Dealing With Digital Academic Dishonesty

For some time, universities have been concerned about digital academic dishonesty, particularly with respect to plagiarized term papers and reports. Recently, many universities have adopted classroom management software, such as Blackboard ™or WebCT™. These classroom management applications afford faculty and students many additional electronic capabilities, including easy posting of class notes or presentation files for downloading, collection of student assignments in digital drop boxes, online testing, chat rooms, and so forth. The inventive student intent on earning an acceptable course grade may use classroom management software, email, and the Web in ways that violate academic integrity standards. Now, in addition to the problem of electronically plagiarized term papers and reports, students are discovering ways to cheat in online and computer-based testing

Phase Stability and Segregation in Alloy 22 Base Metal and Weldments

The current design of the waste disposal containers relies heavily on encasement in a multi-layered container, featuring a corrosion barrier of Alloy 22, a Ni-Cr-Mo-W based alloy with excellent corrosion resistance over a wide range of conditions. The fundamental concern from the perspective of the Yucca Mountain Project, however, is the inherent uncertainty in the (very) long-term stability of the base metal and welds. Should the properties of the selected materials change over the long service life of the waste packages, it is conceivable that the desired performance characteristics (such as corrosion reistance) will become compromised, leading to premature failure of the system. To address this, we will study the phase stability and solute segregation characteristics of Alloy 22 base metal and welds. A better understanding of the underlying microstructural evolution tendencies, and their connections with corrosion behavior will (in turn) produce a higher confidence in the extrapolated behavior of the container materials over time periods that are not feasibly tested in a laboratory. Additionally, the knowledge gained here may potentially lead to cost savings through development of safe and realistic design constraints and model assumptions throughout the entire disposal system

Assessing the Performance and Risk-Adjusted Returns of Financial Mutual Funds

In this study, we provide a comprehensive examination of the performance of financial (specialty sector financial) mutual funds over a 23-year period, a much longer time frame than what has been analyzed in previous literature. To fully understand the performance of these mutual funds, we consider multiple factors, including risk-adjusted performance, both unconditional and conditional multifactor analysis, and market timing and selectivity. Financial mutual funds have higher risk-adjusted performance than the overall market and financial sector benchmarks. However, fund alphas are not different from zero, and managers do not exhibit market timing or security selection abilities. Our analysis not only includes the overall performance of these mutual funds, but we also delve into sub-samples before and after the 2008 financial crisis and during the recent Coronavirus pandemic

Environmental Effects on Corrosion Properties of Alloy 22

During the regulatory life of the Yucca Mountain High Level Nuclear Waste (HLNW) repository the primary engineered barrier that is to prevent release of radioactive material into the environment is proposed to be a Corrosion-Resistant Material (CRM) outer shell covering the Waste Package (WP) container. The current selection for the CRM is Alloy 22 (UNS N06022), a Ni-Cr-Mo-W-Fe alloy. Alloy 22 forms a defective chromic oxide passive film which results in excellent corrosion resistance; the presence of molybdenum in Alloy 22 offers corrosion resistance in reducing environments as well as oxidizing environments

A Heterodimer of Thioredoxin and IB2 Cooperates with Sec18p (NSF) to Promote Yeast Vacuole Inheritance

Early in S phase, the vacuole (lysosome) of Saccharomyces cerevisiae projects a stream of vesicles and membranous tubules into the bud where they fuse and establish the daughter vacuole. This inheritance reaction can be studied in vitro with isolated vacuoles. Rapid and efficient homotypic fusion between saltwashed vacuoles requires the addition of only two purified soluble proteins, Sec18p (NSF) and LMA1, a novel heterodimer with a thioredoxin subunit. We now report the identity of the second subunit of LMA1 as IB2, a previously identified cytosolic inhibitor of vacuolar proteinase B. Both subunits are needed for efficient vacuole inheritance in vivo and for the LMA1 activity in cell extracts. Each subunit acts via a novel mechanism, as the thioredoxin subunit is not acting through redox chemistry and LMA1 is still needed for the fusion of vacuoles which do not contain proteinase B. Both Sec18p and LMA1 act at an early stage of the in vitro reaction. Though LMA1 does not stimulate Sec18p-mediated Sec17p release, LMA1 cannot fulfill its function before Sec18p. Upon Sec17p/Sec18p action, vacuoles become labile but are rapidly stabilized by LMA1. The action of LMA1 and Sec18p is thus coupled and ordered. These data establish LMA1 as a novel factor in trafficking of yeast vacuoles

Conceptualising cultural ecosystem services: A novel framework for research and critical engagement

The construction of culture as a class of ecosystem service presents a significant test of the holistic ambitions of an ecosystems approach to decision making. In this paper we explore the theoretical challenges arising from efforts to understand ecosystems as objects of cultural concern and consider the operational complexities associated with understanding how, and with what consequences, knowledge about cultural ecosystem services are created, communicated and accounted for in real world decision making. We specifically forward and develop a conceptual framework for understanding cultural ecosystem services and related benefits in terms of the environmental spaces and cultural practices that arise from interactions between humans and ecosystems. The types of knowledge, and approaches to knowledge production, presumed by this relational, non-linear and place-based perspective on cultural ecosystem services are discussed and reviewed. The framework not only helps navigate more fully the challenge of operationalising ‘cultural ecosystem services’ but points to a more relational understanding of the ecosystem services framework as a whole. Extending and refining understanding through more ambitious engagements in interdisciplinarity remains important

A pulsed-laser calibration system for the laser backscatter diagnostics at the Omega laser

A calibration system has been developed that allows a direct determination of the sensitivity of the laser backscatter diagnostics at the Omega laser. A motorized mirror at the target location redirects individual pulses of a mJ-class laser onto the diagnostic to allow the in-situ measurement of the local point response of the backscatter diagnostics. Featuring dual wavelength capability at the 2nd and 3rd harmonic of the Nd:YAG laser, both spectral channels of the backscatter diagnostics can be directly calibrated. In addition, channel cross-talk and polarization sensitivity can be determined. The calibration system has been employed repeatedly over the last two years and has enabled precise backscatter measurements of both stimulated Brillouin scattering and stimulated Raman scattering in gas-filled hohlraum targets that emulate conditions relevant to those in inertial confinement fusion targets

55 Cancri: Stellar Astrophysical Parameters, a Planet in the Habitable Zone, and Implications for the Radius of a Transiting Super-Earth

The bright star 55 Cancri is known to host five planets, including a transiting super-Earth. The study presented here yields directly determined values for 55 Cnc's stellar astrophysical parameters based on improved interferometry: $R=0.943 \pm 0.010 R_{\odot}$, $T_{\rm EFF} = 5196 \pm 24$ K. We use isochrone fitting to determine 55 Cnc's age to be 10.2 $\pm$ 2.5 Gyr, implying a stellar mass of $0.905 \pm 0.015 M_{\odot}$. Our analysis of the location and extent of the system's habitable zone (0.67--1.32 AU) shows that planet f, with period $\sim$ 260 days and $M \sin i = 0.155 M_{Jupiter}$, spends the majority of the duration of its elliptical orbit in the circumstellar habitable zone. Though planet f is too massive to harbor liquid water on any planetary surface, we elaborate on the potential of alternative low-mass objects in planet f's vicinity: a large moon, and a low-mass planet on a dynamically stable orbit within the habitable zone. Finally, our direct value for 55 Cancri's stellar radius allows for a model-independent calculation of the physical diameter of the transiting super-Earth 55 Cnc e (\sim 2.05 \pm 0.15 R_{\earth}), which, depending on the planetary mass assumed, implies a bulk density of 0.76 \rho_{\earth} or 1.07 \rho_{\earth}.Comment: revised version after incorporating referee's comments and suggestions by members of the astronomical community; 7 pages, 4 figures, 2 tables; accepted for publication in Ap

Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts