Rehabilitación de una vivienda unifamiliar con refuerzo estructural y calificación alta en Albacete

[ES] El siguiente trabajo final de grado se desarrolla en la modalidad de desarrollo de proyectos técnicos de construcción y se centrará en la rehabilitación de una vivienda unifamiliar con refuerzo estructural en la ciudad de Albacete con una calificación alta. Antes de comenzar con el desarrollo de este proyecto se realizará una breve introducción de la vivienda, describiendo su situación, emplazamiento, encuadramiento geográfico y su entorno. Con el desarrollo de esta rehabilitación se pretende hacer que la casa sea lo más sostenible posible y hacer, además, que alcance una eficiencia energética alta, logrando así disminuir su consumo energético. Para lograr este trabajo y cumplir con los objetivos propuestos, se buscará toda la información necesaria, estudiaremos todas las posibles soluciones de rehabilitación escogiendo la más adecuada para nuestra situación, y con ayuda de soportes informáticos se llevará a cabo esta propuesta de intervención. Para finalizar, se comprobará que tras la intervención, esta vivienda cumple con los requisitos de ahorro energético que exige la normativa vigente, realizando así su calificación energética que se comparará con su estado inicial, verificando así la mejora energética.[EN] The following final degree paperwork has been done following the approach normally used for the development of construction technical projects. It will be focusing in the rehabilitation process f or a house using structural reinforcement in Albacete with a high qualification. Before starting, there will be a brief introduction of the house, its situation, location, geographical framework and environment. With this rehabilitation process we intend to make the house as much sustainable as possible and to reach a high efficiency in terms of energy, achieving lower energy consumption. To accomplish this work and reach the goals we have set forth, we will seek all the necessary information and study every possible rehabilitation solution to choose the most suitable one for the situation described. After that we will make our intervention proposal aided by the adequate computer support. Finally, we will check if after intervening the house meets all the energy saving requirements established by current regulation , thus we will realize an energy rating and will compare it with its initial state, verifying the energy improvement.Rodriguez De Guzman Sanchez, C. (2015). Rehabilitación de una vivienda unifamiliar con refuerzo estructural y calificación alta en Albacete. http://hdl.handle.net/10251/54598.TFG

Cabbage and fermented vegetables : From death rate heterogeneity in countries to candidates for mitigation strategies of severe COVID-19

Large differences in COVID-19 death rates exist between countries and between regions of the same country. Some very low death rate countries such as Eastern Asia, Central Europe, or the Balkans have a common feature of eating large quantities of fermented foods. Although biases exist when examining ecological studies, fermented vegetables or cabbage have been associated with low death rates in European countries. SARS-CoV-2 binds to its receptor, the angiotensin-converting enzyme 2 (ACE2). As a result of SARS-CoV-2 binding, ACE2 downregulation enhances the angiotensin II receptor type 1 (AT(1)R) axis associated with oxidative stress. This leads to insulin resistance as well as lung and endothelial damage, two severe outcomes of COVID-19. The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is the most potent antioxidant in humans and can block in particular the AT(1)R axis. Cabbage contains precursors of sulforaphane, the most active natural activator of Nrf2. Fermented vegetables contain many lactobacilli, which are also potent Nrf2 activators. Three examples are: kimchi in Korea, westernized foods, and the slum paradox. It is proposed that fermented cabbage is a proof-of-concept of dietary manipulations that may enhance Nrf2-associated antioxidant effects, helpful in mitigating COVID-19 severity.Peer reviewe

Nrf2-interacting nutrients and COVID-19 : time for research to develop adaptation strategies

There are large between- and within-country variations in COVID-19 death rates. Some very low death rate settings such as Eastern Asia, Central Europe, the Balkans and Africa have a common feature of eating large quantities of fermented foods whose intake is associated with the activation of the Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) anti-oxidant transcription factor. There are many Nrf2-interacting nutrients (berberine, curcumin, epigallocatechin gallate, genistein, quercetin, resveratrol, sulforaphane) that all act similarly to reduce insulin resistance, endothelial damage, lung injury and cytokine storm. They also act on the same mechanisms (mTOR: Mammalian target of rapamycin, PPAR gamma:Peroxisome proliferator-activated receptor, NF kappa B: Nuclear factor kappa B, ERK: Extracellular signal-regulated kinases and eIF2 alpha:Elongation initiation factor 2 alpha). They may as a result be important in mitigating the severity of COVID-19, acting through the endoplasmic reticulum stress or ACE-Angiotensin-II-AT(1)R axis (AT(1)R) pathway. Many Nrf2-interacting nutrients are also interacting with TRPA1 and/or TRPV1. Interestingly, geographical areas with very low COVID-19 mortality are those with the lowest prevalence of obesity (Sub-Saharan Africa and Asia). It is tempting to propose that Nrf2-interacting foods and nutrients can re-balance insulin resistance and have a significant effect on COVID-19 severity. It is therefore possible that the intake of these foods may restore an optimal natural balance for the Nrf2 pathway and may be of interest in the mitigation of COVID-19 severity

Calificación, Valorización y Turismo. Aproximaciones al patrimonio agroalimentario

Libro científico sobre los espacios rurales y sus procesos de revalorización y resignificación en el siglo XXI.A partir de la segunda mitad del siglo XXI, los espacios rurales han transformado su estructura y funcionalidad de cara a las sociedades de consumo de la economía postindustrial. Al respecto, se ha generado un proceso de revalorización y resignificación del espacio rural que se centra en la atención sobre sus aspectos sociales, culturales, ecológicos, económicos y recreativos. En ese sentido, puede observarse la emergencia de algunas prácticas trasversales que se presentan como tendencias globales de la planificación, política y económica, de los espacios rurales y el aprovechamientos recreativos del capital natural y cultural del campo. La presente obra constituye un compendio de estudios de caso sobre los procesos de calificación, valorización y turistificación de ciertos recursos locales diferenciados, característicos del altiplano central mexicano. En este primer volumen se abordan los procesos de valorización y diversificación productiva de los recursos rurales, desde el enfoque turístico metodológico de los Sistemas Agroalimentarios Localizados (SIAL). Este es un trabajo colectivo que refleja los esfuerzos invertidos en los procesos de trasformación socioeconómica del espacio rural, gestados desde la Maestría en Agroindustria Rural, Desarrollo Territorial y Turismo Agroalimentario, de la Universidad Autónoma del Estado de México

International Nosocomial Infection Control Consortiu (INICC) report, data summary of 43 countries for 2007-2012. Device-associated module

We report the results of an International Nosocomial Infection Control Consortium (INICC) surveillance study from January 2007-December 2012 in 503 intensive care units (ICUs) in Latin America, Asia, Africa, and Europe. During the 6-year study using the Centers for Disease Control and Prevention's (CDC) U.S. National Healthcare Safety Network (NHSN) definitions for device-associated health care–associated infection (DA-HAI), we collected prospective data from 605,310 patients hospitalized in the INICC's ICUs for an aggregate of 3,338,396 days. Although device utilization in the INICC's ICUs was similar to that reported from ICUs in the U.S. in the CDC's NHSN, rates of device-associated nosocomial infection were higher in the ICUs of the INICC hospitals: the pooled rate of central line–associated bloodstream infection in the INICC's ICUs, 4.9 per 1,000 central line days, is nearly 5-fold higher than the 0.9 per 1,000 central line days reported from comparable U.S. ICUs. The overall rate of ventilator-associated pneumonia was also higher (16.8 vs 1.1 per 1,000 ventilator days) as was the rate of catheter-associated urinary tract infection (5.5 vs 1.3 per 1,000 catheter days). Frequencies of resistance of Pseudomonas isolates to amikacin (42.8% vs 10%) and imipenem (42.4% vs 26.1%) and Klebsiella pneumoniae isolates to ceftazidime (71.2% vs 28.8%) and imipenem (19.6% vs 12.8%) were also higher in the INICC's ICUs compared with the ICUs of the CDC's NHSN