An energy flow study of a double-deck tunnel under quasi-static and harmonic excitations

© 2016. This version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/This paper presents a comparison between the vibration energy flow radiated by a double-deck tunnel and the one radiated by a simple tunnel when both are excited by constant or by harmonic moving loads. For both cases, the radiated energy is computed using a three-dimensional semi-analytical model of the system. The total energy radiated upwards is presented for a wide range of load speeds, when a constant moving load is considered, and for a wide range of excitation frequencies, when the excitation is a harmonic moving load. Significant differences have been obtained, first, for constant loads moving at very high speeds and, second, for harmonic loads moving at typical speeds for underground trains.Peer ReviewedPostprint (author's final draft

Las Bases de datos multimedia revisadas

Se estudian las bases de datos multimedia en relación con la industria, los contenidos y el usuario multimedia, las políticas de desarrollo, el mercado, los soportes y el acceso, los contenidos y los sectores del mercado; con el almacenamiento masivo; con las aplicaciones a la documentación y la gestión de la información; y, en fin, con las aplicaciones a la formación y a la investigación en multimedia

Perspectiva

Treballs Finals de Grau de Matemàtiques, Facultat de Matemàtiques, Universitat de Barcelona, Any: 2017, Director: Eduard Casas AlveroSince before the Renaissance the rules for doing perspective drawings were known, obtaining representations of the reality just like a well placed observer’s eye would perceive it. We use our knowledge of extended projective geometry to study the basis of these rules. We obtain some of the basic properties of perspective drawings and learn how to construct simple examples. Finally, we apply this knowledge to a practical exercise, namely to study the perspective in some Canaletto’s paintings

Deciphering the crosstalk of the mTORC1 and MAPK networks in cancer

Signaal transductie is een process waarin signalen worden doorgegeven in een cell, resulterend in een gecoordineerde cellulaire respons. Externe signalen worden gedetecteerd door receptoren op het cell oppervlakte. Deze receptoren induceren een ketting reactie van intracellulaire biochemische gebeurtenissen dit wordt een signaal route genoemd. Wanneer signaal routes met elkaar interacteren vormen zij een netwerk, hierdoor kunnen verscheidene externe signalen geintegreerd worden en kunnen meerder cellulaire processens worden gereguleerd op een gecoordineerde manier.In kanker komt het vaak voor dat signaal routes ontregeld zijn zodat tumor cell ongecontroleerd kunnen groeien. De signaal routes die rondom de mammalian target of rapamycin (mTOR) en de mitogen-activated protein kinase (MAPK) zijn gesitueeerd bestaan uit twee grote kernpunten die gericht zijn op het controleren van groei, deze zijn dan ook vaak ontregeld in tumoren. Veel medicatie die wordt gebruikt in de kliniek of in klinische proeven richten zich dan ook op deze twee sleutel oncogene routes, ondanks beperkt succes. In mijn thesis focus ik op een beter begrip van de complexe communicatie van de mTOR en MAPK routes wat misschien bijdraagt aan kanker therapie resistentie. Mijn bevindingen dragen misschien bij aan het ontwerp van combinatie en meer effectieve kanker therapie strategieën.Signal transduction is the process by which signals are transmitted through a cell, resulting in a coordinated cellular response. External signals are detected by receptors at the cellular surface. These receptors induce a chain of intracellular biochemical events known as signaling pathways. When signaling pathways interact with each other they form networks, which enable the integration of multiple external inputs and the regulation of multiple cellular processes in a coordinated manner. In cancer, signaling pathways are often dysregulated such that tumor cells escape growth control. The signaling pathways centered on the mammalian target of rapamycin (mTOR) and the mitogen-activated protein kinase (MAPK) kinases constitute two major hubs of growth control, which are dysregulated in many tumour entities. Thus, many drugs that are in the clinics or in clinical trials target these two key oncogenic pathways, however only with limited success. In my thesis, I focus on a better understanding of the complex crosstalk of the mTOR and MAPK pathways, which may contribute to cancer therapy escape. My findings may contribute to the design of combinatorial and more effective cancer treatment strategies

A dynamical model of a double-deck circular tunnel embedded in a full-space

This thesis presents a three-dimensional dynamic model of a double-deck circular tunnel embedded in a full-space. The model uses the receptance method to obtain the response of the complete structure from the response of its parts. The considered subsystems are the interior floor and the tunnel-soil coupled system. The classical thin plate theory is considered to represent the behaviour of the first and the Pipe in Pipe model is chosen to describe the second. Because the complete model is assumed to be geometrically invariant in the train circulation direction, the coupling of both systems is performed in the wavenumber-frequency domain. After the model formulation, some important issues about its numerical computation are detailed and the obtained results are discussed. The response of a double-deck tunnel to a dynamic and to a quasistatic excitation is compared to the response obtained for a simple tunnel. The first comparison is done performing a power flow study of both tunnel structures when a harmonic line load is applied on them. The main differences between their radiation magnitudes and patterns are identified and discussed. The second comparison is done calculating the total amount of energy crossing a certain surface when a static load moving at a constant speed is considered. Results for a wide range of load speeds and radial distances are presented. A complete track-tunnel-soil model is finally obtained coupling a superstructure model to the interior floor model previously presented.Postprint (published version

De la puerta del sol a la plaza dignidad: participación cívica, impulso democrático y procesos formativos en las grandes movilizaciones ciudadanas

Este trabajo explora el modo en que se concretan los procesos de enseñanza-aprendizajeen las grandes movilizaciones ciudadanas y de qué manera aportan a la consolidación de una educación para la ciudadanía en la vertiente de educación no formal. La argumentación se apoya en dos investigaciones etnográficas realizadas sobre el Movimiento 15M y el Estallido social en Chile.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Dynamic response of a double-deck circular tunnel embedded in a full-space

© 2016. This version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/A three-dimensional dynamic model for calculating the ground-borne vibrations generated by harmonic loads applied on the interior floor of a double-deck circular tunnel is developed. The response of the system is obtained coupling the interior floor subsystem and the tunnel-soil subsystem in the wavenumber-frequency domain. The interior floor is modeled as a thin plate of infinite length in the train circulation direction and the tunnel-soil system is described using the Pipe in Pipe model. Some numerical instabilities of the resulting expressions are overcome by using analytic approximations. The results show that the dynamic behavior of the interior floor clearly influences the magnitude of the coupling loads acting on the tunnel structure. The soil response to a harmonic load acting on the double-deck tunnel is compared to the one obtained for the case of a simple tunnel finding significant differences between them for the whole range of frequencies studied. The proposed model extends the prediction of train-induced vibrations using computationally efficient models to this type of tunnel structure.Peer ReviewedPostprint (author's final draft

Introducción

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