Flood risk assessment for the Prut river hydrographic basin in Romania

The eastern part of Romania is frequently affected by floods. The flood regime in the Prut river catchment is characterised by short, high intensity intensity rainfall, coupled with low infiltration in the soil, that lead to flash floodings in the upland areas. The upper cathcment is controlled by the Stanca-Costesti reservoir that grately influences the flow regime and decreseas significantly the flood risk for the downstream areas. Significant floods were recorded during 2005 – 2020, with istoric maximum flows and total volumes. Through successive discharges of different downstream flows, safe transit of volumes was achieved, without endangering downstream objectives. This paper presents a comparative study of the maximum flows registered at the hydrometric stations and flood propagation times between the succesive control sections. In order to maintain the safe operation of the defense lines on the Prut River (the dykes), the personnel of Water Basinal Administration Prut – Barlad carried out immediate interventions at the critical points highlighted on the embankment network (infiltrations, erosions, areas under the projected elevation, under passages), depending on their seriousness and their negative effects. This paper can be used to further improve the existing basinal flood defence plans

Deriving a unit hydrograph for Tazlău River Basin using ArcGIS

Hydrographs are used in hydrological studies to illustrate the fluctuation of the stream during rainfall. A hydrograph's total flow includes runoff and base flow. The unit hydrograph (UH) only measures direct surface runoff. Modeling rain events by using unit hydrograph theory has the advantage of being easier to determine than hydraulic distributed modeling and can yield desirable outcomes for objectives of applied hydrology. The purpose of this research is to generate a unit hydrograph for a section of the Tazlău River Basin by utilizing the physical properties of its basin. For this purpose, parameters such as peak discharge, time to peak discharge and the base width of the unit hydrograph were determined. This research explored the use of Geographic Information System (GIS) and Digital Elevation Model (DEM) in the development of unit hydrograph. This research explored the use of GIS and Digital Elevation Model in the development of unit hydrograph for uses in streamflow predictions and rainfall runoff modeling. The most common uses after creating a unit hydrograph are designing flood prediction, which estimates flood flows in real time based on rainfall records, runoff assessment from ungauged watersheds and supplement the incomplete archives

[In Press] The adolescent peer relations instrument - bully/target : measurement invariance across gender, age, and clinical status

Adolescent Peer Relations Instrument–Bully/Target (APRI-BT) is a multidimensional scale designed to assess bullying involvement both as target and perpetrator. Although existing research has shown that the APRI-BT satisfies the assumption of measurement invariance across age and gender, these findings come from western individualistic countries (e.g., Australia). This study aimed to investigate the factorial structure and measurement invariance across age, gender, and clinical status in a sample of Romanian youths. Participants were 1,024 adolescents, 10 to 18 years, recruited from both community and clinical setting. Our results confirmed a six first-order factor structure and two second-order factors (Bully including Bullying Physical, Bullying Verbal, Bullying Social and Victimization including Physical Victimization, Verbal Victimization, Social Victimization). In addition, measurement invariance across age, gender, and clinical status was demonstrated. This study identifies APRI-BT as an instrument with solid psychometric proprieties for measuring bullying and victimization among preadolescents and adolescents

Retained Placenta Percreta with Acquired Uterine Arteriovenous Malformation—Case Report and Short Review of the Literature

Placenta accreta spectrum disorder (PAS) has an increased frequency due to the high number of cesarean sections. The abnormal placentation associated with a retained placenta can cause persistent uterine bleeding, with ultrasound Doppler examination being the main choice to assess the uterine hemorrhage. An acquired uterine arteriovenous malformation (AVM) may occur because of uterine trauma, spontaneous abortion, dilation and curettage, endometrial carcinoma or gestational trophoblastic disease. The treatment for abnormal placentation associated with AVM can be conservative, represented by methotrexate therapy, arterial embolization, uterine curettage, hysteroscopic loop resection or radical, which takes into consideration total hysterectomy. Therapeutic management always considers the degree of placental invasion, the patient hemodynamic state and fertility preservation. Considering the aspects described, we present a case of retained placenta percreta associated with acquired uterine AVM, with imagistic and clinical features suggestive of a gestational trophoblastic disease, successfully treated by hysterectomy, along with a small review of the literature, as only a few publications have reported a similar association of diagnostics and therapy

The Interplay between Tumour Microenvironment Components in Malignant Melanoma

Malignant melanoma has shown an increasing incidence during the last two decades, exhibiting a large spectrum of locations and clinicopathological characteristics. Although current histopathological, biochemical, immunohistochemical, and molecular methods provide a deep insight into its biological behaviour and outcome, melanoma is still an unpredictable disease, with poor outcome. This review of the literature is aimed at updating the knowledge regarding melanoma’s clinicopathological and molecular hallmarks, including its heterogeneity and plasticity, involving cancer stem cells population. A special focus is given on the interplay between different cellular components and their secretion products in melanoma, considering its contribution to tumour progression, invasion, metastasis, recurrences, and resistance to classical therapy. Furthermore, the influences of the specific tumour microenvironment or “inflammasome”, its association with adipose tissue products, including the release of “extracellular vesicles”, and distinct microbiota are currently studied, considering their influences on diagnosis and prognosis. An insight into melanoma’s particular features may reveal new molecular pathways which may be exploited in order to develop innovative therapeutic approaches or tailored therapy

A Real-Life Reproducibility Assessment for NMR Metabolomics

Nuclear magnetic resonance (NMR) metabolomics is currently popular enough to attract both specialized and non-specialized NMR groups involving both analytical trained personnel and newcomers, including undergraduate students. Recent interlaboratory studies performed by established NMR metabolomics groups demonstrated high reproducibility of the state-of-the-art NMR equipment and SOPs. There is, however, no assessment of NMR reproducibility when mixing both analytical experts and newcomers. An interlaboratory assessment of NMR quantitation reproducibility was performed using two NMR instruments belonging to different laboratories and involving several operators with different backgrounds and metabolomics expertise for the purpose of assessing the limiting factors for data reproducibility in a multipurpose NMR environment. The variability induced by the operator, automatic pipettes, NMR tubes and NMR instruments was evaluated in order to assess the limiting factors for quantitation reproducibility. The results estimated the expected reproducibility data in a real-life multipurpose NMR laboratory to a maximum 4% variability, demonstrating that the current NMR equipment and SOPs may compensate some of the operator-induced variability

A Prospective Study on the Progression, Recurrence, and Regression of Cervical Lesions: Assessing Various Screening Approaches

(1) Background: The prediction of cervical lesion evolution is a challenge for clinicians. This prospective study aimed to determine and compare the predictive accuracy of cytology, HPV genotyping, and p16/Ki67 dual staining alone or in combination with personal risk factors in the prediction of progression, regression, or persistence of cervical lesions in human papillomavirus (HPV)-infected patients; (2) Methods: This prospective study included HPV-positive patients with or without cervical lesions who underwent follow-up in a private clinic. We calculated the predictive performance of individual tests (cervical cytology, HPV genotyping, CINtecPlus results, and clinical risk factors) or their combination in the prediction of cervical lesion progression, regression, and persistence; (3) Results: The highest predictive performance for the progression of cervical lesions was achieved by a model comprising a Pap smear suggestive of high-grade squamous intraepithelial lesion (HSIL), the presence of 16/18 HPV strains, a positive p16/Ki67 dual staining result along with the presence of at least three clinical risk factors, which had a sensitivity (Se) of 74.42%, a specificity of 97.92%, an area under the receiver operating curve (AUC) of 0.961, and an accuracy of 90.65%. The prediction of cervical lesion regression or persistence was modest when using individual or combined tests; (4) Conclusions: Multiple testing or new biomarkers should be used to improve HPV-positive patient surveillance, especially for cervical lesion regression or persistence prediction