97 research outputs found
Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects
Remote loading of liposomes with a <sup>124</sup>I-radioiodinated compound and their in vivo evaluation by PET/CT in a murine tumor model
Global patterns in endemicity and vulnerability of soil fungi
Fungi are highly diverse organisms, which provide multiple ecosystem services. However, compared with charismatic animals and plants, the distribution patterns and conservation needs of fungi have been little explored. Here, we examined endemicity patterns, global change vulnerability and conservation priority areas for functional groups of soil fungi based on six global surveys using a high-resolution, long-read metabarcoding approach. We found that the endemicity of all fungi and most functional groups peaks in tropical habitats, including Amazonia, Yucatan, West-Central Africa, Sri Lanka, and New Caledonia, with a negligible island effect compared with plants and animals. We also found that fungi are predominantly vulnerable to drought, heat and land-cover change, particularly in dry tropical regions with high human population density. Fungal conservation areas of highest priority include herbaceous wetlands, tropical forests, and woodlands. We stress that more attention should be focused on the conservation of fungi, especially root symbiotic arbuscular mycorrhizal and ectomycorrhizal fungi in tropical regions as well as unicellular early-diverging groups and macrofungi in general. Given the low overlap between the endemicity of fungi and macroorganisms, but high conservation needs in both groups, detailed analyses on distribution and conservation requirements are warranted for other microorganisms and soil organisms
Global patterns in endemicity and vulnerability of soil fungi
Fungi are highly diverse organisms, which provide multiple ecosystem services.
However, compared with charismatic animals and plants, the distribution patterns and
conservation needs of fungi have been little explored. Here, we examined endemicity
patterns, global change vulnerability and conservation priority areas for functional
groups of soil fungi based on six global surveys using a high-resolution, long-read metabarcoding approach. We found that the endemicity of all fungi and most functional
groups peaks in tropical habitats, including Amazonia, Yucatan, West-Central Africa,
Sri Lanka, and New Caledonia, with a negligible island effect compared with plants
and animals. We also found that fungi are predominantly vulnerable to drought, heat
and land-cover change, particularly in dry tropical regions with high human population
density. Fungal conservation areas of highest priority include herbaceous wetlands,
tropical forests, and woodlands. We stress that more attention should be focused on
the conservation of fungi, especially root symbiotic arbuscular mycorrhizal and ectomycorrhizal fungi in tropical regions as well as unicellular early-diverging groups and
macrofungi in general. Given the low overlap between the endemicity of fungi and
macroorganisms, but high conservation needs in both groups, detailed analyses on
distribution and conservation requirements are warranted for other microorganisms
and soil organisms
Novel Approach toward 3,3-Difluoropiperidines from Easily Available Starting Materials and Synthesis of a New Phosphodiesterase Inhibitor
Modulation of burst firing of neurons in nucleus reticularis of the thalamus by GluN2C-containing NMDA receptors
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