98 research outputs found
Lipodystrophy in HIV/AIDS patients with different levels of physical activity while on antiretroviral therapy
- Author
- Alexandre Martins Portelinha Filho
- Aline Francielle Mota Segatto
- Bedimo RJ
- Coll B
- Crum NC
- Diehl LA
- Domingo P
- Dulce Aparecida Barbosa
- Eidam CL
- Florindo AA
- Henrique Luiz Monteiro
- Ismael Forte Freitas Junior
- Kelly Cristina Pinto Alves
- La Perriere A
- Lichtenstein KA
- Lindegaard B
- Martinez E
- Miller J
- Mutimura E
- Mutimura E
- Mutimura E
- Nash D
- Palella FJ
- Perna FM
- Potthoff A
- RamĂrez-Marrero FA
- Robinson FP
- Sanches RS
- Sansores CC
- Santos CP
- Santos EC
- Seidl EM
- Sjöström M
- Terry L
- Thoni GJ
- Tien PC
- Vanessa Ribeiro dos Santos
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Photo-assisted electrochemical copper removal from cyanide solutions using porous TiO2 thin film photo-anodes
- Author
- Acevedo-Peña P
- Acevedo-Peña P
- Acevedo-Peña P
- Addamo M
- Alonso-GonzĂĄlez O
- Alonso-GonzĂĄlez O
- Arabatzis IM
- Arconada N
- Barakat MA
- Bockmeyer M
- Calvo ME
- Chen D
- Craig DQ
- Deepa M
- Dutra AJB
- Elcy M. CĂłrdoba
- Eun-Hee P
- Guo B
- Hidalgo MC
- Kallala M
- Kanki T
- Konstantinou IK
- Lee AC
- Liau LC-K
- López-Muñoz MJ
- Mathews NR
- Mechiakh R
- Mohammadi MR
- Mohammadi MR
- Mohammadu MR
- Negishi N
- Orendorz A
- Park S
- Pedraza-Avella JA
- Peralta-Ruiz YY
- Pineda Arellano CA
- Próspero Acevedo-Peña
- Puigdomenech I
- RamĂrez-Santos AA
- Sanchez C
- Seferlis AK
- Seferlis AK
- Sharma SD
- Sonawane RS
- Takahashi M
- Van Grieken R
- Vohra MS
- VĂĄzquez-Arenas J
- Ălvaro A. RamĂrez-Santos
- Äernigoj U
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
DNA damage by lipid peroxidation products: implications in cancer, inflammation and autoimmunity
- Author
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2017
- Field of study
Oxidative stress and lipid peroxidation (LPO) induced by inflammation, excess metal storage and excess caloric intake cause generalized DNA damage, producing genotoxic and mutagenic effects. The consequent deregulation of cell homeostasis is implicated in the pathogenesis of a number of malignancies and degenerative diseases. Reactive aldehydes produced by LPO, such as malondialdehyde, acrolein, crotonaldehyde and 4-hydroxy-2-nonenal, react with DNA bases, generating promutagenic exocyclic DNA adducts, which likely contribute to the mutagenic and carcinogenic effects associated with oxidative stress-induced LPO. However, reactive aldehydes, when added to tumor cells, can exert an anticancerous effect. They act, analogously to other chemotherapeutic drugs, by forming DNA adducts and, in this way, they drive the tumor cells toward apoptosis. The aldehyde-DNA adducts, which can be observed during inflammation, play an important role by inducing epigenetic changes which, in turn, can modulate the inflammatory process. The pathogenic role of the adducts formed by the products of LPO with biological macromolecules in the breaking of immunological tolerance to self antigens and in the development of autoimmunity has been supported by a wealth of evidence. The instrumental role of the adducts of reactive LPO products with self protein antigens in the sensitization of autoreactive cells to the respective unmodified proteins and in the intermolecular spreading of the autoimmune responses to aldehyde-modified and native DNA is well documented. In contrast, further investigation is required in order to establish whether the formation of adducts of LPO products with DNA might incite substantial immune responsivity and might be instrumental for the spreading of the immunological responses from aldehyde-modified DNA to native DNA and similarly modified, unmodified and/or structurally analogous self protein antigens, thus leading to autoimmunity
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
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- Alvarez J
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- Amargianitakis V
- Amaro R
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- ARIAM-ANDALUCIA
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- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
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- EscĂłrcio S
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- Espinasse F
- Espinel E
- Estagnasie P
- Esteban A
- Estella A
- Estenssoro E
- Evelein-Brugman S
- Facchin F
- Faivre V
- Fang M
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- Farias P
- Faulds MC
- Fave G
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- Feijoo AM
- Feliot E
- Ferez MA
- Fernandes MJ
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- Ferraz AB
- Ferrero-Calleja J
- Ferri F
- Ferry A
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- Fiks T
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- FilekoviÄ S
- Filho CA
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- FINNRESUSCI Study Group
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- Garrouste M
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- Hwang GS
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- Ibañes PG
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- Idei M
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- Idone FA
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- Janotka M
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- Jardim JJ
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- Javadpour S
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- Jiménez GJ
- Jo YH
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- Jonas M
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- Jonas M
- Jones C
- Joshi R
- Joshi V
- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
- Juan WC
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- Jung K
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- Kaczirek K
- Kaese S
- Kalani N
- Kalenka A
- Kalfon P
- Kamali E
- Kaminsky GE
- Kaneko M
- Kang M
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- Kang PL
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- Kao KC
- Kappler F
- Kara A
- Karachi F
- Karanjia N
- Karbing DS
- Karsten E
- Kasdan H
- Kashiya S
- Kashyap R
- Katabami K
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- Katabami K
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- Katira BH
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- Kawano S
- Kay FU
- Kayaaslan B
- Kayambu G
- Kazutoshi F
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- Kellner F
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- Kerhuel L
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- Khaliq W
- Khine H
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- Kirca H
- Kirman M
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- Kleinpell R
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- Kodate A
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- Kokkini S
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- Komuro T
- Kondili E
- Kongpolprom N
- Kooner G
- Kostalas M
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- Kou PS
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- Kwon HM
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- Lafaurie M
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- Lebherz-Eichinger D
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- Lebut J
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- Lissonde F
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- Lortat-Jacob B
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- Lukaszewicz AC
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- Pinsky M
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- SĂĄnchez MJ
- SĂĄnchez MJ
- SĂĄnchez MJ
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- SĂĄnchez PC
- SĂĄnchez PC
- SĂĄnchez-Elvira LA
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- Ălvarez JT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
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- Ahmed ZM
- Ahumada-Castro U
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- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-GĂłmez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
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- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
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- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
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- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
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- Baldari CT
- Balduini W
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- Yen PM
- Yi C
- Yi-Ren Hong C-WH
- Yin X-M
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- Zhang X
- Zhang X
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- Zhang Y
- Zhang Y
- Zhang Y
- Zhang Y
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- Zhang Y-Y
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- Zheng X-L
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- Zhong Q
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- Zhou Z-Y
- Zhu B
- Zhu C
- Zhu G-Q
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- Zhu H
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- Zhu W-G
- Zhu Y
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- Zhuang H
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- Zientara-Rytter K
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- Ziviani E
- Zoladek T
- Zong W-X
- Zorov DB
- Zorzano A
- Zou W
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- Zuryn S
- Zwerschke W
- Ălvarez ĂMC
- Ăvalos Y
- Ănal G
- ĂstĂŒn S
- ÄoliÄ M
- ÄokiÄ J
- Ćœerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Predictors of mortality among elderly dependent home care patients
- Author
- A Requeiro MartĂnez
- AA Ahmed
- AE Korten
- AlĂcia BorrĂ s Santos
- AM Albert
- BJ Braden
- BK Keller
- BM Buurman
- C van de Nadort
- Carlos Ascaso Terén
- D Zekry
- EC Carey
- Ester LimĂłn RamĂrez
- F Landi
- F Landri
- G Lewis
- G Vilagut
- GE Caughey
- J Gené Badia
- J Gené Badia
- J Gené-Badia
- J Librero
- J Martinez de la Iglesia
- J McCusker
- JM Morales-Asencio
- JM Mossey
- Joan Carles Contel Segura
- Joan Gené Badia
- KK Brody
- Laura Corredoira GonzĂĄlez
- M Bernabeu-Wittel
- M Buzziin
- M Kizuya
- ME Charlson
- MT AlarcĂłn
- MV AlcalĂĄ
- N Minicuci
- Pedro Gallo de Puelles
- PY Takahashi
- R Giannini
- RJ Gobbens
- SF Jencks
- WHO
- Y Lee
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Ecological scenario and Trypanosoma cruzi DTU characterization of a fatal acute Chagas disease case transmitted orally (EspĂrito Santo state, Brazil)
- Author
- A Fernandes
- A Marcili
- A Marcili
- A Marcili
- A Martinez-Perez
- A Ramos-Ligonio
- A Verma
- AA Nobrega
- AC Silveira
- AF Read
- AL Roque
- ALR Roque
- AM Jansen
- AM Jansen
- Ana Maria Jansen
- André Luiz Rodrigues Roque
- B Zingales
- B Zingales
- BA Noya de
- C Aliaga
- C GalvĂŁo
- CA Hoare
- CA Machado
- CAC AraĂșjo
- CB Santos
- CB Santos
- CB Santos
- CE Greer
- CI Cura
- CJ Marinkelle
- CJ Schofield
- CM Davies
- CM Morel
- CM Pinto
- CP Herrera
- CR Bonvicino
- CV Lisboa
- CV Lisboa
- CV Lisboa
- CV Lisboa
- DA DâĂvila
- DH Molyneux
- E Perez
- F Guhl
- F Guhl
- FL Rocha
- FY Maeda
- G Ibanez-Cervantes
- GA Vallejo
- GR Leite
- H Broutin
- H Lent
- HA Noyes
- ICL Acosta
- JA Dvorak
- JA Dvorak
- JC Mantilla
- JCP Dias
- JD RamĂrez
- JD RamĂrez
- JD RamĂrez
- JR Baker
- JR Coura
- Juliana Helena da Silva Barros
- K Martins
- K Rueda
- K Tamura
- L Lima
- L Lima
- L Mouton
- M Cavazzana Jr
- M Choisy
- M Rozas
- M Rozas
- M Yeo
- MA Shikanai-Yasuda
- MA Toso
- Maria Augusta Dario
- Marina Silva Rodrigues
- ME Camargo
- MF Bosseno
- MM Monje-Rumi
- MM Monje-Rumi
- MP Deane
- MP Oliveira
- MV Cardinal
- MY Feldman
- N Anez
- N Schweigmann
- N Yoshida
- N Yoshida
- NG Abolis
- O Fernandes
- P Truc
- PA Sessa
- Paulo SĂ©rgio DâAndrea
- PB Hamilton
- PP Joshi
- R Coura
- R Romero
- RA Gardner
- RA Gardner
- RS Sikes
- RV Monteiro
- RV Monteiro
- S Brisse
- S Gosh
- S Xavier
- SA Valente
- Samanta Cristina das Chagas Xavier
- SCC Xavier
- SE Goelz
- SF BreniĂšre
- SJ Westenberger
- SPC Novo
- TC Borghesan
- TC Gonçalves
- VC Vaz
- VS Lima
- VS Lima
- W Apt
- WM Monteiro
- WM Monteiro
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- AbellĂĄn Am
- AbellĂĄn Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
- Argenio G
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- Ashraf N
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- Atzeni J
- Avalapati H
- Avanzolini A
- Avanzolini A
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- AyllĂłn-GĂĄmez S
- Ayube-Brown J
- Azabdaftari A
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- Azevedo Jm
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- Baeza-Murcia M
- Bagga R
- Baginski A
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- Bailon-Cuadrado M
- Baird C
- Bairos F
- Baker B
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- Balasubramaniam A
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- Ballabio M
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- Barker T
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- Baseggio M
- Bastianpillai J
- Bawa S
- Baz-Figueroa C
- BazĂĄn-Hinojo Mc
- BazĂĄn-Hinojo Mc
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- Berry B
- Berti S
- Bevan Ke
- Bevan V
- Beverstock A
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- Bhanderi S
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- Bhangu A. Nepogodiev D
- Bhangu A
- Bhangu A
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- Biancafarina A
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- Borges Fc
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- Ferrer-Vilela I
- Fijo Lm
- Finch Jg
- Finlayson H
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- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16â45âyears presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which twoâthirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; Pâ<â0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cutâoff score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cutâoff score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decisionâmaking by identifying adults in the UK at low risk of appendicitis were identified
Modification of Ïc1(3872) and Ï(2S) production in pPb collisions at âsNN = 8.16 TeV
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- Xu A
- Xu J
- Xu L
- Xu L
- Xu M
- Xu Z
- Xu Z
- Xu Z
- Yang D
- Yang S
- Yang X
- Yang Y
- Yang Z
- Yang Z
- Yeroshenko V
- Yeung H
- Yin H
- Yu CY
- Yu J
- Yuan X
- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
- Zhang C
- Zhang D
- Zhang J
- Zhang L
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang YZ
- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng XZ
- Zheng Y
- Zhou T
- Zhou X
- Zhou Y
- Zhovkovska V
- Zhu LZ
- Zhu X
- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- American Physical Society
- Publication date
- 01/01/2024
- Field of study
The LHCb Collaboration measures production of the exotic hadron Ïc1(3872) in proton-nucleus collisions for the first time. Comparison with the charmonium state Ï(2S) suggests that the exotic Ïc1(3872) experiences different dynamics in the nuclear medium than conventional hadrons, and comparison with data from proton-proton collisions indicates that the presence of the nucleus may modify Ïc1(3872) production rates. This is the first measurement of the nuclear modification factor of an exotic hadron
Enhanced production of Îb0 baryons in high-multiplicity pp collisions at âs = 13 TeV
- Author
- Aaij R
- Abdelmotteleb ASW
- Abellan Beteta C
- Abudinén F
- Ackernley T
- Adeva B
- Adinolfi M
- Adlarson P
- Agapopoulou C
- Aidala CA
- Ajaltouni Z
- Akar S
- Akiba K
- Albicocco P
- Albrecht J
- Alessio F
- Alexander M
- Alfonso Albero A
- Aliouche Z
- Alvarez Cartelle P
- Amalric R
- Amato S
- Amey JL
- Amhis Y
- An L
- Anderlini L
- Andersson M
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- Konoplyannikov A
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- LHCb Collaboration
- Li A
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- Wislicki W
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- Wyllie K
- Xian S
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- Yeroshenko V
- Yeung H
- Yin H
- Yu CY
- Yu J
- Yuan X
- Zaffaroni E
- Zavertyaev M
- Zdybal M
- Zeng M
- Zhang C
- Zhang D
- Zhang J
- Zhang L
- Zhang S
- Zhang S
- Zhang Y
- Zhang Y
- Zhang YZ
- Zhao Y
- Zharkova A
- Zhelezov A
- Zheng XZ
- Zheng Y
- Zhou T
- Zhou X
- Zhou Y
- Zhovkovska V
- Zhu LZ
- Zhu X
- Zhu X
- Zhu Z
- Zhukov V
- Zhuo J
- Zou Q
- Zuliani D
- Zunica G
- Publication venue
- American Physical Society
- Publication date
- 01/01/2024
- Field of study
The production rate of
Î
0
b
baryons relative to
B
0
mesons in
p
p
collisions at a center-of-mass energy
â
s
=
13
â
â
TeV
is measured by the LHCb experiment. The ratio of
Î
0
b
to
B
0
production cross sections shows a significant dependence on both the transverse momentum and the measured charged-particle multiplicity. At low multiplicity, the ratio measured at LHCb is consistent with the value measured in
e
+
e
â
collisions, and increases by a factor of
âŒ
2
with increasing multiplicity. At relatively low transverse momentum, the ratio of
Î
0
b
to
B
0
cross sections is higher than what is measured in
e
+
e
â
collisions, but converges with the
e
+
e
â
ratio as the momentum increases. These results imply that the evolution of heavy
b
quarks into final-state hadrons is influenced by the density of the hadronic environment produced in the collision. Comparisons with several models and implications for the mechanisms enforcing quark confinement are discussed
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