 4 has been released, and proton excitation data is now included, principally for ground configuration levels that are close in energy. The fitting procedure for excitation data, both electrons and protons, has been extended to allow 9 point spline fits in addition to the previous 5 point spline fits. This allows higher quality fits to data from close-coupling calculations where resonances can lead to significant structure in the Maxwellian-averaged collision strengths. The effects of photoexcitation and stimulated emission by a blackbody radiation field in a spherical geometry on the level balance equations of the CHIANTI ions can now be studied following modifications to the CHIANTI software. With the addition of H I, He I and N I, the first neutral species have been added to CHIANTI. Many updates to existing ion data-sets are described, while several new ions have been added to the database, including Ar IV, Fe VI and Ni XXI. The two-photon continuum is now included in the spectral synthesis routines, and a new code for calculating the relativistic free-free continuum has been added. The treatment of the free-bound continuum has also been updated.Comment: CHIANTI is available at http://wwwsolar.nrl.navy.mil/chianti.htm