1,403 research outputs found
Replication confers β cell immaturity.
Pancreatic β cells are highly specialized to regulate systemic glucose levels by secreting insulin. In adults, increase in β-cell mass is limited due to brakes on cell replication. In contrast, proliferation is robust in neonatal β cells that are functionally immature as defined by a lower set point for glucose-stimulated insulin secretion. Here we show that β-cell proliferation and immaturity are linked by tuning expression of physiologically relevant, non-oncogenic levels of c-Myc. Adult β cells induced to replicate adopt gene expression and metabolic profiles resembling those of immature neonatal β that proliferate readily. We directly demonstrate that priming insulin-producing cells to enter the cell cycle promotes a functionally immature phenotype. We suggest that there exists a balance between mature functionality and the ability to expand, as the phenotypic state of the β cell reverts to a less functional one in response to proliferative cues
In search of the authentic nation: landscape and national identity in Canada and Switzerland
While the study of nationalism and national identity has flourished in the last decade, little attention has been devoted to the conditions under which natural environments acquire significance in definitions of nationhood. This article examines the identity-forming role of landscape depictions in two polyethnic nation-states: Canada and Switzerland. Two types of geographical national identity are identified. The first – what we call the ‘nationalisation of nature’– portrays zarticular landscapes as expressions of national authenticity. The second pattern – what we refer to as the ‘naturalisation of the nation’– rests upon a notion of geographical determinism that depicts specific landscapes as forces capable of determining national identity. The authors offer two reasons why the second pattern came to prevail in the cases under consideration: (1) the affinity between wild landscape and the Romantic ideal of pure, rugged nature, and (2) a divergence between the nationalist ideal of ethnic homogeneity and the polyethnic composition of the two societies under consideration
Recommended from our members
Barley production in Oregon
Published June 1938. Facts and recommendations in this publication may no longer be valid. Please look for up-to-date information in the OSU Extension Catalog: http://extension.oregonstate.edu/catalo
Recommended from our members
Analysis of electromagnetic scattering by nearly periodic structures: an LDRD report.
In this LDRD we examine techniques to analyze the electromagnetic scattering from structures that are nearly periodic. Nearly periodic could mean that one of the structure's unit cells is different from all the others--a defect. It could also mean that the structure is truncated, or butted up against another periodic structure to form a seam. Straightforward electromagnetic analysis of these nearly periodic structures requires us to grid the entire structure, which would overwhelm today's computers and the computers in the foreseeable future. In this report we will examine various approximations that allow us to continue to exploit some aspects of the structure's periodicity and thereby reduce the number of unknowns required for analysis. We will use the Green's Function Interpolation with a Fast Fourier Transform (GIFFT) to examine isolated defects both in the form of a source dipole over a meta-material slab and as a rotated dipole in a finite array of dipoles. We will look at the numerically exact solution of a one-dimensional seam. In order to solve a two-dimensional seam, we formulate an efficient way to calculate the Green's function of a 1d array of point sources. We next formulate ways of calculating the far-field due to a seam and due to array truncation based on both array theory and high-frequency asymptotic methods. We compare the high-frequency and GIFFT results. Finally, we use GIFFT to solve a simple, two-dimensional seam problem
The dominant ethnic moment: towards the abolition of 'whiteness'?
International audienc
Energy and system size dependence of \phi meson production in Cu+Cu and Au+Au collisions
We study the beam-energy and system-size dependence of \phi meson production
(using the hadronic decay mode \phi -- K+K-) by comparing the new results from
Cu+Cu collisions and previously reported Au+Au collisions at \sqrt{s_NN} = 62.4
and 200 GeV measured in the STAR experiment at RHIC. Data presented are from
mid-rapidity (|y|<0.5) for 0.4 < pT < 5 GeV/c. At a given beam energy, the
transverse momentum distributions for \phi mesons are observed to be similar in
yield and shape for Cu+Cu and Au+Au colliding systems with similar average
numbers of participating nucleons. The \phi meson yields in nucleus-nucleus
collisions, normalised by the average number of participating nucleons, are
found to be enhanced relative to those from p+p collisions with a different
trend compared to strange baryons. The enhancement for \phi mesons is observed
to be higher at \sqrt{s_NN} = 200 GeV compared to 62.4 GeV. These observations
for the produced \phi(s\bar{s}) mesons clearly suggest that, at these collision
energies, the source of enhancement of strange hadrons is related to the
formation of a dense partonic medium in high energy nucleus-nucleus collisions
and cannot be alone due to canonical suppression of their production in smaller
systems.Comment: 20 pages and 5 figure
Who Benefits From Teams? Comparing Workers, Supervisors, and Managers
This paper offers a political explanation for the diffusion and sustainability of team-based work systems by examining the differential outcomes of team structures for 1200 workers, supervisors, and middle managers in a large unionized telecommunications company. Regression analyses show that participation in self-managed teams is associated with significantly higher levels of perceived discretion, employment security, and satisfaction for workers and the opposite for supervisors. Middle managers who initiate team innovations report higher employment security, but otherwise are not significantly different from their counterparts who are not involved in innovations. By contrast, there are no significant outcomes for employees associated with their participation in offline problem-solving teams
MARVELS-1: A face-on double-lined binary star masquerading as a resonant planetary system; and consideration of rare false positives in radial velocity planet searches
We have analyzed new and previously published radial velocity observations of
MARVELS-1, known to have an ostensibly substellar companion in a ~6- day orbit.
We find significant (~100 m/s) residuals to the best-fit model for the
companion, and these residuals are naively consistent with an interior giant
planet with a P = 1.965d in a nearly perfect 3:1 period commensuribility
(|Pb/Pc - 3| < 10^{-4}). We have performed several tests for the reality of
such a companion, including a dynamical analysis, a search for photometric
variability, and a hunt for contaminating stellar spectra. We find many reasons
to be critical of a planetary interpretation, including the fact that most of
the three-body dynamical solutions are unstable. We find no evidence for
transits, and no evidence of stellar photometric variability. We have
discovered two apparent companions to MARVELS-1 with adaptive optics imaging at
Keck; both are M dwarfs, one is likely bound, and the other is likely a
foreground object. We explore false-alarm scenarios inspired by various
curiosities in the data. Ultimately, a line profile and bisector analysis lead
us to conclude that the ~100 m/s residuals are an artifact of spectral
contamination from a stellar companion contributing ~15-30% of the optical
light in the system. We conclude that origin of this contamination is the
previously detected radial velocity companion to MARVELS-1, which is not, as
previously reported, a brown dwarf, but in fact a G dwarf in a face-on orbit.Comment: ApJ 770, 119. 24 pp emulate ApJ style, 12 figures (One is very
large). v2: corrects two (important!) errors: A priori chance of this
alignment or worse is 0.1% (not 0.01%) and the primary has THREE total
companions (not four
- …