Infrared study of transitional disks in Ophiuchus with Herschel

Context. Observations of nearby star-forming regions with the Herschel Space Observatory complement our view of the protoplanetary disks in Ophiuchus with information about the outer disks. Aims. The main goal of this project is to provide new far-infrared fluxes for the known disks in the core region of Ophiuchus and to identify potential transitional disks using data from Herschel. Methods. We obtained PACS and SPIRE photometry of previously spectroscopically confirmed young stellar objects (YSO) in the region and analysed their spectral energy distributions. Results. From an initial sample of 261 objects with spectral types in Ophiuchus, we detect 49 disks in at least one Herschel band. We provide new far-infrared fluxes for these objects. One of them is clearly a new transitional disk candidate. Conclusions. The data from Herschel Space Observatory provides fluxes that complement previous infrared data and that we use to identify a new transitional disk candidate.Comment: 21 pages, with 5 figures. Accepted in Astronomy & Astrophysic

A New Variational Association Process for the Verification of Geometrical Specifications”,

When this new association process of a datum is performed to verify a geometrical specification, measured points are considered as perturbations which generate modifications of the nominal geometry by variation of its location, orientation, and intrinsic dimensional characteristics, without requiring rotation and translation variables as the traditional methods usually do (Bourdet, et al., 1996, Advanced Mathematical Tools in Metrology II, World Scientific) with torsors or matrices. This new association process (Choley, 2005, Ph.D. thesis, Ecole Central, Paris; Choley, et al., 2006, Advanced Mathematica

Safety evaluation of food enzyme glucan 1,4-α-maltohydrolase produced with a genetically modified Bacillus subtilis (strain MAM)

Acknowledgements: The Panel wishes to thank the member of the Working Group on Applications: Davor Zeljezic for the preparatory work on this scientific output and EFSA staff members: Margarita Aguilera-Gomez and Magdalena Andryszkiewicz for the support provided to this scienti fic output.Publisher PD

Safety evaluation of the food enzyme α-amylase from a genetically modified Aspergillus niger (strain NZYM-SB)

Acknowledgements: The Panel wishes to thank EFSA staff members: Jaime Aguilera, Ana Gomes,Christine Horn, Joaquim Maia and Annamaria Rossi for the support provided to this scientic outputPublisher PD

The clinical significance of small copy number variants in neurodevelopmental disorders

BACKGROUND Despite abundant evidence for pathogenicity of large copy number variants (CNVs) in neurodevelopmental disorders (NDDs), the individual significance of genome-wide rare CNVs <500 kb has not been well elucidated in a clinical context. METHODS By high-resolution chromosomal microarray analysis, we investigated the clinical significance of all rare non-polymorphic exonic CNVs sizing 1-500 kb in a cohort of 714 patients with undiagnosed NDDs. RESULTS We detected 96 rare CNVs <500 kb affecting coding regions, of which 58 (60.4%) were confirmed. 6 of 14 confirmed de novo, one of two homozygous and four heterozygous inherited CNVs affected the known microdeletion regions 17q21.31, 16p11.2 and 2p21 or OMIM morbid genes (CASK, CREBBP, PAFAH1B1, SATB2; AUTS2, NRXN3, GRM8). Two further de novo CNVs affecting single genes (MED13L, CTNND2) were instrumental in delineating novel recurrent conditions. For the first time, we here report exonic deletions of CTNND2 causing low normal IQ with learning difficulties with or without autism spectrum disorder. Additionally, we discovered a homozygous out-of-frame deletion of ACOT7 associated with features comparable to the published mouse model. In total, 24.1% of the confirmed small CNVs were categorised as pathogenic or likely pathogenic (median size 130 kb), 17.2% as likely benign, 3.4% represented incidental findings and 55.2% remained unclear. CONCLUSIONS These results verify the diagnostic relevance of genome-wide rare CNVs <500 kb, which were found pathogenic in ∼2% (14/714) of cases (1.1% de novo, 0.3% homozygous, 0.6% inherited) and highlight their inherent potential for discovery of new conditions

Etude par spectrométrie mécanique isotherme à basse fréquence d'alliages CuAlNi et relation avec la microstructure

POITIERS-BU Sciences (861942102) / SudocSudocFranceF

Actes du congrès River Flow 2018

International audience250 papers250 communications : River Flow 2018 - 9th International Conference on Fluvial Hydraulics, 5-8 septembre 201

Actes du congrès River Flow 2018

International audience250 papers250 communications : River Flow 2018 - 9th International Conference on Fluvial Hydraulics, 5-8 septembre 201

Relations entre microstructure et spectrométrie mécanique à haute température dans un alliage de cuivre à oxydation interne

POITIERS-BU Sciences (861942102) / SudocSudocFranceF